IMP

Process View

Danio rerio

14 genes annotated in zebrafish

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "bone development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "bone development" (in gray)

Name	Description	Probability	Func Analog Organism
gli2a	GLI-Kruppel family member GLI2a	0.841
bmp2b	bone morphogenetic protein 2b	0.817	Human
foxi1	forkhead box I1	0.718	Zebrafish
col5a1	procollagen, type V, alpha 1	0.698
pitx3	paired-like homeodomain transcription factor 3	0.680
bmp4	bone morphogenetic protein 4	0.649	Mouse
wu:fv91b12	wu:fv91b12	0.552
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.494
bmp1a	bone morphogenetic protein 1a	0.440
runx2b	runt-related transcription factor 2b	0.430	Mouse
jag1b	jagged 1b	0.411
bglap	bone gamma-carboxyglutamate (gla) protein	0.320
dld	deltaD	0.319	Zebrafish
il17rd	interleukin 17 receptor D	0.299
ntla	no tail a	0.279	Mouse
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.264
efnb2a	ephrin B2a	0.259
shha	sonic hedgehog a	0.258
nkx3.2	NK3 homeobox 2	0.254
ripply1	ripply1	0.249	Mouse
notch1a	notch homolog 1a	0.246	Zebrafish
col1a2	collagen, type I, alpha 2	0.230
prdm1a	PR domain containing 1a, with ZNF domain	0.210
bmp2a	bone morphogenetic protein 2a	0.167	Human
sox9a	SRY-box containing gene 9a	0.163	Human Mouse
ctgf	connective tissue growth factor	0.162
msxe	muscle segment homeobox E	0.162	Mouse
hoxa11a	homeo box A11a	0.151
ihha	Indian hedgehog homolog a	0.145
notch2	notch homolog 2	0.141
fgf17	fibroblast growth factor 17	0.131
prdm5	PR domain containing 5	0.126
fgfrl1a	fibroblast growth factor receptor-like 1a	0.116
col9a3	collagen, type IX, alpha 3	0.116
gpr126	G protein-coupled receptor 126	0.114
msxc	muscle segment homeobox C	0.108
myod1	myogenic differentiation 1	0.108
gbx2	gastrulation brain homeo box 2	0.107
angptl2	angiopoietin-like 2	0.103
mmp15b	matrix metallopeptidase 15b	0.101
twist1b	twist1b	0.101
neo1	neogenin 1	0.100
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.097
hapln1a	hyaluronan and proteoglycan link protein 1a	0.096
sox2	SRY-box containing gene 2	0.094
msxb	muscle segment homeobox B	0.092
msxd	muscle segment homeobox D	0.087
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.085
hmx1	H6 homeo box 1	0.084
barx1	BarH-like homeobox 1	0.081
alcama	activated leukocyte cell adhesion molecule a	0.079
her1	hairy-related 1	0.077
fgfr2	fibroblast growth factor receptor 2	0.077	Mouse
dlx5a	distal-less homeobox gene 5a	0.074	Mouse
mmp2	matrix metalloproteinase 2	0.073
hmx4	H6 family homeobox 4	0.071
axin2	axin 2 (conductin, axil)	0.066	Mouse
fgf3	fibroblast growth factor 3	0.065
eya1	eyes absent homolog 1	0.062
chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1	0.062
edar	ectodysplasin A receptor	0.061
runx2a	runt-related transcription factor 2a	0.060	Mouse
wnt11	wingless-type MMTV integration site family, member 11	0.059
fgf20a	fibroblast growth factor 20a	0.058
notch3	notch homolog 3	0.057	Zebrafish
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.056
raraa	retinoic acid receptor, alpha a	0.056	Mouse
LOC100000687	signal peptide, CUB and EGF-like domain-containing protein 3-like	0.054
lmo4a	LIM domain only 4a	0.054
ripply2	ripply2	0.052	Mouse
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.050	Mouse
tshb	thyroid stimulating hormone, beta subunit	0.049
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.049
hoxb4a	homeo box B4a	0.045	Mouse
vwf	von Willebrand factor	0.045
pdgfrl	platelet-derived growth factor receptor-like	0.045
tgfbi	transforming growth factor, beta-induced	0.045
mgp	matrix Gla protein	0.044
fzd5	frizzled homolog 5	0.043
runx3	runt-related transcription factor 3	0.043
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.043
prrx1a	paired related homeobox 1a	0.043
col5a2l	collagen, type V, alpha 2-like	0.041
pkd2	polycystic kidney disease 2	0.040
crabp2a	cellular retinoic acid binding protein 2, a	0.039
tbx2b	T-box 2b	0.039
nr2f5	nuclear receptor subfamily 2, group F, member 5	0.039
edn1	endothelin 1	0.039
LOC566708	FL cytokine receptor-like	0.038
epha4b	eph receptor A4b	0.037
tbx16	T-box gene 16	0.037
col27a1a	collagen, type XXVII, alpha 1a	0.037	Mouse
foxa1	forkhead box A1	0.036	Zebrafish
dlx4a	distal-less homeobox gene 4a	0.036
col1a1a	collagen, type I, alpha 1a	0.035	Mouse
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.035
gli1	GLI-Kruppel family member 1	0.035
foxa2	forkhead box A2	0.033	Zebrafish
fzd10	frizzled homolog 10	0.033
sox10	SRY-box containing gene 10	0.033
fgfr1b	fibroblast growth factor receptor 1b	0.032
sulf1	sulfatase 1	0.032	Mouse
gli3	GLI-Kruppel family member GLI3	0.031
tcf12	transcription factor 12	0.030
cmn	calymmin	0.030
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.030
ahr2	aryl hydrocarbon receptor 2	0.029
chsy1	chondroitin sulfate synthase 1	0.029
hoxd13a	homeo box D13a	0.029
alp	alkaline phosphatase	0.028	Mouse
stac3	SH3 and cysteine rich domain 3	0.027
polr2d	polymerase (RNA) II (DNA directed) polypeptide D	0.026
sp7	Sp7 transcription factor	0.026
wif1	wnt inhibitory factor 1	0.025
hoxa10b	homeo box A10b	0.025
prl	prolactin	0.025
LOC100000500	sclerostin-like	0.025
nog3	noggin 3	0.025
hoxd10a	homeo box D10a	0.024
hoxa13a	homeo box A13a	0.024
tbx24	T-box 24	0.024
hoxa4a	homeo box A4a	0.024
grem2	gremlin 2, cysteine knot superfamily	0.024
ghra	growth hormone receptor a	0.024	Rat
col2a1a	collagen type II, alpha-1a	0.023	Mouse Rat
mab21l2	mab-21-like 2	0.022
fbn2b	fibrillin 2b	0.022
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.022
cdh2	cadherin 2, neuronal	0.022
hoxa9b	homeo box A9b	0.022
alpi	alkaline phosphatase, intestinal	0.022
pax6a	paired box gene 6a	0.022
sdc2	syndecan 2	0.022
wnt11r	wingless-type MMTV integration site family, member 11, related	0.022
pmp22a	peripheral myelin protein 22a	0.022
chd	chordin	0.021
pdzrn3	PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3	0.021
hmgcs1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	0.021
bmper	BMP binding endothelial regulator	0.021
col10a1	collagen, type X, alpha 1	0.021
col9a2	procollagen, type IX, alpha 2	0.021
loxl2b	lysyl oxidase-like 2b	0.021
shhb	sonic hedgehog b	0.020
mstna	myostatin a	0.020
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.020
lhx1b	LIM homeobox 1b	0.020
igfbp3	insulin-like growth factor binding protein 3	0.019
matn4	matrilin 4	0.019
fn1	fibronectin 1	0.019
pax8	paired box gene 8	0.019
hnf1ba	HNF1 homeobox Ba	0.019
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.019
dnmt4	DNA (cytosine-5-)-methyltransferase 4	0.018
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.018
hoxc8a	homeo box C8a	0.018
twist1a	twist1a	0.018
her12	hairy-related 12	0.018
tsku	tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)	0.017
pax2a	paired box gene 2a	0.017
plp1a	proteolipid protein 1a	0.017
dacha	dachshund a	0.017
ephb3a	eph receptor B3a	0.017
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.017
egr2b	early growth response 2b	0.017
mdka	midkine-related growth factor	0.017
sparc	secreted acidic cysteine rich glycoprotein	0.017	Mouse
hoxa13b	homeo box A13b	0.017
si:rp71-39b20.7	si:rp71-39b20.7	0.016
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.016
tgfb2	transforming growth factor, beta 2	0.016	Rat
atoh1a	atonal homolog 1a	0.016
dlx3b	distal-less homeobox gene 3b	0.016
btg1	B-cell translocation gene 1	0.016
rerea	arginine-glutamic acid dipeptide (RE) repeats a	0.016
gbx1	gastrulation brain homeobox 1	0.016
fzd7a	frizzled homolog 7a	0.016
zgc:77051	zgc:77051	0.016
hoxd12a	homeo box D12a	0.016
rxrab	retinoid x receptor, alpha b	0.016
jag1a	jagged 1a	0.015	Zebrafish
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.015
fabp11a	fatty acid binding protein 11a	0.015
hoxa5a	homeo box A5a	0.015
fgf23	fibroblast growth factor 23	0.015
bambib	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b	0.015
vegfc	vascular endothelial growth factor c	0.015
slc4a1b	solute carrier family 4, anion exchanger, member 1b	0.015
cxcr3.2	chemokine (C-X-C motif) receptor 3.2	0.014
evx1	even-skipped homeobox 1	0.014
postn	periostin, osteoblast specific factor	0.014
hoxb2a	homeo box B2a	0.014
sox32	SRY-box containing gene 32	0.014
hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.014
neb	nebulin	0.013
ass1	argininosuccinate synthetase 1	0.013
bmp3	bone morphogenetic protein 3	0.013
cart1	cartilage paired-class homeoprotein 1	0.013
duox	dual oxidase	0.013
fli1a	friend leukemia integration 1a	0.013
dlb	deltaB	0.013	Zebrafish
zbtb16a	zinc finger and BTB domain containing 16a	0.013
six4b	sine oculis homeobox homolog 4b	0.013
rarab	retinoic acid receptor, alpha b	0.013	Mouse
tg	thyroglobulin	0.012
LOC100151531	zinc finger protein Gfi-1b-like	0.012
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.012
slit3	slit (Drosophila) homolog 3	0.012
flncb	filamin C, gamma b (actin binding protein 280)	0.012
bcl2	B-cell leukemia/lymphoma 2	0.012
sec31a	sec31 homolog A (S. cerevisiae)	0.012
eda	ectodysplasin A	0.012
adipor2	adiponectin receptor 2	0.012
tfe3b	transcription factor binding to IGHM enhancer 3b	0.012
foxd3	forkhead box D3	0.012
notch1b	notch homolog 1b	0.011	Zebrafish
ctsl1b	cathepsin L, 1 b	0.011
lrrc17	leucine rich repeat containing 17	0.011	Mouse
b2m	beta-2-microglobulin	0.011
cdx4	caudal type homeo box transcription factor 4	0.011
hoxd9a	homeo box D9a	0.011
mespb	mesoderm posterior b	0.011
ryr1a	ryanodine receptor 1a (skeletal)	0.011
fgfr4	fibroblast growth factor receptor 4	0.011
zgc:111821	zgc:111821	0.011
drd4-rs	dopamine receptor D4 related sequence	0.011
gyltl1b	glycosyltransferase-like 1b	0.011
foxa3	forkhead box A3	0.011	Zebrafish
col12a1	collagen, type XII, alpha 1	0.011
hoxd4a	homeo box D4a	0.011
lef1	lymphocyte enhancer binding factor 1	0.011
wnt10a	wingless-type MMTV integration site family, member 10a	0.011
igf2a	insulin-like growth factor 2a	0.011
hoxb5a	homeo box B5a	0.011
fras1	Fraser syndrome 1	0.010
nkd1	naked cuticle homolog 1 (Drosophila)	0.010
fgf10a	fibroblast growth factor 10a	0.010
bmp7b	bone morphogenetic protein 7b	0.010
pax9	paired box gene 9	0.010
fzd8a	frizzled homolog 8a	0.010
smarcal1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	0.010
igfbp5a	insulin-like growth factor binding protein 5a	0.010
fgf18a	fibroblast growth factor 18a	0.010