The network for 'nitric oxide metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nitric oxide metabolic process

The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.

Homo sapiens
Name Description Probability Func Analog Organism
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.990
EGFR epidermal growth factor receptor 0.987
TICAM2 toll-like receptor adaptor molecule 2 0.682
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.570
IL1R1 interleukin 1 receptor, type I 0.528
INSR insulin receptor 0.523
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.484
ESR1 estrogen receptor 1 0.419
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.412
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.313
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.301
NOSTRIN nitric oxide synthase trafficker 0.296
DERL1 Der1-like domain family, member 1 0.210
IRAK2 interleukin-1 receptor-associated kinase 2 0.198
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.181
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.148
IL10RA interleukin 10 receptor, alpha 0.112
TNIP2 TNFAIP3 interacting protein 2 0.105
LAT linker for activation of T cells 0.102
PRKCZ protein kinase C, zeta 0.099
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.095
BCAR1 breast cancer anti-estrogen resistance 1 0.095
KLF4 Kruppel-like factor 4 (gut) 0.092
NOXA1 NADPH oxidase activator 1 0.088
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.086
CAV1 caveolin 1, caveolae protein, 22kDa 0.072
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.071
IGF1R insulin-like growth factor 1 receptor 0.066
VAC14 Vac14 homolog (S. cerevisiae) 0.060
DLG2 discs, large homolog 2 (Drosophila) 0.045
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.041
KLF6 Kruppel-like factor 6 0.040
STAT5A signal transducer and activator of transcription 5A 0.039
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.038
SOCS3 suppressor of cytokine signaling 3 0.038
IL8 interleukin 8 0.038
IRS1 insulin receptor substrate 1 0.037
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.037
ALDOB aldolase B, fructose-bisphosphate 0.035
DLG4 discs, large homolog 4 (Drosophila) 0.035
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.035
PPP5C protein phosphatase 5, catalytic subunit 0.033
DUSP1 dual specificity phosphatase 1 0.032
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.032
MPDZ multiple PDZ domain protein 0.031
MYLK2 myosin light chain kinase 2 0.030
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.030
SSTR2 somatostatin receptor 2 0.029
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.028
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.028
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.028
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.027
CDCP1 CUB domain containing protein 1 0.026
DDR2 discoidin domain receptor tyrosine kinase 2 0.025
FYN FYN oncogene related to SRC, FGR, YES 0.025
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.024
APP amyloid beta (A4) precursor protein 0.024
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.024
IL1RAP interleukin 1 receptor accessory protein 0.024
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.023
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.022
IL1R2 interleukin 1 receptor, type II 0.021
MYD88 myeloid differentiation primary response gene (88) 0.021
ZC3H12A zinc finger CCCH-type containing 12A 0.020
CCL14 chemokine (C-C motif) ligand 14 0.020
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.019
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.019
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.019
FOSL2 FOS-like antigen 2 0.019
JUN jun proto-oncogene 0.018
PECAM1 platelet/endothelial cell adhesion molecule 0.017
MAP2K4 mitogen-activated protein kinase kinase 4 0.017
CALCA calcitonin-related polypeptide alpha 0.017
GHR growth hormone receptor 0.016
XPO7 exportin 7 0.016
MAPT microtubule-associated protein tau 0.016
SH2D1A SH2 domain containing 1A 0.016
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.015
SYK spleen tyrosine kinase 0.015
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.015
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.015
MATK megakaryocyte-associated tyrosine kinase 0.015
SH3RF1 SH3 domain containing ring finger 1 0.015
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.015
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.015
PPARG peroxisome proliferator-activated receptor gamma 0.014
SSTR3 somatostatin receptor 3 0.014
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.014
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 0.013
PRKCD protein kinase C, delta 0.013
CDH5 cadherin 5, type 2 (vascular endothelium) 0.013
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.013
PGRMC1 progesterone receptor membrane component 1 0.013
NUMB numb homolog (Drosophila) 0.013
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.013
SQSTM1 sequestosome 1 0.012
NCF4 neutrophil cytosolic factor 4, 40kDa 0.012
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.012
PLAUR plasminogen activator, urokinase receptor 0.012
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.012
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
smyhc1l slow myosin heavy chain 1, like 0.648
LOC799612 prolactin 2 0.317
insrb insulin receptor b 0.302
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.261
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.254
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.224
mapk3 mitogen-activated protein kinase 3 0.209
cav1 caveolin 1 0.190
epas1b endothelial PAS domain protein 1b 0.187
il6r interleukin 6 receptor 0.163
nos2a nitric oxide synthase 2a, inducible 0.161
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.158
ca8 carbonic anhydrase VIII 0.158
tnnc1b troponin C type 1b (slow) 0.142
myog myogenin 0.133
acta1a actin, alpha 1a, skeletal muscle 0.124
stc1l stanniocalcin 1, like 0.123
tp53bp2 tumor protein p53 binding protein, 2 0.121
vangl2 vang-like 2 (van gogh, Drosophila) 0.121
itgb1b integrin, beta 1b 0.120
ankrd6 ankyrin repeat domain 6 0.116
smyhc1 slow myosin heavy chain 1 0.111
cx39.9 connexin 39.9 0.103
plxnb2a plexin b2a 0.102
nrg1 neuregulin 1 0.102
mbp myelin basic protein 0.090
vasn vasorin 0.088
elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.087
neb nebulin 0.085
sema3ab semaphorin 3ab 0.083
gcm2 glial cells missing homolog 2 (Drosophila) 0.083
il6st interleukin 6 signal transducer 0.082
jam2a junctional adhesion molecule 2a 0.081
mapk6 mitogen-activated protein kinase 6 0.081
dbh dopamine beta hydroxylase 0.076
plcg1 phospholipase C, gamma 1 0.076
ripk2 receptor-interacting serine-threonine kinase 2 0.075
mxi1 max interacting protein 0.075
slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 0.074
shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 0.073
casrl calcium-sensing receptor, like 0.071
kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.071
tecrb trans-2,3-enoyl-CoA reductase b 0.068
rab11fip4a RAB11 family interacting protein 4 (class II) a 0.068
tlr3 toll-like receptor 3 0.066
vdra vitamin D receptor a 0.066
ifnphi1 interferon phi 1 0.066
zgc:110105 zgc:110105 0.064
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.063
mstna myostatin a 0.063
il8 interleukin 8 0.062
mchr1b melanin-concentrating hormone receptor 1b 0.062
ttna titin a 0.062
hrh3 histamine receptor H3 0.061
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.060
furinb furin (paired basic amino acid cleaving enzyme) b 0.059
ar androgen receptor 0.057
tnnt1 troponin T1, skeletal, slow 0.057
smad2 MAD homolog 2 (Drosophila) 0.056
si:ch211-232m7.1 si:ch211-232m7.1 0.055
col27a1a collagen, type XXVII, alpha 1a 0.054
grid2 glutamate receptor, ionotropic, delta 2 0.054
th2 tyrosine hydroxylase 2 0.054
slc2a1a solute carrier family 2 (facilitated glucose transporter), member 1a 0.054
bsk146 brain specific kinase 146 0.053
mid1ip1a MID1 interacting protein 1a 0.052
tpma alpha-tropomyosin 0.052
abcc1 ATP-binding cassette, sub-family C, member 1 0.052
cxcr4a chemokine (C-X-C motif) receptor 4a 0.052
LOC100330405 transmembrane protein 176B-like 0.051
nr5a1b nuclear receptor subfamily 5, group A, member 1b 0.051
nos2b nitric oxide synthase 2b, inducible 0.050
acsl3a acyl-CoA synthetase long-chain family member 3a 0.050
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.049
rest RE1-silencing transcription factor 0.049
icn ictacalcin 0.049
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.049
zgc:112986 zgc:112986 0.049
olig1 oligodendrocyte lineage transcription factor 1 0.048
fhla four and a half LIM domains a 0.048
pth1a parathyroid hormone 1a 0.046
acox3 acyl-Coenzyme A oxidase 3, pristanoyl 0.046
tlr20f toll-like receptor 20f 0.045
ednra endothelin receptor type A 0.045
sgk1 serum/glucocorticoid regulated kinase 1 0.044
fabp11a fatty acid binding protein 11a 0.044
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.044
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.044
sat1b spermidine/spermine N1-acetyl transferase 1b 0.044
ucp3 uncoupling protein 3 0.043
bnc2 basonuclin 2 0.043
nrp1b neuropilin 1b 0.043
ppp3cb protein phosphatase 3, catalytic subunit, beta isozyme 0.041
irf11 interferon regulatory factor 11 0.041
zgc:110298 zgc:110298 0.041
cecr1a cat eye syndrome chromosome region, candidate 1a 0.041
npy4r neuropeptide Y receptor Y4 0.041
LOC100332193 growth hormone secretagogue receptor type 1-like 0.040
jam3b junctional adhesion molecule 3b 0.040
acvr1b activin A receptor, type IB 0.039
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Drosophila melanogaster
Name Description Probability Func Analog Organism
RpL34b Ribosomal protein L34b 0.054
RpL19 Ribosomal protein L19 0.051
alpha-Cat alpha Catenin 0.029
Myb Myb oncogene-like 0.027
RpL40 Ribosomal protein L40 0.026
CG9797 CG9797 gene product from transcript CG9797-RA 0.025
Prp19 CG5519 gene product from transcript CG5519-RA 0.024
ssp sunspot 0.023
CG6459 CG6459 gene product from transcript CG6459-RA 0.023
Su(var)205 Suppressor of variegation 205 0.023
mrn marionette 0.022
RpL31 Ribosomal protein L31 0.022
Dsp1 Dorsal switch protein 1 0.021
Paf-AHalpha Platelet-activating factor acetylhydrolase alpha 0.021
Slip1 CG1783 gene product from transcript CG1783-RA 0.019
RpII215 RNA polymerase II 215kD subunit 0.019
exd extradenticle 0.019
SF2 CG6987 gene product from transcript CG6987-RA 0.017
Nopp140 CG7421 gene product from transcript CG7421-RB 0.017
Aos1 CG12276 gene product from transcript CG12276-RA 0.017
Cp190 Centrosomal protein 190kD 0.017
Aats-asp Aspartyl-tRNA synthetase 0.016
gammaTub23C gamma-Tubulin at 23C 0.016
CG7028 CG7028 gene product from transcript CG7028-RA 0.016
skpA CG16983 gene product from transcript CG16983-RD 0.015
CG8878 CG8878 gene product from transcript CG8878-RA 0.015
gus gustavus 0.015
p120ctn Adherens junction protein p120 0.015
Iswi Imitation SWI 0.014
Bx42 CG8264 gene product from transcript CG8264-RA 0.014
CG9915 CG9915 gene product from transcript CG9915-RB 0.014
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.014
CG4751 CG4751 gene product from transcript CG4751-RA 0.014
CG14464 CG14464 gene product from transcript CG14464-RC 0.014
pum pumilio 0.014
Snr1 Snf5-related 1 0.014
E(z) Enhancer of zeste 0.014
Rad23 CG1836 gene product from transcript CG1836-RB 0.014
CG17528 CG17528 gene product from transcript CG17528-RC 0.013
Exp6 Exportin 6 0.013
Rpd3 CG7471 gene product from transcript CG7471-RA 0.013
geminin CG3183 gene product from transcript CG3183-RA 0.013
Rcd1 Reduction in Cnn dots 1 0.013
esc extra sexcombs 0.013
sti sticky 0.013
Ranbp9 CG5252 gene product from transcript CG5252-RA 0.012
hyx hyrax 0.012
d4 CG2682 gene product from transcript CG2682-RB 0.012
CG1416 CG1416 gene product from transcript CG1416-RA 0.012
Sep1 Septin-1 0.012
Dref DNA replication-related element factor 0.012
e(r) enhancer of rudimentary 0.012
Sas10 CG4202 gene product from transcript CG4202-RA 0.012
lig lingerer 0.012
mod modulo 0.012
me31B maternal expression at 31B 0.012
eIF5 CG9177 gene product from transcript CG9177-RE 0.012
CG10267 CG10267 gene product from transcript CG10267-RB 0.012
La La autoantigen-like 0.011
CG5708 CG5708 gene product from transcript CG5708-RB 0.011
lwr lesswright 0.011
CG11376 CG11376 gene product from transcript CG11376-RA 0.011
pnut peanut 0.011
CG8939 CG8939 gene product from transcript CG8939-RA 0.011
didum dilute class unconventional myosin 0.011
dome domeless 0.011
TfIIB Transcription factor IIB 0.011
Ge-1 CG6181 gene product from transcript CG6181-RA 0.011
Mapmodulin CG5784 gene product from transcript CG5784-RB 0.011
CG8289 CG8289 gene product from transcript CG8289-RA 0.011
CG1962 CG1962 gene product from transcript CG1962-RA 0.011
CG18292 CG18292 gene product from transcript CG18292-RA 0.010
put punt 0.010
cta concertina 0.010
Caf1 Chromatin assembly factor 1 subunit 0.010
l(1)10Bb lethal (1) 10Bb 0.010
CG5641 CG5641 gene product from transcript CG5641-RA 0.010
CG7006 CG7006 gene product from transcript CG7006-RA 0.010
CG11444 CG11444 gene product from transcript CG11444-RA 0.010
Su(fu) Suppressor of fused 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Tlr4 toll-like receptor 4 0.947
Nos2 nitric oxide synthase 2, inducible 0.930
Lepr leptin receptor 0.894
Nos1 nitric oxide synthase 1, neuronal 0.786
B2m beta-2 microglobulin 0.751
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.734
Tnf tumor necrosis factor 0.718
H2-K1 histocompatibility 2, K1, K region 0.718
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.717
H2-D1 histocompatibility 2, D region locus 1 0.620
Ptgs2 prostaglandin-endoperoxide synthase 2 0.573
Cav1 caveolin 1, caveolae protein 0.507
Ccl2 chemokine (C-C motif) ligand 2 0.456
Nos3 nitric oxide synthase 3, endothelial cell 0.343
Lyz2 lysozyme 2 0.329
Ccr2 chemokine (C-C motif) receptor 2 0.319
Ren1 renin 1 structural 0.266
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.254
Atxn1 ataxin 1 0.243
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.221
Myd88 myeloid differentiation primary response gene 88 0.218
Tgfb1 transforming growth factor, beta 1 0.203
Insr insulin receptor 0.202
Esr1 estrogen receptor 1 (alpha) 0.156
Plau plasminogen activator, urokinase 0.134
Clec4n C-type lectin domain family 4, member n 0.122
Vdr vitamin D receptor 0.118
Tlr2 toll-like receptor 2 0.115
Pparg peroxisome proliferator activated receptor gamma 0.109
Mmp9 matrix metallopeptidase 9 0.109
Ar androgen receptor 0.107
Il10 interleukin 10 0.102
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.099
H2-Q7 histocompatibility 2, Q region locus 7 0.096
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.091
Pyhin1 pyrin and HIN domain family, member 1 0.086
H2-Q6 histocompatibility 2, Q region locus 6 0.083
Cd180 CD180 antigen 0.083
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.078
Ptrf polymerase I and transcript release factor 0.077
Il6 interleukin 6 0.075
Il1a interleukin 1 alpha 0.071
Cp ceruloplasmin 0.070
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.070
Col1a1 collagen, type I, alpha 1 0.068
Gcet2 germinal center expressed transcript 2 0.066
Agtr1a angiotensin II receptor, type 1a 0.066
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.063
Wt1 Wilms tumor 1 homolog 0.062
Cd44 CD44 antigen 0.062
Lif leukemia inhibitory factor 0.059
Apoe apolipoprotein E 0.058
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.057
Dmd dystrophin, muscular dystrophy 0.057
Vhl von Hippel-Lindau tumor suppressor 0.056
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.055
Plat plasminogen activator, tissue 0.053
Aoah acyloxyacyl hydrolase 0.052
Invs inversin 0.050
Il7r interleukin 7 receptor 0.050
Ncr1 natural cytotoxicity triggering receptor 1 0.050
Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C 0.048
H2-Eb1 histocompatibility 2, class II antigen E beta 0.047
Ccr6 chemokine (C-C motif) receptor 6 0.046
Hspa8 heat shock protein 8 0.046
Ghr growth hormone receptor 0.046
Cd14 CD14 antigen 0.045
Nt5e 5' nucleotidase, ecto 0.045
Fasl Fas ligand (TNF superfamily, member 6) 0.044
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.044
Lair1 leukocyte-associated Ig-like receptor 1 0.044
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.044
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.043
F9 coagulation factor IX 0.042
Fpr1 formyl peptide receptor 1 0.041
Gzmk granzyme K 0.041
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.040
Gzma granzyme A 0.039
Itgb3 integrin beta 3 0.038
Ccr5 chemokine (C-C motif) receptor 5 0.038
Blk B lymphoid kinase 0.037
Vegfa vascular endothelial growth factor A 0.036
Hsph1 heat shock 105kDa/110kDa protein 1 0.036
Ifna1 interferon alpha 1 0.036
Thbd thrombomodulin 0.036
Cys1 cystin 1 0.035
Casp1 caspase 1 0.035
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.034
Bcar1 breast cancer anti-estrogen resistance 1 0.034
Ptprc protein tyrosine phosphatase, receptor type, C 0.033
Prnp prion protein 0.033
Spna1 spectrin alpha 1 0.033
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.031
Adam23 a disintegrin and metallopeptidase domain 23 0.031
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.030
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.029
Cxcr6 chemokine (C-X-C motif) receptor 6 0.029
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.029
Cblb Casitas B-lineage lymphoma b 0.028
Emr4 EGF-like module containing, mucin-like, hormone receptor-like sequence 4 0.028
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hsph1 heat shock 105/110 protein 1 0.015
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.014
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism