The network for 'negative regulation of vasculature development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of vasculature development

Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.

Mus musculus
Name Description Probability Func Analog Organism
Ccr2 chemokine (C-C motif) receptor 2 0.848
Lepr leptin receptor 0.750
Cd44 CD44 antigen 0.741
Col3a1 collagen, type III, alpha 1 0.593
Ptgs2 prostaglandin-endoperoxide synthase 2 0.581
Bmp5 bone morphogenetic protein 5 0.559
Ccr1 chemokine (C-C motif) receptor 1 0.525
Clock circadian locomotor output cycles kaput 0.489
Col4a1 collagen, type IV, alpha 1 0.469
Pgr progesterone receptor 0.452
Ccl2 chemokine (C-C motif) ligand 2 0.394
Prl8a2 prolactin family 8, subfamily a, member 2 0.387
Cyr61 cysteine rich protein 61 0.387
Col4a2 collagen, type IV, alpha 2 0.380
Col4a5 collagen, type IV, alpha 5 0.330
Apc adenomatosis polyposis coli 0.316
Postn periostin, osteoblast specific factor 0.300
Bmper BMP-binding endothelial regulator 0.288
Lox lysyl oxidase 0.253
Cd59a CD59a antigen 0.241
Skil SKI-like 0.230
Col5a2 collagen, type V, alpha 2 0.213
Pcdh12 protocadherin 12 0.212
Nab2 Ngfi-A binding protein 2 0.211
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.199
Lyz2 lysozyme 2 0.185
Dusp1 dual specificity phosphatase 1 0.176
Apoe apolipoprotein E 0.173
Pmp22 peripheral myelin protein 22 0.163
Fzd1 frizzled homolog 1 (Drosophila) 0.158
Ikzf1 IKAROS family zinc finger 1 0.158
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.156
Nog noggin 0.155
Cry2 cryptochrome 2 (photolyase-like) 0.155
Cfh complement component factor h 0.154
Ccr5 chemokine (C-C motif) receptor 5 0.150
Prrx1 paired related homeobox 1 0.149
Cd19 CD19 antigen 0.146
Thbs1 thrombospondin 1 0.146
Ccl3 chemokine (C-C motif) ligand 3 0.146
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.144
Eng endoglin 0.138
Ctgf connective tissue growth factor 0.135
Ifng interferon gamma 0.134
Psg19 pregnancy specific glycoprotein 19 0.134
Prdm1 PR domain containing 1, with ZNF domain 0.133
Prf1 perforin 1 (pore forming protein) 0.126
Smad3 MAD homolog 3 (Drosophila) 0.123
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.120
Nos2 nitric oxide synthase 2, inducible 0.111
Ncor2 nuclear receptor co-repressor 2 0.110
Tbx18 T-box18 0.110
Selp selectin, platelet 0.109
Bmx BMX non-receptor tyrosine kinase 0.108
Gfra3 glial cell line derived neurotrophic factor family receptor alpha 3 0.105
Tlr4 toll-like receptor 4 0.104
Rhbdf1 rhomboid family 1 (Drosophila) 0.101
Ren1 renin 1 structural 0.099
H2-Ob histocompatibility 2, O region beta locus 0.099
Ptgfr prostaglandin F receptor 0.098
Rb1 retinoblastoma 1 0.097
Tgfbr3 transforming growth factor, beta receptor III 0.097
Fstl1 follistatin-like 1 0.096
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.096
Il1r1 interleukin 1 receptor, type I 0.094
Per1 period homolog 1 (Drosophila) 0.092
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.090
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.088
Ciita class II transactivator 0.086
Lum lumican 0.086
Gprc6a G protein-coupled receptor, family C, group 6, member A 0.084
Col6a3 collagen, type VI, alpha 3 0.083
Ltb lymphotoxin B 0.083
Tpbpa trophoblast specific protein alpha 0.081
Ctsr cathepsin R 0.080
Olfr64 olfactory receptor 64 0.079
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.077
Col4a3 collagen, type IV, alpha 3 0.076
Gzmc granzyme C 0.076
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.075
Fgf7 fibroblast growth factor 7 0.074
Ceacam9 carcinoembryonic antigen-related cell adhesion molecule 9 0.074
Tll1 tolloid-like 0.072
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.072
Gli2 GLI-Kruppel family member GLI2 0.071
Dock1 dedicator of cytokinesis 1 0.071
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.070
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.070
Sox17 SRY-box containing gene 17 0.070
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.069
Icam1 intercellular adhesion molecule 1 0.069
Stab2 stabilin 2 0.068
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.068
Rp1 retinitis pigmentosa 1 (human) 0.068
Thbs2 thrombospondin 2 0.067
Snai1 snail homolog 1 (Drosophila) 0.067
Nf2 neurofibromatosis 2 0.066
Ctnnb1 catenin (cadherin associated protein), beta 1 0.066
Tcf21 transcription factor 21 0.065
Foxf1a forkhead box F1a 0.064
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.088
bmp4 bone morphogenetic protein 4 0.077
etv2 ets variant gene 2 0.063
kdrl kinase insert domain receptor like 0.052
wt1a wilms tumor 1a 0.041
ccm2 cerebral cavernous malformation 2 0.033
plcg1 phospholipase C, gamma 1 0.031
notch3 notch homolog 3 0.029
nrp1a neuropilin 1a 0.028
cdh5 cadherin 5 0.023
plxnd1 plexin D1 0.021
tie2 endothelium-specific receptor tyrosine kinase 2 0.021
nphs1l nephrosis 1, congenital, Finnish type (nephrin)-like 0.020
vegfc vascular endothelial growth factor c 0.019
col2a1a collagen type II, alpha-1a 0.017
hoxb4a homeo box B4a 0.017
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.015
efnb2a ephrin B2a 0.014
mib mind bomb 0.014
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.013
angptl7 angiopoietin-like 7 0.012
pitx3 paired-like homeodomain transcription factor 3 0.012
cx43 connexin 43 0.011
ccbe1 collagen and calcium binding EGF domains 1 0.011
dlc deltaC 0.011
hoxa9b homeo box A9b 0.011
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.010
hnf1ba HNF1 homeobox Ba 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TEK TEK tyrosine kinase, endothelial 0.998
YAP1 Yes-associated protein 1 0.960
JAG1 jagged 1 0.893
BMPR1A bone morphogenetic protein receptor, type IA 0.877
IL2RB interleukin 2 receptor, beta 0.865
COL4A2 collagen, type IV, alpha 2 0.847
COL4A1 collagen, type IV, alpha 1 0.836
NOTCH1 notch 1 0.800
NOTCH3 notch 3 0.798
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.753
HOXB5 homeobox B5 0.705
CXCL10 chemokine (C-X-C motif) ligand 10 0.652
IFNG interferon, gamma 0.644
SKIL SKI-like oncogene 0.562
PLAU plasminogen activator, urokinase 0.530
HOXA5 homeobox A5 0.526
ANGPT2 angiopoietin 2 0.496
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.487
JAK1 Janus kinase 1 0.480
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.458
TP53 tumor protein p53 0.453
CCR2 chemokine (C-C motif) receptor 2 0.449
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.438
FGA fibrinogen alpha chain 0.437
AMOT angiomotin 0.399
CREBBP CREB binding protein 0.397
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.369
GFI1B growth factor independent 1B transcription repressor 0.341
PLAT plasminogen activator, tissue 0.336
JAK2 Janus kinase 2 0.336
CXCR3 chemokine (C-X-C motif) receptor 3 0.320
HOXA7 homeobox A7 0.306
HOXA10 homeobox A10 0.305
MEF2C myocyte enhancer factor 2C 0.295
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.286
COL4A4 collagen, type IV, alpha 4 0.274
CXCL11 chemokine (C-X-C motif) ligand 11 0.268
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.255
CXCL9 chemokine (C-X-C motif) ligand 9 0.252
MAPK7 mitogen-activated protein kinase 7 0.244
ANGPT1 angiopoietin 1 0.229
CCR7 chemokine (C-C motif) receptor 7 0.228
NID1 nidogen 1 0.220
CXCR6 chemokine (C-X-C motif) receptor 6 0.217
F13A1 coagulation factor XIII, A1 polypeptide 0.207
IRF9 interferon regulatory factor 9 0.202
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.197
CCL5 chemokine (C-C motif) ligand 5 0.188
IL4R interleukin 4 receptor 0.182
CFLAR CASP8 and FADD-like apoptosis regulator 0.178
CCR5 chemokine (C-C motif) receptor 5 0.175
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.169
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.169
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.167
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.162
KLF4 Kruppel-like factor 4 (gut) 0.158
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.158
HOXA4 homeobox A4 0.157
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.155
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.154
DLL1 delta-like 1 (Drosophila) 0.151
CD93 CD93 molecule 0.150
HOXC10 homeobox C10 0.150
COL4A5 collagen, type IV, alpha 5 0.146
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.143
HOXA11 homeobox A11 0.142
HOXB7 homeobox B7 0.140
PF4 platelet factor 4 0.140
HOXB3 homeobox B3 0.137
TIMP3 TIMP metallopeptidase inhibitor 3 0.135
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.130
COL4A6 collagen, type IV, alpha 6 0.125
HOXB6 homeobox B6 0.122
CD40LG CD40 ligand 0.121
FAS Fas (TNF receptor superfamily, member 6) 0.117
RHOA ras homolog gene family, member A 0.114
CCL8 chemokine (C-C motif) ligand 8 0.112
AMOTL1 angiomotin like 1 0.110
CCR4 chemokine (C-C motif) receptor 4 0.107
HOXA6 homeobox A6 0.107
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.104
FGG fibrinogen gamma chain 0.102
NCOR1 nuclear receptor corepressor 1 0.101
IL12RB2 interleukin 12 receptor, beta 2 0.101
JUN jun proto-oncogene 0.099
KLF6 Kruppel-like factor 6 0.099
CXCL13 chemokine (C-X-C motif) ligand 13 0.098
NOTCH2 notch 2 0.096
IRF4 interferon regulatory factor 4 0.096
TIMP2 TIMP metallopeptidase inhibitor 2 0.094
STAT2 signal transducer and activator of transcription 2, 113kDa 0.094
DAXX death-domain associated protein 0.093
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.093
CYR61 cysteine-rich, angiogenic inducer, 61 0.092
HOXB9 homeobox B9 0.092
FOXP3 forkhead box P3 0.091
ZBTB16 zinc finger and BTB domain containing 16 0.091
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.091
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.090
PLXND1 plexin D1 0.089
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl4 chemokine (C-C motif) ligand 4 0.321
Il6 interleukin 6 0.282
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.254
Ccl2 chemokine (C-C motif) ligand 2 0.239
Cxcl2 chemokine (C-X-C motif) ligand 2 0.177
Prdm2 PR domain containing 2, with ZNF domain 0.164
Fosl1 fos-like antigen 1 0.108
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.102
Alb albumin 0.092
Dio2 deiodinase, iodothyronine, type II 0.089
Ahsg alpha-2-HS-glycoprotein 0.088
Rup2 urinary protein 2 0.074
Asgr2 asialoglycoprotein receptor 2 0.068
Cxcl10 chemokine (C-X-C motif) ligand 10 0.063
Iapp islet amyloid polypeptide 0.051
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.051
Spp2 secreted phosphoprotein 2 0.050
Emcn endomucin 0.050
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.045
Syt8 synaptotagmin VIII 0.042
Twist2 twist homolog 2 (Drosophila) 0.042
Fgf2 fibroblast growth factor 2 0.040
Mbl1 mannose-binding lectin (protein A) 1 0.036
LOC299282 Serine protease inhibitor 0.036
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.035
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.033
Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 0.033
Edn1 endothelin 1 0.032
Prl3d1 Prolactin family 3, subfamily d, member 1 0.032
Proc protein C 0.031
Serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.030
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.029
Gpr116 G protein-coupled receptor 116 0.029
Ctsh cathepsin H 0.029
Serpinb7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 0.027
Tacr2 tachykinin receptor 2 0.027
Ltb4r2 leukotriene B4 receptor 2 0.024
Apoa5 apolipoprotein A-V 0.024
Ccr2 chemokine (C-C motif) receptor 2 0.022
Pemt phosphatidylethanolamine N-methyltransferase 0.022
Fgb fibrinogen beta chain 0.022
Ncan neurocan 0.021
Cxcr5 chemokine (C-X-C motif) receptor 5 0.021
Tnni1 troponin I type 1 (skeletal, slow) 0.021
Il9r interleukin 9 receptor 0.020
Col10a1 collagen, type X, alpha 1 0.020
Hpx hemopexin 0.020
Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 0.020
Mbl2 mannose-binding lectin (protein C) 2 0.020
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.020
Ngf nerve growth factor (beta polypeptide) 0.019
Gucy1b2 guanylate cyclase 1, soluble, beta 2 0.018
Gfap glial fibrillary acidic protein 0.018
Pitx3 paired-like homeodomain 3 0.018
Fgfr2 fibroblast growth factor receptor 2 0.018
Cit citron 0.017
LOC100364500 RT1 class I, locus CE11-like 0.016
Il1a interleukin 1 alpha 0.016
Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 0.016
Has2 hyaluronan synthase 2 0.016
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.016
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.016
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.016
Ccl20 chemokine (C-C motif) ligand 20 0.016
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.016
Gc group specific component 0.016
Scpep1 serine carboxypeptidase 1 0.015
Nos3 nitric oxide synthase 3, endothelial cell 0.015
Cga glycoprotein hormones, alpha polypeptide 0.015
Chrna6 cholinergic receptor, nicotinic, alpha 6 0.015
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.015
Il1rn interleukin 1 receptor antagonist 0.015
Mmp12 matrix metallopeptidase 12 0.015
Wisp2 WNT1 inducible signaling pathway protein 2 0.015
Tdo2 tryptophan 2,3-dioxygenase 0.014
RGD1565859 RGD1565859 0.014
Apoa2 apolipoprotein A-II 0.014
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.014
Fgf14 fibroblast growth factor 14 0.014
Serpina11 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 0.014
Olr416 olfactory receptor 416 0.014
Fga fibrinogen alpha chain 0.014
Apcs amyloid P component, serum 0.013
Mbtps1 membrane-bound transcription factor peptidase, site 1 0.013
Csrp3 cysteine and glycine-rich protein 3 0.013
Aqp8 aquaporin 8 0.013
Crhbp corticotropin releasing hormone binding protein 0.013
Adora2a adenosine A2a receptor 0.013
Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.013
Igfals insulin-like growth factor binding protein, acid labile subunit 0.013
Folh1 folate hydrolase 1 0.013
Trim28 tripartite motif-containing 28 0.013
Cpa3 carboxypeptidase A3, mast cell 0.012
Testin testin gene 0.012
Arl5c ADP-ribosylation factor-like 5C 0.012
Tlr4 toll-like receptor 4 0.012
Atf3 activating transcription factor 3 0.012
RGD1308165 similar to hypothetical protein MGC17337 0.012
Col8a1 collagen, type VIII, alpha 1 0.012
Ms4a8a membrane-spanning 4-domains, subfamily A, member 8A 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism