IMP

Process View

Homo sapiens

15 genes annotated in human

response to corticosteroid

GO:0031960

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to corticosteroid"

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Name	Description	Probability	Func Analog Organism
CXCL2	chemokine (C-X-C motif) ligand 2	0.622	Rat
IL8	interleukin 8	0.605
ANXA1	annexin A1	0.479
ESR1	estrogen receptor 1	0.475
SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	0.471	Rat
SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	0.385	Rat
NRP1	neuropilin 1	0.382
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.345	Human
JUN	jun proto-oncogene	0.342
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.338	Human
RNF144B	ring finger protein 144B	0.333
EGFR	epidermal growth factor receptor	0.330
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.277	Rat
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.276
THBS1	thrombospondin 1	0.257
SULT1A4	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4	0.236	Rat
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.231	Rat
NOSTRIN	nitric oxide synthase trafficker	0.208
IL1R1	interleukin 1 receptor, type I	0.197
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.192	Rat
NCOA1	nuclear receptor coactivator 1	0.183
JAK2	Janus kinase 2	0.175	Mouse
CXCL3	chemokine (C-X-C motif) ligand 3	0.160	Rat
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.157	Rat
APAF1	apoptotic peptidase activating factor 1	0.144
CDK2	cyclin-dependent kinase 2	0.142
IL6	interleukin 6 (interferon, beta 2)	0.134
SCP2	sterol carrier protein 2	0.121
SOCS1	suppressor of cytokine signaling 1	0.116
DUSP1	dual specificity phosphatase 1	0.114	Rat
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.104
PLAU	plasminogen activator, urokinase	0.099
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.098
NRIP1	nuclear receptor interacting protein 1	0.092
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.089
PTPRB	protein tyrosine phosphatase, receptor type, B	0.080
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.080
JUNB	jun B proto-oncogene	0.079
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.078
C1QA	complement component 1, q subcomponent, A chain	0.075
XIAP	X-linked inhibitor of apoptosis	0.074
MYD88	myeloid differentiation primary response gene (88)	0.062
IQGAP1	IQ motif containing GTPase activating protein 1	0.062
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.060
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.060
IER3	immediate early response 3	0.059
ENG	endoglin	0.059
S100A10	S100 calcium binding protein A10	0.057
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.055
KLHL24	kelch-like 24 (Drosophila)	0.052
STAT5A	signal transducer and activator of transcription 5A	0.051
CCL2	chemokine (C-C motif) ligand 2	0.051
BCL2L1	BCL2-like 1	0.050
MAPK14	mitogen-activated protein kinase 14	0.049
COL1A2	collagen, type I, alpha 2	0.049
BCL2	B-cell CLL/lymphoma 2	0.048	Mouse Rat
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.046
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.046
PDCD6	programmed cell death 6	0.046
BCL3	B-cell CLL/lymphoma 3	0.045
CCND3	cyclin D3	0.044
EP300	E1A binding protein p300	0.043
CCR5	chemokine (C-C motif) receptor 5	0.042
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.041
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.041
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.041
IL10RA	interleukin 10 receptor, alpha	0.040
CRH	corticotropin releasing hormone	0.040	Rat
BBS1	Bardet-Biedl syndrome 1	0.039
APOA1	apolipoprotein A-I	0.037
RB1	retinoblastoma 1	0.036
CCL20	chemokine (C-C motif) ligand 20	0.036
CRHR1	corticotropin releasing hormone receptor 1	0.036	Human
PLAUR	plasminogen activator, urokinase receptor	0.036
ATF3	activating transcription factor 3	0.036
SMAD3	SMAD family member 3	0.035
EMP1	epithelial membrane protein 1	0.034
RARA	retinoic acid receptor, alpha	0.032
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.032
PLAT	plasminogen activator, tissue	0.031	Rat
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.030
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.029
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.029
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.029
EPOR	erythropoietin receptor	0.029
IGFBP3	insulin-like growth factor binding protein 3	0.028
RICTOR	RPTOR independent companion of MTOR, complex 2	0.028
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.027
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.027
MAPK8	mitogen-activated protein kinase 8	0.027
ANXA2	annexin A2	0.027	Human
ARRDC3	arrestin domain containing 3	0.027
BID	BH3 interacting domain death agonist	0.026
COL3A1	collagen, type III, alpha 1	0.025
S100A11	S100 calcium binding protein A11	0.024
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.023
PPP5C	protein phosphatase 5, catalytic subunit	0.023
VIM	vimentin	0.023
FYN	FYN oncogene related to SRC, FGR, YES	0.023
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.022
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.022
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.022	Rat
SOCS3	suppressor of cytokine signaling 3	0.022	Rat
TGFB3	transforming growth factor, beta 3	0.021
IRS1	insulin receptor substrate 1	0.021
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.020
HLA-DMB	major histocompatibility complex, class II, DM beta	0.020
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.020
ANXA5	annexin A5	0.020	Human
IL22RA1	interleukin 22 receptor, alpha 1	0.020
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.020
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.019
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.019
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.019
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.018
S100A4	S100 calcium binding protein A4	0.018
LAT	linker for activation of T cells	0.017
IER2	immediate early response 2	0.017
FAM107A	family with sequence similarity 107, member A	0.017
EGLN1	egl nine homolog 1 (C. elegans)	0.017
PDPK1	3-phosphoinositide dependent protein kinase-1	0.017
BAD	BCL2-associated agonist of cell death	0.016
LY96	lymphocyte antigen 96	0.016
EIF3F	eukaryotic translation initiation factor 3, subunit F	0.016
BCAR1	breast cancer anti-estrogen resistance 1	0.016
IGF1R	insulin-like growth factor 1 receptor	0.016
RUNX1	runt-related transcription factor 1	0.016
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.016
HAX1	HCLS1 associated protein X-1	0.015
MYLK2	myosin light chain kinase 2	0.015
EGR1	early growth response 1	0.015
AHR	aryl hydrocarbon receptor	0.015	Rat
CCL4	chemokine (C-C motif) ligand 4	0.015
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.015
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.015
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.015
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.014
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.014
S100A2	S100 calcium binding protein A2	0.014
MAPK3	mitogen-activated protein kinase 3	0.014
KCTD17	potassium channel tetramerisation domain containing 17	0.014
DUSP6	dual specificity phosphatase 6	0.013
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.013
TP53	tumor protein p53	0.013
CSF3	colony stimulating factor 3 (granulocyte)	0.013
AGXT2	alanine--glyoxylate aminotransferase 2	0.013
TICAM2	toll-like receptor adaptor molecule 2	0.013
PRDX1	peroxiredoxin 1	0.013
SKIL	SKI-like oncogene	0.013
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.013
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.013
INO80B	INO80 complex subunit B	0.012
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.012
CTTN	cortactin	0.012
GADD45B	growth arrest and DNA-damage-inducible, beta	0.012
APOB	apolipoprotein B (including Ag(x) antigen)	0.012
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.012	Rat
PGK1	phosphoglycerate kinase 1	0.012
CCND1	cyclin D1	0.012	Rat
SIRT2	sirtuin 2	0.012
EID1	EP300 interacting inhibitor of differentiation 1	0.012
UBE2L6	ubiquitin-conjugating enzyme E2L 6	0.012	Human
DARC	Duffy blood group, chemokine receptor	0.011
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.011	Rat
ARNT	aryl hydrocarbon receptor nuclear translocator	0.011
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.011
IL6R	interleukin 6 receptor	0.011	Rat
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.011
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.011	Rat
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.011
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.011
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.011
RNR2	l-rRNA	0.010
CXCL5	chemokine (C-X-C motif) ligand 5	0.010
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.010
JUND	jun D proto-oncogene	0.010
IL1R2	interleukin 1 receptor, type II	0.010
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.010