IMP

Process View

Mus musculus

1 genes annotated in mouse

positive regulation of cell proliferation involved in heart valve morphogenesis

Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of cell proliferation involved in heart valve morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of cell proliferation involved in heart valve morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
Ctnnb1	catenin (cadherin associated protein), beta 1	1.000
Apc	adenomatosis polyposis coli	1.000
Smad4	MAD homolog 4 (Drosophila)	1.000
Smad1	MAD homolog 1 (Drosophila)	1.000	Mouse
Axin1	axin 1	0.997
Pten	phosphatase and tensin homolog	0.997
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.996
Smad3	MAD homolog 3 (Drosophila)	0.990	Mouse
Erbb2ip	Erbb2 interacting protein	0.989
Trp53	transformation related protein 53	0.985
Fgfr2	fibroblast growth factor receptor 2	0.967
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.947
Bmp4	bone morphogenetic protein 4	0.883
Ptch1	patched homolog 1	0.857
Gsk3b	glycogen synthase kinase 3 beta	0.852
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.795
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.765
Gata4	GATA binding protein 4	0.741
Kit	kit oncogene	0.671
Meox2	mesenchyme homeobox 2	0.670
Acvr1	activin A receptor, type 1	0.633
Col1a1	collagen, type I, alpha 1	0.612
Fgfr1	fibroblast growth factor receptor 1	0.582
Gli3	GLI-Kruppel family member GLI3	0.559
Rnf111	ring finger 111	0.555
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.553
Sox9	SRY-box containing gene 9	0.536
Prkg1	protein kinase, cGMP-dependent, type I	0.523
Il6st	interleukin 6 signal transducer	0.493
Vhl	von Hippel-Lindau tumor suppressor	0.463
Stat3	signal transducer and activator of transcription 3	0.455
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.427
Braf	Braf transforming gene	0.362
Thbs1	thrombospondin 1	0.359
Shh	sonic hedgehog	0.359
Ptgs2	prostaglandin-endoperoxide synthase 2	0.343
Foxc1	forkhead box C1	0.338
Kitl	kit ligand	0.335
Hif1a	hypoxia inducible factor 1, alpha subunit	0.334
Vegfa	vascular endothelial growth factor A	0.316
Lrp6	low density lipoprotein receptor-related protein 6	0.316
Nos3	nitric oxide synthase 3, endothelial cell	0.315
Tgfbr2	transforming growth factor, beta receptor II	0.284
Arid1a	AT rich interactive domain 1A (SWI-like)	0.281
Smad7	MAD homolog 7 (Drosophila)	0.270	Mouse
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.259
Bptf	bromodomain PHD finger transcription factor	0.252
Rxra	retinoid X receptor alpha	0.226
Zmym2	zinc finger, MYM-type 2	0.214
Lepr	leptin receptor	0.209
Tgfb2	transforming growth factor, beta 2	0.208
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.201
Foxp1	forkhead box P1	0.189
Pbx1	pre B-cell leukemia transcription factor 1	0.188
Gja1	gap junction protein, alpha 1	0.186
Fzd1	frizzled homolog 1 (Drosophila)	0.166
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.160
Hes1	hairy and enhancer of split 1 (Drosophila)	0.153
Stk11	serine/threonine kinase 11	0.152
Vdr	vitamin D receptor	0.148
Smad6	MAD homolog 6 (Drosophila)	0.148	Mouse
Fgfr3	fibroblast growth factor receptor 3	0.137
Lrp5	low density lipoprotein receptor-related protein 5	0.125
Otx2	orthodenticle homolog 2 (Drosophila)	0.122
Tbx3	T-box 3	0.118
Adam17	a disintegrin and metallopeptidase domain 17	0.115
Tcf4	transcription factor 4	0.115
Amhr2	anti-Mullerian hormone type 2 receptor	0.110
Efnb2	ephrin B2	0.109
Tcf12	transcription factor 12	0.106
Bcl2	B-cell leukemia/lymphoma 2	0.105
Pknox1	Pbx/knotted 1 homeobox	0.104
Nf1	neurofibromatosis 1	0.104
Pitx2	paired-like homeodomain transcription factor 2	0.103
Jag1	jagged 1	0.098
Esr1	estrogen receptor 1 (alpha)	0.094
Smo	smoothened homolog (Drosophila)	0.094
Smad2	MAD homolog 2 (Drosophila)	0.093	Mouse
Ahr	aryl-hydrocarbon receptor	0.091
Eif4enif1	eukaryotic translation initiation factor 4E nuclear import factor 1	0.091
Tgfbr1	transforming growth factor, beta receptor I	0.090
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.085
Zfp362	zinc finger protein 362	0.081
Bmp2	bone morphogenetic protein 2	0.077
Crebbp	CREB binding protein	0.073
Gata6	GATA binding protein 6	0.071
Yap1	yes-associated protein 1	0.071
Smad5	MAD homolog 5 (Drosophila)	0.069	Mouse
Chuk	conserved helix-loop-helix ubiquitous kinase	0.068
March7	membrane-associated ring finger (C3HC4) 7	0.062
Tgfb1	transforming growth factor, beta 1	0.062
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.062
Notch1	Notch gene homolog 1 (Drosophila)	0.062
Nf2	neurofibromatosis 2	0.059
Efnb1	ephrin B1	0.058
Foxc2	forkhead box C2	0.058
Mdm2	transformed mouse 3T3 cell double minute 2	0.054
Rara	retinoic acid receptor, alpha	0.053
Fgf8	fibroblast growth factor 8	0.050
Rb1	retinoblastoma 1	0.050
Gli2	GLI-Kruppel family member GLI2	0.046
Rnf44	ring finger protein 44	0.043
Rarg	retinoic acid receptor, gamma	0.042
Bach1	BTB and CNC homology 1	0.041
Nodal	nodal	0.040
Htt	huntingtin	0.039
Mrc2	mannose receptor, C type 2	0.039
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.038
Nog	noggin	0.038
Bmp7	bone morphogenetic protein 7	0.038
Egfr	epidermal growth factor receptor	0.036
Esr2	estrogen receptor 2 (beta)	0.035
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.033
Psen1	presenilin 1	0.033
Hhex	hematopoietically expressed homeobox	0.033
Lef1	lymphoid enhancer binding factor 1	0.032
Efna4	ephrin A4	0.032
Csnk1e	casein kinase 1, epsilon	0.032
Jun	Jun oncogene	0.031
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.031
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.030
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.030
Peli1	pellino 1	0.029
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.029
Vangl2	vang-like 2 (van gogh, Drosophila)	0.028
Acvr2a	activin receptor IIA	0.028
Nkd1	naked cuticle 1 homolog (Drosophila)	0.028
Ski	ski sarcoma viral oncogene homolog (avian)	0.028
Zeb1	zinc finger E-box binding homeobox 1	0.028
Klf3	Kruppel-like factor 3 (basic)	0.028
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.028
Ptk2	PTK2 protein tyrosine kinase 2	0.027
Klf10	Kruppel-like factor 10	0.027
Axin2	axin2	0.027
Cbfb	core binding factor beta	0.027
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.025
Itga3	integrin alpha 3	0.025
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.024
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.023
Hand2	heart and neural crest derivatives expressed transcript 2	0.023
Mll5	myeloid/lymphoid or mixed-lineage leukemia 5	0.022
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.022
Rac1	RAS-related C3 botulinum substrate 1	0.022
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.021
Ddx5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.021
Cyr61	cysteine rich protein 61	0.020
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.020
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.020
Wwtr1	WW domain containing transcription regulator 1	0.020
Hivep1	human immunodeficiency virus type I enhancer binding protein 1	0.020
Tbx2	T-box 2	0.019
Traf6	TNF receptor-associated factor 6	0.019
Spin1	spindlin 1	0.019
Foxa2	forkhead box A2	0.019
Ikbkg	inhibitor of kappaB kinase gamma	0.019
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.018
Npc1	Niemann Pick type C1	0.018
Ccnd1	cyclin D1	0.018
Cd44	CD44 antigen	0.018
Ptk7	PTK7 protein tyrosine kinase 7	0.017
Tgfbr3	transforming growth factor, beta receptor III	0.017
Grb10	growth factor receptor bound protein 10	0.017
Rarb	retinoic acid receptor, beta	0.017
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.017
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.017
Sox4	SRY-box containing gene 4	0.016
Klf7	Kruppel-like factor 7 (ubiquitous)	0.016
Tbx1	T-box 1	0.016
Snai1	snail homolog 1 (Drosophila)	0.016
Gpc3	glypican 3	0.015
Egr1	early growth response 1	0.015
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.015
Igf1r	insulin-like growth factor I receptor	0.015
Vezf1	vascular endothelial zinc finger 1	0.014
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.014
Fzd7	frizzled homolog 7 (Drosophila)	0.014
Prrx1	paired related homeobox 1	0.014
Ncoa2	nuclear receptor coactivator 2	0.014
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.014
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.014
Gtf2i	general transcription factor II I	0.013
Hp1bp3	heterochromatin protein 1, binding protein 3	0.013
Mcl1	myeloid cell leukemia sequence 1	0.013
Wwc2	WW, C2 and coiled-coil domain containing 2	0.013
Klf6	Kruppel-like factor 6	0.013
Ep300	E1A binding protein p300	0.013
Gas1	growth arrest specific 1	0.013
Id3	inhibitor of DNA binding 3	0.013
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.013
Notch2	Notch gene homolog 2 (Drosophila)	0.012
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.012
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.012
2400003C14Rik	RIKEN cDNA 2400003C14 gene	0.012
Sp1	trans-acting transcription factor 1	0.012
Usp22	ubiquitin specific peptidase 22	0.012
Brd4	bromodomain containing 4	0.011
Dlg1	discs, large homolog 1 (Drosophila)	0.011
Prkd3	protein kinase D3	0.011
Pkd1	polycystic kidney disease 1 homolog	0.011
Ncoa6	nuclear receptor coactivator 6	0.011
Ucn	urocortin	0.011
Gna13	guanine nucleotide binding protein, alpha 13	0.011
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.011
Ids	iduronate 2-sulfatase	0.011
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.011
Epas1	endothelial PAS domain protein 1	0.011
Phf13	PHD finger protein 13	0.011
D15Ertd621e	DNA segment, Chr 15, ERATO Doi 621, expressed	0.011
Wnt5a	wingless-related MMTV integration site 5A	0.010
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.010
Ar	androgen receptor	0.010
Fzd2	frizzled homolog 2 (Drosophila)	0.010
Arid1b	AT rich interactive domain 1B (SWI-like)	0.010