IMP

Process View

Mus musculus

17 genes annotated in mouse

immunoglobulin secretion

The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "immunoglobulin secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "immunoglobulin secretion" (in gray)

Name	Description	Probability	Func Analog Organism
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	1.000
Tnf	tumor necrosis factor	0.999
Igh	immunoglobulin heavy chain complex	0.999
Ifng	interferon gamma	0.996
Lta	lymphotoxin A	0.992	Mouse
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.988
Cd40	CD40 antigen	0.987
Fas	Fas (TNF receptor superfamily member 6)	0.969
Cd19	CD19 antigen	0.947
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.928
Il10	interleukin 10	0.913
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.911
Il4	interleukin 4	0.873
Ikzf1	IKAROS family zinc finger 1	0.862
Rag1	recombination activating gene 1	0.733
Socs1	suppressor of cytokine signaling 1	0.732
Rag2	recombination activating gene 2	0.651
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.601
Il2	interleukin 2	0.575
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.447
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.431	Mouse
Traf6	TNF receptor-associated factor 6	0.376
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.340
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.339	Mouse
Bcl6	B-cell leukemia/lymphoma 6	0.311
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.269
Fasl	Fas ligand (TNF superfamily, member 6)	0.239	Mouse
Otx2	orthodenticle homolog 2 (Drosophila)	0.233
Traf2	TNF receptor-associated factor 2	0.214
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.192
S1pr2	sphingosine-1-phosphate receptor 2	0.168
Ltb	lymphotoxin B	0.161
Cd40lg	CD40 ligand	0.160
Sox2	SRY-box containing gene 2	0.158
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.156
Ccl4	chemokine (C-C motif) ligand 4	0.144
Batf	basic leucine zipper transcription factor, ATF-like	0.137
Ptgs2	prostaglandin-endoperoxide synthase 2	0.124
Nos2	nitric oxide synthase 2, inducible	0.114
Myd88	myeloid differentiation primary response gene 88	0.112
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.111	Mouse
Btk	Bruton agammaglobulinemia tyrosine kinase	0.111
Il7	interleukin 7	0.105
Chd7	chromodomain helicase DNA binding protein 7	0.097
Il6	interleukin 6	0.097	Human
Tox	thymocyte selection-associated high mobility group box	0.096
Cd28	CD28 antigen	0.096
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.087
Icos	inducible T-cell co-stimulator	0.079
Ikbkg	inhibitor of kappaB kinase gamma	0.075
Il2rg	interleukin 2 receptor, gamma chain	0.070
Tcra	T-cell receptor alpha chain	0.069
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.068
Tcrd	T-cell receptor delta chain	0.068
Prkcd	protein kinase C, delta	0.065
Irf4	interferon regulatory factor 4	0.065
Bcl3	B-cell leukemia/lymphoma 3	0.062
Traf3ip2	TRAF3 interacting protein 2	0.061
Cxcl13	chemokine (C-X-C motif) ligand 13	0.060
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.059
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.055
Il17a	interleukin 17A	0.055
Pdcd1	programmed cell death 1	0.052
Il2rb	interleukin 2 receptor, beta chain	0.051
Sall3	sal-like 3 (Drosophila)	0.050
Pax2	paired box gene 2	0.048
Birc3	baculoviral IAP repeat-containing 3	0.047
Tcrb	T-cell receptor beta chain	0.046
Prf1	perforin 1 (pore forming protein)	0.045
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.044
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.043
Lat	linker for activation of T cells	0.042
Tnip1	TNFAIP3 interacting protein 1	0.042
Il1r1	interleukin 1 receptor, type I	0.039
Il12rb1	interleukin 12 receptor, beta 1	0.039
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.038
Mavs	mitochondrial antiviral signaling protein	0.037
Tbx10	T-box 10	0.035
Mmp24	matrix metallopeptidase 24	0.034
Tlr4	toll-like receptor 4	0.033
Sh2d2a	SH2 domain protein 2A	0.033
Hes5	hairy and enhancer of split 5 (Drosophila)	0.032
Lag3	lymphocyte-activation gene 3	0.032
Card11	caspase recruitment domain family, member 11	0.031
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.031
Ticam1	toll-like receptor adaptor molecule 1	0.031
Cxcl2	chemokine (C-X-C motif) ligand 2	0.029
Aicda	activation-induced cytidine deaminase	0.029
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.029
Cd160	CD160 antigen	0.029
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.029
Atoh7	atonal homolog 7 (Drosophila)	0.028
Rel	reticuloendotheliosis oncogene	0.028
Cxcr5	chemokine (C-X-C motif) receptor 5	0.026
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.026
Spp1	secreted phosphoprotein 1	0.025
Tcf3	transcription factor 3	0.025
Il1rl1	interleukin 1 receptor-like 1	0.025
Hrh2	histamine receptor H2	0.025
Lhx1	LIM homeobox protein 1	0.024
Insm1	insulinoma-associated 1	0.023
Otx1	orthodenticle homolog 1 (Drosophila)	0.023
Ccl2	chemokine (C-C motif) ligand 2	0.023
Il2ra	interleukin 2 receptor, alpha chain	0.022
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.022
Ubd	ubiquitin D	0.022
Vdr	vitamin D receptor	0.021
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.021
Pou2af1	POU domain, class 2, associating factor 1	0.021
Foxp3	forkhead box P3	0.020
Pou3f4	POU domain, class 3, transcription factor 4	0.020	Mouse
Ccr7	chemokine (C-C motif) receptor 7	0.019
Hmx3	H6 homeobox 3	0.018
Itk	IL2-inducible T-cell kinase	0.018
Bdnf	brain derived neurotrophic factor	0.018
Fgf3	fibroblast growth factor 3	0.018
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.017
Irg1	immunoresponsive gene 1	0.017
Grxcr1	glutaredoxin, cysteine rich 1	0.017
Tnfsf9	tumor necrosis factor (ligand) superfamily, member 9	0.017
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.016
Nanog	Nanog homeobox	0.016
Serp1	stress-associated endoplasmic reticulum protein 1	0.016
Wnt7b	wingless-related MMTV integration site 7B	0.016
Sox3	SRY-box containing gene 3	0.016
Id2	inhibitor of DNA binding 2	0.016
Oas3	2'-5' oligoadenylate synthetase 3	0.016
Ikzf4	IKAROS family zinc finger 4	0.016
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.015
Gm12185	predicted gene 12185	0.015
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.015
Pdcd1lg2	programmed cell death 1 ligand 2	0.015
Jak3	Janus kinase 3	0.015
Traf1	TNF receptor-associated factor 1	0.014	Mouse
Pax6	paired box gene 6	0.014
Gpr132	G protein-coupled receptor 132	0.014
Ush1g	Usher syndrome 1G homolog (human)	0.014
Gzmk	granzyme K	0.014
Creld2	cysteine-rich with EGF-like domains 2	0.013
Cdx1	caudal type homeobox 1	0.013
Eomes	eomesodermin homolog (Xenopus laevis)	0.013
Trafd1	TRAF type zinc finger domain containing 1	0.013
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.013
Cd8a	CD8 antigen, alpha chain	0.012
Sox11	SRY-box containing gene 11	0.012
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.012
Phf19	PHD finger protein 19	0.012
2010106G01Rik	RIKEN cDNA 2010106G01 gene	0.012
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.012
Nog	noggin	0.012
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.011
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.011
Elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.011
Tg	thyroglobulin	0.011
Lck	lymphocyte protein tyrosine kinase	0.011
Cd4	CD4 antigen	0.011
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.011
Emx2	empty spiracles homolog 2 (Drosophila)	0.011
Xcl1	chemokine (C motif) ligand 1	0.011
Mvp	major vault protein	0.011
Foxb1	forkhead box B1	0.011
Foxn1	forkhead box N1	0.011
Stat3	signal transducer and activator of transcription 3	0.011
Cd247	CD247 antigen	0.010
Sh2b2	SH2B adaptor protein 2	0.010
Ikzf3	IKAROS family zinc finger 3	0.010
Ccr8	chemokine (C-C motif) receptor 8	0.010
Adcyap1	adenylate cyclase activating polypeptide 1	0.010
Atoh1	atonal homolog 1 (Drosophila)	0.010
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.010
Pkp3	plakophilin 3	0.010
Adora2b	adenosine A2b receptor	0.010
Ccl17	chemokine (C-C motif) ligand 17	0.010