IMP

Process View

Mus musculus

18 genes annotated in mouse

osteoblast proliferation

The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "osteoblast proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "osteoblast proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
Fgfr2	fibroblast growth factor receptor 2	0.912
Gli3	GLI-Kruppel family member GLI3	0.910
Jun	Jun oncogene	0.601	Mouse
Arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	0.563
Bmp4	bone morphogenetic protein 4	0.474	Mouse
Trp53	transformation related protein 53	0.471
Ctnnb1	catenin (cadherin associated protein), beta 1	0.363
Fos	FBJ osteosarcoma oncogene	0.347
Bcl2	B-cell leukemia/lymphoma 2	0.331
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.309
Nf1	neurofibromatosis 1	0.299
Smad6	MAD homolog 6 (Drosophila)	0.273	Mouse
Nodal	nodal	0.263
Gata4	GATA binding protein 4	0.257	Mouse
Shh	sonic hedgehog	0.225
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.217
Gata6	GATA binding protein 6	0.178	Mouse
Gli2	GLI-Kruppel family member GLI2	0.158
Smad1	MAD homolog 1 (Drosophila)	0.140	Mouse
Fgfr1	fibroblast growth factor receptor 1	0.140
Axin1	axin 1	0.132
Dusp1	dual specificity phosphatase 1	0.125
Itga3	integrin alpha 3	0.122	Mouse
Wt1	Wilms tumor 1 homolog	0.115
Apc	adenomatosis polyposis coli	0.114
Fgfr3	fibroblast growth factor receptor 3	0.111
Ptk2	PTK2 protein tyrosine kinase 2	0.107
Smad4	MAD homolog 4 (Drosophila)	0.107	Mouse
Hand1	heart and neural crest derivatives expressed transcript 1	0.107
Vangl2	vang-like 2 (van gogh, Drosophila)	0.104
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.103
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.099
Emx2	empty spiracles homolog 2 (Drosophila)	0.097
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.086
Kit	kit oncogene	0.083
Tbx3	T-box 3	0.075
Vegfa	vascular endothelial growth factor A	0.074
Smad3	MAD homolog 3 (Drosophila)	0.070
Meox2	mesenchyme homeobox 2	0.068
Hhex	hematopoietically expressed homeobox	0.067
Cd151	CD151 antigen	0.066
Klf6	Kruppel-like factor 6	0.064
Lef1	lymphoid enhancer binding factor 1	0.063
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.063
Nynrin	NYN domain and retroviral integrase containing	0.062
Tgfb2	transforming growth factor, beta 2	0.060
Tcf21	transcription factor 21	0.059
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.058
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.057
Lama5	laminin, alpha 5	0.055
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.051
Pax3	paired box gene 3	0.050
Rara	retinoic acid receptor, alpha	0.050
Foxf1a	forkhead box F1a	0.050
Erbb2ip	Erbb2 interacting protein	0.049
Adam17	a disintegrin and metallopeptidase domain 17	0.046
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.046
Ltbp1	latent transforming growth factor beta binding protein 1	0.045
Rarg	retinoic acid receptor, gamma	0.045
Fgf10	fibroblast growth factor 10	0.045
Gas1	growth arrest specific 1	0.044
Wnt5a	wingless-related MMTV integration site 5A	0.044
Lrp6	low density lipoprotein receptor-related protein 6	0.042	Mouse
Zfp36	zinc finger protein 36	0.041
Prkg1	protein kinase, cGMP-dependent, type I	0.039
Efnb1	ephrin B1	0.038
Thbs1	thrombospondin 1	0.038
Gp9	glycoprotein 9 (platelet)	0.038
Ptch1	patched homolog 1	0.037
Egr1	early growth response 1	0.037
Rnf111	ring finger 111	0.036
Pax2	paired box gene 2	0.036
Eng	endoglin	0.036
Btg2	B-cell translocation gene 2, anti-proliferative	0.036
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.034
Pten	phosphatase and tensin homolog	0.033
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.033
Vhl	von Hippel-Lindau tumor suppressor	0.031
Tbx1	T-box 1	0.031
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.031
Wwtr1	WW domain containing transcription regulator 1	0.030
App	amyloid beta (A4) precursor protein	0.030
Pdgfb	platelet derived growth factor, B polypeptide	0.030
She	src homology 2 domain-containing transforming protein E	0.030
Gpc3	glypican 3	0.030
Sox7	SRY-box containing gene 7	0.029	Mouse
Plaur	plasminogen activator, urokinase receptor	0.029
Sox17	SRY-box containing gene 17	0.028	Mouse
Apoe	apolipoprotein E	0.028
Tal1	T-cell acute lymphocytic leukemia 1	0.028
Bmp7	bone morphogenetic protein 7	0.027
Atf3	activating transcription factor 3	0.027
Fgf8	fibroblast growth factor 8	0.027
Hes1	hairy and enhancer of split 1 (Drosophila)	0.027
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.026
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.026
Sox4	SRY-box containing gene 4	0.026	Mouse
Flt1	FMS-like tyrosine kinase 1	0.026
Tbx2	T-box 2	0.026
Ednrb	endothelin receptor type B	0.026
Il10ra	interleukin 10 receptor, alpha	0.025
Rxra	retinoid X receptor alpha	0.025
Spn	sialophorin	0.025
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.025
Kitl	kit ligand	0.024
Smad2	MAD homolog 2 (Drosophila)	0.024	Mouse
Apaf1	apoptotic peptidase activating factor 1	0.023
Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	0.023
Mrc2	mannose receptor, C type 2	0.022
Upk3b	uroplakin 3B	0.022
Fgf3	fibroblast growth factor 3	0.022
Ric8	resistance to inhibitors of cholinesterase 8 homolog (C. elegans)	0.022
Dok1	docking protein 1	0.022
Epha4	Eph receptor A4	0.021
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.021
Tgfa	transforming growth factor alpha	0.021
Prrx1	paired related homeobox 1	0.021
Rarb	retinoic acid receptor, beta	0.021
Col4a3	collagen, type IV, alpha 3	0.021
Jag1	jagged 1	0.021
Itgb3	integrin beta 3	0.021
Efs	embryonal Fyn-associated substrate	0.020
Mc5r	melanocortin 5 receptor	0.020
Sox11	SRY-box containing gene 11	0.020	Mouse
Ngp	neutrophilic granule protein	0.020
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.020
Elf4	E74-like factor 4 (ets domain transcription factor)	0.019
Fzd4	frizzled homolog 4 (Drosophila)	0.019
Acvrl1	activin A receptor, type II-like 1	0.019
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.019
Fzd1	frizzled homolog 1 (Drosophila)	0.019
Ptgs2	prostaglandin-endoperoxide synthase 2	0.019
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.019
Adcy4	adenylate cyclase 4	0.019
Camp	cathelicidin antimicrobial peptide	0.018
Hbegf	heparin-binding EGF-like growth factor	0.018
Klf4	Kruppel-like factor 4 (gut)	0.018
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.018
Aplnr	apelin receptor	0.018
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.018
Notch3	Notch gene homolog 3 (Drosophila)	0.018
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.018
Pbx1	pre B-cell leukemia transcription factor 1	0.017
Hoxa5	homeobox A5	0.017
Gsk3b	glycogen synthase kinase 3 beta	0.017
Gja1	gap junction protein, alpha 1	0.017
Zfpm1	zinc finger protein, multitype 1	0.017
Eda	ectodysplasin-A	0.017
Sdc3	syndecan 3	0.017
Twist2	twist homolog 2 (Drosophila)	0.017
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.017
Grb10	growth factor receptor bound protein 10	0.017
Ggta1	glycoprotein galactosyltransferase alpha 1, 3	0.017
Rhob	ras homolog gene family, member B	0.017	Mouse
Snai1	snail homolog 1 (Drosophila)	0.017
Ret	ret proto-oncogene	0.017
Lamc1	laminin, gamma 1	0.016
Nkx2-1	NK2 homeobox 1	0.016
Rac2	RAS-related C3 botulinum substrate 2	0.016
Gp5	glycoprotein 5 (platelet)	0.016
Bmp1	bone morphogenetic protein 1	0.016
Epha2	Eph receptor A2	0.016
Klf3	Kruppel-like factor 3 (basic)	0.016
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.016
Nfia	nuclear factor I/A	0.016
Kif3a	kinesin family member 3A	0.016
Epas1	endothelial PAS domain protein 1	0.016
Amotl2	angiomotin-like 2	0.016
Runx2	runt related transcription factor 2	0.016
S1pr2	sphingosine-1-phosphate receptor 2	0.016
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.015
Itga4	integrin alpha 4	0.015	Mouse
Tln1	talin 1	0.015
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.015
Rac1	RAS-related C3 botulinum substrate 1	0.015
Bach1	BTB and CNC homology 1	0.015
Vasp	vasodilator-stimulated phosphoprotein	0.015
C5ar1	complement component 5a receptor 1	0.015
Myo1f	myosin IF	0.015
Foxj1	forkhead box J1	0.015
Msx1	homeobox, msh-like 1	0.015
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.015
Smad7	MAD homolog 7 (Drosophila)	0.015	Mouse
Selp	selectin, platelet	0.014
Hoxb3	homeobox B3	0.014
Col12a1	collagen, type XII, alpha 1	0.014
Egr2	early growth response 2	0.014
Acvr1	activin A receptor, type 1	0.014
Alox12	arachidonate 12-lipoxygenase	0.014
Ier2	immediate early response 2	0.014
Lrp5	low density lipoprotein receptor-related protein 5	0.014
Hoxb4	homeobox B4	0.014
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.014
Adam8	a disintegrin and metallopeptidase domain 8	0.014
Braf	Braf transforming gene	0.014
Foxp1	forkhead box P1	0.014
Inpp5d	inositol polyphosphate-5-phosphatase D	0.014
Gpr132	G protein-coupled receptor 132	0.013
Itgam	integrin alpha M	0.013	Mouse
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.013
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.013
Lyst	lysosomal trafficking regulator	0.013
Hdac2	histone deacetylase 2	0.013
Gna15	guanine nucleotide binding protein, alpha 15	0.013
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.013
Bmp5	bone morphogenetic protein 5	0.013
Cyr61	cysteine rich protein 61	0.013	Human
Mfn2	mitofusin 2	0.013
Nrp1	neuropilin 1	0.013
Mapk14	mitogen-activated protein kinase 14	0.013
Fstl3	follistatin-like 3	0.013
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.013
Des	desmin	0.013
Nos3	nitric oxide synthase 3, endothelial cell	0.013
Muc13	mucin 13, epithelial transmembrane	0.013
Hip1	huntingtin interacting protein 1	0.013
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.013
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.012
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.012
Skil	SKI-like	0.012
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.012
Trp63	transformation related protein 63	0.012
Nes	nestin	0.012
Ksr1	kinase suppressor of ras 1	0.012
Cxcr4	chemokine (C-X-C motif) receptor 4	0.012
Mapk1	mitogen-activated protein kinase 1	0.012
Emp2	epithelial membrane protein 2	0.012
Pcdh12	protocadherin 12	0.012
Junb	Jun-B oncogene	0.012
Stom	stomatin	0.012
Itgal	integrin alpha L	0.012	Mouse
Wrn	Werner syndrome homolog (human)	0.012
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.012
Tnfrsf12a	tumor necrosis factor receptor superfamily, member 12a	0.012
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.012	Mouse
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.012
Gdnf	glial cell line derived neurotrophic factor	0.012
Gata2	GATA binding protein 2	0.011	Mouse
Dok2	docking protein 2	0.011
Runx1	runt related transcription factor 1	0.011
Axin2	axin2	0.011
Zic3	zinc finger protein of the cerebellum 3	0.011
Nkd1	naked cuticle 1 homolog (Drosophila)	0.011
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.011
Hoxa13	homeobox A13	0.011
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.011
Cux1	cut-like homeobox 1	0.011
Ciita	class II transactivator	0.011
Gadd45b	growth arrest and DNA-damage-inducible 45 beta	0.011
Ptk7	PTK7 protein tyrosine kinase 7	0.011
Efna4	ephrin A4	0.011
Itgax	integrin alpha X	0.011	Mouse
Lrp2	low density lipoprotein receptor-related protein 2	0.011	Mouse
Gfi1b	growth factor independent 1B	0.011
Wwc2	WW, C2 and coiled-coil domain containing 2	0.011
Zfp503	zinc finger protein 503	0.011
Yap1	yes-associated protein 1	0.011
Tspan9	tetraspanin 9	0.011
Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	0.010
Mpo	myeloperoxidase	0.010
Batf	basic leucine zipper transcription factor, ATF-like	0.010
Sertad2	SERTA domain containing 2	0.010
Lhx1	LIM homeobox protein 1	0.010
Tbxas1	thromboxane A synthase 1, platelet	0.010
Tead4	TEA domain family member 4	0.010
Cx3cr1	chemokine (C-X3-C) receptor 1	0.010
Sox13	SRY-box containing gene 13	0.010
Igll1	immunoglobulin lambda-like polypeptide 1	0.010
Cdh6	cadherin 6	0.010
Col13a1	collagen, type XIII, alpha 1	0.010
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.010
Wls	wntless homolog (Drosophila)	0.010
Tnks1bp1	tankyrase 1 binding protein 1	0.010
Usp25	ubiquitin specific peptidase 25	0.010