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Danio rerio

0 genes annotated in zebrafish

colorectal cancer

DOID:9256

A large intestine cancer that is located in the colon and/or located in the rectum.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "colorectal cancer" (in gray)

Name	Description	Probability	Func Analog Organism
wls	wntless homolog (Drosophila)	0.360
smad5	MAD homolog 5 (Drosophila)	0.335
neo1	neogenin 1	0.272
gli2a	GLI-Kruppel family member GLI2a	0.228
her9	hairy-related 9	0.191
cdh2	cadherin 2, neuronal	0.164
znf503	zinc finger protein 503	0.155
slc2a10	solute carrier family 2 (facilitated glucose transporter), member 10	0.140
fgfr4	fibroblast growth factor receptor 4	0.135
pbx4	pre-B-cell leukemia transcription factor 4	0.135
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.117
bactin1	bactin1	0.116
sox11b	SRY-box containing gene 11b	0.106
gata1a	GATA binding protein 1a	0.102
dag1	dystroglycan 1	0.093
fzd7a	frizzled homolog 7a	0.083
pcna	proliferating cell nuclear antigen	0.080
rarga	retinoic acid receptor gamma a	0.076
dusp6	dual specificity phosphatase 6	0.071
meis1	myeloid ecotropic viral integration 1	0.064
celf1	cugbp, Elav-like family member 1	0.064
fzd7b	frizzled homolog 7b	0.060
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.060
fgfr2	fibroblast growth factor receptor 2	0.056
lfng	lunatic fringe homolog	0.055
ccng1	cyclin G1	0.052
znf703	zinc finger protein 703	0.052
tp53	tumor protein p53	0.052	Human
cdc25	cell division cycle 25 homolog	0.049
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.047
mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.046
ccnb1	cyclin B1	0.046
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.045
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.043
ccnd1	cyclin D1	0.042	Human
cdc20	cell division cycle 20 homolog	0.039
ccnb2	cyclin B2	0.039
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.038
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.038
ef1a	elongation factor 1-alpha	0.038
wnt11r	wingless-type MMTV integration site family, member 11, related	0.037
pcdh19	protocadherin 19	0.036
her6	hairy-related 6	0.035
nrarpa	notch-regulated ankyrin repeat protein a	0.035
hoxb8a	homeo box B8a	0.035
gli3	GLI-Kruppel family member GLI3	0.035
axin2	axin 2 (conductin, axil)	0.034	Human
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.034
met	met proto-oncogene (hepatocyte growth factor receptor)	0.034
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.034
lamc1	laminin, gamma 1	0.033
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.033
tcf12	transcription factor 12	0.032
lef1	lymphocyte enhancer binding factor 1	0.032
krt4	keratin 4	0.032
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.032
ccna2	cyclin A2	0.031
zgc:101724	zgc:101724	0.030
med24	mediator complex subunit 24	0.029
chd7	chromodomain helicase DNA binding protein 7	0.029
gclm	glutamate-cysteine ligase, modifier subunit	0.029
elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.028
plk1	polo-like kinase 1 (Drosophila)	0.028
sfrp1a	secreted frizzled-related protein 1a	0.028
notch3	notch homolog 3	0.027
chek2	CHK2 checkpoint homolog (S. pombe)	0.027
mmp9	matrix metalloproteinase 9	0.027
zgc:112425	zgc:112425	0.027
cahz	carbonic anhydrase	0.027
sox21a	SRY-box containing gene 21a	0.027
rnd3a	Rho family GTPase 3a	0.026
ptpn1	protein tyrosine phosphatase, non-receptor type 1	0.026
eaf2	ELL associated factor 2	0.026
nr2f5	nuclear receptor subfamily 2, group F, member 5	0.026
zic2b	zic family member 2 (odd-paired homolog, Drosophila) b	0.026
hmga1a	high mobility group AT-hook 1a	0.025
lamb1a	laminin, beta 1a	0.025
orc1	origin recognition complex, subunit 1	0.025
trim71	tripartite motif-containing 71	0.024
ahctf1	AT hook containing transcription factor 1	0.024
pcdh18a	protocadherin 18a	0.024
dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.023
fgfr1b	fibroblast growth factor receptor 1b	0.023
pdgfaa	platelet-derived growth factor alpha a	0.023
mcl1a	myeloid cell leukemia sequence 1a	0.023
slc4a1a	solute carrier family 4, anion exchanger, member 1a	0.023
rhoab	ras homolog gene family, member Ab	0.022
eef2b	eukaryotic translation elongation factor 2b	0.022
tgif1	TGFB-induced factor homeobox 1	0.021
id1	inhibitor of DNA binding 1	0.021
rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.021
zeb2a	zinc finger E-box binding homeobox 2a	0.021
si:ch211-69g19.2	si:ch211-69g19.2	0.021
zgc:162630	zgc:162630	0.021
hoxa4a	homeo box A4a	0.020
pea3	ETS-domain transcription factor pea3	0.020
dnmt7	DNA (cytosine-5-)-methyltransferase 7	0.020
prmt1	protein arginine methyltransferase 1	0.020
zbtb16a	zinc finger and BTB domain containing 16a	0.020
hoxb3a	homeo box B3a	0.019
yap1	Yes-associated protein 1	0.019
psen1	presenilin 1	0.019
myca	myelocytomatosis oncogene a	0.019
slc20a1b	solute carrier family 20, member 1b	0.019
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.019
pdcd2	programmed cell death 2	0.019
rasl11b	RAS-like, family 11, member B	0.019
boc	brother of CDO	0.019
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.018
khsrp	KH-type splicing regulatory protein	0.018
atp6v0ca	ATPase, H+ transporting, lysosomal, V0 subunit c, a	0.018
irx3a	iroquois homeobox protein 3a	0.018
zgc:55671	zgc:55671	0.018
urod	uroporphyrinogen decarboxylase	0.018
twist1b	twist1b	0.018
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.017
tfr1a	transferrin receptor 1a	0.017
mych	myelocytomatosis oncogene homolog	0.017
khdrbs1b	KH domain containing, RNA binding, signal transduction associated 1b	0.017
max	myc-associated factor X	0.017
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.017
grnb	granulin b	0.016
plod1a	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a	0.016
tmpoa	thymopoietin a	0.016
st8sia6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	0.016
puf60a	poly-U binding splicing factor a	0.016
gfer	growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)	0.016
fgfrl1a	fibroblast growth factor receptor-like 1a	0.016
mtdha	metadherin a	0.016
st8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.016
ryk	receptor-like tyrosine kinase	0.016
ctnnb1	catenin (cadherin-associated protein), beta 1	0.015	Human
mbtps1	membrane-bound transcription factor protease, site 1	0.015
zgc:110687	zgc:110687	0.015
nr2f1a	nuclear receptor subfamily 2, group F, member 1a	0.015
melk	maternal embryonic leucine zipper kinase	0.015
k23	k23 gene	0.015
cx43.4	connexin 43.4	0.015
mapk14a	mitogen-activated protein kinase 14a	0.015
pdlim4	PDZ and LIM domain 4	0.015
grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.015
myod1	myogenic differentiation 1	0.014
lmo4a	LIM domain only 4a	0.014
lhx2b	LIM homeobox 2b	0.014
khdrbs1a	KH domain containing, RNA binding, signal transduction associated 1a	0.014
stil	TAL1 (SCL) interrupting locus	0.014
acsl4a	acyl-CoA synthetase long-chain family member 4a	0.014
ctsl1a	cathepsin L, 1 a	0.014
mcm4	MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)	0.014
wdhd1	WD repeat and HMG-box DNA binding protein 1	0.014
rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.014
shha	sonic hedgehog a	0.014
ctsd	cathepsin D	0.014
hoxb2a	homeo box B2a	0.014
hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.014
zeb1	zinc finger E-box binding homeobox 1	0.014
thoc4	THO complex 4	0.013
kif23	kinesin family member 23	0.013
baxa	bcl2-associated X protein, a	0.013	Human
smc4	structural maintenance of chromosomes 4	0.013
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.013
hhip	hedgehog interacting protein	0.013
dhfr	dihydrofolate reductase	0.013
snai1a	snail homolog 1a (Drosophila)	0.013
chaf1b	chromatin assembly factor 1, subunit B	0.013
nid2a	nidogen 2a (osteonidogen)	0.013
slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.013
tm9sf4	transmembrane 9 superfamily protein member 4	0.013
fktn	fukutin	0.013
eomesa	eomesodermin homolog a	0.013
npc1	Niemann-Pick disease, type C1	0.013
st8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.013
tjp1	tight junction protein 1 (zona occludens 1)	0.013
gro2	groucho 2	0.013
mgea5	meningioma expressed antigen 5 (hyaluronidase)	0.013
zgc:64114	zgc:64114	0.013
sec23a	Sec23 homolog A (S. cerevisiae)	0.013
sox11a	SRY-box containing gene 11a	0.013
pabpc1a	poly A binding protein, cytoplasmic 1 a	0.013
jag2	jagged 2	0.012
fancd2	Fanconi anemia, complementation group D2	0.012
diexf	digestive organ expansion factor homolog	0.012
ube2v2	ubiquitin-conjugating enzyme E2 variant 2	0.012
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.012
grna	granulin a	0.012
nras	neuroblastoma RAS viral (v-ras) oncogene homolog	0.012
bms1l	BMS1-like, ribosome assembly protein (yeast)	0.012
appa	amyloid beta (A4) precursor protein a	0.012
spred1	sprouty-related, EVH1 domain containing 1	0.012
mapk3	mitogen-activated protein kinase 3	0.012
ptprsa	protein tyrosine phosphatase, receptor type, s, a	0.012
sumo3a	SMT3 suppressor of mif two 3 homolog 3a	0.012
nup107	nucleoporin 107	0.012
id2a	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a	0.012
scube2	signal peptide, CUB domain, EGF-like 2	0.012
polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.012
trim33	tripartite motif-containing 33	0.012
sdcbp	syndecan binding protein (syntenin)	0.011
nr4a2b	nuclear receptor subfamily 4, group A, member 2b	0.011
dnm2l	dynamin2-like	0.011
marcksb	myristoylated alanine rich protein kinase C substrate b	0.011
egfl6	EGF-like-domain, multiple 6	0.011
tal1	T-cell acute lymphocytic leukemia 1	0.011
ruvbl2	RuvB-like 2 (E. coli)	0.011
eif4a1a	eukaryotic translation initiation factor 4A, isoform 1A	0.011
pomt2	protein-O-mannosyltransferase 2	0.011
crabp2b	cellular retinoic acid binding protein 2, b	0.011
mpped2	metallophosphoesterase domain containing 2	0.011
gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.011
hs6st2	heparan sulfate 6-O-sulfotransferase 2	0.011
atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.011
odc1	ornithine decarboxylase 1	0.011	Human
rrm2b	ribonucleotide reductase M2 b	0.011
prkci	protein kinase C, iota	0.011
tbp	TATA box binding protein	0.011
epha2	eph receptor A2	0.011
actn1	actinin, alpha 1	0.011
epb41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.011
tlr3	toll-like receptor 3	0.011
plagx	pleiomorphic adenoma gene X	0.011
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.011
irx5a	iroquois homeobox protein 5a	0.011
slit2	slit (Drosophila) homolog 2	0.011
sulf1	sulfatase 1	0.011
gdf6a	growth differentiation factor 6a	0.011
erf	Ets2 repressor factor	0.011
bcl2	B-cell leukemia/lymphoma 2	0.011
hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.010
napa	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.010
akap12b	A kinase (PRKA) anchor protein (gravin) 12b	0.010
si:dkey-261h17.1	si:dkey-261h17.1	0.010
dld	deltaD	0.010
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.010
LOC567131	calcitonin gene-related peptide type 1 receptor-like	0.010
foxa3	forkhead box A3	0.010
pafah1b1a	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a	0.010
cx30.3	connexin 30.3	0.010
ntn1a	netrin 1a	0.010
rbl1	retinoblastoma-like 1 (p107)	0.010
ttnb	titin b	0.010