The network for 'system process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.999
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.998
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.998
DLG4 discs, large homolog 4 (Drosophila) 0.994
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.987
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.986
EGFR epidermal growth factor receptor 0.984
FLNA filamin A, alpha 0.983
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.982
PSEN1 presenilin 1 0.981
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.980
YAP1 Yes-associated protein 1 0.972
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.971
APP amyloid beta (A4) precursor protein 0.969
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.963
FYN FYN oncogene related to SRC, FGR, YES 0.960
SMAD2 SMAD family member 2 0.955
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.949
FHL2 four and a half LIM domains 2 0.947
GSK3B glycogen synthase kinase 3 beta 0.932
ILK integrin-linked kinase 0.931
ATF2 activating transcription factor 2 0.929
JUP junction plakoglobin 0.924
FGFR2 fibroblast growth factor receptor 2 0.924
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.922
CRYAB crystallin, alpha B 0.921
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.920
KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 0.908
TTN titin 0.905
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.898
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.895
TNNI1 troponin I type 1 (skeletal, slow) 0.889
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.881
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.880
MAPT microtubule-associated protein tau 0.875
NCOA3 nuclear receptor coactivator 3 0.874
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.873
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.871
NCOR2 nuclear receptor corepressor 2 0.854
ACTN2 actinin, alpha 2 0.832
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.831
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.827
CRHR1 corticotropin releasing hormone receptor 1 0.823
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.821
CRYBB2 crystallin, beta B2 0.821
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.808
TRIM63 tripartite motif containing 63 0.796
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.796
NRP1 neuropilin 1 0.795
MAPK1 mitogen-activated protein kinase 1 0.793
JAG1 jagged 1 0.793
HNF4A hepatocyte nuclear factor 4, alpha 0.786
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.786
FGFR1 fibroblast growth factor receptor 1 0.784
QKI quaking homolog, KH domain RNA binding (mouse) 0.781
LRRK2 leucine-rich repeat kinase 2 0.779
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.779
DRD2 dopamine receptor D2 0.775
FGF1 fibroblast growth factor 1 (acidic) 0.771
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.771
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.764
CCKBR cholecystokinin B receptor 0.763
FN1 fibronectin 1 0.762
TGFB1 transforming growth factor, beta 1 0.759
MYOD1 myogenic differentiation 1 0.757
NCAM1 neural cell adhesion molecule 1 0.755
CRYBB1 crystallin, beta B1 0.754
HSPB1 heat shock 27kDa protein 1 0.754
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.751
PKM2 pyruvate kinase, muscle 0.748
JUN jun proto-oncogene 0.737
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.736
NCOR1 nuclear receptor corepressor 1 0.731
HLA-F major histocompatibility complex, class I, F 0.729
HSPB8 heat shock 22kDa protein 8 0.725
TNRC6A trinucleotide repeat containing 6A 0.720
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.719
LBX1 ladybird homeobox 1 0.719
RARA retinoic acid receptor, alpha 0.716
HLA-A major histocompatibility complex, class I, A 0.712
TEK TEK tyrosine kinase, endothelial 0.712
C1QA complement component 1, q subcomponent, A chain 0.710
CHRNA4 cholinergic receptor, nicotinic, alpha 4 0.710
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.710
CALCA calcitonin-related polypeptide alpha 0.707
AMOT angiomotin 0.705
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.704
MEF2C myocyte enhancer factor 2C 0.702
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 0.697
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.693
ZFYVE9 zinc finger, FYVE domain containing 9 0.682
PTEN phosphatase and tensin homolog 0.681
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.681
CRYBB3 crystallin, beta B3 0.679
DSP desmoplakin 0.676
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.674
HTR4 5-hydroxytryptamine (serotonin) receptor 4 0.669
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.667
PAX8 paired box 8 0.659
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
atn-1 Protein ATN-1 0.847
pha-4 Protein PHA-4 0.770
unc-9 Protein UNC-9 0.724
pkg-1 Protein PKG-1 0.651
sup-12 Protein SUP-12 0.609
egl-18 Protein EGL-18 0.523
inx-15 Protein INX-15 0.504
rig-6 Protein RIG-6 0.478
goa-1 Protein GOA-1 0.475
unc-27 Protein UNC-27 0.467
syg-1 Protein SYG-1 0.462
egl-13 Protein EGL-13 0.455
odr-3 Protein ODR-3 0.449
lag-1 Protein LAG-1 0.436
alx-1 Protein ALX-1 0.424
nlg-1 Protein NLG-1 0.403
flt-1 Protein FLT-1 0.385
myo-3 Protein MYO-3 0.381
daf-11 Protein DAF-11 0.379
unc-43 Protein UNC-43 0.378
glp-1 Protein GLP-1 0.374
egl-27 Protein EGL-27 0.358
unc-32 Protein UNC-32 0.350
lev-11 Protein LEV-11 0.349
mig-5 Protein MIG-5 0.347
eps-8 Protein EPS-8 0.346
vab-8 Protein VAB-8 0.331
ipp-5 Protein IPP-5 0.329
inx-1 Protein INX-1 0.324
plc-3 Protein PLC-3 0.316
vab-3 Protein VAB-3 0.304
egl-15 Protein EGL-15 0.301
che-2 Protein CHE-2 0.297
pkn-1 Protein PKN-1 0.294
gld-1 Protein GLD-1 0.293
T25F10.6 Protein T25F10.6 0.292
unc-73 Protein UNC-73 0.282
pkc-2 Protein PKC-2 0.281
msp-78 Protein MSP-78 0.280
zyx-1 Protein ZYX-1 0.278
unc-104 Protein UNC-104 0.271
hum-4 Protein HUM-4 0.271
lin-36 Protein LIN-36 0.270
tni-1 Protein TNI-1 0.266
efn-2 Protein EFN-2 0.256
vab-10 Protein VAB-10 0.254
Y40C5A.1 Protein Y40C5A.1 0.242
lin-11 Protein LIN-11 0.242
pal-1 Protein PAL-1 0.241
tax-6 Protein TAX-6 0.239
CELE_Y37A1B.17 Protein Y37A1B.17 0.231
pkc-1 Protein PKC-1 0.230
bar-1 Protein BAR-1 0.227
uig-1 Protein UIG-1 0.226
ida-1 Protein IDA-1 0.226
hif-1 Protein HIF-1 0.225
Y44E3A.6 Protein Y44E3A.6 0.224
eat-4 Protein EAT-4 0.223
msp-77 Protein MSP-77 0.220
pat-3 Protein PAT-3 0.220
wrk-1 Protein WRK-1 0.219
unc-38 Protein UNC-38 0.216
osm-5 Protein OSM-5 0.214
brp-1 Protein BRP-1 0.212
abts-1 Protein ABTS-1 0.210
msp-76 Protein MSP-76 0.210
lbp-7 Protein LBP-7 0.209
daf-12 Protein DAF-12 0.206
pdfr-1 Protein PDFR-1 0.204
lin-15A Protein LIN-15A 0.202
unc-95 Protein UNC-95 0.201
let-60 Protein LET-60 0.201
nhr-69 Protein NHR-69 0.201
mig-38 Protein MIG-38 0.201
aap-1 Protein AAP-1 0.200
H43E16.1 Protein H43E16.1 0.191
pmk-1 Protein PMK-1 0.191
mpz-2 Protein MPZ-2 0.189
nhr-2 Protein NHR-2 0.187
egl-46 Protein EGL-46 0.186
C54E4.2 Protein C54E4.2 0.186
inx-13 Protein INX-13 0.185
C46C11.3 Protein C46C11.3 0.185
ahr-1 Protein AHR-1 0.184
T28B4.1 Protein T28B4.1 0.182
unc-7 Protein UNC-7 0.177
pxf-1 Protein PXF-1 0.176
hlh-2 Protein HLH-2 0.173
gei-18 Protein GEI-18 0.171
epi-1 Protein EPI-1 0.171
add-1 Protein ADD-1 0.171
par-1 Protein PAR-1 0.171
let-23 Protein LET-23 0.170
egl-36 Protein EGL-36 0.170
ceh-6 Protein CEH-6 0.167
pes-7 Protein PES-7 0.167
unc-89 Protein UNC-89 0.167
twk-18 Protein TWK-18 0.164
msp-63 Protein MSP-63 0.164
itr-1 Protein ITR-1 0.163
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Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.980
notch1a notch homolog 1a 0.954
shha sonic hedgehog a 0.945
plcg1 phospholipase C, gamma 1 0.931
cdh23 cadherin-like 23 0.929
cx43 connexin 43 0.926
lama2 laminin, alpha 2 0.923
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.901
dmd dystrophin 0.891
her6 hairy-related 6 0.861
tnnt2a troponin T2a, cardiac 0.770
lama4 laminin, alpha 4 0.769
lhx2b LIM homeobox 2b 0.756
sox10 SRY-box containing gene 10 0.744
musk muscle, skeletal, receptor tyrosine kinase 0.734
crb2a crumbs homolog 2a 0.731
hnf1ba HNF1 homeobox Ba 0.731
dag1 dystroglycan 1 0.729
ascl1a achaete-scute complex-like 1a (Drosophila) 0.703
hsp90a.1 heat shock protein 90-alpha 1 0.701
mylz2 myosin, light polypeptide 2, skeletal muscle 0.697
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.692
myf5 myogenic factor 5 0.685
ptch1 patched 1 0.684
gli1 GLI-Kruppel family member 1 0.681
prnprs3 prion protein, related sequence 3 0.675
unc45b unc-45 homolog B (C. elegans) 0.675
lepr leptin receptor 0.673
smyd1b SET and MYND domain containing 1b 0.667
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.651
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.650
neurod neurogenic differentiation 0.641
sh3gl1b SH3-domain GRB2-like 1b 0.641
dlc deltaC 0.638
ndr2 nodal-related 2 0.637
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.625
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.623
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.610
sema3aa semaphorin 3aa 0.605
rag1 recombination activating gene 1 0.605
prdm1a PR domain containing 1a, with ZNF domain 0.592
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.583
pdgfaa platelet-derived growth factor alpha a 0.583
myod1 myogenic differentiation 1 0.582
igf1 insulin-like growth factor 1 0.580
fgfr3 fibroblast growth factor receptor 3 0.575
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.572
tnnc1a troponin C type 1a (slow) 0.571
egr1 early growth response 1 0.571
ywhag1 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1 0.564
opn4l opsin 4, like 0.558
tnni1b troponin I, skeletal, slow b 0.558
scn12ab sodium channel, voltage gated, type XII, alpha b 0.538
tnnc1b troponin C type 1b (slow) 0.535
th tyrosine hydroxylase 0.535
ndrg4 N-myc downstream regulated gene 4 0.533
her15.1 hairy and enhancer of split-related 15.1 0.531
nf1a neurofibromin 1a 0.528
scn8aa sodium channel, voltage-gated, type VIII, alpha a 0.520
evx1 even-skipped homeobox 1 0.515
tbx1 T-box 1 0.513
atp1a3a ATPase, Na+/K+ transporting, alpha 3a polypeptide 0.510
myog myogenin 0.508
spaw southpaw 0.504
atoh7 atonal homolog 7 0.502
tie1 endothelium-specific receptor tyrosine kinase 1 0.502
actc1a actin, alpha, cardiac muscle 1a 0.501
ttna titin a 0.497
wt1a wilms tumor 1a 0.497
wnt2ba wingless-type MMTV integration site family, member 2Ba 0.489
efnb2a ephrin B2a 0.487
fezf2 FEZ family zinc finger 2 0.484
kif17 kinesin family member 17 0.474
foxn4 forkhead box N4 0.471
gria2b glutamate receptor, ionotropic, AMPA 2b 0.469
sncgb synuclein, gamma b (breast cancer-specific protein 1) 0.464
lef1 lymphocyte enhancer binding factor 1 0.462
slc17a6b solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b 0.462
fabp7a fatty acid binding protein 7, brain, a 0.462
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.460
foxh1 forkhead box H1 0.454
zgc:66286 zgc:66286 0.453
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.451
lhx1a LIM homeobox 1a 0.445
ptmaa prothymosin, alpha a 0.441
ttnb titin b 0.440
actn1 actinin, alpha 1 0.435
dzip1 DAZ interacting protein 1 0.430
vmhc ventricular myosin heavy chain 0.429
mib mind bomb 0.428
fzd7b frizzled homolog 7b 0.425
mpz myelin protein zero 0.419
sall1a sal-like 1a (Drosophila) 0.417
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.417
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.416
krt18 keratin 18 0.415
pax7a paired box gene 7a 0.411
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.406
klf4a Kruppel-like transcription factor 4a 0.401
fgfr1a fibroblast growth factor receptor 1a 0.395
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism