IMP

Process View

Mus musculus

11 genes annotated in mouse

negative regulation of chemotaxis

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of chemotaxis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of chemotaxis" (in gray)

Name	Description	Probability	Func Analog Organism
Robo1	roundabout homolog 1 (Drosophila)	0.983	Human
Axl	AXL receptor tyrosine kinase	0.980	Mouse
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.978	Mouse
Slit3	slit homolog 3 (Drosophila)	0.959	Worm
Slit2	slit homolog 2 (Drosophila)	0.931	Human Rat Worm
Robo2	roundabout homolog 2 (Drosophila)	0.785	Human Zebrafish
Arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	0.761
Plxna1	plexin A1	0.549	Mouse
Fzd1	frizzled homolog 1 (Drosophila)	0.511
Slit1	slit homolog 1 (Drosophila)	0.464	Rat Worm
Nrp2	neuropilin 2	0.376	Mouse
Pax8	paired box gene 8	0.374
Epha4	Eph receptor A4	0.367
Ednra	endothelin receptor type A	0.315
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.305
Fgf18	fibroblast growth factor 18	0.302
Fgfr1	fibroblast growth factor receptor 1	0.297
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.246
Tyro3	TYRO3 protein tyrosine kinase 3	0.227	Mouse
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.223
Fzd8	frizzled homolog 8 (Drosophila)	0.197
Gab1	growth factor receptor bound protein 2-associated protein 1	0.195
Ephb2	Eph receptor B2	0.177
Wnt4	wingless-related MMTV integration site 4	0.154	Mouse
Efnb2	ephrin B2	0.145
Ltbp1	latent transforming growth factor beta binding protein 1	0.144
Smo	smoothened homolog (Drosophila)	0.139
Dll1	delta-like 1 (Drosophila)	0.124
Cdh11	cadherin 11	0.112
Ddr2	discoidin domain receptor family, member 2	0.112
Gli2	GLI-Kruppel family member GLI2	0.112
Smad3	MAD homolog 3 (Drosophila)	0.110
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.104
Mrc2	mannose receptor, C type 2	0.102
Lhx1	LIM homeobox protein 1	0.102
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.101
Gdnf	glial cell line derived neurotrophic factor	0.093
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.089
Ephb3	Eph receptor B3	0.088
Foxf1a	forkhead box F1a	0.085
Lrp1	low density lipoprotein receptor-related protein 1	0.085
Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	0.084
Rara	retinoic acid receptor, alpha	0.083
Lox	lysyl oxidase	0.077
Cxcr4	chemokine (C-X-C motif) receptor 4	0.077	Zebrafish
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.070
Wnt10b	wingless related MMTV integration site 10b	0.070	Mouse
Pax3	paired box gene 3	0.068
Fgf8	fibroblast growth factor 8	0.068
Igf1	insulin-like growth factor 1	0.066
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.064
Mertk	c-mer proto-oncogene tyrosine kinase	0.064	Mouse
Dlg4	discs, large homolog 4 (Drosophila)	0.064
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.061
Col13a1	collagen, type XIII, alpha 1	0.058
Hgf	hepatocyte growth factor	0.057
Porcn	porcupine homolog (Drosophila)	0.056
Bmp1	bone morphogenetic protein 1	0.055
Flt1	FMS-like tyrosine kinase 1	0.053
Jag2	jagged 2	0.052
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.052
Acvr1	activin A receptor, type 1	0.051
Fjx1	four jointed box 1 (Drosophila)	0.050
Emp2	epithelial membrane protein 2	0.049
Rarg	retinoic acid receptor, gamma	0.049
Aebp1	AE binding protein 1	0.049
Cpxm1	carboxypeptidase X 1 (M14 family)	0.048
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.048
Snai1	snail homolog 1 (Drosophila)	0.047
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.047	Mouse
Rarb	retinoic acid receptor, beta	0.046
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.043
Tbx1	T-box 1	0.042
Notch3	Notch gene homolog 3 (Drosophila)	0.041
Hic1	hypermethylated in cancer 1	0.040
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.040
Zfpm2	zinc finger protein, multitype 2	0.040
Sdc3	syndecan 3	0.039
Fn1	fibronectin 1	0.039
Fgf10	fibroblast growth factor 10	0.039
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.038
Fgf2	fibroblast growth factor 2	0.037
Matn4	matrilin 4	0.037
Gdf11	growth differentiation factor 11	0.036
Runx1	runt related transcription factor 1	0.035
Psen1	presenilin 1	0.034
Timp1	tissue inhibitor of metalloproteinase 1	0.034
Ltb	lymphotoxin B	0.034
Notch2	Notch gene homolog 2 (Drosophila)	0.034
Pcdh18	protocadherin 18	0.033
Hoxc9	homeobox C9	0.033
Cdx1	caudal type homeobox 1	0.033
Epha3	Eph receptor A3	0.033
Nes	nestin	0.032
Lama5	laminin, alpha 5	0.032
Sfrp1	secreted frizzled-related protein 1	0.032
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.032
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.031
Muc5ac	mucin 5, subtypes A and C, tracheobronchial/gastric	0.031
Fgf5	fibroblast growth factor 5	0.031
Cd248	CD248 antigen, endosialin	0.030
Gab2	growth factor receptor bound protein 2-associated protein 2	0.030
Nptx1	neuronal pentraxin 1	0.030
Mgat3	mannoside acetylglucosaminyltransferase 3	0.030
Trp73	transformation related protein 73	0.029
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.029
Plxna4	plexin A4	0.029	Mouse
Plat	plasminogen activator, tissue	0.029
Pou3f3	POU domain, class 3, transcription factor 3	0.028
Nodal	nodal	0.028
Grid1	glutamate receptor, ionotropic, delta 1	0.027
Gata6	GATA binding protein 6	0.027
Inhbb	inhibin beta-B	0.027
Adra2a	adrenergic receptor, alpha 2a	0.027
Wnt3a	wingless-related MMTV integration site 3A	0.026
Stra6	stimulated by retinoic acid gene 6	0.026
Timp3	tissue inhibitor of metalloproteinase 3	0.026
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.026
Plcg1	phospholipase C, gamma 1	0.026
Gjb5	gap junction protein, beta 5	0.026
Rspo1	R-spondin homolog (Xenopus laevis)	0.025
Itga3	integrin alpha 3	0.025
Fbln1	fibulin 1	0.025
Acvrl1	activin A receptor, type II-like 1	0.024
Hoxd11	homeobox D11	0.024
Unc5c	unc-5 homolog C (C. elegans)	0.024
Fgf15	fibroblast growth factor 15	0.024
Tcf21	transcription factor 21	0.024
Grb10	growth factor receptor bound protein 10	0.024
Syt10	synaptotagmin X	0.024
Bnc1	basonuclin 1	0.024
Col12a1	collagen, type XII, alpha 1	0.024
App	amyloid beta (A4) precursor protein	0.024
Trp53	transformation related protein 53	0.023
Fzd2	frizzled homolog 2 (Drosophila)	0.023
Fgfr4	fibroblast growth factor receptor 4	0.023
Gpc3	glypican 3	0.023
Tgfb2	transforming growth factor, beta 2	0.022
Pgf	placental growth factor	0.022
Npnt	nephronectin	0.022
Sh3pxd2a	SH3 and PX domains 2A	0.022
Sh3rf1	SH3 domain containing ring finger 1	0.022
Hoxc5	homeobox C5	0.022
Fosl2	fos-like antigen 2	0.022
Rgnef	Rho-guanine nucleotide exchange factor	0.022
Wnt2b	wingless related MMTV integration site 2b	0.022	Mouse
Wnt9a	wingless-type MMTV integration site 9A	0.022	Mouse
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.021
Nrp1	neuropilin 1	0.021
Cdk14	cyclin-dependent kinase 14	0.021
Des	desmin	0.021
Edn1	endothelin 1	0.021
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.021
Twist1	twist homolog 1 (Drosophila)	0.021
Myf5	myogenic factor 5	0.021
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.021
Fbn1	fibrillin 1	0.020
Ccdc24	coiled-coil domain containing 24	0.020
Ptgs2	prostaglandin-endoperoxide synthase 2	0.020
Tbx2	T-box 2	0.020
Pld1	phospholipase D1	0.019
Adra2c	adrenergic receptor, alpha 2c	0.019
Chst2	carbohydrate sulfotransferase 2	0.019
Cdx2	caudal type homeobox 2	0.019
Met	met proto-oncogene	0.019	Mouse
Htra3	HtrA serine peptidase 3	0.018
Neurog1	neurogenin 1	0.018
4933407C03Rik	RIKEN cDNA 4933407C03 gene	0.018
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.018
Timp2	tissue inhibitor of metalloproteinase 2	0.018
Mmp15	matrix metallopeptidase 15	0.018
Cxcl12	chemokine (C-X-C motif) ligand 12	0.018	Zebrafish
Dock1	dedicator of cytokinesis 1	0.017
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.017
Npr1	natriuretic peptide receptor 1	0.017
Itgb5	integrin beta 5	0.017
Gata5	GATA binding protein 5	0.017
9030425E11Rik	RIKEN cDNA 9030425E11 gene	0.017
Pvrl1	poliovirus receptor-related 1	0.017
Ptk7	PTK7 protein tyrosine kinase 7	0.017
Gpr3	G-protein coupled receptor 3	0.017
Wnt7a	wingless-related MMTV integration site 7A	0.017	Mouse
Pou3f2	POU domain, class 3, transcription factor 2	0.017
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.017
Cd44	CD44 antigen	0.017
Ntf3	neurotrophin 3	0.017
Ifnar1	interferon (alpha and beta) receptor 1	0.016
Efna4	ephrin A4	0.016
Sphk1	sphingosine kinase 1	0.016
Epha2	Eph receptor A2	0.016
Apc2	adenomatosis polyposis coli 2	0.016
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.016
Angpt1	angiopoietin 1	0.016
Mdm2	transformed mouse 3T3 cell double minute 2	0.016
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.016
Clip2	CAP-GLY domain containing linker protein 2	0.016
Bdkrb2	bradykinin receptor, beta 2	0.016
Nbl1	neuroblastoma, suppression of tumorigenicity 1	0.016
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.016
Hoxb3	homeobox B3	0.016
Dock4	dedicator of cytokinesis 4	0.016
Axin2	axin2	0.016
Id1	inhibitor of DNA binding 1	0.015
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.015
Nynrin	NYN domain and retroviral integrase containing	0.015
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.015
Rassf1	Ras association (RalGDS/AF-6) domain family member 1	0.015
Slc6a2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.015
Rtkn	rhotekin	0.015
Arhgef17	Rho guanine nucleotide exchange factor (GEF) 17	0.015
Srgap1	SLIT-ROBO Rho GTPase activating protein 1	0.015
Ldb2	LIM domain binding 2	0.015
Ret	ret proto-oncogene	0.015
Cacng7	calcium channel, voltage-dependent, gamma subunit 7	0.015
Cul7	cullin 7	0.015
Il12b	interleukin 12b	0.015
Amh	anti-Mullerian hormone	0.015
Hoxa13	homeobox A13	0.015
Thbs2	thrombospondin 2	0.015
Sycn	syncollin	0.014
Ltbp2	latent transforming growth factor beta binding protein 2	0.014
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.014
Ager	advanced glycosylation end product-specific receptor	0.014
C3ar1	complement component 3a receptor 1	0.014
Ptk2	PTK2 protein tyrosine kinase 2	0.014
Fzd7	frizzled homolog 7 (Drosophila)	0.014
Foxf2	forkhead box F2	0.014
Pax2	paired box gene 2	0.014
C5ar1	complement component 5a receptor 1	0.013
Cachd1	cache domain containing 1	0.013
T	brachyury	0.013
Msi1	Musashi homolog 1(Drosophila)	0.013
Ids	iduronate 2-sulfatase	0.013
Ptpru	protein tyrosine phosphatase, receptor type, U	0.013
Osr1	odd-skipped related 1 (Drosophila)	0.013
Sirpa	signal-regulatory protein alpha	0.013
Kl	klotho	0.013
Tacr1	tachykinin receptor 1	0.013
Bcl2	B-cell leukemia/lymphoma 2	0.013
Pdpn	podoplanin	0.013
Pdgfb	platelet derived growth factor, B polypeptide	0.013
Numb	numb gene homolog (Drosophila)	0.013
Selp	selectin, platelet	0.013
Sorbs3	sorbin and SH3 domain containing 3	0.013
Adora2b	adenosine A2b receptor	0.013
Hoxb4	homeobox B4	0.013
Fgf3	fibroblast growth factor 3	0.013
Hip1	huntingtin interacting protein 1	0.013
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.012
Plekhh2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	0.012
Fgf17	fibroblast growth factor 17	0.012
Msr1	macrophage scavenger receptor 1	0.012
Gata4	GATA binding protein 4	0.012
Npas1	neuronal PAS domain protein 1	0.012
Grem2	gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)	0.012
Colec12	collectin sub-family member 12	0.012
Adam8	a disintegrin and metallopeptidase domain 8	0.012
Mfap4	microfibrillar-associated protein 4	0.012
Slc7a11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	0.012
Zfp503	zinc finger protein 503	0.012
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.012
Col4a3	collagen, type IV, alpha 3	0.012
Emx2	empty spiracles homolog 2 (Drosophila)	0.012
Meox1	mesenchyme homeobox 1	0.012
Ednrb	endothelin receptor type B	0.012
Rdh10	retinol dehydrogenase 10 (all-trans)	0.011
Nkd1	naked cuticle 1 homolog (Drosophila)	0.011
Hnf1b	HNF1 homeobox B	0.011
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.011
Cdh6	cadherin 6	0.011
Sstr1	somatostatin receptor 1	0.011
Fat4	FAT tumor suppressor homolog 4 (Drosophila)	0.011
Dchs1	dachsous 1 (Drosophila)	0.011
Sftpb	surfactant associated protein B	0.011
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.011
Psen2	presenilin 2	0.011
Kitl	kit ligand	0.011
Col16a1	collagen, type XVI, alpha 1	0.011
Nkx2-1	NK2 homeobox 1	0.011
Mmp10	matrix metallopeptidase 10	0.011	Mouse
Dkk3	dickkopf homolog 3 (Xenopus laevis)	0.011
Has1	hyaluronan synthase1	0.011
Chrd	chordin	0.011
Sfrp2	secreted frizzled-related protein 2	0.011
Pnmt	phenylethanolamine-N-methyltransferase	0.011
Hoxa2	homeobox A2	0.011
Tead3	TEA domain family member 3	0.011
Spdef	SAM pointed domain containing ets transcription factor	0.011
Fam20c	family with sequence similarity 20, member C	0.011
Lhx9	LIM homeobox protein 9	0.011
Mmp7	matrix metallopeptidase 7	0.011	Mouse
Mkl2	MKL/myocardin-like 2	0.010
Pou3f1	POU domain, class 3, transcription factor 1	0.010
Map3k6	mitogen-activated protein kinase kinase kinase 6	0.010
Oc90	otoconin 90	0.010
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.010
Pdgfa	platelet derived growth factor, alpha	0.010
Bmp5	bone morphogenetic protein 5	0.010
Ccnd1	cyclin D1	0.010
Hes1	hairy and enhancer of split 1 (Drosophila)	0.010
Prx	periaxin	0.010
Fzd6	frizzled homolog 6 (Drosophila)	0.010
Wnt3	wingless-related MMTV integration site 3	0.010
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.010
Mid2	midline 2	0.010