The network for 'bone morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

bone morphogenesis

The process in which bones are generated and organized.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Prrx1 paired related homeobox 1 1.000
Pax2 paired box gene 2 0.999
Fgfr2 fibroblast growth factor receptor 2 0.999
Msx1 homeobox, msh-like 1 0.998
Pax3 paired box gene 3 0.998
Col1a1 collagen, type I, alpha 1 0.996
Pitx2 paired-like homeodomain transcription factor 2 0.995
Fgf8 fibroblast growth factor 8 0.995
Tgfb2 transforming growth factor, beta 2 0.995
Fgfr1 fibroblast growth factor receptor 1 0.994
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.992
Rarg retinoic acid receptor, gamma 0.990
Runx2 runt related transcription factor 2 0.989
Bmp7 bone morphogenetic protein 7 0.983
Bmp4 bone morphogenetic protein 4 0.978
Nodal nodal 0.976
Pax9 paired box gene 9 0.974
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.974
Fgfr3 fibroblast growth factor receptor 3 0.973
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.971
Foxc1 forkhead box C1 0.969
Hoxd11 homeobox D11 0.969
Otx2 orthodenticle homolog 2 (Drosophila) 0.967
Gli2 GLI-Kruppel family member GLI2 0.960
Hoxa11 homeobox A11 0.955
Col2a1 collagen, type II, alpha 1 0.950
Tgfbr2 transforming growth factor, beta receptor II 0.949
Nos3 nitric oxide synthase 3, endothelial cell 0.945
Tbx3 T-box 3 0.944
Twist2 twist homolog 2 (Drosophila) 0.939
En1 engrailed 1 0.935
Fbn1 fibrillin 1 0.933
Lhx1 LIM homeobox protein 1 0.931
Pkd1 polycystic kidney disease 1 homolog 0.930
Tbx1 T-box 1 0.929
Hand2 heart and neural crest derivatives expressed transcript 2 0.929
Chrd chordin 0.926
Hand1 heart and neural crest derivatives expressed transcript 1 0.914
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.901
Meox2 mesenchyme homeobox 2 0.896
Hoxd13 homeobox D13 0.890
Zic3 zinc finger protein of the cerebellum 3 0.885
Tcfap2a transcription factor AP-2, alpha 0.884
Hoxa1 homeobox A1 0.860
Dlx5 distal-less homeobox 5 0.852
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.848
Foxc2 forkhead box C2 0.835
Jag1 jagged 1 0.831
Pitx1 paired-like homeodomain transcription factor 1 0.815
Foxh1 forkhead box H1 0.812
Prrx2 paired related homeobox 2 0.799
Egfr epidermal growth factor receptor 0.798
Sfrp2 secreted frizzled-related protein 2 0.775
Eya1 eyes absent 1 homolog (Drosophila) 0.762
Pten phosphatase and tensin homolog 0.753
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.747
Apc adenomatosis polyposis coli 0.740
Vegfa vascular endothelial growth factor A 0.739
T brachyury 0.734
Pthlh parathyroid hormone-like peptide 0.731
Vangl2 vang-like 2 (van gogh, Drosophila) 0.728
Gata4 GATA binding protein 4 0.728
Isl1 ISL1 transcription factor, LIM/homeodomain 0.720
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.702
Wt1 Wilms tumor 1 homolog 0.699
Rara retinoic acid receptor, alpha 0.694
Mmp2 matrix metallopeptidase 2 0.694
Ptch1 patched homolog 1 0.689
Lef1 lymphoid enhancer binding factor 1 0.672
Wnt5a wingless-related MMTV integration site 5A 0.672
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.644
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.636
Hoxa13 homeobox A13 0.628
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.612
Thra thyroid hormone receptor alpha 0.582
Bmp5 bone morphogenetic protein 5 0.560
Smad7 MAD homolog 7 (Drosophila) 0.558
Tcf21 transcription factor 21 0.557
Smad3 MAD homolog 3 (Drosophila) 0.547
Snai1 snail homolog 1 (Drosophila) 0.543
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.540
Smo smoothened homolog (Drosophila) 0.537
Grem1 gremlin 1 0.534
Gdnf glial cell line derived neurotrophic factor 0.525
Nog noggin 0.522
Eln elastin 0.521
Il6st interleukin 6 signal transducer 0.489
Tgfb1 transforming growth factor, beta 1 0.488
Foxa2 forkhead box A2 0.487
Alx3 aristaless-like homeobox 3 0.487
Lhx3 LIM homeobox protein 3 0.478
Gas1 growth arrest specific 1 0.475
Wnt6 wingless-related MMTV integration site 6 0.474
Neurog3 neurogenin 3 0.469
Msx2 homeobox, msh-like 2 0.463
Neurog2 neurogenin 2 0.452
Egr2 early growth response 2 0.450
Trp53 transformation related protein 53 0.449
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
foxi1 forkhead box I1 0.945
jag1b jagged 1b 0.814
gli2a GLI-Kruppel family member GLI2a 0.802
bmp2b bone morphogenetic protein 2b 0.764
col5a1 procollagen, type V, alpha 1 0.724
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.677
col1a2 collagen, type I, alpha 2 0.529
bmp4 bone morphogenetic protein 4 0.524
notch1a notch homolog 1a 0.498
col2a1a collagen type II, alpha-1a 0.458
pitx3 paired-like homeodomain transcription factor 3 0.271
col27a1a collagen, type XXVII, alpha 1a 0.231
her1 hairy-related 1 0.231
eya1 eyes absent homolog 1 0.215
bmper BMP binding endothelial regulator 0.189
hoxa11a homeo box A11a 0.180
twist2 twist2 0.171
postn periostin, osteoblast specific factor 0.155
ntla no tail a 0.155
LOC100000500 sclerostin-like 0.150
mab21l2 mab-21-like 2 0.149
tbx5a T-box 5a 0.145
gli3 GLI-Kruppel family member GLI3 0.142
sox9a SRY-box containing gene 9a 0.139
dlx4a distal-less homeobox gene 4a 0.139
shha sonic hedgehog a 0.120
dld deltaD 0.118
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.116
notch3 notch homolog 3 0.115
prrx1a paired related homeobox 1a 0.113
col1a1a collagen, type I, alpha 1a 0.111
edn1 endothelin 1 0.110
wu:fv91b12 wu:fv91b12 0.108
barx1 BarH-like homeobox 1 0.105
fgfr2 fibroblast growth factor receptor 2 0.098
foxi3a forkhead box I3a 0.098
pax7a paired box gene 7a 0.096
runx2b runt-related transcription factor 2b 0.095
tead3a TEA domain family member 3 a 0.092
foxa2 forkhead box A2 0.089
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.088
fgf3 fibroblast growth factor 3 0.087
ripply2 ripply2 0.086
myod1 myogenic differentiation 1 0.084
hoxb3a homeo box B3a 0.082
sox10 SRY-box containing gene 10 0.080
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.078
efnb2a ephrin B2a 0.077
col5a2l collagen, type V, alpha 2-like 0.076
mgp matrix Gla protein 0.075
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.074
twist3 twist3 0.074
boc brother of CDO 0.072
col9a3 collagen, type IX, alpha 3 0.070
fli1a friend leukemia integration 1a 0.069
runx2a runt-related transcription factor 2a 0.065
tcf12 transcription factor 12 0.064
tbx16 T-box gene 16 0.061
bglap bone gamma-carboxyglutamate (gla) protein 0.058
tp63 tumor protein p63 0.056
rbp4 retinol binding protein 4, plasma 0.056
epha4b eph receptor A4b 0.056
lhx1b LIM homeobox 1b 0.055
angptl2 angiopoietin-like 2 0.053
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.053
twist1b twist1b 0.052
dct dopachrome tautomerase 0.051
fgf20a fibroblast growth factor 20a 0.050
fgfrl1a fibroblast growth factor receptor-like 1a 0.050
col12a1 collagen, type XII, alpha 1 0.050
gata3 GATA-binding protein 3 0.050
nog3 noggin 3 0.048
fgfrl1b fibroblast growth factor receptor-like 1b 0.048
ctgf connective tissue growth factor 0.046
hoxa2b homeo box A2b 0.045
tbx24 T-box 24 0.044
foxi3b forkhead box I3b 0.044
dlx3b distal-less homeobox gene 3b 0.043
hoxd9a homeo box D9a 0.043
ghra growth hormone receptor a 0.043
cart1 cartilage paired-class homeoprotein 1 0.042
ctsl1b cathepsin L, 1 b 0.042
lama2 laminin, alpha 2 0.041
gdf6a growth differentiation factor 6a 0.041
sesn1 sestrin 1 0.041
cmn calymmin 0.041
bmp2a bone morphogenetic protein 2a 0.041
raraa retinoic acid receptor, alpha a 0.040
dlx5a distal-less homeobox gene 5a 0.040
prdm1a PR domain containing 1a, with ZNF domain 0.039
fgf10a fibroblast growth factor 10a 0.039
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.037
grem2 gremlin 2, cysteine knot superfamily 0.037
tfe3b transcription factor binding to IGHM enhancer 3b 0.036
matn4 matrilin 4 0.035
runx3 runt-related transcription factor 3 0.034
gpr126 G protein-coupled receptor 126 0.034
sparc secreted acidic cysteine rich glycoprotein 0.033
mmp15b matrix metallopeptidase 15b 0.033
hoxa13b homeo box A13b 0.033
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.739
POU5F1 POU class 5 homeobox 1 0.522
FGF1 fibroblast growth factor 1 (acidic) 0.158
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.115
FSTL1 follistatin-like 1 0.114
TGFB1 transforming growth factor, beta 1 0.103
TGFB3 transforming growth factor, beta 3 0.103
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.101
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.099
ENG endoglin 0.095
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.085
MED25 mediator complex subunit 25 0.080
FN1 fibronectin 1 0.078
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.078
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.071
APP amyloid beta (A4) precursor protein 0.059
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.059
VEGFA vascular endothelial growth factor A 0.057
FGFR1 fibroblast growth factor receptor 1 0.054
EP300 E1A binding protein p300 0.050
SETD8 SET domain containing (lysine methyltransferase) 8 0.049
NOTCH1 notch 1 0.046
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.041
FGF7 fibroblast growth factor 7 0.039
NOTCH3 notch 3 0.036
POU3F2 POU class 3 homeobox 2 0.036
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.034
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.034
ANGPT2 angiopoietin 2 0.031
BCAR1 breast cancer anti-estrogen resistance 1 0.026
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.026
THBS1 thrombospondin 1 0.024
MSX1 msh homeobox 1 0.022
MSX2 msh homeobox 2 0.022
COL6A1 collagen, type VI, alpha 1 0.022
MEOX1 mesenchyme homeobox 1 0.021
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.021
TGFBR1 transforming growth factor, beta receptor 1 0.021
CDH5 cadherin 5, type 2 (vascular endothelium) 0.020
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.020
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.020
FGF10 fibroblast growth factor 10 0.019
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.019
ANGPT1 angiopoietin 1 0.018
ESR1 estrogen receptor 1 0.018
IDI1 isopentenyl-diphosphate delta isomerase 1 0.017
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.017
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.017
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.017
PTHLH parathyroid hormone-like hormone 0.017
NRP2 neuropilin 2 0.017
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) 0.017
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.016
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.016
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.016
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.016
SMAD7 SMAD family member 7 0.015
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.015
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.015
RXRA retinoid X receptor, alpha 0.015
GLRX glutaredoxin (thioltransferase) 0.015
STC1 stanniocalcin 1 0.014
NCOA1 nuclear receptor coactivator 1 0.014
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.013
TIMP2 TIMP metallopeptidase inhibitor 2 0.013
COL1A1 collagen, type I, alpha 1 0.013
MMP10 matrix metallopeptidase 10 (stromelysin 2) 0.013
IGFBP3 insulin-like growth factor binding protein 3 0.013
HIPK2 homeodomain interacting protein kinase 2 0.013
IGFBP5 insulin-like growth factor binding protein 5 0.013
INHBA inhibin, beta A 0.012
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.012
LRRK2 leucine-rich repeat kinase 2 0.012
SC4MOL sterol-C4-methyl oxidase-like 0.012
CTGF connective tissue growth factor 0.011
NRP1 neuropilin 1 0.011
COL1A2 collagen, type I, alpha 2 0.011
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.011
PGRMC1 progesterone receptor membrane component 1 0.011
COL5A1 collagen, type V, alpha 1 0.010
SREBF2 sterol regulatory element binding transcription factor 2 0.010
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.010
SMAD4 SMAD family member 4 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.789
Col3a1 collagen, type III, alpha 1 0.600
Col1a2 collagen, type I, alpha 2 0.412
Col5a1 collagen, type V, alpha 1 0.195
Fbn1 fibrillin 1 0.101
Eln elastin 0.100
Col12a1 collagen, type XII, alpha 1 0.085
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.067
Postn periostin, osteoblast specific factor 0.048
Bgn biglycan 0.038
Fstl1 follistatin-like 1 0.032
Col4a1 collagen, type IV, alpha 1 0.030
Col5a2 collagen, type V, alpha 2 0.029
Pcolce procollagen C-endopeptidase enhancer 0.023
Dab2 disabled homolog 2 (Drosophila) 0.022
Lamc1 laminin, gamma 1 0.015
Aebp1 AE binding protein 1 0.014
Rhoj ras homolog gene family, member J 0.014
Fkbp10 FK506 binding protein 10 0.013
Lum lumican 0.013
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.013
Emcn endomucin 0.013
Col9a1 collagen, type IX, alpha 1 0.013
Fn1 fibronectin 1 0.013
Socs3 suppressor of cytokine signaling 3 0.012
Loxl1 lysyl oxidase-like 1 0.012
Lef1 lymphoid enhancer binding factor 1 0.012
Pxdn peroxidasin homolog (Drosophila) 0.011
Lox lysyl oxidase 0.011
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.011
Vim vimentin 0.011
Cgnl1 cingulin-like 1 0.011
Col4a2 collagen, type IV, alpha 2 0.011
Col11a2 collagen, type XI, alpha 2 0.011
Elk3 ELK3, ETS-domain protein 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism