The network for 'regulation of tumor necrosis factor production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of tumor necrosis factor production

Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.

Homo sapiens
Name Description Probability Func Analog Organism
BIRC3 baculoviral IAP repeat containing 3 0.999
MYD88 myeloid differentiation primary response gene (88) 0.999
IRAK2 interleukin-1 receptor-associated kinase 2 0.994
C1QA complement component 1, q subcomponent, A chain 0.994
TRAF6 TNF receptor-associated factor 6 0.922
IRAK3 interleukin-1 receptor-associated kinase 3 0.908
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.897
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.863
IRAK1 interleukin-1 receptor-associated kinase 1 0.783
CCR1 chemokine (C-C motif) receptor 1 0.729
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.705
MAPK14 mitogen-activated protein kinase 14 0.667
FAS Fas (TNF receptor superfamily, member 6) 0.606
TLR2 toll-like receptor 2 0.604
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.596
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.582
CD14 CD14 molecule 0.576
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.570
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.440
CXCL10 chemokine (C-X-C motif) ligand 10 0.440
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.434
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.427
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.415
IL10RA interleukin 10 receptor, alpha 0.412
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.389
TNF tumor necrosis factor 0.366
CXCL2 chemokine (C-X-C motif) ligand 2 0.346
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.335
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.321
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.302
TLR4 toll-like receptor 4 0.302
SETD8 SET domain containing (lysine methyltransferase) 8 0.264
CYBB cytochrome b-245, beta polypeptide 0.253
MSR1 macrophage scavenger receptor 1 0.246
NLRC4 NLR family, CARD domain containing 4 0.241
C1QB complement component 1, q subcomponent, B chain 0.236
CD163 CD163 molecule 0.227
TICAM2 toll-like receptor adaptor molecule 2 0.224
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.201
CCR5 chemokine (C-C motif) receptor 5 0.199
CXCL9 chemokine (C-X-C motif) ligand 9 0.199
CXCL11 chemokine (C-X-C motif) ligand 11 0.190
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.190
HSF1 heat shock transcription factor 1 0.188
CCL5 chemokine (C-C motif) ligand 5 0.186
TRAF1 TNF receptor-associated factor 1 0.180
TRAF5 TNF receptor-associated factor 5 0.179
CCL8 chemokine (C-C motif) ligand 8 0.177
NCOA3 nuclear receptor coactivator 3 0.176
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.174
TRAF2 TNF receptor-associated factor 2 0.169
PTAFR platelet-activating factor receptor 0.168
SLA Src-like-adaptor 0.167
CCL4 chemokine (C-C motif) ligand 4 0.164
C1QC complement component 1, q subcomponent, C chain 0.163
HSPB1 heat shock 27kDa protein 1 0.162
PLEK pleckstrin 0.155
PILRA paired immunoglobin-like type 2 receptor alpha 0.150
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.150
SIGLEC7 sialic acid binding Ig-like lectin 7 0.140
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.139
CFLAR CASP8 and FADD-like apoptosis regulator 0.138
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.131
SYK spleen tyrosine kinase 0.130
IL23A interleukin 23, alpha subunit p19 0.128
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.123
MED15 mediator complex subunit 15 0.122
IDE insulin-degrading enzyme 0.116
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.110
CCL2 chemokine (C-C motif) ligand 2 0.105
CD86 CD86 molecule 0.104
TEK TEK tyrosine kinase, endothelial 0.099
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.096
SLAMF8 SLAM family member 8 0.094
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.090
SBNO2 strawberry notch homolog 2 (Drosophila) 0.089
TRAF3 TNF receptor-associated factor 3 0.088
F13A1 coagulation factor XIII, A1 polypeptide 0.087
IGSF6 immunoglobulin superfamily, member 6 0.087
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.086
PF4 platelet factor 4 0.084
SOCS1 suppressor of cytokine signaling 1 0.082
FADD Fas (TNFRSF6)-associated via death domain 0.082
FOS FBJ murine osteosarcoma viral oncogene homolog 0.081
HK3 hexokinase 3 (white cell) 0.078
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.078
TMEM173 transmembrane protein 173 0.077
SPOP speckle-type POZ protein 0.075
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.075
PML promyelocytic leukemia 0.074
MEFV Mediterranean fever 0.074
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.073
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.072
CCL13 chemokine (C-C motif) ligand 13 0.070
UBD ubiquitin D 0.070
NLRP3 NLR family, pyrin domain containing 3 0.070
HDAC7 histone deacetylase 7 0.068
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.068
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.066
IRF1 interferon regulatory factor 1 0.064
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Lyz2 lysozyme 2 0.998
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.997
Tnf tumor necrosis factor 0.995
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.983
Myd88 myeloid differentiation primary response gene 88 0.982
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.981
Tlr4 toll-like receptor 4 0.980
Ccr1 chemokine (C-C motif) receptor 1 0.961
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.946
Cd44 CD44 antigen 0.926
Ptprc protein tyrosine phosphatase, receptor type, C 0.919
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.886
Clec4n C-type lectin domain family 4, member n 0.851
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.843
Il10 interleukin 10 0.818
Axl AXL receptor tyrosine kinase 0.810
Ikzf1 IKAROS family zinc finger 1 0.770
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.764
Tcra T-cell receptor alpha chain 0.743
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.723
Fasl Fas ligand (TNF superfamily, member 6) 0.719
C3ar1 complement component 3a receptor 1 0.702
Otx2 orthodenticle homolog 2 (Drosophila) 0.681
Ccr6 chemokine (C-C motif) receptor 6 0.674
Traf6 TNF receptor-associated factor 6 0.656
Socs1 suppressor of cytokine signaling 1 0.609
Il1b interleukin 1 beta 0.604
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.602
Blk B lymphoid kinase 0.592
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.583
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.581
Clec4d C-type lectin domain family 4, member d 0.570
Ccr2 chemokine (C-C motif) receptor 2 0.564
Sfpi1 SFFV proviral integration 1 0.547
Il2rg interleukin 2 receptor, gamma chain 0.511
Ccl2 chemokine (C-C motif) ligand 2 0.510
Ccl3 chemokine (C-C motif) ligand 3 0.494
Cd14 CD14 antigen 0.470
Il1rn interleukin 1 receptor antagonist 0.458
AF251705 cDNA sequence AF251705 0.445
Emx2 empty spiracles homolog 2 (Drosophila) 0.435
Pax6 paired box gene 6 0.427
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.421
Ccl4 chemokine (C-C motif) ligand 4 0.379
Nlrp3 NLR family, pyrin domain containing 3 0.376
Tlr2 toll-like receptor 2 0.364
Ifnar1 interferon (alpha and beta) receptor 1 0.359
Ptf1a pancreas specific transcription factor, 1a 0.356
Ticam1 toll-like receptor adaptor molecule 1 0.346
Itgal integrin alpha L 0.344
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.343
Il4 interleukin 4 0.338
Foxp3 forkhead box P3 0.327
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.327
Casp8 caspase 8 0.326
Cd40 CD40 antigen 0.321
Cd209a CD209a antigen 0.320
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.317
Slamf8 SLAM family member 8 0.316
Cd7 CD7 antigen 0.303
Tnip1 TNFAIP3 interacting protein 1 0.300
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.290
Fgd3 FYVE, RhoGEF and PH domain containing 3 0.287
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.287
Clec7a C-type lectin domain family 7, member a 0.281
Gzma granzyme A 0.280
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.279
Casp1 caspase 1 0.272
Il10ra interleukin 10 receptor, alpha 0.271
Gab1 growth factor receptor bound protein 2-associated protein 1 0.271
Msr1 macrophage scavenger receptor 1 0.269
Fcrla Fc receptor-like A 0.259
Neurod1 neurogenic differentiation 1 0.256
Mmp8 matrix metallopeptidase 8 0.254
Trim30d tripartite motif-containing 30D 0.252
Gzmk granzyme K 0.249
Pyhin1 pyrin and HIN domain family, member 1 0.248
Fcgr2b Fc receptor, IgG, low affinity IIb 0.244
Osr1 odd-skipped related 1 (Drosophila) 0.235
Cd86 CD86 antigen 0.234
Apoe apolipoprotein E 0.229
Ifng interferon gamma 0.228
Runx1 runt related transcription factor 1 0.225
Ccr5 chemokine (C-C motif) receptor 5 0.224
Ccr7 chemokine (C-C motif) receptor 7 0.222
Stat3 signal transducer and activator of transcription 3 0.218
Pax2 paired box gene 2 0.215
Ccl6 chemokine (C-C motif) ligand 6 0.212
Madcam1 mucosal vascular addressin cell adhesion molecule 1 0.210
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.209
Aoah acyloxyacyl hydrolase 0.208
Gzmb granzyme B 0.207
Ctsw cathepsin W 0.206
Ear2 eosinophil-associated, ribonuclease A family, member 2 0.206
Il7r interleukin 7 receptor 0.203
Inpp5d inositol polyphosphate-5-phosphatase D 0.202
Cd300ld CD300 molecule-like family member d 0.200
Flt3 FMS-like tyrosine kinase 3 0.198
Ncr1 natural cytotoxicity triggering receptor 1 0.191
Cmklr1 chemokine-like receptor 1 0.189
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Rattus norvegicus
Name Description Probability Func Analog Organism
Icam1 intercellular adhesion molecule 1 0.380
Il1b interleukin 1 beta 0.231
Ccl7 chemokine (C-C motif) ligand 7 0.161
Ccl2 chemokine (C-C motif) ligand 2 0.147
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.124
Cd14 CD14 molecule 0.090
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.070
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.062
Ccl3 chemokine (C-C motif) ligand 3 0.045
Xcl1 chemokine (C motif) ligand 1 0.039
Stat3 signal transducer and activator of transcription 3 0.038
Cxcl10 chemokine (C-X-C motif) ligand 10 0.036
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.035
Igsf6 immunoglobulin superfamily, member 6 0.030
Cxcl2 chemokine (C-X-C motif) ligand 2 0.030
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.028
Folr2 folate receptor 2 (fetal) 0.028
Cdk4 cyclin-dependent kinase 4 0.027
Myd88 myeloid differentiation primary response gene 88 0.025
Litaf lipopolysaccharide-induced TNF factor 0.023
Ccl4 chemokine (C-C motif) ligand 4 0.023
Il4ra interleukin 4 receptor, alpha 0.022
C5ar1 complement component 5a receptor 1 0.022
Slpi secretory leukocyte peptidase inhibitor 0.022
Ier3 immediate early response 3 0.021
Junb jun B proto-oncogene 0.021
Fcnb ficolin B 0.021
Ccl20 chemokine (C-C motif) ligand 20 0.020
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.020
Il2rb interleukin 2 receptor, beta 0.019
Tlr2 toll-like receptor 2 0.018
Rab32 RAB32, member RAS oncogene family 0.018
Timp1 TIMP metallopeptidase inhibitor 1 0.018
Xdh xanthine dehydrogenase 0.017
Selp selectin P 0.017
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.016
Atp5g2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9) 0.016
Bcl3 B-cell CLL/lymphoma 3 0.016
Cd44 Cd44 molecule 0.016
Plau plasminogen activator, urokinase 0.015
Hmox1 heme oxygenase (decycling) 1 0.015
Sell selectin L 0.015
Pnpla2 patatin-like phospholipase domain containing 2 0.015
Arl11 ADP-ribosylation factor-like 11 0.014
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.014
Csf1 colony stimulating factor 1 (macrophage) 0.014
Gzmk granzyme K 0.014
Jak1 Janus kinase 1 0.013
Runx1 runt-related transcription factor 1 0.013
Hpgds hematopoietic prostaglandin D synthase 0.013
Adrb2 adrenergic, beta-2-, receptor, surface 0.013
Il1a interleukin 1 alpha 0.012
Casp12 caspase 12 0.012
Clec10a C-type lectin domain family 10, member A 0.012
Cd40 CD40 molecule, TNF receptor superfamily member 5 0.012
Lcn2 lipocalin 2 0.012
Igsf7 immunoglobulin superfamily, member 7 0.012
Il6 interleukin 6 0.011
Tspan4 tetraspanin 4 0.011
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.011
Shc1 SHC (Src homology 2 domain containing) transforming protein 1 0.011
Tbc1d2b TBC1 domain family, member 2B 0.011
Pion pigeon homolog (Drosophila) 0.011
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.011
Cd8a CD8a molecule 0.011
LOC100361007 rCG32064-like 0.011
Irs3 insulin receptor substrate 3 0.010
Fabp4 fatty acid binding protein 4, adipocyte 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism