IMP
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negative regulation of keratinocyte differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of keratinocyte differentiation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Msx2 | homeobox, msh-like 2 | 0.960 | ||
| Pax3 | paired box gene 3 | 0.951 | ||
| Trp63 | transformation related protein 63 | 0.950 | ||
| Shh | sonic hedgehog | 0.916 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.870 | ||
| Pten | phosphatase and tensin homolog | 0.807 | ||
| Sox9 | SRY-box containing gene 9 | 0.714 | ||
| Prrx1 | paired related homeobox 1 | 0.427 | ||
| Dlx5 | distal-less homeobox 5 | 0.411 | ||
| Trp53 | transformation related protein 53 | 0.368 | Mouse | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.362 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.305 | ||
| Runx2 | runt related transcription factor 2 | 0.245 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.226 | ||
| Trp73 | transformation related protein 73 | 0.224 | Mouse | |
| Bmp7 | bone morphogenetic protein 7 | 0.213 | ||
| Hr | hairless | 0.205 | ||
| Chrd | chordin | 0.195 | ||
| Alx4 | aristaless-like homeobox 4 | 0.189 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.168 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.167 | ||
| Pax9 | paired box gene 9 | 0.167 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.163 | ||
| Egfr | epidermal growth factor receptor | 0.163 | ||
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.154 | ||
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.152 | ||
| Reg1 | regenerating islet-derived 1 | 0.146 | Mouse | |
| 2210010C04Rik | RIKEN cDNA 2210010C04 gene | 0.145 | ||
| Foxc1 | forkhead box C1 | 0.143 | ||
| Nog | noggin | 0.141 | ||
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.139 | ||
| Cdx2 | caudal type homeobox 2 | 0.117 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.115 | ||
| Reg2 | regenerating islet-derived 2 | 0.106 | Mouse | |
| Sfn | stratifin | 0.098 | ||
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.093 | ||
| Apc | adenomatosis polyposis coli | 0.091 | ||
| Zg16 | zymogen granule protein 16 | 0.090 | ||
| Reg3b | regenerating islet-derived 3 beta | 0.089 | Mouse | |
| Reg3g | regenerating islet-derived 3 gamma | 0.085 | ||
| Rara | retinoic acid receptor, alpha | 0.083 | ||
| Wnt3a | wingless-related MMTV integration site 3A | 0.074 | ||
| Reg3d | regenerating islet-derived 3 delta | 0.072 | Mouse | |
| Tbx3 | T-box 3 | 0.070 | ||
| Krt14 | keratin 14 | 0.070 | ||
| Dlx2 | distal-less homeobox 2 | 0.069 | ||
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.068 | ||
| Rxra | retinoid X receptor alpha | 0.068 | ||
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.067 | ||
| Alx1 | ALX homeobox 1 | 0.062 | ||
| Prss2 | protease, serine, 2 | 0.062 | ||
| Hoxa13 | homeobox A13 | 0.061 | ||
| Plac1 | placental specific protein 1 | 0.059 | ||
| Srsf2 | serine/arginine-rich splicing factor 2 | 0.059 | ||
| Sp6 | trans-acting transcription factor 6 | 0.057 | ||
| Dmbt1 | deleted in malignant brain tumors 1 | 0.057 | ||
| Gli2 | GLI-Kruppel family member GLI2 | 0.056 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.056 | ||
| Muc13 | mucin 13, epithelial transmembrane | 0.055 | ||
| Tcfap2a | transcription factor AP-2, alpha | 0.052 | ||
| Mmp7 | matrix metallopeptidase 7 | 0.052 | ||
| Prrx2 | paired related homeobox 2 | 0.050 | ||
| Pax6 | paired box gene 6 | 0.048 | ||
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.047 | ||
| Meox2 | mesenchyme homeobox 2 | 0.047 | ||
| Hnrpdl | heterogeneous nuclear ribonucleoprotein D-like | 0.046 | ||
| Gp2 | glycoprotein 2 (zymogen granule membrane) | 0.046 | ||
| Cdon | cell adhesion molecule-related/down-regulated by oncogenes | 0.046 | ||
| Smo | smoothened homolog (Drosophila) | 0.045 | ||
| Ms4a10 | membrane-spanning 4-domains, subfamily A, member 10 | 0.044 | ||
| Ins1 | insulin I | 0.043 | ||
| Fgf10 | fibroblast growth factor 10 | 0.041 | ||
| Prss32 | protease, serine, 32 | 0.041 | ||
| Cpa1 | carboxypeptidase A1 | 0.041 | ||
| Tff2 | trefoil factor 2 (spasmolytic protein 1) | 0.039 | ||
| Yap1 | yes-associated protein 1 | 0.039 | ||
| Sycn | syncollin | 0.039 | ||
| Itga3 | integrin alpha 3 | 0.039 | ||
| Tbx15 | T-box 15 | 0.039 | ||
| Reg3a | regenerating islet-derived 3 alpha | 0.038 | ||
| Pklr | pyruvate kinase liver and red blood cell | 0.038 | ||
| Elavl1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.038 | ||
| Gucy2c | guanylate cyclase 2c | 0.036 | ||
| Krt4 | keratin 4 | 0.034 | ||
| Rb1 | retinoblastoma 1 | 0.033 | ||
| Tff3 | trefoil factor 3, intestinal | 0.033 | ||
| Il10 | interleukin 10 | 0.033 | ||
| Ptf1a | pancreas specific transcription factor, 1a | 0.032 | ||
| Hnrnph1 | heterogeneous nuclear ribonucleoprotein H1 | 0.032 | ||
| Gsc | goosecoid homeobox | 0.031 | ||
| Fut2 | fucosyltransferase 2 | 0.031 | ||
| Gpr87 | G protein-coupled receptor 87 | 0.031 | ||
| Rnase1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.030 | ||
| Foxe3 | forkhead box E3 | 0.030 | ||
| Dsc3 | desmocollin 3 | 0.029 | ||
| Ptch1 | patched homolog 1 | 0.029 | ||
| Braf | Braf transforming gene | 0.029 | ||
| Hoxa2 | homeobox A2 | 0.028 | ||
| Chuk | conserved helix-loop-helix ubiquitous kinase | 0.028 | ||
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.028 | ||
| 1810030J14Rik | RIKEN cDNA 1810030J14 gene | 0.028 | ||
| Clps | colipase, pancreatic | 0.028 | ||
| Etv4 | ets variant gene 4 (E1A enhancer binding protein, E1AF) | 0.027 | ||
| Huwe1 | HECT, UBA and WWE domain containing 1 | 0.027 | ||
| Defa-rs12 | defensin, alpha, related sequence 12 | 0.027 | ||
| Hsd17b13 | hydroxysteroid (17-beta) dehydrogenase 13 | 0.026 | ||
| Krt32 | keratin 32 | 0.025 | ||
| Krtap3-1 | keratin associated protein 3-1 | 0.024 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.024 | ||
| Crb3 | crumbs homolog 3 (Drosophila) | 0.024 | ||
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.024 | ||
| Amelx | amelogenin X chromosome | 0.024 | ||
| Cuzd1 | CUB and zona pellucida-like domains 1 | 0.024 | ||
| Irf6 | interferon regulatory factor 6 | 0.023 | ||
| Nodal | nodal | 0.023 | ||
| Smn1 | survival motor neuron 1 | 0.023 | ||
| Galr1 | galanin receptor 1 | 0.023 | ||
| Prss29 | protease, serine, 29 | 0.023 | ||
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.023 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.023 | ||
| Rnase4 | ribonuclease, RNase A family 4 | 0.022 | ||
| Gata5 | GATA binding protein 5 | 0.022 | ||
| Defa-rs2 | defensin, alpha, related sequence 2 | 0.022 | ||
| Pnliprp1 | pancreatic lipase related protein 1 | 0.022 | ||
| Ropn1 | ropporin, rhophilin associated protein 1 | 0.022 | ||
| Ces4a | carboxylesterase 4A | 0.022 | ||
| Sel1l2 | sel-1 suppressor of lin-12-like 2 (C. elegans) | 0.022 | ||
| Tial1 | Tia1 cytotoxic granule-associated RNA binding protein-like 1 | 0.021 | ||
| Sry | sex determining region of Chr Y | 0.020 | ||
| Pla2g2a | phospholipase A2, group IIA (platelets, synovial fluid) | 0.020 | ||
| Nxf1 | nuclear RNA export factor 1 homolog (S. cerevisiae) | 0.020 | ||
| Krt27 | keratin 27 | 0.019 | ||
| Vmn1r65 | vomeronasal 1 receptor 65 | 0.019 | ||
| Ctrc | chymotrypsin C (caldecrin) | 0.019 | ||
| Krtap16-4 | keratin associated protein 16-4 | 0.019 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.019 | ||
| Pax4 | paired box gene 4 | 0.019 | ||
| Gast | gastrin | 0.019 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.019 | ||
| Ins2 | insulin II | 0.018 | ||
| Serpini2 | serine (or cysteine) peptidase inhibitor, clade I, member 2 | 0.018 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.018 | ||
| Hoxc9 | homeobox C9 | 0.018 | ||
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.018 | ||
| Psen1 | presenilin 1 | 0.018 | ||
| Defa-rs1 | defensin, alpha, related sequence 1 | 0.018 | ||
| Klk1b24 | kallikrein 1-related peptidase b24 | 0.018 | ||
| Alx3 | aristaless-like homeobox 3 | 0.018 | ||
| Gja1 | gap junction protein, alpha 1 | 0.018 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.018 | ||
| Pla2g2d | phospholipase A2, group IID | 0.018 | ||
| Hhat | hedgehog acyltransferase | 0.018 | ||
| Nlrp6 | NLR family, pyrin domain containing 6 | 0.017 | ||
| Rag1 | recombination activating gene 1 | 0.017 | ||
| Krt6a | keratin 6A | 0.017 | ||
| Tardbp | TAR DNA binding protein | 0.017 | ||
| Wnt11 | wingless-related MMTV integration site 11 | 0.017 | ||
| 2210407C18Rik | RIKEN cDNA 2210407C18 gene | 0.017 | ||
| Bhlha15 | basic helix-loop-helix family, member a15 | 0.017 | ||
| 9930023K05Rik | RIKEN cDNA 9930023K05 gene | 0.017 | ||
| Olfr480 | olfactory receptor 480 | 0.017 | ||
| Tshz1 | teashirt zinc finger family member 1 | 0.017 | ||
| Ahr | aryl-hydrocarbon receptor | 0.016 | ||
| Aicda | activation-induced cytidine deaminase | 0.016 | ||
| Gabrp | gamma-aminobutyric acid (GABA) A receptor, pi | 0.016 | ||
| Epha1 | Eph receptor A1 | 0.016 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.016 | ||
| Foxn1 | forkhead box N1 | 0.016 | ||
| Ctrb1 | chymotrypsinogen B1 | 0.016 | ||
| Crct1 | cysteine-rich C-terminal 1 | 0.016 | ||
| Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | 0.016 | ||
| B4galnt2 | beta-1,4-N-acetyl-galactosaminyl transferase 2 | 0.016 | ||
| Cldn4 | claudin 4 | 0.016 | ||
| Spink3 | serine peptidase inhibitor, Kazal type 3 | 0.016 | ||
| Mep1b | meprin 1 beta | 0.015 | ||
| Dlx3 | distal-less homeobox 3 | 0.015 | ||
| Trim31 | tripartite motif-containing 31 | 0.015 | ||
| Tff1 | trefoil factor 1 | 0.015 | ||
| Sprr2a2 | small proline-rich protein 2A2 | 0.015 | ||
| Rarb | retinoic acid receptor, beta | 0.015 | ||
| H2-M9 | histocompatibility 2, M region locus 9 | 0.015 | ||
| Cela2a | chymotrypsin-like elastase family, member 2A | 0.015 | ||
| Lamc2 | laminin, gamma 2 | 0.015 | ||
| Nmur1 | neuromedin U receptor 1 | 0.015 | ||
| Mapk14 | mitogen-activated protein kinase 14 | 0.014 | ||
| Twist2 | twist homolog 2 (Drosophila) | 0.014 | ||
| Tead4 | TEA domain family member 4 | 0.014 | ||
| Srsf7 | serine/arginine-rich splicing factor 7 | 0.014 | ||
| Srsf11 | serine/arginine-rich splicing factor 11 | 0.014 | ||
| Muc3 | mucin 3, intestinal | 0.014 | ||
| Slc7a9 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 | 0.014 | ||
| Cldn7 | claudin 7 | 0.014 | ||
| Osta | organic solute transporter alpha | 0.014 | ||
| Psapl1 | prosaposin-like 1 | 0.014 | ||
| Rrs1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 0.014 | ||
| Cldn6 | claudin 6 | 0.014 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.014 | ||
| Hoxa11 | homeobox A11 | 0.014 | ||
| Aurkb | aurora kinase B | 0.014 | ||
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.013 | ||
| Runx1 | runt related transcription factor 1 | 0.013 | ||
| Olfr870 | olfactory receptor 870 | 0.013 | ||
| Cela3b | chymotrypsin-like elastase family, member 3B | 0.013 | ||
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.013 | ||
| Rab25 | RAB25, member RAS oncogene family | 0.013 | ||
| Syt8 | synaptotagmin VIII | 0.013 | ||
| Edn3 | endothelin 3 | 0.013 | ||
| Trim29 | tripartite motif-containing 29 | 0.013 | ||
| Gip | gastric inhibitory polypeptide | 0.013 | ||
| Nkx2-1 | NK2 homeobox 1 | 0.013 | ||
| Cdca3 | cell division cycle associated 3 | 0.013 | ||
| Itgb4 | integrin beta 4 | 0.013 | ||
| Prss21 | protease, serine, 21 | 0.013 | ||
| Myc | myelocytomatosis oncogene | 0.013 | ||
| Klk7 | kallikrein related-peptidase 7 (chymotryptic, stratum corneum) | 0.013 | ||
| Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 0.013 | ||
| Olfr15 | olfactory receptor 15 | 0.013 | ||
| En1 | engrailed 1 | 0.013 | ||
| Hoxa5 | homeobox A5 | 0.013 | ||
| Muc4 | mucin 4 | 0.013 | ||
| Sall4 | sal-like 4 (Drosophila) | 0.012 | ||
| Il1f6 | interleukin 1 family, member 6 | 0.012 | ||
| Myl7 | myosin, light polypeptide 7, regulatory | 0.012 | ||
| Csf2 | colony stimulating factor 2 (granulocyte-macrophage) | 0.012 | ||
| Lce1b | late cornified envelope 1B | 0.012 | ||
| Sox2 | SRY-box containing gene 2 | 0.012 | ||
| Tmem54 | transmembrane protein 54 | 0.012 | ||
| Krt33b | keratin 33B | 0.012 | ||
| 5430421N21Rik | RIKEN cDNA 5430421N21 gene | 0.012 | ||
| Ly6g6c | lymphocyte antigen 6 complex, locus G6C | 0.012 | ||
| Edaradd | EDAR (ectodysplasin-A receptor)-associated death domain | 0.012 | ||
| Pnliprp2 | pancreatic lipase-related protein 2 | 0.012 | ||
| Tmem79 | transmembrane protein 79 | 0.012 | ||
| Bmp2 | bone morphogenetic protein 2 | 0.012 | ||
| Nmur2 | neuromedin U receptor 2 | 0.012 | ||
| Msgn1 | mesogenin 1 | 0.012 | ||
| Abp1 | amiloride binding protein 1 (amine oxidase, copper-containing) | 0.012 | ||
| Alox12e | arachidonate lipoxygenase, epidermal | 0.012 | ||
| Mep1a | meprin 1 alpha | 0.012 | ||
| Adam3 | a disintegrin and metallopeptidase domain 3 (cyritestin) | 0.012 | ||
| Brca2 | breast cancer 2 | 0.012 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.012 | ||
| Prss3 | protease, serine, 3 | 0.012 | ||
| Tbx1 | T-box 1 | 0.012 | ||
| Cyp2d34 | cytochrome P450, family 2, subfamily d, polypeptide 34 | 0.012 | ||
| Phox2b | paired-like homeobox 2b | 0.012 | ||
| Asb18 | ankyrin repeat and SOCS box-containing 18 | 0.012 | ||
| Fgf8 | fibroblast growth factor 8 | 0.012 | ||
| Gpa33 | glycoprotein A33 (transmembrane) | 0.012 | ||
| Yipf7 | Yip1 domain family, member 7 | 0.012 | ||
| 2010109I03Rik | RIKEN cDNA 2010109I03 gene | 0.012 | ||
| Dsg4 | desmoglein 4 | 0.011 | ||
| Acd | adrenocortical dysplasia | 0.011 | ||
| Trim15 | tripartite motif-containing 15 | 0.011 | ||
| Atp2c2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.011 | ||
| Myo7b | myosin VIIB | 0.011 | ||
| Olfr1507 | olfactory receptor 1507 | 0.011 | ||
| Scgb3a2 | secretoglobin, family 3A, member 2 | 0.011 | ||
| Smpd3 | sphingomyelin phosphodiesterase 3, neutral | 0.011 | ||
| Gpx2 | glutathione peroxidase 2 | 0.011 | ||
| Duoxa2 | dual oxidase maturation factor 2 | 0.011 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.011 | ||
| Taf1d | TATA box binding protein (Tbp)-associated factor, RNA polymerase I, D | 0.011 | ||
| Tubgcp3 | tubulin, gamma complex associated protein 3 | 0.011 | ||
| Pprc1 | peroxisome proliferative activated receptor, gamma, coactivator-related 1 | 0.011 | ||
| Hoxa9 | homeobox A9 | 0.011 | ||
| Foxp3 | forkhead box P3 | 0.011 | ||
| Atp6v0a4 | ATPase, H+ transporting, lysosomal V0 subunit A4 | 0.011 | ||
| Lce1i | late cornified envelope 1I | 0.011 | ||
| Akp3 | alkaline phosphatase 3, intestine, not Mn requiring | 0.011 | ||
| Tcam1 | testicular cell adhesion molecule 1 | 0.011 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.011 | ||
| Lce3c | late cornified envelope 3C | 0.011 | ||
| Gbgt1 | globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 | 0.011 | ||
| Krt71 | keratin 71 | 0.011 | ||
| P2ry4 | pyrimidinergic receptor P2Y, G-protein coupled, 4 | 0.011 | ||
| Gprc6a | G protein-coupled receptor, family C, group 6, member A | 0.011 | ||
| Gjb3 | gap junction protein, beta 3 | 0.011 | ||
| Pnlip | pancreatic lipase | 0.011 | ||
| Pgrmc1 | progesterone receptor membrane component 1 | 0.011 | ||
| Rbpjl | recombination signal binding protein for immunoglobulin kappa J region-like | 0.011 | ||
| Gprc5d | G protein-coupled receptor, family C, group 5, member D | 0.011 | ||
| Gdf3 | growth differentiation factor 3 | 0.011 | ||
| Ptch2 | patched homolog 2 | 0.011 | ||
| Trim69 | tripartite motif-containing 69 | 0.011 | ||
| Osr2 | odd-skipped related 2 (Drosophila) | 0.010 | ||
| Bfsp1 | beaded filament structural protein 1, in lens-CP94 | 0.010 | ||
| Fmr1nb | fragile X mental retardation 1 neighbor | 0.010 | ||
| Pla2g1b | phospholipase A2, group IB, pancreas | 0.010 | ||
| Rnf138 | ring finger protein 138 | 0.010 | ||
| Krt84 | keratin 84 | 0.010 | ||
| Evx1 | even skipped homeotic gene 1 homolog | 0.010 | ||
| Agr2 | anterior gradient 2 (Xenopus laevis) | 0.010 | ||
| Htr3a | 5-hydroxytryptamine (serotonin) receptor 3A | 0.010 | ||
| Rep15 | RAB15 effector protein | 0.010 | ||
| Plekhg6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | 0.010 | ||
| Tgfb2 | transforming growth factor, beta 2 | 0.010 | ||
| Parp2 | poly (ADP-ribose) polymerase family, member 2 | 0.010 | ||
| Htatip2 | HIV-1 tat interactive protein 2, homolog (human) | 0.010 | ||
| Tmed11 | transmembrane emp24 protein transport domain containing | 0.010 | ||
| Cyp2b13 | cytochrome P450, family 2, subfamily b, polypeptide 13 | 0.010 | ||
| Prss44 | protease, serine, 44 | 0.010 |