IMP

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Mus musculus

2 genes annotated in mouse

Multi-species View

activation of rac gtpase activity

GO:0032863

Any process that initiates the activity of an inactive GTPase of the Rac family through the replacement of GDP by GTP.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "activation of rac gtpase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "activation of rac gtpase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Grb2	growth factor receptor bound protein 2	0.995
Tgfb1	transforming growth factor, beta 1	0.847
Efnb2	ephrin B2	0.782
Efna1	ephrin A1	0.532
Vav3	vav 3 oncogene	0.445	Fly
Vav1	vav 1 oncogene	0.440	Fly
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.404
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.395
Vav2	vav 2 oncogene	0.359	Fly
Shc1	src homology 2 domain-containing transforming protein C1	0.350
Ncf1	neutrophil cytosolic factor 1	0.340
Nf1	neurofibromatosis 1	0.328
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.252
Braf	Braf transforming gene	0.228
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.216
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.201
Dck	deoxycytidine kinase	0.167
Cd37	CD37 antigen	0.159
Cbl	Casitas B-lineage lymphoma	0.159
Vdr	vitamin D receptor	0.120
Lepr	leptin receptor	0.114
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.110
Inpp5d	inositol polyphosphate-5-phosphatase D	0.107
Irf5	interferon regulatory factor 5	0.079
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.075
Arhgap9	Rho GTPase activating protein 9	0.074
Depdc1a	DEP domain containing 1a	0.066
Frs2	fibroblast growth factor receptor substrate 2	0.066
Prkcd	protein kinase C, delta	0.066
Egfr	epidermal growth factor receptor	0.065
Elmo1	engulfment and cell motility 1, ced-12 homolog (C. elegans)	0.064
Selplg	selectin, platelet (p-selectin) ligand	0.063
Nckap1l	NCK associated protein 1 like	0.056
Cxcr4	chemokine (C-X-C motif) receptor 4	0.054
Kit	kit oncogene	0.054
Stk10	serine/threonine kinase 10	0.050
Ntf3	neurotrophin 3	0.049
Laptm5	lysosomal-associated protein transmembrane 5	0.049
Sykb	spleen tyrosine kinase	0.047
Myo1f	myosin IF	0.046
Adam17	a disintegrin and metallopeptidase domain 17	0.045
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.045
Dok1	docking protein 1	0.044
Il17ra	interleukin 17 receptor A	0.043
Hmha1	histocompatibility (minor) HA-1	0.042
Vasp	vasodilator-stimulated phosphoprotein	0.040
Gab2	growth factor receptor bound protein 2-associated protein 2	0.040
Fbrs	fibrosin	0.040
Gmip	Gem-interacting protein	0.040
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.039
Plcg2	phospholipase C, gamma 2	0.037
Arhgap21	Rho GTPase activating protein 21	0.037
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.036
Slc6a2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.035
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.033
Adrbk1	adrenergic receptor kinase, beta 1	0.031
Lrrk1	leucine-rich repeat kinase 1	0.031
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.031
Abi1	abl-interactor 1	0.030
Klf3	Kruppel-like factor 3 (basic)	0.029
Pdcd6ip	programmed cell death 6 interacting protein	0.029
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.028
4732456N10Rik	RIKEN cDNA 4732456N10 gene	0.027
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.027
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.026
Csk	c-src tyrosine kinase	0.026
Ncoa6	nuclear receptor coactivator 6	0.026
Cd22	CD22 antigen	0.026
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.026
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.025
Rac2	RAS-related C3 botulinum substrate 2	0.025
Hcls1	hematopoietic cell specific Lyn substrate 1	0.025
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.025
Gab1	growth factor receptor bound protein 2-associated protein 1	0.025
Zfyve16	zinc finger, FYVE domain containing 16	0.024
Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0.023
Was	Wiskott-Aldrich syndrome homolog (human)	0.023
Sh3kbp1	SH3-domain kinase binding protein 1	0.023
Prkcb	protein kinase C, beta	0.023
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.023
Ltbr	lymphotoxin B receptor	0.022
Plekho2	pleckstrin homology domain containing, family O member 2	0.022
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.022	Rat
Cpeb2	cytoplasmic polyadenylation element binding protein 2	0.021
Zfp398	zinc finger protein 398	0.021
Fes	feline sarcoma oncogene	0.021
Plp2	proteolipid protein 2	0.021
Hsf1	heat shock factor 1	0.020
Ptpra	protein tyrosine phosphatase, receptor type, A	0.020
Rgs14	regulator of G-protein signaling 14	0.020
Sgpp1	sphingosine-1-phosphate phosphatase 1	0.019
Smc4	structural maintenance of chromosomes 4	0.019
Cpne2	copine II	0.019
Elmo2	engulfment and cell motility 2, ced-12 homolog (C. elegans)	0.019
Map3k11	mitogen-activated protein kinase kinase kinase 11	0.019
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.019
Kif16b	kinesin family member 16B	0.019
Tmc6	transmembrane channel-like gene family 6	0.019
Necap2	NECAP endocytosis associated 2	0.019
Cotl1	coactosin-like 1 (Dictyostelium)	0.018
Capn1	calpain 1	0.018
Dpy19l4	dpy-19-like 4 (C. elegans)	0.018
Ikbke	inhibitor of kappaB kinase epsilon	0.018
Plaur	plasminogen activator, urokinase receptor	0.018
2310014H01Rik	RIKEN cDNA 2310014H01 gene	0.018
Ptpre	protein tyrosine phosphatase, receptor type, E	0.018
Sh3bp1	SH3-domain binding protein 1	0.018
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.018
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.018
Bcl3	B-cell leukemia/lymphoma 3	0.017
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.017
Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	0.017
Rnls	renalase, FAD-dependent amine oxidase	0.017
Prkce	protein kinase C, epsilon	0.017
Itga3	integrin alpha 3	0.017
Unc93b1	unc-93 homolog B1 (C. elegans)	0.016
Ptprc	protein tyrosine phosphatase, receptor type, C	0.016
Sirpa	signal-regulatory protein alpha	0.016
Hivep1	human immunodeficiency virus type I enhancer binding protein 1	0.016
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.016
Arhgap30	Rho GTPase activating protein 30	0.016
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.016
Itga4	integrin alpha 4	0.016
Plcb1	phospholipase C, beta 1	0.016
Shank2	SH3/ankyrin domain gene 2	0.015
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.015
Ptprj	protein tyrosine phosphatase, receptor type, J	0.015
Sema4d	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.015
Sh3bp2	SH3-domain binding protein 2	0.015
Rad21	RAD21 homolog (S. pombe)	0.015
Gltp	glycolipid transfer protein	0.015
Prnp	prion protein	0.015
Sh3rf1	SH3 domain containing ring finger 1	0.015
Mis18bp1	MIS18 binding protein 1	0.015
Blnk	B-cell linker	0.014
Hhex	hematopoietically expressed homeobox	0.014
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.014
Fbxo11	F-box protein 11	0.014
Eml6	echinoderm microtubule associated protein like 6	0.014
Sos1	son of sevenless homolog 1 (Drosophila)	0.014	Mouse
Lrrc58	leucine rich repeat containing 58	0.014
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.014
A830007P12Rik	RIKEN cDNA A830007P12 gene	0.014
C78339	expressed sequence C78339	0.014
Rassf2	Ras association (RalGDS/AF-6) domain family member 2	0.014
Csf1	colony stimulating factor 1 (macrophage)	0.014
Cd3e	CD3 antigen, epsilon polypeptide	0.014
Spint1	serine protease inhibitor, Kunitz type 1	0.013
Mib1	mindbomb homolog 1 (Drosophila)	0.013
Cpsf1	cleavage and polyadenylation specific factor 1	0.013
Sfpi1	SFFV proviral integration 1	0.013
Smad3	MAD homolog 3 (Drosophila)	0.013
Il16	interleukin 16	0.013
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.013
Fam105a	family with sequence similarity 105, member A	0.013
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.013
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.013
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.013
Chga	chromogranin A	0.013
Shcbp1	Shc SH2-domain binding protein 1	0.013
Lcp2	lymphocyte cytosolic protein 2	0.013
Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	0.013
Ly9	lymphocyte antigen 9	0.013
Junb	Jun-B oncogene	0.013
Il10ra	interleukin 10 receptor, alpha	0.013
Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	0.013
Ren1	renin 1 structural	0.013
Mkl1	MKL (megakaryoblastic leukemia)/myocardin-like 1	0.013
Myh9	myosin, heavy polypeptide 9, non-muscle	0.013
Coro1a	coronin, actin binding protein 1A	0.013
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.012
Dnm2	dynamin 2	0.012
Sept9	septin 9	0.012
Dock5	dedicator of cytokinesis 5	0.012	Fly
Ccr2	chemokine (C-C motif) receptor 2	0.012
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.012
Rps6ka4	ribosomal protein S6 kinase, polypeptide 4	0.012
Abcd1	ATP-binding cassette, sub-family D (ALD), member 1	0.012
Myo1e	myosin IE	0.012
Arhgef1	Rho guanine nucleotide exchange factor (GEF) 1	0.012
BC037034	cDNA sequence BC037034	0.012
Trim59	tripartite motif-containing 59	0.012
Ids	iduronate 2-sulfatase	0.012
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.012
Osbpl11	oxysterol binding protein-like 11	0.012
Kitl	kit ligand	0.012
Cnr2	cannabinoid receptor 2 (macrophage)	0.012
Entpd7	ectonucleoside triphosphate diphosphohydrolase 7	0.012
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.012
Fermt3	fermitin family homolog 3 (Drosophila)	0.012
Agtr1a	angiotensin II receptor, type 1a	0.012
Prkca	protein kinase C, alpha	0.011
Hpcal1	hippocalcin-like 1	0.011
Tjp1	tight junction protein 1	0.011
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.011
5031439G07Rik	RIKEN cDNA 5031439G07 gene	0.011
Golim4	golgi integral membrane protein 4	0.011
Abcg1	ATP-binding cassette, sub-family G (WHITE), member 1	0.011
Anln	anillin, actin binding protein	0.011
Ptk2	PTK2 protein tyrosine kinase 2	0.011
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.011
Elmo3	engulfment and cell motility 3, ced-12 homolog (C. elegans)	0.011
Dlg2	discs, large homolog 2 (Drosophila)	0.011
Sash3	SAM and SH3 domain containing 3	0.011
Idua	iduronidase, alpha-L-	0.011
Src	Rous sarcoma oncogene	0.011
Dlg4	discs, large homolog 4 (Drosophila)	0.011
Pyhin1	pyrin and HIN domain family, member 1	0.011
Pvrl2	poliovirus receptor-related 2	0.011
Mapk14	mitogen-activated protein kinase 14	0.011
P2ry2	purinergic receptor P2Y, G-protein coupled 2	0.011
Vamp4	vesicle-associated membrane protein 4	0.011
Plcg1	phospholipase C, gamma 1	0.011
Tagln2	transgelin 2	0.011
Cd72	CD72 antigen	0.011
Ctbp2	C-terminal binding protein 2	0.011
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.011
Cul4a	cullin 4A	0.011
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.011
Dock8	dedicator of cytokinesis 8	0.010
Tgfbr1	transforming growth factor, beta receptor I	0.010
Lrrc33	leucine rich repeat containing 33	0.010
Arhgdib	Rho, GDP dissociation inhibitor (GDI) beta	0.010
Adcy7	adenylate cyclase 7	0.010
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.010
Tradd	TNFRSF1A-associated via death domain	0.010
Ncapg2	non-SMC condensin II complex, subunit G2	0.010
Cdk14	cyclin-dependent kinase 14	0.010
Fam65b	family with sequence similarity 65, member B	0.010
Lyst	lysosomal trafficking regulator	0.010
Jag1	jagged 1	0.010
Pom121	nuclear pore membrane protein 121	0.010
Sp100	nuclear antigen Sp100	0.010
Bcr	breakpoint cluster region	0.010
Homer1	homer homolog 1 (Drosophila)	0.010
Ubr1	ubiquitin protein ligase E3 component n-recognin 1	0.010
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.010
Sla	src-like adaptor	0.010
Dok3	docking protein 3	0.010
Lcp1	lymphocyte cytosolic protein 1	0.010
Csf1r	colony stimulating factor 1 receptor	0.010
Fmnl1	formin-like 1	0.010