The network for 'execution phase of apoptosis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

execution phase of apoptosis

A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 1.000
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.976
BCL2L1 BCL2-like 1 0.963
XIAP X-linked inhibitor of apoptosis 0.916
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.891
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.888
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.828
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.819
FASLG Fas ligand (TNF superfamily, member 6) 0.628
CFLAR CASP8 and FADD-like apoptosis regulator 0.598
BID BH3 interacting domain death agonist 0.580
SNX6 sorting nexin 6 0.522
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.499
FAS Fas (TNF receptor superfamily, member 6) 0.493
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.451
SOCS3 suppressor of cytokine signaling 3 0.375
FKBP1A FK506 binding protein 1A, 12kDa 0.356
APAF1 apoptotic peptidase activating factor 1 0.327
BAX BCL2-associated X protein 0.312
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.302
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.263
FADD Fas (TNFRSF6)-associated via death domain 0.234
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.230
TGFB1 transforming growth factor, beta 1 0.224
BAD BCL2-associated agonist of cell death 0.222
BAK1 BCL2-antagonist/killer 1 0.218
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.200
CCL5 chemokine (C-C motif) ligand 5 0.194
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.183
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.177
BMP2 bone morphogenetic protein 2 0.170
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.166
TRAF1 TNF receptor-associated factor 1 0.150
POU5F1 POU class 5 homeobox 1 0.147
STRN4 striatin, calmodulin binding protein 4 0.146
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.141
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.137
EXOSC3 exosome component 3 0.124
CCR2 chemokine (C-C motif) receptor 2 0.122
TP53 tumor protein p53 0.119
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.115
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.093
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.092
IL2RB interleukin 2 receptor, beta 0.083
BIRC2 baculoviral IAP repeat containing 2 0.081
FNBP1 formin binding protein 1 0.081
ENG endoglin 0.077
CCR5 chemokine (C-C motif) receptor 5 0.075
LRRK2 leucine-rich repeat kinase 2 0.074
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.071
IFNG interferon, gamma 0.070
PRKG1 protein kinase, cGMP-dependent, type I 0.065
STK4 serine/threonine kinase 4 0.065
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.065
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.064
CXCR6 chemokine (C-X-C motif) receptor 6 0.058
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.055
GDF5 growth differentiation factor 5 0.053
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.052
CCL22 chemokine (C-C motif) ligand 22 0.047
EXOSC2 exosome component 2 0.045
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.043
TGFBR1 transforming growth factor, beta receptor 1 0.042
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.042
BIK BCL2-interacting killer (apoptosis-inducing) 0.041
GATA4 GATA binding protein 4 0.041
DIS3 DIS3 mitotic control homolog (S. cerevisiae) 0.040
FAM40B family with sequence similarity 40, member B 0.039
EXOSC10 exosome component 10 0.038
ACVR1 activin A receptor, type I 0.037
BBC3 BCL2 binding component 3 0.037
CXCR3 chemokine (C-X-C motif) receptor 3 0.036
STRN3 striatin, calmodulin binding protein 3 0.036
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.034
C4orf14 chromosome 4 open reading frame 14 0.034
CXCL9 chemokine (C-X-C motif) ligand 9 0.033
MAPK8 mitogen-activated protein kinase 8 0.032
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.032
EXOSC4 exosome component 4 0.031
FSTL1 follistatin-like 1 0.030
STRN striatin, calmodulin binding protein 0.030
IRF4 interferon regulatory factor 4 0.030
TGFB3 transforming growth factor, beta 3 0.029
CD40LG CD40 ligand 0.029
RANBP3 RAN binding protein 3 0.026
CCR7 chemokine (C-C motif) receptor 7 0.026
BECN1 beclin 1, autophagy related 0.026
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.026
NLRC4 NLR family, CARD domain containing 4 0.025
XAB2 XPA binding protein 2 0.025
NMI N-myc (and STAT) interactor 0.024
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 0.024
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.024
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.024
CXCR4 chemokine (C-X-C motif) receptor 4 0.024
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.023
SLAMF7 SLAM family member 7 0.023
SLMAP sarcolemma associated protein 0.022
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.022
CCR4 chemokine (C-C motif) receptor 4 0.022
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
th thread 0.831
imd immune deficiency 0.579
rpr reaper 0.450
Nc Nedd2-like caspase 0.353
caz cabeza 0.181
p53 CG33336 gene product from transcript CG33336-RB 0.158
Dcp-1 Death caspase-1 0.149
Ark Apaf-1-related-killer 0.110
S6k RPS6-p70-protein kinase 0.108
AGO2 Argonaute 2 0.102
Drep-2 DNA fragmentation factor-related protein 2 0.063
grim CG4345 gene product from transcript CG4345-RA 0.059
Ice CG7788 gene product from transcript CG7788-RA 0.056
tefu telomere fusion 0.048
brat brain tumor 0.048
scny scrawny 0.045
Pc Polycomb 0.042
Rrp42 CG8395 gene product from transcript CG8395-RA 0.040
CG11347 CG11347 gene product from transcript CG11347-RE 0.039
Rpp30 RNaseP protein p30 0.032
cmet CENP-meta 0.031
skl sickle 0.030
mib1 mind bomb 1 0.027
DNApol-alpha60 DNA polymerase alpha 60kD 0.026
Gmd GDP-mannose 4,6-dehydratase 0.026
CG8636 CG8636 gene product from transcript CG8636-RA 0.024
CG5854 CG5854 gene product from transcript CG5854-RA 0.024
cathD CG1548 gene product from transcript CG1548-RA 0.024
Drep-4 DNA fragmentation factor-related protein 4 0.023
ik2 IkappaB kinase-like 2 0.023
Sox14 Sox box protein 14 0.023
Lnk CG17367 gene product from transcript CG17367-RC 0.022
egr eiger 0.021
hpo hippo 0.021
pix pixie 0.016
nct nicastrin 0.015
Sep4 Septin 4 0.015
Ptp69D Protein tyrosine phosphatase 69D 0.012
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.012
myoglianin CG1838 gene product from transcript CG1838-RD 0.011
rin rasputin 0.011
RpS20 Ribosomal protein S20 0.010
lin19 lin-19-like 0.010
Uba1 Ubiquitin activating enzyme 1 0.010
MED31 Mediator complex subunit 31 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Gbp5 guanylate binding protein 5 0.750
Pycard PYD and CARD domain containing 0.487
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.363
Gopc golgi associated PDZ and coiled-coil motif containing 0.356
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.191
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.165
Igh immunoglobulin heavy chain complex 0.122
Ikbkb inhibitor of kappaB kinase beta 0.119
Dlg4 discs, large homolog 4 (Drosophila) 0.116
Bcl2 B-cell leukemia/lymphoma 2 0.089
Dffb DNA fragmentation factor, beta subunit 0.086
Il18 interleukin 18 0.075
Ikbkg inhibitor of kappaB kinase gamma 0.070
Casp1 caspase 1 0.066
Wnt5a wingless-related MMTV integration site 5A 0.052
Sharpin SHANK-associated RH domain interacting protein 0.046
Axin1 axin 1 0.046
Nmi N-myc (and STAT) interactor 0.044
Dlg1 discs, large homolog 1 (Drosophila) 0.044
Akt1 thymoma viral proto-oncogene 1 0.042
Rnf31 ring finger protein 31 0.040
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.038
Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.037
Adam10 a disintegrin and metallopeptidase domain 10 0.034
Plin1 perilipin 1 0.032
Prc1 protein regulator of cytokinesis 1 0.032
Ldb3 LIM domain binding 3 0.029
Ehmt2 euchromatic histone lysine N-methyltransferase 2 0.029
Cd28 CD28 antigen 0.029
Tgfbr1 transforming growth factor, beta receptor I 0.028
Fzd8 frizzled homolog 8 (Drosophila) 0.028
Safb scaffold attachment factor B 0.027
Erh enhancer of rudimentary homolog (Drosophila) 0.027
Tbx3 T-box 3 0.027
Dlg2 discs, large homolog 2 (Drosophila) 0.026
Atr ataxia telangiectasia and Rad3 related 0.026
Casp8 caspase 8 0.025
Cxcl9 chemokine (C-X-C motif) ligand 9 0.025
H2afz H2A histone family, member Z 0.025
Scn5a sodium channel, voltage-gated, type V, alpha 0.024
Dck deoxycytidine kinase 0.023
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.022
Bag6 BCL2-associated athanogene 6 0.022
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.022
Bak1 BCL2-antagonist/killer 1 0.022
Mtx2 metaxin 2 0.021
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.021
Rbl1 retinoblastoma-like 1 (p107) 0.020
Gpc3 glypican 3 0.020
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.020
Becn1 beclin 1, autophagy related 0.020
Nfya nuclear transcription factor-Y alpha 0.019
Sardh sarcosine dehydrogenase 0.019
Apaf1 apoptotic peptidase activating factor 1 0.019
Csnk1g2 casein kinase 1, gamma 2 0.019
Add1 adducin 1 (alpha) 0.019
Ighmbp2 immunoglobulin mu binding protein 2 0.018
Hif1a hypoxia inducible factor 1, alpha subunit 0.018
Sfrp2 secreted frizzled-related protein 2 0.018
Eya2 eyes absent 2 homolog (Drosophila) 0.017
Coro1b coronin, actin binding protein 1B 0.017
Rbm42 RNA binding motif protein 42 0.017
Aim2 absent in melanoma 2 0.017
Ctdnep1 CTD nuclear envelope phosphatase 1 0.016
Hsf1 heat shock factor 1 0.016
Sfrp1 secreted frizzled-related protein 1 0.016
Hmgb1 high mobility group box 1 0.016
Bbc3 BCL2 binding component 3 0.016
Fjx1 four jointed box 1 (Drosophila) 0.016
Tlr4 toll-like receptor 4 0.016
Hmgb2 high mobility group box 2 0.016
Akt2 thymoma viral proto-oncogene 2 0.016
Pygo2 pygopus 2 0.015
Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.015
Hibch 3-hydroxyisobutyryl-Coenzyme A hydrolase 0.015
Gja5 gap junction protein, alpha 5 0.015
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.015
Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A 0.015
Drosha drosha, ribonuclease type III 0.015
Vhl von Hippel-Lindau tumor suppressor 0.015
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.015
Fam96a family with sequence similarity 96, member A 0.015
Rbck1 RanBP-type and C3HC4-type zinc finger containing 1 0.014
Tspan12 tetraspanin 12 0.014
Mfap2 microfibrillar-associated protein 2 0.014
Smo smoothened homolog (Drosophila) 0.014
Vars valyl-tRNA synthetase 0.014
Cd40 CD40 antigen 0.014
Ptgfr prostaglandin F receptor 0.014
Hcfc1 host cell factor C1 0.014
Nsa2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.014
Ncln nicalin homolog (zebrafish) 0.014
Adprhl2 ADP-ribosylhydrolase like 2 0.014
Tfam transcription factor A, mitochondrial 0.014
Ldb1 LIM domain binding 1 0.014
Tmpo thymopoietin 0.014
Tead2 TEA domain family member 2 0.014
Nr1h2 nuclear receptor subfamily 1, group H, member 2 0.014
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.013
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.013
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.017
Copb1 coatomer protein complex, subunit beta 1 0.016
Fyttd1 forty-two-three domain containing 1 0.015
Sec62 SEC62 homolog (S. cerevisiae) 0.014
LOC682967 similar to Protein disulfide-isomerase TXNDC10 precursor (Thioredoxin domain-containing protein 10) 0.014
Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.014
Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d 0.014
Ddx3x DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.013
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.013
Eif3m eukaryotic translation initiation factor 3, subunit M 0.013
Sfrs11 splicing factor, arginine/serine-rich 11 0.013
Ndufb10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 0.013
Pnrc2 proline-rich nuclear receptor coactivator 2 0.012
Paip2 poly(A) binding protein interacting protein 2 0.012
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.011
Narg1 NMDA receptor regulated 1 0.011
Tcea1 transcription elongation factor A (SII) 1 0.010
Hiat1 hippocampus abundant gene transcript 1 0.010
Atp5l ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism