IMP

Process View

Mus musculus

15 genes annotated in mouse

Multi-species View

establishment of spindle orientation

GO:0051294

Any process that set the alignment of spindle relative to other cellular structures.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "establishment of spindle orientation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "establishment of spindle orientation" (in gray)

Name	Description	Probability	Func Analog Organism
Vangl2	vang-like 2 (van gogh, Drosophila)	0.877
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.816	Worm
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.798
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.778	Worm
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.683	Worm
Plcg2	phospholipase C, gamma 2	0.586
Pax2	paired box gene 2	0.420
Dlg4	discs, large homolog 4 (Drosophila)	0.394	Fly
Kif20a	kinesin family member 20A	0.247
Ncaph	non-SMC condensin I complex, subunit H	0.246
Lrrk2	leucine-rich repeat kinase 2	0.234
Vangl1	vang-like 1 (van gogh, Drosophila)	0.205
Pafah1b1	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1	0.188	Human Worm
Ndel1	nuclear distribution gene E-like homolog 1 (A. nidulans)	0.159
Cenpf	centromere protein F	0.152
Kif22	kinesin family member 22	0.134
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.134
Macf1	microtubule-actin crosslinking factor 1	0.128
Kif2c	kinesin family member 2C	0.119	Fly
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.112	Worm
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.098
Plk1	polo-like kinase 1 (Drosophila)	0.095
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.093	Worm
Kif4	kinesin family member 4	0.091
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.085	Worm
Rpgrip1l	Rpgrip1-like	0.084
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.084
Sept7	septin 7	0.082
Cdkn3	cyclin-dependent kinase inhibitor 3	0.076
Incenp	inner centromere protein	0.076
Rac1	RAS-related C3 botulinum substrate 1	0.075
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.074
Efnb2	ephrin B2	0.073
Kif3a	kinesin family member 3A	0.062
Spna2	spectrin alpha 2	0.060
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.055
Ncoa2	nuclear receptor coactivator 2	0.053
Shc3	src homology 2 domain-containing transforming protein C3	0.053
Myh9	myosin, heavy polypeptide 9, non-muscle	0.053
Fam64a	family with sequence similarity 64, member A	0.051
Iqgap3	IQ motif containing GTPase activating protein 3	0.049
Zeb1	zinc finger E-box binding homeobox 1	0.048
Spry4	sprouty homolog 4 (Drosophila)	0.047	Mouse
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.046
Hif1a	hypoxia inducible factor 1, alpha subunit	0.045
Homer1	homer homolog 1 (Drosophila)	0.045
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.044
Fyn	Fyn proto-oncogene	0.044	Worm
Myo6	myosin VI	0.043
Foxm1	forkhead box M1	0.043
Ckap2	cytoskeleton associated protein 2	0.043
Fgf10	fibroblast growth factor 10	0.040
Mis18bp1	MIS18 binding protein 1	0.040
Kif5c	kinesin family member 5C	0.040	Worm
Ccna2	cyclin A2	0.039
Hmx3	H6 homeobox 3	0.039	Worm
Ube2c	ubiquitin-conjugating enzyme E2C	0.036
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.035	Worm Fly
Ccnf	cyclin F	0.035
Kif11	kinesin family member 11	0.034
Tmod3	tropomodulin 3	0.034
Clip1	CAP-GLY domain containing linker protein 1	0.034
Sox2	SRY-box containing gene 2	0.034
Wdr1	WD repeat domain 1	0.033
Ccnb2	cyclin B2	0.033
Gtse1	G two S phase expressed protein 1	0.033
Gbx2	gastrulation brain homeobox 2	0.033
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.032
Itga6	integrin alpha 6	0.032
Prc1	protein regulator of cytokinesis 1	0.031
Spnb2	spectrin beta 2	0.031
Mks1	Meckel syndrome, type 1	0.031
Ptk2	PTK2 protein tyrosine kinase 2	0.030
Stil	Scl/Tal1 interrupting locus	0.030
Mtpn	myotrophin	0.029
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.028
Spry2	sprouty homolog 2 (Drosophila)	0.028
Prkce	protein kinase C, epsilon	0.028
Nf2	neurofibromatosis 2	0.028
Apc	adenomatosis polyposis coli	0.027
Lims1	LIM and senescent cell antigen-like domains 1	0.027
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.027
Tsc2	tuberous sclerosis 2	0.027
Ptpre	protein tyrosine phosphatase, receptor type, E	0.026
Tbx15	T-box 15	0.026
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.025
Kif23	kinesin family member 23	0.025
Aurka	aurora kinase A	0.025
Akap8l	A kinase (PRKA) anchor protein 8-like	0.025
Ret	ret proto-oncogene	0.024
Ap3b1	adaptor-related protein complex 3, beta 1 subunit	0.024
Pacsin1	protein kinase C and casein kinase substrate in neurons 1	0.024
Mxd3	Max dimerization protein 3	0.023
Hmx1	H6 homeobox 1	0.023	Worm
Diap3	diaphanous homolog 3 (Drosophila)	0.023
Sgol1	shugoshin-like 1 (S. pombe)	0.023
Sstr1	somatostatin receptor 1	0.023
Gata3	GATA binding protein 3	0.023
Fgf3	fibroblast growth factor 3	0.023	Mouse
Was	Wiskott-Aldrich syndrome homolog (human)	0.022
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.022
Dlx1	distal-less homeobox 1	0.022
Nsf	N-ethylmaleimide sensitive fusion protein	0.022
Pi4kb	phosphatidylinositol 4-kinase, catalytic, beta polypeptide	0.022
Ptk7	PTK7 protein tyrosine kinase 7	0.021
Pou3f3	POU domain, class 3, transcription factor 3	0.021
Ctnnd1	catenin (cadherin associated protein), delta 1	0.021
Mybl2	myeloblastosis oncogene-like 2	0.021
Tmem123	transmembrane protein 123	0.021
Cdh23	cadherin 23 (otocadherin)	0.021
Gli3	GLI-Kruppel family member GLI3	0.020
Rasa1	RAS p21 protein activator 1	0.020
Ccnb1	cyclin B1	0.020
Ttk	Ttk protein kinase	0.020
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.020
Mapre1	microtubule-associated protein, RP/EB family, member 1	0.020
Rad51ap1	RAD51 associated protein 1	0.020
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.019
Cdca8	cell division cycle associated 8	0.019
Ccdc99	coiled-coil domain containing 99	0.019	Human
Lmnb1	lamin B1	0.019
Fgf13	fibroblast growth factor 13	0.019	Mouse
Clip2	CAP-GLY domain containing linker protein 2	0.019
Mprip	myosin phosphatase Rho interacting protein	0.019
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.018
Tbx10	T-box 10	0.018
Top2a	topoisomerase (DNA) II alpha	0.018
Cbl	Casitas B-lineage lymphoma	0.018
Nefl	neurofilament, light polypeptide	0.018
Add1	adducin 1 (alpha)	0.018
Cit	citron	0.018
Ptprc	protein tyrosine phosphatase, receptor type, C	0.018
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.018
Tpm4	tropomyosin 4	0.018
Sstr4	somatostatin receptor 4	0.017
Wipf1	WAS/WASL interacting protein family, member 1	0.017
Sykb	spleen tyrosine kinase	0.017
Pou4f3	POU domain, class 4, transcription factor 3	0.017
Eya1	eyes absent 1 homolog (Drosophila)	0.017
Ift57	intraflagellar transport 57 homolog (Chlamydomonas)	0.017
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.016
Pvrl3	poliovirus receptor-related 3	0.016
Dpysl2	dihydropyrimidinase-like 2	0.016
Cltc	clathrin, heavy polypeptide (Hc)	0.016
Anln	anillin, actin binding protein	0.016
Tbx1	T-box 1	0.016
Fzd3	frizzled homolog 3 (Drosophila)	0.016
Gnb3	guanine nucleotide binding protein (G protein), beta 3	0.016
Lmx1a	LIM homeobox transcription factor 1 alpha	0.016
Hcls1	hematopoietic cell specific Lyn substrate 1	0.016
Iqgap1	IQ motif containing GTPase activating protein 1	0.016
Fgfr3	fibroblast growth factor receptor 3	0.015
Irf6	interferon regulatory factor 6	0.015
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.015
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.015
Sh3bgrl	SH3-binding domain glutamic acid-rich protein like	0.015
Dync1h1	dynein cytoplasmic 1 heavy chain 1	0.015	Worm
Slmap	sarcolemma associated protein	0.015
Pthlh	parathyroid hormone-like peptide	0.015
Drd4	dopamine receptor D4	0.014
Prkcz	protein kinase C, zeta	0.014
Ckap5	cytoskeleton associated protein 5	0.014
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.014
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.014
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.014
Mark1	MAP/microtubule affinity-regulating kinase 1	0.014
Racgap1	Rac GTPase-activating protein 1	0.014
Ubr4	ubiquitin protein ligase E3 component n-recognin 4	0.014
Spry1	sprouty homolog 1 (Drosophila)	0.014
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.014
Prph2	peripherin 2	0.014
Foxc1	forkhead box C1	0.014
Jag2	jagged 2	0.013
Atoh7	atonal homolog 7 (Drosophila)	0.013
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.013
Tecta	tectorin alpha	0.013
Gsk3b	glycogen synthase kinase 3 beta	0.013
Nodal	nodal	0.013
Pou3f4	POU domain, class 3, transcription factor 4	0.013
Cdca5	cell division cycle associated 5	0.013
Tcf21	transcription factor 21	0.013
Pak1	p21 protein (Cdc42/Rac)-activated kinase 1	0.013
Otp	orthopedia homolog (Drosophila)	0.013
Otx1	orthodenticle homolog 1 (Drosophila)	0.013
Emx1	empty spiracles homolog 1 (Drosophila)	0.013
Adra2c	adrenergic receptor, alpha 2c	0.013
Exo1	exonuclease 1	0.013
Btrc	beta-transducin repeat containing protein	0.013
Klc1	kinesin light chain 1	0.012
Snap25	synaptosomal-associated protein 25	0.012
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.012	Human
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.012
Xrcc2	X-ray repair complementing defective repair in Chinese hamster cells 2	0.012
Cenpe	centromere protein E	0.012
Tsc1	tuberous sclerosis 1	0.012
Sult4a1	sulfotransferase family 4A, member 1	0.012
Oprd1	opioid receptor, delta 1	0.012
Laptm5	lysosomal-associated protein transmembrane 5	0.012
Ctnnb1	catenin (cadherin associated protein), beta 1	0.012
Tuba1a	tubulin, alpha 1A	0.012
Lhx1	LIM homeobox protein 1	0.012
Ina	internexin neuronal intermediate filament protein, alpha	0.012
Fam54a	family with sequence similarity 54, member A	0.012
Aurkb	aurora kinase B	0.012	Fly
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.012
Mybph	myosin binding protein H	0.012
Ntn1	netrin 1	0.012
Sass6	spindle assembly 6 homolog (C. elegans)	0.011
Msn	moesin	0.011	Fly
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.011
Csnk1e	casein kinase 1, epsilon	0.011
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.011
Smc2	structural maintenance of chromosomes 2	0.011
Wwc1	WW, C2 and coiled-coil domain containing 1	0.011
Casp8	caspase 8	0.011
Cdk1	cyclin-dependent kinase 1	0.011
Myh10	myosin, heavy polypeptide 10, non-muscle	0.011
Lrp2	low density lipoprotein receptor-related protein 2	0.011
Cst11	cystatin 11	0.011
Eno1	enolase 1, alpha non-neuron	0.011
Dlg1	discs, large homolog 1 (Drosophila)	0.011	Fly
Srrm4	serine/arginine repetitive matrix 4	0.011
Ugdh	UDP-glucose dehydrogenase	0.011
Fanci	Fanconi anemia, complementation group I	0.011
Nf1	neurofibromatosis 1	0.011
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.011
Mtap1b	microtubule-associated protein 1B	0.011
Zfpm2	zinc finger protein, multitype 2	0.011
Caprin1	cell cycle associated protein 1	0.011
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.010
Pif1	PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)	0.010
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.010
Enah	enabled homolog (Drosophila)	0.010
Invs	inversin	0.010
S1pr3	sphingosine-1-phosphate receptor 3	0.010
Cdh3	cadherin 3	0.010
Rbl1	retinoblastoma-like 1 (p107)	0.010
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.010
Ckap2l	cytoskeleton associated protein 2-like	0.010
Epha4	Eph receptor A4	0.010
Cdc45	cell division cycle 45 homolog (S. cerevisiae)	0.010
Psen1	presenilin 1	0.010
Lef1	lymphoid enhancer binding factor 1	0.010
Ddx3x	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked	0.010
Otx2	orthodenticle homolog 2 (Drosophila)	0.010
Lin7c	lin-7 homolog C (C. elegans)	0.010
Lrrc58	leucine rich repeat containing 58	0.010
Rtn4	reticulon 4	0.010
Pak2	p21 protein (Cdc42/Rac)-activated kinase 2	0.010
Eif3a	eukaryotic translation initiation factor 3, subunit A	0.010
Fgfbp1	fibroblast growth factor binding protein 1	0.010