The network for 'regulation of vasculature development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of vasculature development

Any process that modulates the frequency, rate or extent of vasculature development.

Homo sapiens
Name Description Probability Func Analog Organism
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.970
TEK TEK tyrosine kinase, endothelial 0.946
SKIL SKI-like oncogene 0.930
FGFR2 fibroblast growth factor receptor 2 0.922
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.914
JAG1 jagged 1 0.912
VEGFA vascular endothelial growth factor A 0.906
NOTCH1 notch 1 0.897
LAT linker for activation of T cells 0.880
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.871
CCR5 chemokine (C-C motif) receptor 5 0.859
YAP1 Yes-associated protein 1 0.839
ENG endoglin 0.819
CAV2 caveolin 2 0.810
IL8 interleukin 8 0.774
CXCL2 chemokine (C-X-C motif) ligand 2 0.728
CREBBP CREB binding protein 0.714
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.686
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.685
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.684
TAL1 T-cell acute lymphocytic leukemia 1 0.681
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.667
DUSP1 dual specificity phosphatase 1 0.643
TGFB1 transforming growth factor, beta 1 0.627
IL2RB interleukin 2 receptor, beta 0.614
FGFR1 fibroblast growth factor receptor 1 0.586
EFNA1 ephrin-A1 0.565
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.559
CD34 CD34 molecule 0.554
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.524
NRP1 neuropilin 1 0.521
HSPB8 heat shock 22kDa protein 8 0.512
CYR61 cysteine-rich, angiogenic inducer, 61 0.506
HTT huntingtin 0.504
RUNX1 runt-related transcription factor 1 0.497
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.492
PLAUR plasminogen activator, urokinase receptor 0.492
PLAU plasminogen activator, urokinase 0.488
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.486
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.480
FGB fibrinogen beta chain 0.478
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.470
PML promyelocytic leukemia 0.464
CCL2 chemokine (C-C motif) ligand 2 0.463
CAV1 caveolin 1, caveolae protein, 22kDa 0.463
COL4A2 collagen, type IV, alpha 2 0.452
BCL6 B-cell CLL/lymphoma 6 0.444
FGA fibrinogen alpha chain 0.440
TIMP1 TIMP metallopeptidase inhibitor 1 0.429
EPAS1 endothelial PAS domain protein 1 0.421
FAS Fas (TNF receptor superfamily, member 6) 0.406
CXCL3 chemokine (C-X-C motif) ligand 3 0.398
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.384
PBX1 pre-B-cell leukemia homeobox 1 0.381
NID1 nidogen 1 0.375
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.367
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.364
VEGFC vascular endothelial growth factor C 0.360
CCR2 chemokine (C-C motif) receptor 2 0.359
MEF2C myocyte enhancer factor 2C 0.339
SMAD3 SMAD family member 3 0.336
SMAD2 SMAD family member 2 0.335
CDH5 cadherin 5, type 2 (vascular endothelium) 0.333
HOXB5 homeobox B5 0.319
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.308
COL1A1 collagen, type I, alpha 1 0.306
CCL5 chemokine (C-C motif) ligand 5 0.306
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.299
IL1B interleukin 1, beta 0.298
PPL periplakin 0.294
CRYAB crystallin, alpha B 0.293
NOTCH3 notch 3 0.290
FOS FBJ murine osteosarcoma viral oncogene homolog 0.290
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.289
COL4A1 collagen, type IV, alpha 1 0.289
TIMP3 TIMP metallopeptidase inhibitor 3 0.289
IRF9 interferon regulatory factor 9 0.284
CXCL5 chemokine (C-X-C motif) ligand 5 0.282
FSTL1 follistatin-like 1 0.272
EP300 E1A binding protein p300 0.268
IFNG interferon, gamma 0.258
PDGFC platelet derived growth factor C 0.256
CXCL10 chemokine (C-X-C motif) ligand 10 0.251
VCAM1 vascular cell adhesion molecule 1 0.250
CD44 CD44 molecule (Indian blood group) 0.245
BMPR1B bone morphogenetic protein receptor, type IB 0.244
BMPR1A bone morphogenetic protein receptor, type IA 0.236
CTGF connective tissue growth factor 0.234
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.231
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.228
CXCL11 chemokine (C-X-C motif) ligand 11 0.227
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.219
ANGPTL2 angiopoietin-like 2 0.218
PSEN2 presenilin 2 (Alzheimer disease 4) 0.214
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.214
PRKCD protein kinase C, delta 0.213
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.210
IL4R interleukin 4 receptor 0.210
EGFR epidermal growth factor receptor 0.210
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.204
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.737
notch3 notch homolog 3 0.493
krit1 KRIT1, ankyrin repeat containing 0.337
ccm2 cerebral cavernous malformation 2 0.336
plcg1 phospholipase C, gamma 1 0.319
nrp1a neuropilin 1a 0.304
fn1 fibronectin 1 0.301
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.249
nrarpa notch-regulated ankyrin repeat protein a 0.248
sox9a SRY-box containing gene 9a 0.248
plxnd1 plexin D1 0.219
fbn2b fibrillin 2b 0.212
dll4 delta-like 4 (Drosophila) 0.188
etv2 ets variant gene 2 0.179
tie1 endothelium-specific receptor tyrosine kinase 1 0.154
col12a1 collagen, type XII, alpha 1 0.148
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.142
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.139
tal1 T-cell acute lymphocytic leukemia 1 0.135
vegfc vascular endothelial growth factor c 0.129
thbs1 thrombospondin 1 0.121
cnn2 calponin 2 0.112
tpm4 tropomyosin 4 0.108
dlc deltaC 0.104
agtr2 angiotensin II receptor, type 2 0.102
acvrl1 activin A receptor type II-like 1 0.100
wu:fv91b12 wu:fv91b12 0.092
vegfaa vascular endothelial growth factor Aa 0.092
notch1b notch homolog 1b 0.091
hs6st2 heparan sulfate 6-O-sulfotransferase 2 0.087
dlb deltaB 0.087
tp63 tumor protein p63 0.086
mrc1a mannose receptor, C type 1a 0.086
pcdh18b protocadherin 18b 0.084
bty bloodthirsty 0.083
col5a2l collagen, type V, alpha 2-like 0.082
lama5 laminin, alpha 5 0.079
pax8 paired box gene 8 0.077
bmp2b bone morphogenetic protein 2b 0.076
si:ch211-212m21.5 si:ch211-212m21.5 0.074
efnb2a ephrin B2a 0.072
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.071
arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.071
sox2 SRY-box containing gene 2 0.070
wt1a wilms tumor 1a 0.067
rxrbb retinoid x receptor, beta b 0.065
cdh5 cadherin 5 0.064
flt4 fms-related tyrosine kinase 4 0.063
igf2b insulin-like growth factor 2b 0.060
fras1 Fraser syndrome 1 0.060
egr2b early growth response 2b 0.058
sulf2l sulfatase 2, like 0.058
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.058
gli2a GLI-Kruppel family member GLI2a 0.057
olig4 oligodendrocyte transcription factor 4 0.057
tie2 endothelium-specific receptor tyrosine kinase 2 0.057
mmp2 matrix metalloproteinase 2 0.056
ednra endothelin receptor type A 0.056
tbx20 T-box 20 0.056
mcamb melanoma cell adhesion molecule b 0.055
tagln2 transgelin 2 0.055
selp selectin P 0.055
otpb orthopedia homolog b 0.055
egr1 early growth response 1 0.054
ephb4a eph receptor B4a 0.054
isl1 islet1 0.053
jag1b jagged 1b 0.052
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.051
sulf2 sulfatase 2 0.051
nphs1l nephrosis 1, congenital, Finnish type (nephrin)-like 0.051
hand2 heart and neural crest derivatives expressed transcript 2 0.050
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.050
hspa12b heat shock protein 12B 0.049
pdgfrl platelet-derived growth factor receptor-like 0.049
prdm16 PR domain containing 16 0.048
nf1a neurofibromin 1a 0.047
calcrla calcitonin receptor-like a 0.046
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.045
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.044
hlxb9lb homeo box HB9 like b 0.044
zgc:64042 zgc:64042 0.044
insm1b insulinoma-associated 1b 0.043
postn periostin, osteoblast specific factor 0.043
ilk integrin linked kinase 0.043
podxl podocalyxin-like 0.043
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.043
nf1b neurofibromin 1b 0.041
osr2 odd-skipped related 2 (Drosophila) 0.040
atoh8 atonal homolog 8 0.040
itgb3b integrin beta 3b 0.040
hoxb2a homeo box B2a 0.039
ptgs1 prostaglandin-endoperoxide synthase 1 0.039
unc5b unc-5 homolog B (C. elegans) 0.039
jun jun proto-oncogene 0.038
cpb1 carboxypeptidase B1 (tissue) 0.038
antxr1 anthrax toxin receptor 1 0.038
sulf1 sulfatase 1 0.038
epas1b endothelial PAS domain protein 1b 0.038
esama endothelial cell adhesion molecule a 0.038
ptprf protein tyrosine phosphatase, receptor type, F 0.037
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Efnb2 ephrin B2 0.987
Wt1 Wilms tumor 1 homolog 0.952
Epha4 Eph receptor A4 0.934
Kdr kinase insert domain protein receptor 0.921
Nos2 nitric oxide synthase 2, inducible 0.904
Csf1 colony stimulating factor 1 (macrophage) 0.894
Smad6 MAD homolog 6 (Drosophila) 0.893
Cxcl12 chemokine (C-X-C motif) ligand 12 0.877
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.862
Smad3 MAD homolog 3 (Drosophila) 0.845
Apc adenomatosis polyposis coli 0.845
Ccr2 chemokine (C-C motif) receptor 2 0.843
Jag1 jagged 1 0.841
Gata6 GATA binding protein 6 0.838
Cxcl13 chemokine (C-X-C motif) ligand 13 0.826
Flt4 FMS-like tyrosine kinase 4 0.816
Ptgs2 prostaglandin-endoperoxide synthase 2 0.803
Flt1 FMS-like tyrosine kinase 1 0.783
Gata4 GATA binding protein 4 0.770
Nog noggin 0.769
Gli3 GLI-Kruppel family member GLI3 0.767
Acvrl1 activin A receptor, type II-like 1 0.704
Npr3 natriuretic peptide receptor 3 0.701
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.699
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.693
Bmp5 bone morphogenetic protein 5 0.693
Ephb2 Eph receptor B2 0.650
Lox lysyl oxidase 0.621
Pax2 paired box gene 2 0.612
Clock circadian locomotor output cycles kaput 0.610
Snai1 snail homolog 1 (Drosophila) 0.594
Eng endoglin 0.593
Sox7 SRY-box containing gene 7 0.582
Ccl2 chemokine (C-C motif) ligand 2 0.557
Tgfb2 transforming growth factor, beta 2 0.555
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.552
Epha3 Eph receptor A3 0.552
Col4a2 collagen, type IV, alpha 2 0.546
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.532
Ntf3 neurotrophin 3 0.524
Foxf2 forkhead box F2 0.522
Adra2b adrenergic receptor, alpha 2b 0.509
Ikzf1 IKAROS family zinc finger 1 0.506
Vegfa vascular endothelial growth factor A 0.504
Fzd1 frizzled homolog 1 (Drosophila) 0.501
Tcf21 transcription factor 21 0.492
Bmpr1a bone morphogenetic protein receptor, type 1A 0.491
Selp selectin, platelet 0.491
Emx1 empty spiracles homolog 1 (Drosophila) 0.487
Id3 inhibitor of DNA binding 3 0.469
Foxg1 forkhead box G1 0.462
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.461
Fgf8 fibroblast growth factor 8 0.461
Rag1 recombination activating gene 1 0.460
Pcdh12 protocadherin 12 0.444
Pgr progesterone receptor 0.441
Cfh complement component factor h 0.436
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.435
Lepr leptin receptor 0.433
C3ar1 complement component 3a receptor 1 0.432
Twist2 twist homolog 2 (Drosophila) 0.432
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.429
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.423
Id1 inhibitor of DNA binding 1 0.421
Tcf3 transcription factor 3 0.418
Hoxd13 homeobox D13 0.418
Skil SKI-like 0.415
Ccbp2 chemokine binding protein 2 0.409
Lhx1 LIM homeobox protein 1 0.406
Mfap2 microfibrillar-associated protein 2 0.405
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.400
Adm adrenomedullin 0.399
Il1b interleukin 1 beta 0.393
Tlr4 toll-like receptor 4 0.392
Igk immunoglobulin kappa chain complex 0.391
Foxc1 forkhead box C1 0.390
Hes1 hairy and enhancer of split 1 (Drosophila) 0.389
Tgfbr2 transforming growth factor, beta receptor II 0.384
Epas1 endothelial PAS domain protein 1 0.380
Folr2 folate receptor 2 (fetal) 0.380
Fgfr2 fibroblast growth factor receptor 2 0.377
Sox3 SRY-box containing gene 3 0.370
Prl8a2 prolactin family 8, subfamily a, member 2 0.366
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.359
Emx2 empty spiracles homolog 2 (Drosophila) 0.350
Cdh5 cadherin 5 0.344
Ncor2 nuclear receptor co-repressor 2 0.343
Tgfb1 transforming growth factor, beta 1 0.340
Ghr growth hormone receptor 0.336
Gpc3 glypican 3 0.333
Dab2 disabled homolog 2 (Drosophila) 0.330
Cd7 CD7 antigen 0.327
Mitf microphthalmia-associated transcription factor 0.324
Smad4 MAD homolog 4 (Drosophila) 0.324
Src Rous sarcoma oncogene 0.318
Ccr8 chemokine (C-C motif) receptor 8 0.316
Myod1 myogenic differentiation 1 0.314
Gdnf glial cell line derived neurotrophic factor 0.312
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.308
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.303
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Rattus norvegicus
Name Description Probability Func Analog Organism
Egr2 early growth response 2 0.661
Ccl2 chemokine (C-C motif) ligand 2 0.563
Mdfic MyoD family inhibitor domain containing 0.509
Mmp3 matrix metallopeptidase 3 0.484
Csf1 colony stimulating factor 1 (macrophage) 0.375
Fgfr2 fibroblast growth factor receptor 2 0.356
Ccr2 chemokine (C-C motif) receptor 2 0.324
Hpx hemopexin 0.321
Adora2a adenosine A2a receptor 0.302
Reg1a regenerating islet-derived 1 alpha 0.240
Fosl1 fos-like antigen 1 0.213
Tacr1 tachykinin receptor 1 0.211
Smgb neonatal submandibular gland protein B 0.209
Iapp islet amyloid polypeptide 0.199
Il1rn interleukin 1 receptor antagonist 0.195
Il8rb interleukin 8 receptor, beta 0.190
Il6 interleukin 6 0.180
Gucy2d guanylate cyclase 2d 0.179
Stip1 stress-induced phosphoprotein 1 0.174
Nos3 nitric oxide synthase 3, endothelial cell 0.171
Ccr5 chemokine (C-C motif) receptor 5 0.169
A1i3 alpha-1-inhibitor III 0.166
Flt1 FMS-related tyrosine kinase 1 0.164
Ccl3 chemokine (C-C motif) ligand 3 0.163
Tpsab1 tryptase alpha/beta 1 0.163
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.160
Cd151 CD151 molecule (Raph blood group) 0.158
Cd4 Cd4 molecule 0.157
Gzmk granzyme K 0.155
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.155
Cd200r1 CD200 receptor 1 0.153
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.153
Il9r interleukin 9 receptor 0.151
Met met proto-oncogene 0.150
Id3 inhibitor of DNA binding 3 0.146
Eln elastin 0.132
Asgr2 asialoglycoprotein receptor 2 0.131
Tas2r126 taste receptor, type 2, member 126 0.131
Ngf nerve growth factor (beta polypeptide) 0.128
Anxa1 annexin A1 0.126
Cxcl2 chemokine (C-X-C motif) ligand 2 0.121
Trim47 tripartite motif-containing 47 0.120
Dusp1 dual specificity phosphatase 1 0.117
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.116
LOC100361571 keratin associated protein 1-3-like 0.109
Mmp10 matrix metallopeptidase 10 0.107
Emcn endomucin 0.106
Gper G protein-coupled estrogen receptor 1 0.106
Ctsl1 cathepsin L1 0.103
Ccl11 chemokine (C-C motif) ligand 11 0.103
Il7 interleukin 7 0.100
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.099
LOC100363783 rCG53773-like 0.098
Cpa3 carboxypeptidase A3, mast cell 0.098
Mmp9 matrix metallopeptidase 9 0.098
Prok2 prokineticin 2 0.097
Il1b interleukin 1 beta 0.096
Dusp6 dual specificity phosphatase 6 0.094
LOC60591 calcium-activated potassium channel beta subunit 0.094
Prkch protein kinase C, eta 0.091
Hoxa2 homeo box A2 0.091
Acvrl1 activin A receptor type II-like 1 0.091
Itgam integrin, alpha M 0.090
Phyhd1 phytanoyl-CoA dioxygenase domain containing 1 0.087
Ccl4 chemokine (C-C motif) ligand 4 0.086
Adora3 adenosine A3 receptor 0.086
Tpc1808 tropic 1808 0.086
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.085
Calcrl calcitonin receptor-like 0.082
Anxa4 annexin A4 0.082
Hspa5 heat shock protein 5 0.081
Sell selectin L 0.079
Chordc1 cysteine and histidine-rich domain (CHORD)-containing 1 0.078
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.077
Fos FBJ osteosarcoma oncogene 0.076
Adam7 ADAM metallopeptidase domain 7 0.076
Crhr2 corticotropin releasing hormone receptor 2 0.074
Cd80 Cd80 molecule 0.074
Nmbr neuromedin B receptor 0.073
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.073
Plau plasminogen activator, urokinase 0.071
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.071
Ptpre protein tyrosine phosphatase, receptor type, E 0.070
Mmp2 matrix metallopeptidase 2 0.069
Pou3f2 POU class 3 homeobox 2 0.068
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.068
Akr1c18 aldo-keto reductase family 1, member C18 0.067
Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 0.067
Pemt phosphatidylethanolamine N-methyltransferase 0.067
Slc6a12 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 0.066
Bst1 bone marrow stromal cell antigen 1 0.065
Cd8a CD8a molecule 0.064
Fgf2 fibroblast growth factor 2 0.063
Serpina11 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 0.063
Junb jun B proto-oncogene 0.063
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.063
Crisp1 cysteine-rich secretory protein 1 0.062
Il2ra interleukin 2 receptor, alpha 0.062
Vip vasoactive intestinal peptide 0.062
Egfl7 EGF-like-domain, multiple 7 0.061
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism