The network for 'anterior posterior axis specification embryo' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

anterior posterior axis specification embryo

The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.

Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.995
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.994
EIF4A3 eukaryotic translation initiation factor 4A3 0.990
OCRL oculocerebrorenal syndrome of Lowe 0.975
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.966
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.923
SNAP25 synaptosomal-associated protein, 25kDa 0.918
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.878
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.848
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.837
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.832
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.826
DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae) 0.825
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.813
EZR ezrin 0.790
SCHIP1 schwannomin interacting protein 1 0.787
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.752
PRMT5 protein arginine methyltransferase 5 0.711
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.697
GDA guanine deaminase 0.692
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.680
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.672
RBL2 retinoblastoma-like 2 (p130) 0.661
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.613
PRKCZ protein kinase C, zeta 0.602
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 0.577
ARAF v-raf murine sarcoma 3611 viral oncogene homolog 0.574
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.564
KEAP1 kelch-like ECH-associated protein 1 0.541
NXF1 nuclear RNA export factor 1 0.510
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.495
ZYX zyxin 0.488
CHRD chordin 0.480
LIN9 lin-9 homolog (C. elegans) 0.477
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.472
RFWD2 ring finger and WD repeat domain 2 0.463
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.457
PRKCI protein kinase C, iota 0.441
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.425
APC adenomatous polyposis coli 0.415
ADAM17 ADAM metallopeptidase domain 17 0.410
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.408
CDK9 cyclin-dependent kinase 9 0.406
CUL2 cullin 2 0.403
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.394
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.386
CUL1 cullin 1 0.380
BMP1 bone morphogenetic protein 1 0.374
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.369
SORBS3 sorbin and SH3 domain containing 3 0.362
BRAF v-raf murine sarcoma viral oncogene homolog B1 0.361
DLG4 discs, large homolog 4 (Drosophila) 0.337
ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.336
MAPK1 mitogen-activated protein kinase 1 0.335
MDC1 mediator of DNA-damage checkpoint 1 0.312
CD44 CD44 molecule (Indian blood group) 0.309
STRADA STE20-related kinase adaptor alpha 0.296
EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae) 0.296
ANAPC7 anaphase promoting complex subunit 7 0.294
SRSF2 serine/arginine-rich splicing factor 2 0.287
KIF5B kinesin family member 5B 0.282
SET SET nuclear oncogene 0.282
SNRPG small nuclear ribonucleoprotein polypeptide G 0.270
HSPA8 heat shock 70kDa protein 8 0.260
FGFR1 fibroblast growth factor receptor 1 0.255
CAB39 calcium binding protein 39 0.254
CDC16 cell division cycle 16 homolog (S. cerevisiae) 0.253
YAP1 Yes-associated protein 1 0.248
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.245
SRRM1 serine/arginine repetitive matrix 1 0.243
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.243
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.241
AKIP1 A kinase (PRKA) interacting protein 1 0.239
PBK PDZ binding kinase 0.236
DCAF7 DDB1 and CUL4 associated factor 7 0.235
LARP1 La ribonucleoprotein domain family, member 1 0.218
MYH9 myosin, heavy chain 9, non-muscle 0.216
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.216
JMJD6 jumonji domain containing 6 0.215
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.215
SDSL serine dehydratase-like 0.215
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.213
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.212
VHL von Hippel-Lindau tumor suppressor 0.212
AKAP11 A kinase (PRKA) anchor protein 11 0.207
FBF1 Fas (TNFRSF6) binding factor 1 0.205
MAP2K1 mitogen-activated protein kinase kinase 1 0.202
ACTN1 actinin, alpha 1 0.198
SH3RF3 SH3 domain containing ring finger 3 0.197
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.188
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.186
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.185
GAB1 GRB2-associated binding protein 1 0.184
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.184
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.179
RHOA ras homolog gene family, member A 0.178
WNT3A wingless-type MMTV integration site family, member 3A 0.175
COBRA1 cofactor of BRCA1 0.175
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.170
CHN2 chimerin (chimaerin) 2 0.168
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
nanos3 nanos homolog 3 0.566
piwil1 piwi-like 1 (Drosophila) 0.512
ca15b carbonic anhydrase XV b 0.396
ndr2 nodal-related 2 0.343
lft1 lefty1 0.262
tbx16 T-box gene 16 0.221
aplnrb apelin receptor b 0.180
dharma dharma 0.156
brca2 breast cancer 2, early onset 0.077
spaw southpaw 0.061
org oogenesis-related gene 0.058
pou5f1 POU domain, class 5, transcription factor 1 0.054
dazl daz-like gene 0.053
acvr1l activin A receptor, type I like 0.042
piwil2 piwi-like 2 (Drosophila) 0.040
flh floating head 0.039
cdx4 caudal type homeo box transcription factor 4 0.037
etv2 ets variant gene 2 0.037
sox32 SRY-box containing gene 32 0.035
ntla no tail a 0.034
dlg2 discs, large (Drosophila) homolog 2 0.034
runx1 runt-related transcription factor 1 0.034
bmp4 bone morphogenetic protein 4 0.032
spsb4a splA/ryanodine receptor domain and SOCS box containing 4a 0.032
chd chordin 0.031
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.029
tmem2 transmembrane protein 2 0.026
znf711 zinc finger protein 711 0.024
cdh2 cadherin 2, neuronal 0.024
lft2 lefty2 0.024
pnx posterior neuron-specific homeobox 0.023
epb4.1l4 erythrocyte protein band 4.1-like 4 0.023
pglyrp2 peptidoglycan recognition protein 2 0.023
klf4 Kruppel-like factor 4 0.023
mib mind bomb 0.023
bmp7a bone morphogenetic protein 7a 0.022
zgc:113210 zgc:113210 0.022
hand2 heart and neural crest derivatives expressed transcript 2 0.022
sap18 sin3-associated polypeptide 0.020
fancl Fanconi anemia, complementation group L 0.019
foxh1 forkhead box H1 0.019
si:ch1073-351m12.1 si:ch1073-351m12.1 0.019
smo smoothened homolog (Drosophila) 0.018
dlg1 discs, large (Drosophila) homolog 1 0.018
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.018
six4b sine oculis homeobox homolog 4b 0.018
tdrd1 tudor domain containing 1 0.017
wnt11 wingless-type MMTV integration site family, member 11 0.017
csrp1a cysteine and glycine-rich protein 1a 0.017
pcdh8 protocadherin 8 0.016
tbx1 T-box 1 0.015
gfi1.1 growth factor independent 1.1 0.015
brd4 bromodomain containing 4 0.014
vent ventral expressed homeobox 0.014
tbx20 T-box 20 0.014
tmem88a transmembrane protein 88 a 0.014
spsb1 splA/ryanodine receptor domain and SOCS box containing 1 0.014
smx5 smx5 0.013
smad5 MAD homolog 5 (Drosophila) 0.012
buc bucky ball 0.012
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.012
dld deltaD 0.012
copeb core promoter element binding protein 0.012
col8a1a collagen, type VIII, alpha 1a 0.011
fli1b friend leukemia integration 1b 0.011
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.011
eif5a eukaryotic translation initiation factor 5A 0.011
gpia glucose phosphate isomerase a 0.011
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.011
nog1 noggin 1 0.011
gdf9 growth differentiation factor 9 0.011
ilk integrin linked kinase 0.011
pfn2 profilin 2 0.011
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.010
vangl2 vang-like 2 (van gogh, Drosophila) 0.010
im:7153558 im:7153558 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
baz bazooka 0.999
aPKC atypical protein kinase C 0.991
osk oskar 0.985
stau staufen 0.976
sqd squid 0.970
brat brain tumor 0.965
tral trailer hitch 0.959
mago mago nashi 0.958
bcd bicoid 0.948
par-1 CG8201 gene product from transcript CG8201-RA 0.934
aret arrest 0.925
Src64B Src oncogene at 64B 0.918
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.909
par-6 CG5884 gene product from transcript CG5884-RA 0.889
BicD Bicaudal D 0.868
hb hunchback 0.861
spir spire 0.859
ksr kinase suppressor of ras 0.780
vls valois 0.751
Cdc42 CG12530 gene product from transcript CG12530-RA 0.734
CG6854 CG6854 gene product from transcript CG6854-RC 0.712
lola longitudinals lacking 0.707
tsu tsunagi 0.692
pum pumilio 0.682
pita CG3941 gene product from transcript CG3941-RA 0.680
spn-E spindle E 0.680
Lis-1 Lissencephaly-1 0.675
fs(1)M3 female sterile (1) M3 0.629
Dcp1 Decapping protein 1 0.619
orb oo18 RNA-binding protein 0.614
Dhc64C Dynein heavy chain 64C 0.598
spen split ends 0.563
ftz-f1 ftz transcription factor 1 0.547
Gprk2 G protein-coupled receptor kinase 2 0.540
psq pipsqueak 0.522
Myd88 CG2078 gene product from transcript CG2078-RA 0.519
EcR Ecdysone receptor 0.518
sec5 CG8843 gene product from transcript CG8843-RA 0.506
exu exuperantia 0.502
me31B maternal expression at 31B 0.498
sax saxophone 0.490
TER94 CG2331 gene product from transcript CG2331-RA 0.472
CG10260 CG10260 gene product from transcript CG10260-RB 0.456
arm armadillo 0.450
grk gurken 0.447
cact cactus 0.444
Dlic Dynein light intermediate chain 0.430
tud tudor 0.430
Lam Lamin 0.426
eya eyes absent 0.425
Hel25E Helicase at 25E 0.419
trk trunk 0.414
shg shotgun 0.412
CG4771 CG4771 gene product from transcript CG4771-RA 0.397
crb crumbs 0.392
Grip128 CG9201 gene product from transcript CG9201-RB 0.392
cnc cap-n-collar 0.387
slmb supernumerary limbs 0.386
Dad Daughters against dpp 0.383
Atx2 Ataxin-2 0.382
Tl Toll 0.375
tkv thickveins 0.347
ens ensconsin 0.345
Pabp2 CG2163 gene product from transcript CG2163-RA 0.342
trc tricornered 0.336
ovo CG6824 gene product from transcript CG6824-RE 0.334
fkh fork head 0.329
scw screw 0.319
lilli lilliputian 0.315
CG11188 CG11188 gene product from transcript CG11188-RA 0.312
Btk29A Btk family kinase at 29A 0.305
mael maelstrom 0.303
ecd ecdysoneless 0.299
rok Rho-kinase 0.294
retn retained 0.294
Fmr1 CG6203 gene product from transcript CG6203-RC 0.284
cpa capping protein alpha 0.282
al aristaless 0.279
mirr mirror 0.277
Rac1 CG2248 gene product from transcript CG2248-RA 0.263
ttk tramtrack 0.263
dpp decapentaplegic 0.262
dally division abnormally delayed 0.254
LanA Laminin A 0.248
jagn jagunal 0.247
UBL3 CG9038 gene product from transcript CG9038-RC 0.244
usp ultraspiracle 0.232
tho2 CG31671 gene product from transcript CG31671-RA 0.229
lic licorne 0.226
egg eggless 0.222
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.220
ari-1 ariadne 0.219
gcm glial cells missing 0.216
raw CG12437 gene product from transcript CG12437-RB 0.216
shn schnurri 0.213
NetB Netrin-B 0.212
bic bicaudal 0.212
btz barentsz 0.201
puc puckered 0.198
qm quemao 0.196
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Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 0.982
Nodal nodal 0.974
Shh sonic hedgehog 0.899
Fgf8 fibroblast growth factor 8 0.871
Lhx1 LIM homeobox protein 1 0.863
Pitx2 paired-like homeodomain transcription factor 2 0.722
Apc adenomatosis polyposis coli 0.687
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.671
Bmpr1a bone morphogenetic protein receptor, type 1A 0.602
Sox9 SRY-box containing gene 9 0.585
Htt huntingtin 0.568
Otx2 orthodenticle homolog 2 (Drosophila) 0.516
Gata4 GATA binding protein 4 0.503
Pax2 paired box gene 2 0.455
Fgfr1 fibroblast growth factor receptor 1 0.455
Fgfr2 fibroblast growth factor receptor 2 0.393
Rarb retinoic acid receptor, beta 0.385
Rxra retinoid X receptor alpha 0.375
Rara retinoic acid receptor, alpha 0.372
Wnt4 wingless-related MMTV integration site 4 0.352
Tbx1 T-box 1 0.344
Rarg retinoic acid receptor, gamma 0.330
Gli2 GLI-Kruppel family member GLI2 0.273
Gli3 GLI-Kruppel family member GLI3 0.270
Smad4 MAD homolog 4 (Drosophila) 0.265
Foxc1 forkhead box C1 0.262
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.243
Ece1 endothelin converting enzyme 1 0.229
Inpp5d inositol polyphosphate-5-phosphatase D 0.217
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.216
Foxh1 forkhead box H1 0.207
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.204
Stx1a syntaxin 1A (brain) 0.175
Gsk3b glycogen synthase kinase 3 beta 0.172
Wnt6 wingless-related MMTV integration site 6 0.160
Snap25 synaptosomal-associated protein 25 0.160
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.159
Nog noggin 0.155
Emx2 empty spiracles homolog 2 (Drosophila) 0.153
Fus fusion, derived from t(12;16) malignant liposarcoma (human) 0.150
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.148
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.136
Pitx1 paired-like homeodomain transcription factor 1 0.132
Hand2 heart and neural crest derivatives expressed transcript 2 0.120
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.119
Vasp vasodilator-stimulated phosphoprotein 0.118
Pum1 pumilio 1 (Drosophila) 0.117
Dlx5 distal-less homeobox 5 0.111
Arid1b AT rich interactive domain 1B (SWI-like) 0.107
Ar androgen receptor 0.105
Wt1 Wilms tumor 1 homolog 0.102
Msx1 homeobox, msh-like 1 0.101
Hand1 heart and neural crest derivatives expressed transcript 1 0.100
Fzd7 frizzled homolog 7 (Drosophila) 0.095
Dok2 docking protein 2 0.093
Prrx2 paired related homeobox 2 0.088
Smo smoothened homolog (Drosophila) 0.084
Smad1 MAD homolog 1 (Drosophila) 0.084
Hoxa2 homeobox A2 0.083
Smad3 MAD homolog 3 (Drosophila) 0.083
Cct2 chaperonin containing Tcp1, subunit 2 (beta) 0.082
Bmp4 bone morphogenetic protein 4 0.071
Acvr1 activin A receptor, type 1 0.070
Nf1 neurofibromatosis 1 0.065
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.064
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.062
Amhr2 anti-Mullerian hormone type 2 receptor 0.058
Lhx9 LIM homeobox protein 9 0.057
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.057
Fzd8 frizzled homolog 8 (Drosophila) 0.055
Bmp7 bone morphogenetic protein 7 0.054
Gdf1 growth differentiation factor 1 0.053
Ccnd1 cyclin D1 0.053
Fzd1 frizzled homolog 1 (Drosophila) 0.051
Hoxa1 homeobox A1 0.051
Alx4 aristaless-like homeobox 4 0.050
Numb numb gene homolog (Drosophila) 0.049
Ret ret proto-oncogene 0.047
Msx2 homeobox, msh-like 2 0.047
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.046
Bicd2 bicaudal D homolog 2 (Drosophila) 0.045
Magoh mago-nashi homolog, proliferation-associated (Drosophila) 0.044
Fgf10 fibroblast growth factor 10 0.043
Src Rous sarcoma oncogene 0.042
Emx1 empty spiracles homolog 1 (Drosophila) 0.039
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.039
Trp53 transformation related protein 53 0.038
Ttc7 tetratricopeptide repeat domain 7 0.038
Hic1 hypermethylated in cancer 1 0.038
Arid1a AT rich interactive domain 1A (SWI-like) 0.037
Gata6 GATA binding protein 6 0.037
Ncl nucleolin 0.037
Wnt9a wingless-type MMTV integration site 9A 0.036
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.036
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.036
Twist2 twist homolog 2 (Drosophila) 0.035
Ncoa2 nuclear receptor coactivator 2 0.035
Erh enhancer of rudimentary homolog (Drosophila) 0.035
Vegfa vascular endothelial growth factor A 0.034
Gdnf glial cell line derived neurotrophic factor 0.034
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism