The network for 'platelet activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

platelet activation

A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.

Mus musculus
Name Description Probability Func Analog Organism
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.996
Nos3 nitric oxide synthase 3, endothelial cell 0.957
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.866
Ldb3 LIM domain binding 3 0.832
Itgb3 integrin beta 3 0.803
Fzd8 frizzled homolog 8 (Drosophila) 0.791
Prkce protein kinase C, epsilon 0.773
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.732
Cnn2 calponin 2 0.664
Cd40 CD40 antigen 0.624
Ccr2 chemokine (C-C motif) receptor 2 0.579
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.557
Ptprc protein tyrosine phosphatase, receptor type, C 0.508
Cdh23 cadherin 23 (otocadherin) 0.470
Cd44 CD44 antigen 0.452
Sirpa signal-regulatory protein alpha 0.435
Gata4 GATA binding protein 4 0.422
Cav1 caveolin 1, caveolae protein 0.405
Tpm4 tropomyosin 4 0.399
Wnt4 wingless-related MMTV integration site 4 0.396
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.384
Gp5 glycoprotein 5 (platelet) 0.377
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.371
Ilk integrin linked kinase 0.368
Cd22 CD22 antigen 0.343
LOC100503041 PDZ domain-containing protein 7-like 0.335
Fgg fibrinogen gamma chain 0.331
Was Wiskott-Aldrich syndrome homolog (human) 0.320
Ptgs2 prostaglandin-endoperoxide synthase 2 0.300
Vegfa vascular endothelial growth factor A 0.299
Sdc3 syndecan 3 0.283
Pax2 paired box gene 2 0.275
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.267
Pax8 paired box gene 8 0.264
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.262
Itgb2 integrin beta 2 0.256
Axl AXL receptor tyrosine kinase 0.250
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.250
Lyl1 lymphoblastomic leukemia 1 0.245
Wdr1 WD repeat domain 1 0.224
Itga5 integrin alpha 5 (fibronectin receptor alpha) 0.216
Pten phosphatase and tensin homolog 0.211
Lhx1 LIM homeobox protein 1 0.208
Ncoa3 nuclear receptor coactivator 3 0.204
Gopc golgi associated PDZ and coiled-coil motif containing 0.203
Tln1 talin 1 0.199
Actb actin, beta 0.197
P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 0.196
Mrvi1 MRV integration site 1 0.195
Cd28 CD28 antigen 0.194
Zap70 zeta-chain (TCR) associated protein kinase 0.188
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.188
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.188
Csrp1 cysteine and glycine-rich protein 1 0.186
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.186
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.185
Msn moesin 0.184
Pparg peroxisome proliferator activated receptor gamma 0.183
Efnb2 ephrin B2 0.180
S1pr3 sphingosine-1-phosphate receptor 3 0.180
Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.180
Pou2af1 POU domain, class 2, associating factor 1 0.177
Actn1 actinin, alpha 1 0.176
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.173
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.168
Ush1g Usher syndrome 1G homolog (human) 0.164
Wnt3a wingless-related MMTV integration site 3A 0.159
Wnt1 wingless-related MMTV integration site 1 0.157
Sardh sarcosine dehydrogenase 0.156
Cd19 CD19 antigen 0.153
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.152
Plcg2 phospholipase C, gamma 2 0.148
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.148
Thrb thyroid hormone receptor beta 0.148
Vcl vinculin 0.146
Akt1 thymoma viral proto-oncogene 1 0.142
Tgfb1 transforming growth factor, beta 1 0.142
Ptk2 PTK2 protein tyrosine kinase 2 0.141
Muted muted 0.138
Nos2 nitric oxide synthase 2, inducible 0.136
Pdgfb platelet derived growth factor, B polypeptide 0.136
Lat linker for activation of T cells 0.135
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.134
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.134
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.130
Tgfbr1 transforming growth factor, beta receptor I 0.129
Sell selectin, lymphocyte 0.129
Tagln transgelin 0.127
Plxna1 plexin A1 0.127
Rgs14 regulator of G-protein signaling 14 0.124
Gpc3 glypican 3 0.123
Smad6 MAD homolog 6 (Drosophila) 0.122
Fas Fas (TNF receptor superfamily member 6) 0.122
Adm adrenomedullin 0.122
Ptgir prostaglandin I receptor (IP) 0.120
Zyx zyxin 0.119
Zbtb37 zinc finger and BTB domain containing 37 0.119
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.117
Mertk c-mer proto-oncogene tyrosine kinase 0.117
Zfpm2 zinc finger protein, multitype 2 0.117
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
dusp6 dual specificity phosphatase 6 0.020
tal1 T-cell acute lymphocytic leukemia 1 0.016
pdlim1 PDZ and LIM domain 1 (elfin) 0.015
col11a1a collagen, type XI, alpha 1a 0.014
dag1 dystroglycan 1 0.013
krt8 keratin 8 0.012
alas2 aminolevulinate, delta-, synthetase 2 0.011
lcp1 lymphocyte cytosolic plastin 1 0.011
camk2g1 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 0.011
tagln2 transgelin 2 0.011
cd63 Cd63 antigen 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
NCF1 neutrophil cytosolic factor 1 0.997
ACTB actin, beta 0.989
C1QA complement component 1, q subcomponent, A chain 0.979
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.962
TEK TEK tyrosine kinase, endothelial 0.955
FGA fibrinogen alpha chain 0.949
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.938
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.938
FLNA filamin A, alpha 0.937
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.934
VCAM1 vascular cell adhesion molecule 1 0.931
SYK spleen tyrosine kinase 0.899
TAL1 T-cell acute lymphocytic leukemia 1 0.886
LAT linker for activation of T cells 0.869
MYH9 myosin, heavy chain 9, non-muscle 0.868
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.840
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.806
VEGFA vascular endothelial growth factor A 0.776
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.770
FGB fibrinogen beta chain 0.683
HBA2 hemoglobin, alpha 2 0.652
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.648
CFL1 cofilin 1 (non-muscle) 0.607
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.542
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.538
VAV1 vav 1 guanine nucleotide exchange factor 0.501
NRP1 neuropilin 1 0.500
ARRB1 arrestin, beta 1 0.472
ACTG1 actin, gamma 1 0.460
CXCL2 chemokine (C-X-C motif) ligand 2 0.447
ALB albumin 0.443
PLDN pallidin homolog (mouse) 0.439
LCK lymphocyte-specific protein tyrosine kinase 0.406
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 0.370
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.308
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.304
HP haptoglobin 0.298
MYL9 myosin, light chain 9, regulatory 0.296
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.294
IL8 interleukin 8 0.285
CXCL9 chemokine (C-X-C motif) ligand 9 0.283
C1QC complement component 1, q subcomponent, C chain 0.278
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.272
ACTA2 actin, alpha 2, smooth muscle, aorta 0.262
FYN FYN oncogene related to SRC, FGR, YES 0.259
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.251
CXCL3 chemokine (C-X-C motif) ligand 3 0.244
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.242
VCL vinculin 0.229
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 0.227
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.226
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.223
GAS6 growth arrest-specific 6 0.213
C1QB complement component 1, q subcomponent, B chain 0.210
HBG2 hemoglobin, gamma G 0.208
PF4 platelet factor 4 0.206
BTK Bruton agammaglobulinemia tyrosine kinase 0.202
PGF placental growth factor 0.201
COL6A1 collagen, type VI, alpha 1 0.185
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 0.184
GP1BA glycoprotein Ib (platelet), alpha polypeptide 0.182
FN1 fibronectin 1 0.173
DTNBP1 dystrobrevin binding protein 1 0.172
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.169
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.167
HSPB8 heat shock 22kDa protein 8 0.167
BAG3 BCL2-associated athanogene 3 0.162
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.161
A2M alpha-2-macroglobulin 0.158
MYH11 myosin, heavy chain 11, smooth muscle 0.150
NCF2 neutrophil cytosolic factor 2 0.146
PLCG1 phospholipase C, gamma 1 0.142
TCF4 transcription factor 4 0.140
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.136
PTPRB protein tyrosine phosphatase, receptor type, B 0.135
IL6 interleukin 6 (interferon, beta 2) 0.133
THBS1 thrombospondin 1 0.133
CDH5 cadherin 5, type 2 (vascular endothelium) 0.132
ILK integrin-linked kinase 0.130
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.129
CXCL11 chemokine (C-X-C motif) ligand 11 0.126
CXCL10 chemokine (C-X-C motif) ligand 10 0.126
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.125
CRYAB crystallin, alpha B 0.124
PRKCA protein kinase C, alpha 0.123
MYOG myogenin (myogenic factor 4) 0.123
LRP1 low density lipoprotein receptor-related protein 1 0.122
HSPB2 heat shock 27kDa protein 2 0.118
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.114
TLN1 talin 1 0.113
CXCL5 chemokine (C-X-C motif) ligand 5 0.112
TPM1 tropomyosin 1 (alpha) 0.111
FYB FYN binding protein 0.108
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.101
NCF4 neutrophil cytosolic factor 4, 40kDa 0.100
ACTN1 actinin, alpha 1 0.100
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.098
HSPB1 heat shock 27kDa protein 1 0.096
DPP4 dipeptidyl-peptidase 4 0.095
ALAS1 aminolevulinate, delta-, synthase 1 0.094
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Rattus norvegicus
Name Description Probability Func Analog Organism
Acta2 smooth muscle alpha-actin 0.354
Actb actin, beta 0.135
Ptafr platelet-activating factor receptor 0.095
Flna filamin A, alpha 0.094
Hck hemopoietic cell kinase 0.073
Inpp5d inositol polyphosphate-5-phosphatase D 0.070
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.063
Axl Axl receptor tyrosine kinase 0.061
Gja1 gap junction protein, alpha 1 0.059
Edn1 endothelin 1 0.047
Scamp2 secretory carrier membrane protein 2 0.047
Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.039
Lst1 leukocyte specific transcript 1 0.036
Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.035
Itgb1 integrin, beta 1 0.033
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.033
Gmfg glia maturation factor, gamma 0.031
Laptm5 lysosomal protein transmembrane 5 0.030
Cd4 Cd4 molecule 0.030
Tpm3 tropomyosin 3, gamma 0.029
Ahnak AHNAK nucleoprotein 0.028
Tpm2 tropomyosin 2, beta 0.028
Icam1 intercellular adhesion molecule 1 0.027
Tlr2 toll-like receptor 2 0.026
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.025
Cd37 CD37 molecule 0.025
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.024
Tagln2 transgelin 2 0.023
Vav1 vav 1 guanine nucleotide exchange factor 0.022
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.022
Tlr7 toll-like receptor 7 0.021
Fgfr2 fibroblast growth factor receptor 2 0.021
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.019
Gna15 guanine nucleotide binding protein, alpha 15 0.019
Arl11 ADP-ribosylation factor-like 11 0.018
Evi2a ecotropic viral integration site 2A 0.018
Clic4 chloride intracellular channel 4 0.017
Homer3 homer homolog 3 (Drosophila) 0.017
Loxl1 lysyl oxidase-like 1 0.017
Cga glycoprotein hormones, alpha polypeptide 0.016
Pycard PYD and CARD domain containing 0.016
Lcp1 lymphocyte cytosolic protein 1 0.016
Bin2 bridging integrator 2 0.016
Fga fibrinogen alpha chain 0.016
Ahsg alpha-2-HS-glycoprotein 0.015
Nras neuroblastoma ras oncogene 0.015
Ly86 lymphocyte antigen 86 0.015
Renbp renin binding protein 0.015
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.015
Ccl4 chemokine (C-C motif) ligand 4 0.014
Bcl2 B-cell CLL/lymphoma 2 0.014
Il1rn interleukin 1 receptor antagonist 0.014
Tgfb1 transforming growth factor, beta 1 0.013
Rhoc ras homolog gene family, member C 0.013
Zfp36l1 zinc finger protein 36, C3H type-like 1 0.013
Lrrc33 leucine rich repeat containing 33 0.013
Pzp pregnancy-zone protein 0.013
Lepr leptin receptor 0.012
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.012
Hmha1 histocompatibility (minor) HA-1 0.012
Serpina6 serine (or cysteine) peptidase inhibitor, clade A, member 6 0.011
Klhl6 kelch-like 6 (Drosophila) 0.011
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.011
Syt8 synaptotagmin VIII 0.011
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.011
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.011
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.011
Ptbp1 polypyrimidine tract binding protein 1 0.010
Ccr5 chemokine (C-C motif) receptor 5 0.010
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.010
Cd5 Cd5 molecule 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism