IMP

Process View

Mus musculus

2 genes annotated in mouse

morphogenesis of an endothelium

The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "morphogenesis of an endothelium"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "morphogenesis of an endothelium" (in gray)

Name	Description	Probability	Func Analog Organism
Notch1	Notch gene homolog 1 (Drosophila)	1.000
Dll1	delta-like 1 (Drosophila)	0.997	Mouse
Fgfr2	fibroblast growth factor receptor 2	0.996
Fgfr1	fibroblast growth factor receptor 1	0.982
Shh	sonic hedgehog	0.976
Gli3	GLI-Kruppel family member GLI3	0.971
Notch2	Notch gene homolog 2 (Drosophila)	0.965
Psen1	presenilin 1	0.963
Foxc1	forkhead box C1	0.930
Chd7	chromodomain helicase DNA binding protein 7	0.905
Jag1	jagged 1	0.739	Mouse
Eya1	eyes absent 1 homolog (Drosophila)	0.707
Pbx1	pre B-cell leukemia transcription factor 1	0.661
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.622
Vangl2	vang-like 2 (van gogh, Drosophila)	0.592
Foxg1	forkhead box G1	0.525
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.482
Rb1	retinoblastoma 1	0.404
Efnb2	ephrin B2	0.387
Hes1	hairy and enhancer of split 1 (Drosophila)	0.352
Tgfb2	transforming growth factor, beta 2	0.331
Pitx2	paired-like homeodomain transcription factor 2	0.323
Tbx1	T-box 1	0.322
Pax3	paired box gene 3	0.306
Prrx1	paired related homeobox 1	0.289
Apc	adenomatosis polyposis coli	0.254
Hand2	heart and neural crest derivatives expressed transcript 2	0.200
Wdr1	WD repeat domain 1	0.196
Ednra	endothelin receptor type A	0.185
Pten	phosphatase and tensin homolog	0.184
Dll4	delta-like 4 (Drosophila)	0.183
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.167
Zeb1	zinc finger E-box binding homeobox 1	0.154
Tcf21	transcription factor 21	0.153
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.150
Pax2	paired box gene 2	0.145
Tgfbr2	transforming growth factor, beta receptor II	0.144
Msx1	homeobox, msh-like 1	0.141
Foxc2	forkhead box C2	0.133
Meox2	mesenchyme homeobox 2	0.133
Sox2	SRY-box containing gene 2	0.130
Chrd	chordin	0.108
Vegfa	vascular endothelial growth factor A	0.105
Acvr1	activin A receptor, type 1	0.103
Trp53	transformation related protein 53	0.101
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.101
Cdh5	cadherin 5	0.087
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.087
Tcte3	t-complex-associated testis expressed 3	0.086
Bmp7	bone morphogenetic protein 7	0.082
Hoxa9	homeobox A9	0.081
Ptk7	PTK7 protein tyrosine kinase 7	0.078
Tcfap2a	transcription factor AP-2, alpha	0.077
Sox9	SRY-box containing gene 9	0.074
Prrx2	paired related homeobox 2	0.074
Tcf15	transcription factor 15	0.068
Gata3	GATA binding protein 3	0.068
Tbx10	T-box 10	0.067
Smo	smoothened homolog (Drosophila)	0.065
Dlx5	distal-less homeobox 5	0.063
Fgfr3	fibroblast growth factor receptor 3	0.062
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.056
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.055
Notch3	Notch gene homolog 3 (Drosophila)	0.054
Ece1	endothelin converting enzyme 1	0.053
Psen2	presenilin 2	0.053
Hoxa1	homeobox A1	0.052
Neurl1a	neuralized homolog 1A (Drosophila)	0.052
Jag2	jagged 2	0.051	Mouse
Sfrp2	secreted frizzled-related protein 2	0.050
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.048
Flna	filamin, alpha	0.048
Lrp6	low density lipoprotein receptor-related protein 6	0.048
Rarg	retinoic acid receptor, gamma	0.046
Rbm39	RNA binding motif protein 39	0.041
Hoxa2	homeobox A2	0.041
Twist2	twist homolog 2 (Drosophila)	0.040
Rarb	retinoic acid receptor, beta	0.039
Gpc3	glypican 3	0.039
Efnb1	ephrin B1	0.039
Nrarp	Notch-regulated ankyrin repeat protein	0.038
Mcam	melanoma cell adhesion molecule	0.038
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.038
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.036
Fgf8	fibroblast growth factor 8	0.036
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.035
Sp6	trans-acting transcription factor 6	0.034
Nog	noggin	0.033
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.033
Zmym5	zinc finger, MYM-type 5	0.033
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.033
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.033
Tbx18	T-box18	0.033
Fgf10	fibroblast growth factor 10	0.032
Jmjd1c	jumonji domain containing 1C	0.028
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.027
Lama5	laminin, alpha 5	0.026
Foxf1a	forkhead box F1a	0.026
Ptf1a	pancreas specific transcription factor, 1a	0.025
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.025
Mesp2	mesoderm posterior 2	0.024
Ptch1	patched homolog 1	0.024
Slc12a2	solute carrier family 12, member 2	0.024
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.024
Gli2	GLI-Kruppel family member GLI2	0.024
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.024
Pdgfb	platelet derived growth factor, B polypeptide	0.024
Nrp1	neuropilin 1	0.023
Sox18	SRY-box containing gene 18	0.023
Pou4f3	POU domain, class 4, transcription factor 3	0.023
Zfp503	zinc finger protein 503	0.023
Hoxa5	homeobox A5	0.023
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.022
Zcchc7	zinc finger, CCHC domain containing 7	0.022
Eln	elastin	0.021
Rxra	retinoid X receptor alpha	0.021
Adam33	a disintegrin and metallopeptidase domain 33	0.021
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.021
Rac1	RAS-related C3 botulinum substrate 1	0.021
Wnt4	wingless-related MMTV integration site 4	0.021
Thbs1	thrombospondin 1	0.020
Erbb2ip	Erbb2 interacting protein	0.020
Meox1	mesenchyme homeobox 1	0.020
Tcf12	transcription factor 12	0.020
Lox	lysyl oxidase	0.019
Bcam	basal cell adhesion molecule	0.019
Bcl2	B-cell leukemia/lymphoma 2	0.018
Hoxa3	homeobox A3	0.018
Osr1	odd-skipped related 1 (Drosophila)	0.018
Krt15	keratin 15	0.018
Myo6	myosin VI	0.018
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.018
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.018
Mysm1	myb-like, SWIRM and MPN domains 1	0.018
Zcchc11	zinc finger, CCHC domain containing 11	0.018
Col1a1	collagen, type I, alpha 1	0.017
Trp63	transformation related protein 63	0.017
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.017
Gata4	GATA binding protein 4	0.016
Clic3	chloride intracellular channel 3	0.016
Emx2	empty spiracles homolog 2 (Drosophila)	0.016
Pitx1	paired-like homeodomain transcription factor 1	0.016
Tpm4	tropomyosin 4	0.016
Adamts2	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2	0.016
Tead4	TEA domain family member 4	0.016
Egfr	epidermal growth factor receptor	0.015
Meis2	Meis homeobox 2	0.015
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.015
Dpysl4	dihydropyrimidinase-like 4	0.015
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.015
Wnt11	wingless-related MMTV integration site 11	0.015
Apaf1	apoptotic peptidase activating factor 1	0.015
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.015
Srpx	sushi-repeat-containing protein	0.015
Efs	embryonal Fyn-associated substrate	0.015
Gsk3b	glycogen synthase kinase 3 beta	0.015
Gata2	GATA binding protein 2	0.015
Tgfa	transforming growth factor alpha	0.015
Kdr	kinase insert domain protein receptor	0.015
Adcy4	adenylate cyclase 4	0.015
Pds5a	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.015
Hras1	Harvey rat sarcoma virus oncogene 1	0.015
Vasp	vasodilator-stimulated phosphoprotein	0.014
Ppl	periplakin	0.014
Fzd2	frizzled homolog 2 (Drosophila)	0.014
Ednrb	endothelin receptor type B	0.014
Hes5	hairy and enhancer of split 5 (Drosophila)	0.014
Asna1	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	0.014
A430061O12Rik	RIKEN cDNA A430061O12 gene	0.014
Slurp1	secreted Ly6/Plaur domain containing 1	0.014
Fis1	fission 1 (mitochondrial outer membrane) homolog (yeast)	0.014
Csf1	colony stimulating factor 1 (macrophage)	0.014
Ptrf	polymerase I and transcript release factor	0.013
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.013
Tbx4	T-box 4	0.013
Hoxa11	homeobox A11	0.013
Clic4	chloride intracellular channel 4 (mitochondrial)	0.013
Nkd1	naked cuticle 1 homolog (Drosophila)	0.013
Heg1	HEG homolog 1 (zebrafish)	0.013
Cnn2	calponin 2	0.013
Kif3a	kinesin family member 3A	0.013
Sox11	SRY-box containing gene 11	0.013
Ddr2	discoidin domain receptor family, member 2	0.013
Bcl6b	B-cell CLL/lymphoma 6, member B	0.013
Bnc1	basonuclin 1	0.012
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.012
Zfp280d	zinc finger protein 280D	0.012
Scube1	signal peptide, CUB domain, EGF-like 1	0.012
Mtx1	metaxin 1	0.012
Col7a1	collagen, type VII, alpha 1	0.012
Zfp945	zinc finger protein 945	0.012
Hr	hairless	0.012
Col2a1	collagen, type II, alpha 1	0.012
Otx2	orthodenticle homolog 2 (Drosophila)	0.012
Prmt5	protein arginine N-methyltransferase 5	0.012
Fzd1	frizzled homolog 1 (Drosophila)	0.012
Ager	advanced glycosylation end product-specific receptor	0.012
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.012
Edn3	endothelin 3	0.012
Dlx2	distal-less homeobox 2	0.012
Zfr	zinc finger RNA binding protein	0.012
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.012
Sox7	SRY-box containing gene 7	0.012
Egfl7	EGF-like domain 7	0.012
Mbtd1	mbt domain containing 1	0.012
Wnt3a	wingless-related MMTV integration site 3A	0.012
Hoxb4	homeobox B4	0.012
Hmx3	H6 homeobox 3	0.012
Ephb4	Eph receptor B4	0.012
Sox13	SRY-box containing gene 13	0.012
Apln	apelin	0.012
Nos3	nitric oxide synthase 3, endothelial cell	0.011
Rdh10	retinol dehydrogenase 10 (all-trans)	0.011
Rc3h2	ring finger and CCCH-type zinc finger domains 2	0.011
Psmb5	proteasome (prosome, macropain) subunit, beta type 5	0.011
Foxo1	forkhead box O1	0.011
Zfp521	zinc finger protein 521	0.011
Matn4	matrilin 4	0.011
Sh3bgrl3	SH3 domain binding glutamic acid-rich protein-like 3	0.011
Pofut1	protein O-fucosyltransferase 1	0.011
Baz2b	bromodomain adjacent to zinc finger domain, 2B	0.011
Nadk	NAD kinase	0.011
Itch	itchy, E3 ubiquitin protein ligase	0.011
Sgpl1	sphingosine phosphate lyase 1	0.011
Msx2	homeobox, msh-like 2	0.011
Chuk	conserved helix-loop-helix ubiquitous kinase	0.011
Yap1	yes-associated protein 1	0.011
Hmx2	H6 homeobox 2	0.011
Irx3	Iroquois related homeobox 3 (Drosophila)	0.011
Bmp5	bone morphogenetic protein 5	0.011
Phip	pleckstrin homology domain interacting protein	0.011
Nfib	nuclear factor I/B	0.011
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.011
Tbx2	T-box 2	0.011
Ndn	necdin	0.011
Col11a1	collagen, type XI, alpha 1	0.011
Apoe	apolipoprotein E	0.011
Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.010
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.010
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.010
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.010
Klf3	Kruppel-like factor 3 (basic)	0.010
Cd97	CD97 antigen	0.010
Ap2s1	adaptor-related protein complex 2, sigma 1 subunit	0.010
Sox17	SRY-box containing gene 17	0.010
Cachd1	cache domain containing 1	0.010
Ext1	exostoses (multiple) 1	0.010
Efna2	ephrin A2	0.010
Rgs19	regulator of G-protein signaling 19	0.010
Alx1	ALX homeobox 1	0.010
Fzd8	frizzled homolog 8 (Drosophila)	0.010
Med13	mediator complex subunit 13	0.010
Nipbl	Nipped-B homolog (Drosophila)	0.010
Amotl2	angiomotin-like 2	0.010
Clec3b	C-type lectin domain family 3, member b	0.010
Lrp2	low density lipoprotein receptor-related protein 2	0.010
Vcl	vinculin	0.010
Col13a1	collagen, type XIII, alpha 1	0.010
Wisp2	WNT1 inducible signaling pathway protein 2	0.010