IMP
Process View
The network for 'regulation of extrinsic apoptotic signaling pathway via death domain receptors' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
regulation of extrinsic apoptotic signaling pathway via death domain receptors
Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.999 | |
| TEK | TEK tyrosine kinase, endothelial | 0.969 | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.748 | |
| FAS | Fas (TNF receptor superfamily, member 6) | 0.712 | |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.605 | |
| FGA | fibrinogen alpha chain | 0.591 | |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.500 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.450 | |
| TGIF1 | TGFB-induced factor homeobox 1 | 0.370 | |
| SNAP23 | synaptosomal-associated protein, 23kDa | 0.364 | |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.330 | |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.328 | |
| PDPK1 | 3-phosphoinositide dependent protein kinase-1 | 0.305 | |
| PLAU | plasminogen activator, urokinase | 0.289 | |
| FGB | fibrinogen beta chain | 0.283 | |
| STK3 | serine/threonine kinase 3 | 0.216 | |
| STRN | striatin, calmodulin binding protein | 0.182 | |
| VAMP3 | vesicle-associated membrane protein 3 (cellubrevin) | 0.167 | |
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 0.153 | |
| NAPA | N-ethylmaleimide-sensitive factor attachment protein, alpha | 0.149 | |
| FTL | ferritin, light polypeptide | 0.137 | |
| VIM | vimentin | 0.135 | |
| FN1 | fibronectin 1 | 0.123 | |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.120 | |
| CASP8AP2 | caspase 8 associated protein 2 | 0.119 | |
| FGG | fibrinogen gamma chain | 0.095 | |
| SP100 | SP100 nuclear antigen | 0.092 | |
| MAPK1 | mitogen-activated protein kinase 1 | 0.088 | |
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.083 | |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.074 | |
| PLAT | plasminogen activator, tissue | 0.070 | |
| BCL2 | B-cell CLL/lymphoma 2 | 0.070 | |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.066 | |
| TRAF1 | TNF receptor-associated factor 1 | 0.063 | |
| STK4 | serine/threonine kinase 4 | 0.056 | |
| PPM1F | protein phosphatase, Mg2+/Mn2+ dependent, 1F | 0.055 | |
| MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) | 0.055 | |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.055 | |
| PLAUR | plasminogen activator, urokinase receptor | 0.054 | |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.051 | |
| CA12 | carbonic anhydrase XII | 0.050 | |
| UROD | uroporphyrinogen decarboxylase | 0.050 | |
| TP53BP2 | tumor protein p53 binding protein, 2 | 0.050 | |
| BID | BH3 interacting domain death agonist | 0.050 | |
| PTPRC | protein tyrosine phosphatase, receptor type, C | 0.049 | |
| BAD | BCL2-associated agonist of cell death | 0.046 | |
| MMP2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 0.045 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.042 | |
| FHL2 | four and a half LIM domains 2 | 0.041 | |
| FBN1 | fibrillin 1 | 0.041 | |
| EMP3 | epithelial membrane protein 3 | 0.040 | |
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.039 | |
| PLEK | pleckstrin | 0.038 | |
| MICA | MHC class I polypeptide-related sequence A | 0.038 | |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.038 | |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.038 | |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.037 | |
| CRP | C-reactive protein, pentraxin-related | 0.037 | |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.036 | |
| BCL2L1 | BCL2-like 1 | 0.034 | |
| BAX | BCL2-associated X protein | 0.034 | |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.034 | |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.033 | |
| S100A10 | S100 calcium binding protein A10 | 0.033 | |
| ATXN3 | ataxin 3 | 0.032 | |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.032 | |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | 0.032 | |
| SRI | sorcin | 0.030 | |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.030 | |
| SAMD9 | sterile alpha motif domain containing 9 | 0.029 | |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.029 | |
| NMI | N-myc (and STAT) interactor | 0.028 | |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.025 | |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.025 | |
| GDF5 | growth differentiation factor 5 | 0.024 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.024 | |
| PSEN1 | presenilin 1 | 0.024 | |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.023 | |
| TRIM38 | tripartite motif containing 38 | 0.023 | |
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 0.022 | |
| FAM190B | family with sequence similarity 190, member B | 0.022 | |
| TMSB4X | thymosin beta 4, X-linked | 0.021 | |
| TRAF6 | TNF receptor-associated factor 6 | 0.021 | |
| BBC3 | BCL2 binding component 3 | 0.019 | |
| COL6A2 | collagen, type VI, alpha 2 | 0.019 | |
| CARD11 | caspase recruitment domain family, member 11 | 0.019 | |
| RNF4 | ring finger protein 4 | 0.019 | |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.019 | |
| COL4A1 | collagen, type IV, alpha 1 | 0.018 | |
| TMC6 | transmembrane channel-like 6 | 0.018 | |
| DOCK7 | dedicator of cytokinesis 7 | 0.018 | |
| BECN1 | beclin 1, autophagy related | 0.018 | |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.018 | |
| ORM1 | orosomucoid 1 | 0.018 | |
| BAK1 | BCL2-antagonist/killer 1 | 0.018 | |
| USP15 | ubiquitin specific peptidase 15 | 0.018 | |
| TRADD | TNFRSF1A-associated via death domain | 0.018 | |
| ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 0.017 | |
| LATS2 | LATS, large tumor suppressor, homolog 2 (Drosophila) | 0.017 | |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.017 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Apc | adenomatosis polyposis coli | 0.983 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.794 | |
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.654 | |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.619 | |
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.567 | |
| Braf | Braf transforming gene | 0.558 | |
| Pten | phosphatase and tensin homolog | 0.552 | |
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.540 | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.530 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.505 | |
| Cd44 | CD44 antigen | 0.485 | |
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.470 | |
| Tgfbr1 | transforming growth factor, beta receptor I | 0.403 | |
| Trp53 | transformation related protein 53 | 0.381 | |
| Psen1 | presenilin 1 | 0.289 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.258 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.239 | |
| Mmp9 | matrix metallopeptidase 9 | 0.231 | |
| Vegfa | vascular endothelial growth factor A | 0.200 | |
| Stk3 | serine/threonine kinase 3 (Ste20, yeast homolog) | 0.152 | |
| Egfr | epidermal growth factor receptor | 0.151 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.134 | |
| Esr1 | estrogen receptor 1 (alpha) | 0.126 | |
| Nos1 | nitric oxide synthase 1, neuronal | 0.119 | |
| Casp8 | caspase 8 | 0.115 | |
| Acvr1 | activin A receptor, type 1 | 0.110 | |
| Smad3 | MAD homolog 3 (Drosophila) | 0.103 | |
| Tlr4 | toll-like receptor 4 | 0.099 | |
| Lyz2 | lysozyme 2 | 0.090 | |
| Fgg | fibrinogen gamma chain | 0.083 | |
| Nos2 | nitric oxide synthase 2, inducible | 0.079 | |
| Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.078 | |
| Eng | endoglin | 0.068 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.064 | |
| Smad4 | MAD homolog 4 (Drosophila) | 0.062 | |
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.061 | |
| Bmpr1a | bone morphogenetic protein receptor, type 1A | 0.060 | |
| Rxra | retinoid X receptor alpha | 0.060 | |
| Foxc1 | forkhead box C1 | 0.060 | |
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.058 | |
| Il6st | interleukin 6 signal transducer | 0.056 | |
| Ncstn | nicastrin | 0.054 | |
| Pvr | poliovirus receptor | 0.052 | |
| Vhl | von Hippel-Lindau tumor suppressor | 0.052 | |
| Apoa1 | apolipoprotein A-I | 0.051 | |
| Cav1 | caveolin 1, caveolae protein | 0.051 | |
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.051 | |
| Sufu | suppressor of fused homolog (Drosophila) | 0.050 | |
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.050 | |
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.049 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.047 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.047 | |
| Fst | follistatin | 0.047 | |
| Rb1 | retinoblastoma 1 | 0.044 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.044 | |
| Mcl1 | myeloid cell leukemia sequence 1 | 0.043 | |
| Runx1 | runt related transcription factor 1 | 0.042 | |
| Thbs1 | thrombospondin 1 | 0.042 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.042 | |
| Ambp | alpha 1 microglobulin/bikunin | 0.041 | |
| Tmpo | thymopoietin | 0.039 | |
| Ptch1 | patched homolog 1 | 0.038 | |
| Trp73 | transformation related protein 73 | 0.038 | |
| Inhba | inhibin beta-A | 0.038 | |
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.037 | |
| Serpinc1 | serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 | 0.036 | |
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.034 | |
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.034 | |
| Plaur | plasminogen activator, urokinase receptor | 0.033 | |
| Rras | Harvey rat sarcoma oncogene, subgroup R | 0.033 | |
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.033 | |
| Plau | plasminogen activator, urokinase | 0.032 | |
| Kit | kit oncogene | 0.031 | |
| Psen2 | presenilin 2 | 0.031 | |
| Plg | plasminogen | 0.031 | |
| Itgb3 | integrin beta 3 | 0.030 | |
| Il4ra | interleukin 4 receptor, alpha | 0.030 | |
| F2 | coagulation factor II | 0.029 | |
| Cyld | cylindromatosis (turban tumor syndrome) | 0.029 | |
| Aph1a | anterior pharynx defective 1a homolog (C. elegans) | 0.029 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.029 | |
| Fzd1 | frizzled homolog 1 (Drosophila) | 0.028 | |
| Myc | myelocytomatosis oncogene | 0.028 | |
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.028 | |
| Rbl1 | retinoblastoma-like 1 (p107) | 0.027 | |
| Pml | promyelocytic leukemia | 0.027 | |
| Sav1 | salvador homolog 1 (Drosophila) | 0.027 | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.026 | |
| Lif | leukemia inhibitory factor | 0.026 | |
| Coq7 | demethyl-Q 7 | 0.026 | |
| Ldlr | low density lipoprotein receptor | 0.025 | |
| Stk4 | serine/threonine kinase 4 | 0.025 | |
| Klf3 | Kruppel-like factor 3 (basic) | 0.025 | |
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.025 | |
| Skil | SKI-like | 0.024 | |
| Fadd | Fas (TNFRSF6)-associated via death domain | 0.023 | |
| Stxbp5 | syntaxin binding protein 5 (tomosyn) | 0.023 | |
| Ednra | endothelin receptor type A | 0.023 | |
| Kitl | kit ligand | 0.023 | |
| S100a6 | S100 calcium binding protein A6 (calcyclin) | 0.022 |