IMP

Process View

Homo sapiens

13 genes annotated in human

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "embryonic skeletal system development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "embryonic skeletal system development" (in gray)

Name	Description	Probability	Func Analog Organism
COL1A1	collagen, type I, alpha 1	0.909
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.885	Mouse
HOXB5	homeobox B5	0.881	Mouse
FGF1	fibroblast growth factor 1 (acidic)	0.849
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.797
MEIS1	Meis homeobox 1	0.611	Zebrafish
TGFB1	transforming growth factor, beta 1	0.587
SMAD3	SMAD family member 3	0.570	Mouse
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.512
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.498
PBX1	pre-B-cell leukemia homeobox 1	0.493	Mouse
CREBBP	CREB binding protein	0.473
COL1A2	collagen, type I, alpha 2	0.437	Human
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.396	Mouse
HOXA10	homeobox A10	0.375
SMAD2	SMAD family member 2	0.348	Mouse
EP300	E1A binding protein p300	0.337
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.333
HOXA5	homeobox A5	0.327	Mouse
SMAD7	SMAD family member 7	0.302
HOXA11	homeobox A11	0.297	Mouse
RUNX1	runt-related transcription factor 1	0.278
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.225
HOXC8	homeobox C8	0.215
COL6A1	collagen, type VI, alpha 1	0.203
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.202
HOXB3	homeobox B3	0.186	Mouse
HOXB9	homeobox B9	0.180	Mouse
TAL1	T-cell acute lymphocytic leukemia 1	0.180	Human
FSTL1	follistatin-like 1	0.174
HOXB6	homeobox B6	0.167	Mouse
TRIP6	thyroid hormone receptor interactor 6	0.167
HOXA4	homeobox A4	0.163	Mouse
COL2A1	collagen, type II, alpha 1	0.157
ATN1	atrophin 1	0.152
TP53	tumor protein p53	0.122
HOXC6	homeobox C6	0.120	Mouse
LOX	lysyl oxidase	0.114
HOXA7	homeobox A7	0.109	Mouse
HOXA6	homeobox A6	0.107	Mouse
HOXD9	homeobox D9	0.106	Mouse
HOXC11	homeobox C11	0.098	Mouse
SIRT1	sirtuin 1	0.095
FZD1	frizzled homolog 1 (Drosophila)	0.095
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.094
MDFI	MyoD family inhibitor	0.091
PTCH1	patched 1	0.089
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.089
GATA4	GATA binding protein 4	0.083
POSTN	periostin, osteoblast specific factor	0.079
MEF2A	myocyte enhancer factor 2A	0.079
TGFB3	transforming growth factor, beta 3	0.076	Rat
COL3A1	collagen, type III, alpha 1	0.075	Human
COL11A1	collagen, type XI, alpha 1	0.074	Human Mouse
MEIS2	Meis homeobox 2	0.072
CBX8	chromobox homolog 8	0.070
TJP1	tight junction protein 1 (zona occludens 1)	0.069
CABP1	calcium binding protein 1	0.064
MYOD1	myogenic differentiation 1	0.064
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.063
HOXC10	homeobox C10	0.061
PDX1	pancreatic and duodenal homeobox 1	0.060
HOXD13	homeobox D13	0.059
HDAC4	histone deacetylase 4	0.059	Zebrafish
NCOA1	nuclear receptor coactivator 1	0.057
HOXB7	homeobox B7	0.057	Mouse
HOXA9	homeobox A9	0.056	Mouse
ADAM12	ADAM metallopeptidase domain 12	0.051
FEV	FEV (ETS oncogene family)	0.051
GATA2	GATA binding protein 2	0.051
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.051
CDK6	cyclin-dependent kinase 6	0.050
YAP1	Yes-associated protein 1	0.050
DLX4	distal-less homeobox 4	0.050
ADAM17	ADAM metallopeptidase domain 17	0.048
SMAD1	SMAD family member 1	0.047
NCOR1	nuclear receptor corepressor 1	0.047
PLCG1	phospholipase C, gamma 1	0.046
HOXA3	homeobox A3	0.046	Mouse
FGF18	fibroblast growth factor 18	0.046
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.046	Mouse
NCK2	NCK adaptor protein 2	0.046
HOXB13	homeobox B13	0.045
PAX2	paired box 2	0.044
FOXF2	forkhead box F2	0.044
COL5A1	collagen, type V, alpha 1	0.044	Human
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.042
PIAS1	protein inhibitor of activated STAT, 1	0.041
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.041
TWIST1	twist homolog 1 (Drosophila)	0.041
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.040
AR	androgen receptor	0.039
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.038
SETD8	SET domain containing (lysine methyltransferase) 8	0.037
PRRX2	paired related homeobox 2	0.037	Mouse
FGF3	fibroblast growth factor 3	0.036
HOXA2	homeobox A2	0.036	Human Mouse
DAXX	death-domain associated protein	0.036
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.036
BARX1	BARX homeobox 1	0.035
HOXD10	homeobox D10	0.035	Mouse
PTEN	phosphatase and tensin homolog	0.035
TCF12	transcription factor 12	0.034
HOXA13	homeobox A13	0.034
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.034
CDX2	caudal type homeobox 2	0.034
COL4A1	collagen, type IV, alpha 1	0.034
BGN	biglycan	0.033
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.033
TCF4	transcription factor 4	0.032
BMP2	bone morphogenetic protein 2	0.032
HOXB4	homeobox B4	0.032	Mouse
WISP1	WNT1 inducible signaling pathway protein 1	0.032
TRIM33	tripartite motif containing 33	0.032
DDR2	discoidin domain receptor tyrosine kinase 2	0.032
ENG	endoglin	0.032
FOXC1	forkhead box C1	0.031
VEZF1	vascular endothelial zinc finger 1	0.031
RING1	ring finger protein 1	0.031
HOXD3	homeobox D3	0.031	Mouse
ACAN	aggrecan	0.031
SIX6	SIX homeobox 6	0.031
SIX2	SIX homeobox 2	0.030	Mouse
FOXL1	forkhead box L1	0.030
SNAI1	snail homolog 1 (Drosophila)	0.030
SMAD4	SMAD family member 4	0.030
FBLN2	fibulin 2	0.029
NRP1	neuropilin 1	0.029
TBX2	T-box 2	0.029	Human
BMP4	bone morphogenetic protein 4	0.029	Mouse
LHX5	LIM homeobox 5	0.029
LBX1	ladybird homeobox 1	0.029
LUM	lumican	0.029
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.028
PDGFA	platelet-derived growth factor alpha polypeptide	0.028
MXRA5	matrix-remodelling associated 5	0.028
HOXC4	homeobox C4	0.027
GATA5	GATA binding protein 5	0.027
MBNL1	muscleblind-like (Drosophila)	0.027
SOX11	SRY (sex determining region Y)-box 11	0.026	Mouse
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.026
MSX1	msh homeobox 1	0.025
YY1	YY1 transcription factor	0.025
IGFBP5	insulin-like growth factor binding protein 5	0.025
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.024
HOXD11	homeobox D11	0.024	Mouse
RAX	retina and anterior neural fold homeobox	0.024
POU3F2	POU class 3 homeobox 2	0.023
FGF10	fibroblast growth factor 10	0.023
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.023
OTP	orthopedia homeobox	0.023
HAND2	heart and neural crest derivatives expressed 2	0.023	Human Zebrafish
PITX2	paired-like homeodomain 2	0.023	Zebrafish
FOXA2	forkhead box A2	0.023
HTT	huntingtin	0.022
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.022
HES2	hairy and enhancer of split 2 (Drosophila)	0.022
TBX5	T-box 5	0.022	Human
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.022
HOXC13	homeobox C13	0.021
TP63	tumor protein p63	0.021
SIM2	single-minded homolog 2 (Drosophila)	0.021
FZD8	frizzled homolog 8 (Drosophila)	0.021
HOXD12	homeobox D12	0.020
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.020
HOXC5	homeobox C5	0.020	Mouse
COL6A2	collagen, type VI, alpha 2	0.020
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.020
USP11	ubiquitin specific peptidase 11	0.019
SIX1	SIX homeobox 1	0.018	Mouse
COL5A2	collagen, type V, alpha 2	0.018	Human
KRT15	keratin 15	0.018
EYA2	eyes absent homolog 2 (Drosophila)	0.018
AQP5	aquaporin 5	0.017
WNT10A	wingless-type MMTV integration site family, member 10A	0.017	Human
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.017
HOXA1	homeobox A1	0.017
MSX2	msh homeobox 2	0.017
HMGA2	high mobility group AT-hook 2	0.017
WNT1	wingless-type MMTV integration site family, member 1	0.016	Human
POU4F2	POU class 4 homeobox 2	0.016
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.016
PHOX2A	paired-like homeobox 2a	0.016
NKX3-2	NK3 homeobox 2	0.016	Mouse
CBX4	chromobox homolog 4	0.016
RBPMS	RNA binding protein with multiple splicing	0.016
LAMB1	laminin, beta 1	0.016
GAS1	growth arrest-specific 1	0.016	Mouse
EDNRA	endothelin receptor type A	0.016
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.015
FGF8	fibroblast growth factor 8 (androgen-induced)	0.015
APC	adenomatous polyposis coli	0.015
CBX7	chromobox homolog 7	0.015
DLX5	distal-less homeobox 5	0.015
ECEL1	endothelin converting enzyme-like 1	0.015
COL16A1	collagen, type XVI, alpha 1	0.015
PUM2	pumilio homolog 2 (Drosophila)	0.015
SHOX2	short stature homeobox 2	0.015	Mouse
NCOA2	nuclear receptor coactivator 2	0.015
HIC1	hypermethylated in cancer 1	0.014
ALX4	ALX homeobox 4	0.014	Mouse
VAX2	ventral anterior homeobox 2	0.014
IRX5	iroquois homeobox 5	0.014
RRS1	RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)	0.014
HMX1	H6 family homeobox 1	0.014
TLX1	T-cell leukemia homeobox 1	0.014
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.014
FGF7	fibroblast growth factor 7	0.014
SH3BP4	SH3-domain binding protein 4	0.014
ALX3	ALX homeobox 3	0.014	Mouse
POU5F1	POU class 5 homeobox 1	0.014
FOXO1	forkhead box O1	0.014
WNT11	wingless-type MMTV integration site family, member 11	0.014
CREB1	cAMP responsive element binding protein 1	0.013
PBK	PDZ binding kinase	0.013
COL12A1	collagen, type XII, alpha 1	0.013
SOX1	SRY (sex determining region Y)-box 1	0.013
CRLF1	cytokine receptor-like factor 1	0.013
SFRP2	secreted frizzled-related protein 2	0.013
FZD10	frizzled homolog 10 (Drosophila)	0.013
HOXB8	homeobox B8	0.013	Mouse
BMP1	bone morphogenetic protein 1	0.013
PLXDC1	plexin domain containing 1	0.013
SFRP5	secreted frizzled-related protein 5	0.013
FOXE3	forkhead box E3	0.013
NID2	nidogen 2 (osteonidogen)	0.013
TBX1	T-box 1	0.012
PCGF2	polycomb group ring finger 2	0.012	Mouse
MNX1	motor neuron and pancreas homeobox 1	0.012
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.012
MEF2C	myocyte enhancer factor 2C	0.012	Mouse
PAX1	paired box 1	0.012
SFRP4	secreted frizzled-related protein 4	0.012
PXDN	peroxidasin homolog (Drosophila)	0.012
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.012
BNC1	basonuclin 1	0.011
FZD2	frizzled homolog 2 (Drosophila)	0.011
BHLHE23	basic helix-loop-helix family, member e23	0.011
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.011
UNC5B	unc-5 homolog B (C. elegans)	0.011
LHX3	LIM homeobox 3	0.011
SULF1	sulfatase 1	0.011	Mouse
BMPR1A	bone morphogenetic protein receptor, type IA	0.011
PAX8	paired box 8	0.011
ANGPTL2	angiopoietin-like 2	0.011
WNT6	wingless-type MMTV integration site family, member 6	0.011	Human
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.011
LRP6	low density lipoprotein receptor-related protein 6	0.011
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.011
HOXB1	homeobox B1	0.011	Human Mouse
IRX4	iroquois homeobox 4	0.010	Human
HCFC1	host cell factor C1 (VP16-accessory protein)	0.010
EFNB3	ephrin-B3	0.010
HOXC9	homeobox C9	0.010	Mouse
COL4A2	collagen, type IV, alpha 2	0.010
BCAR1	breast cancer anti-estrogen resistance 1	0.010
OCLN	occludin	0.010
NCOA6	nuclear receptor coactivator 6	0.010
SDC2	syndecan 2	0.010
GDF6	growth differentiation factor 6	0.010	Zebrafish
SIX3	SIX homeobox 3	0.010
BNC2	basonuclin 2	0.010
RARG	retinoic acid receptor, gamma	0.010
FKBP1A	FK506 binding protein 1A, 12kDa	0.010
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.010
IGFBP3	insulin-like growth factor binding protein 3	0.010
GSK3A	glycogen synthase kinase 3 alpha	0.010
TP73	tumor protein p73	0.010	Zebrafish
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.010
DIO3	deiodinase, iodothyronine, type III	0.010
FNDC1	fibronectin type III domain containing 1	0.010