The network for 'leukocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte activation

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.

Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
SYK spleen tyrosine kinase 1.000
LCK lymphocyte-specific protein tyrosine kinase 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 1.000
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 1.000
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.999
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.999
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.998
GRB2 growth factor receptor-bound protein 2 0.998
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.995
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.993
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.985
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.984
VAV1 vav 1 guanine nucleotide exchange factor 0.984
LAT linker for activation of T cells 0.983
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.982
CD2 CD2 molecule 0.982
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.977
PLCG1 phospholipase C, gamma 1 0.974
CCR7 chemokine (C-C motif) receptor 7 0.970
IL2RB interleukin 2 receptor, beta 0.970
PTPRC protein tyrosine phosphatase, receptor type, C 0.964
CCL5 chemokine (C-C motif) ligand 5 0.958
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.939
TRAF1 TNF receptor-associated factor 1 0.936
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.935
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.933
RUNX1 runt-related transcription factor 1 0.928
IL2RG interleukin 2 receptor, gamma 0.926
SH2D1A SH2 domain containing 1A 0.925
SOS1 son of sevenless homolog 1 (Drosophila) 0.917
RB1 retinoblastoma 1 0.914
SLA Src-like-adaptor 0.912
IRF4 interferon regulatory factor 4 0.904
LAPTM5 lysosomal protein transmembrane 5 0.898
SLAMF1 signaling lymphocytic activation molecule family member 1 0.897
CCR5 chemokine (C-C motif) receptor 5 0.896
IL10RA interleukin 10 receptor, alpha 0.895
ITK IL2-inducible T-cell kinase 0.891
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.885
FGFR1 fibroblast growth factor receptor 1 0.885
CXCL9 chemokine (C-X-C motif) ligand 9 0.881
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.878
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.866
CCL22 chemokine (C-C motif) ligand 22 0.862
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.861
BRCA1 breast cancer 1, early onset 0.860
CAV1 caveolin 1, caveolae protein, 22kDa 0.859
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.848
CD80 CD80 molecule 0.848
CCL4 chemokine (C-C motif) ligand 4 0.833
JAG1 jagged 1 0.828
FGFR2 fibroblast growth factor receptor 2 0.828
NOTCH1 notch 1 0.820
HCK hemopoietic cell kinase 0.820
CD247 CD247 molecule 0.809
CCR1 chemokine (C-C motif) receptor 1 0.779
JAK2 Janus kinase 2 0.777
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.774
CXCL10 chemokine (C-X-C motif) ligand 10 0.767
CD48 CD48 molecule 0.767
FHL2 four and a half LIM domains 2 0.765
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.752
IFNG interferon, gamma 0.747
CD86 CD86 molecule 0.746
HLA-E major histocompatibility complex, class I, E 0.740
HLA-DRA major histocompatibility complex, class II, DR alpha 0.735
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.727
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.716
HLA-C major histocompatibility complex, class I, C 0.709
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.709
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.707
BLNK B-cell linker 0.704
FYB FYN binding protein 0.700
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.696
CD28 CD28 molecule 0.693
CARD11 caspase recruitment domain family, member 11 0.693
IL4R interleukin 4 receptor 0.693
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.691
INSR insulin receptor 0.687
NKG7 natural killer cell group 7 sequence 0.679
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.658
ICAM1 intercellular adhesion molecule 1 0.651
PPARA peroxisome proliferator-activated receptor alpha 0.650
AXL AXL receptor tyrosine kinase 0.648
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.644
BCL10 B-cell CLL/lymphoma 10 0.630
B2M beta-2-microglobulin 0.624
TFF1 trefoil factor 1 0.622
CD6 CD6 molecule 0.614
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.613
IL1R1 interleukin 1 receptor, type I 0.613
APP amyloid beta (A4) precursor protein 0.604
IRF8 interferon regulatory factor 8 0.601
CD37 CD37 molecule 0.597
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.592
IL10 interleukin 10 0.587
STAT4 signal transducer and activator of transcription 4 0.585
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
capns1b calpain, small subunit 1 b 0.570
fgf3 fibroblast growth factor 3 0.442
cmyb transcription factor cmyb 0.365
cdx4 caudal type homeo box transcription factor 4 0.353
lhx3 LIM homeobox 3 0.291
bmp2b bone morphogenetic protein 2b 0.274
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.240
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.239
mmp9 matrix metalloproteinase 9 0.217
fgf8a fibroblast growth factor 8 a 0.154
lcp1 lymphocyte cytosolic plastin 1 0.121
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.116
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.111
otx1b orthodenticle homolog 1b 0.104
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.099
satb2 SATB homeobox 2 0.098
tbx1 T-box 1 0.097
csf3r colony stimulating factor 3 receptor (granulocyte) 0.096
il6r interleukin 6 receptor 0.083
ccnd1 cyclin D1 0.081
lyz lysozyme 0.078
fzd7a frizzled homolog 7a 0.077
si:dkey-8l13.4 si:dkey-8l13.4 0.075
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.074
gata3 GATA-binding protein 3 0.074
boc brother of CDO 0.073
myca myelocytomatosis oncogene a 0.073
pcdh18b protocadherin 18b 0.072
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.067
cxcr4b chemokine (C-X-C motif), receptor 4b 0.065
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.063
fzd10 frizzled homolog 10 0.061
nadl1.1 neural adhesion molecule L1.1 0.059
edn1 endothelin 1 0.058
fabp7a fatty acid binding protein 7, brain, a 0.056
rag1 recombination activating gene 1 0.056
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.055
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.051
crip2 cysteine-rich protein 2 0.050
shha sonic hedgehog a 0.049
zgc:56039 zgc:56039 0.047
egr2b early growth response 2b 0.047
tshb thyroid stimulating hormone, beta subunit 0.047
axin2 axin 2 (conductin, axil) 0.045
efna2 ephrin A2 0.045
il12bb interleukin 12B, b 0.044
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.043
fzd5 frizzled homolog 5 0.042
runx2a runt-related transcription factor 2a 0.041
kita kit receptor a 0.041
dlc deltaC 0.039
lft1 lefty1 0.039
il7r interleukin 7 receptor 0.039
tlr3 toll-like receptor 3 0.038
pdcd2 programmed cell death 2 0.037
wnt9b wingless-type MMTV integration site family, member 9B 0.037
arrb2b arrestin, beta 2b 0.035
elk4 ELK4, ETS-domain protein 0.035
zgc:91870 zgc:91870 0.034
nrp2b neuropilin 2b 0.033
eomesb eomesodermin homolog b 0.032
ext2 exostoses (multiple) 2 0.032
fes feline sarcoma oncogene 0.032
runx3 runt-related transcription factor 3 0.031
crfa31.2 IL-4RA-like protein 2 0.031
zgc:64115 zgc:64115 0.031
fn1 fibronectin 1 0.031
chd chordin 0.030
wasa Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a 0.030
zgc:77517 zgc:77517 0.030
tert telomerase reverse transcriptase 0.030
ryk receptor-like tyrosine kinase 0.029
tbx2b T-box 2b 0.029
cd8a CD8 antigen, alpha polypeptide 0.029
caspa caspase a 0.029
jak3 Janus kinase 3 (a protein tyrosine kinase, leukocyte) 0.029
scd stearoyl-CoA desaturase (delta-9-desaturase) 0.028
btk Bruton agammaglobulinemia tyrosine kinase 0.027
si:dkey-27i16.2 si:dkey-27i16.2 0.027
hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.027
LOC100003514 protein kinase C alpha type-like 0.026
gli1 GLI-Kruppel family member 1 0.025
flh floating head 0.025
rad21 RAD21 homolog (S. pombe) 0.025
pglyrp6 peptidoglycan recognition protein 6 0.025
ptger4a prostaglandin E receptor 4 (subtype EP4) a 0.024
hlxb9la homeo box HB9 like a 0.024
cntn2 contactin 2 0.024
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.024
grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.024
fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.024
ip6k2 inositol hexaphosphate kinase 2 0.024
tp53 tumor protein p53 0.024
lrrc33 leucine rich repeat containing 33 0.024
tcf12 transcription factor 12 0.023
tnfsf10l2 tumor necrosis factor (ligand) superfamily, member 10 like 2 0.023
hirip3 HIRA interacting protein 3 0.023
eya2 eyes absent homolog 2 (Drosophila) 0.023
notch3 notch homolog 3 0.023
fcer1gl Fc receptor, IgE, high affinity I, gamma polypeptide like 0.023
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd2 Cd2 molecule 0.961
Ptprc protein tyrosine phosphatase, receptor type, C 0.937
Ccr5 chemokine (C-C motif) receptor 5 0.935
RT1-Ba RT1 class II, locus Ba 0.929
Gzmk granzyme K 0.917
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.896
Casp1 caspase 1 0.880
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.850
Cd247 Cd247 molecule 0.833
Anxa2 annexin A2 0.750
Cd86 CD86 molecule 0.748
Ccl5 chemokine (C-C motif) ligand 5 0.720
Hck hemopoietic cell kinase 0.702
Csf1 colony stimulating factor 1 (macrophage) 0.700
Cd53 Cd53 molecule 0.682
Cd5 Cd5 molecule 0.674
Clec9a C-type lectin domain family 9, member a 0.674
RT1-Da RT1 class II, locus Da 0.671
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.659
Tgfbr2 transforming growth factor, beta receptor II 0.647
Cd4 Cd4 molecule 0.563
Il1b interleukin 1 beta 0.552
RT1-Db1 RT1 class II, locus Db1 0.516
Adora2a adenosine A2a receptor 0.509
Ciita class II, major histocompatibility complex, transactivator 0.504
Flt1 FMS-related tyrosine kinase 1 0.502
Sell selectin L 0.465
Cd38 CD38 molecule 0.421
Ptafr platelet-activating factor receptor 0.419
Il6 interleukin 6 0.392
Xcl1 chemokine (C motif) ligand 1 0.391
Il2rb interleukin 2 receptor, beta 0.388
Cd37 CD37 molecule 0.386
Lcp2 lymphocyte cytosolic protein 2 0.375
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.345
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.337
Cxcr3 chemokine (C-X-C motif) receptor 3 0.305
Arhgap4 Rho GTPase activating protein 4 0.299
Igh-6 immunoglobulin heavy chain 6 0.298
Met met proto-oncogene 0.279
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.279
Cd3g CD3 molecule, gamma 0.277
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.274
Faslg Fas ligand (TNF superfamily, member 6) 0.271
Mmp12 matrix metallopeptidase 12 0.266
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.266
Cd3d CD3 molecule, delta 0.262
Nkg7 natural killer cell group 7 sequence 0.261
Cd8a CD8a molecule 0.259
Fgfr2 fibroblast growth factor receptor 2 0.258
Pecam1 platelet/endothelial cell adhesion molecule 1 0.257
Tfec transcription factor EC 0.254
Calcrl calcitonin receptor-like 0.252
Lst1 leukocyte specific transcript 1 0.251
Tcrb T-cell receptor beta chain 0.237
Ly86 lymphocyte antigen 86 0.233
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.233
Il1r1 interleukin 1 receptor, type I 0.232
Hdac7 histone deacetylase 7 0.229
Vip vasoactive intestinal peptide 0.227
Ccr2 chemokine (C-C motif) receptor 2 0.225
Havcr1 hepatitis A virus cellular receptor 1 0.223
Dock8 dedicator of cytokinesis 8 0.223
Zbp1 Z-DNA binding protein 1 0.221
Kcnq2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.217
Cybb cytochrome b-245, beta polypeptide 0.214
Il4 interleukin 4 0.213
Ctse cathepsin E 0.212
Il7r interleukin 7 receptor 0.209
Bin2 bridging integrator 2 0.208
Igsf6 immunoglobulin superfamily, member 6 0.207
Plau plasminogen activator, urokinase 0.204
Tlr4 toll-like receptor 4 0.202
Scn11a sodium channel, voltage-gated, type XI, alpha 0.200
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.199
Inpp5d inositol polyphosphate-5-phosphatase D 0.197
Gja1 gap junction protein, alpha 1 0.188
Zcwpw1 zinc finger, CW-type with PWWP domain 1 0.187
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.186
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.184
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.183
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.180
Iapp islet amyloid polypeptide 0.179
Lef1 lymphoid enhancer binding factor 1 0.179
Fas Fas (TNF receptor superfamily, member 6) 0.178
Gata6 GATA binding protein 6 0.172
Btg2 BTG family, member 2 0.171
Vcam1 vascular cell adhesion molecule 1 0.170
Calm1 calmodulin 1 0.169
Mcpt2 mast cell protease 2 0.168
N5 DNA binding protein N5 0.167
Itgad integrin, alpha D 0.166
Pgam1 phosphoglycerate mutase 1 (brain) 0.165
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.164
Jak1 Janus kinase 1 0.164
Prm2 protamine 2 0.162
Cd79b Cd79b molecule, immunoglobulin-associated beta 0.162
Ambn ameloblastin 0.161
Gimap4 GTPase, IMAP family member 4 0.161
Ctsj cathepsin J 0.160
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism