The network for 'response to sterol' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to sterol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus.

Mus musculus
Name Description Probability Func Analog Organism
Smad4 MAD homolog 4 (Drosophila) 1.000
Bmpr1a bone morphogenetic protein receptor, type 1A 0.999
Apc adenomatosis polyposis coli 0.998
Tgfbr2 transforming growth factor, beta receptor II 0.994
Ptch1 patched homolog 1 0.958
Smad3 MAD homolog 3 (Drosophila) 0.927
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.919
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.865
Ece1 endothelin converting enzyme 1 0.807
Fst follistatin 0.783
Sox9 SRY-box containing gene 9 0.722
Acvr1 activin A receptor, type 1 0.701
Tgfbr1 transforming growth factor, beta receptor I 0.689
Ctnnb1 catenin (cadherin associated protein), beta 1 0.680
Foxc1 forkhead box C1 0.662
Amhr2 anti-Mullerian hormone type 2 receptor 0.660
Tgfb2 transforming growth factor, beta 2 0.609
Bmi1 Bmi1 polycomb ring finger oncogene 0.584
Csf1 colony stimulating factor 1 (macrophage) 0.573
Meox2 mesenchyme homeobox 2 0.565
Ednra endothelin receptor type A 0.525
Nodal nodal 0.524
Hoxa3 homeobox A3 0.513
Eng endoglin 0.480
Fgfr1 fibroblast growth factor receptor 1 0.442
Smad1 MAD homolog 1 (Drosophila) 0.426
Ccr2 chemokine (C-C motif) receptor 2 0.423
Fgfr3 fibroblast growth factor receptor 3 0.414
Bmp4 bone morphogenetic protein 4 0.407
Atxn1 ataxin 1 0.402
Prrx1 paired related homeobox 1 0.374
Ccr1 chemokine (C-C motif) receptor 1 0.366
Pten phosphatase and tensin homolog 0.346
Prkg1 protein kinase, cGMP-dependent, type I 0.339
Mapkapk2 MAP kinase-activated protein kinase 2 0.336
Cd44 CD44 antigen 0.335
Tef thyrotroph embryonic factor 0.318
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.308
Bptf bromodomain PHD finger transcription factor 0.292
Nos3 nitric oxide synthase 3, endothelial cell 0.287
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.287
Fgf8 fibroblast growth factor 8 0.277
Rnf2 ring finger protein 2 0.261
Inhbb inhibin beta-B 0.259
Bmp7 bone morphogenetic protein 7 0.245
Fgfr2 fibroblast growth factor receptor 2 0.227
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.222
Bmp2 bone morphogenetic protein 2 0.221
Rarg retinoic acid receptor, gamma 0.219
Acvr1b activin A receptor, type 1B 0.214
Rara retinoic acid receptor, alpha 0.211
Vegfa vascular endothelial growth factor A 0.211
Foxc2 forkhead box C2 0.208
Ccl2 chemokine (C-C motif) ligand 2 0.199
Acvr2a activin receptor IIA 0.173
Braf Braf transforming gene 0.170
Chrd chordin 0.169
Ldlr low density lipoprotein receptor 0.157
Kiss1r KISS1 receptor 0.157
Nf1 neurofibromatosis 1 0.147
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.137
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.132
Pcgf2 polycomb group ring finger 2 0.130
Mkl2 MKL/myocardin-like 2 0.128
Cdh5 cadherin 5 0.126
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.123
Smo smoothened homolog (Drosophila) 0.121
Dkc1 dyskeratosis congenita 1, dyskerin homolog (human) 0.121
Shh sonic hedgehog 0.120
Ifng interferon gamma 0.120
Gli2 GLI-Kruppel family member GLI2 0.118
Shc1 src homology 2 domain-containing transforming protein C1 0.106
Tlr2 toll-like receptor 2 0.099
Gja1 gap junction protein, alpha 1 0.094
Pknox1 Pbx/knotted 1 homeobox 0.090
Fshr follicle stimulating hormone receptor 0.090
Agtr1a angiotensin II receptor, type 1a 0.080
Smad5 MAD homolog 5 (Drosophila) 0.079
Baz1a bromodomain adjacent to zinc finger domain 1A 0.079
Inhba inhibin beta-A 0.078
Npr2 natriuretic peptide receptor 2 0.076
Mks1 Meckel syndrome, type 1 0.073
Fbn1 fibrillin 1 0.072
Ehmt1 euchromatic histone methyltransferase 1 0.071
Pdgfb platelet derived growth factor, B polypeptide 0.069
Mga MAX gene associated 0.069
Scmh1 sex comb on midleg homolog 1 0.068
Inha inhibin alpha 0.067
Rc3h1 RING CCCH (C3H) domains 1 0.065
Gsk3b glycogen synthase kinase 3 beta 0.063
Cxcr4 chemokine (C-X-C motif) receptor 4 0.061
Mvd mevalonate (diphospho) decarboxylase 0.061
Arid1a AT rich interactive domain 1A (SWI-like) 0.061
Acvr2b activin receptor IIB 0.059
Rbl2 retinoblastoma-like 2 0.058
Kitl kit ligand 0.058
Esr1 estrogen receptor 1 (alpha) 0.058
Twsg1 twisted gastrulation homolog 1 (Drosophila) 0.058
Chuk conserved helix-loop-helix ubiquitous kinase 0.057
Bmper BMP-binding endothelial regulator 0.057
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
usp ultraspiracle 0.792
nej nejire 0.757
BRWD3 CG31132 gene product from transcript CG31132-RA 0.611
dm diminutive 0.574
tll tailless 0.530
EcR Ecdysone receptor 0.511
ftz-f1 ftz transcription factor 1 0.507
cg combgap 0.487
CG5146 CG5146 gene product from transcript CG5146-RA 0.371
ash1 absent, small, or homeotic discs 1 0.320
byn brachyenteron 0.298
fkh fork head 0.191
fne found in neurons 0.178
tin tinman 0.159
gcm glial cells missing 0.157
brk brinker 0.152
Sir2 CG5216 gene product from transcript CG5216-RA 0.151
CG5741 CG5741 gene product from transcript CG5741-RC 0.148
ttv tout-velu 0.140
vsg visgun 0.131
bwa brain washing 0.130
Trf2 TATA box binding protein-related factor 2 0.125
Gyc76C Guanylyl cyclase at 76C 0.124
Jarid2 CG3654 gene product from transcript CG3654-RD 0.122
Tao-1 CG14217 gene product from transcript CG14217-RF 0.117
disco disconnected 0.113
E(bx) Enhancer of bithorax 0.111
Top1 Topoisomerase 1 0.110
HLH54F CG5005 gene product from transcript CG5005-RA 0.102
nkd naked cuticle 0.101
myoglianin CG1838 gene product from transcript CG1838-RD 0.101
Bre1 CG10542 gene product from transcript CG10542-RA 0.100
Eip74EF Ecdysone-induced protein 74EF 0.097
Iswi Imitation SWI 0.094
CG14869 CG14869 gene product from transcript CG14869-RB 0.089
LIMK1 LIM-kinase1 0.089
dib disembodied 0.086
CG1347 CG1347 gene product from transcript CG1347-RB 0.084
Pkc98E Protein C kinase 98E 0.082
toy twin of eyeless 0.077
hyd hyperplastic discs 0.075
CG6490 CG6490 gene product from transcript CG6490-RB 0.073
CG17018 CG17018 gene product from transcript CG17018-RC 0.072
SuUR Suppressor of Under-Replication 0.070
Su(var)2-10 Suppressor of variegation 2-10 0.070
Ten-a Tenascin accessory 0.070
jeb jelly belly 0.066
Fs Follistatin 0.065
ytr yantar 0.064
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.063
CG11399 CG11399 gene product from transcript CG11399-RB 0.063
simj simjang 0.062
btl breathless 0.062
abs abstrakt 0.061
Exp6 Exportin 6 0.060
CG8709 CG8709 gene product from transcript CG8709-RK 0.060
Tbh Tyramine beta hydroxylase 0.059
retn retained 0.058
l(3)mbt lethal (3) malignant brain tumor 0.055
wde windei 0.055
east enhanced adult sensory threshold 0.055
kto kohtalo 0.054
MED31 Mediator complex subunit 31 0.054
trx trithorax 0.054
tara taranis 0.052
Hr51 Hormone receptor 51 0.052
sno strawberry notch 0.051
slmb supernumerary limbs 0.051
kug kugelei 0.051
cdi center divider 0.050
endoB endophilin B 0.049
Top2 Topoisomerase 2 0.048
Nf1 Neurofibromin 1 0.048
Parg Poly(ADP-ribose) glycohydrolase 0.048
CG3638 CG3638 gene product from transcript CG3638-RE 0.048
iav inactive 0.048
sog short gastrulation 0.047
Sin3A CG8815 gene product from transcript CG8815-RC 0.046
unk unkempt 0.046
Eip75B Ecdysone-induced protein 75B 0.045
Hsc70-4 Heat shock protein cognate 4 0.045
mei-P26 CG12218 gene product from transcript CG12218-RA 0.045
CG34400 CG34400 gene product from transcript CG34400-RD 0.044
CG5591 CG5591 gene product from transcript CG5591-RA 0.044
HDAC4 CG1770 gene product from transcript CG1770-RE 0.044
Upf1 CG1559 gene product from transcript CG1559-RA 0.043
Wnt2 Wnt oncogene analog 2 0.043
Psi P-element somatic inhibitor 0.042
hkb huckebein 0.042
eve even skipped 0.042
Sh Shaker 0.041
gt giant 0.040
MED24 Mediator complex subunit 24 0.039
Scm Sex comb on midleg 0.039
Ctr1B Copper transporter 1B 0.038
fru fruitless 0.038
MED6 Mediator complex subunit 6 0.038
Ptpmeg CG1228 gene product from transcript CG1228-RD 0.037
ph-d polyhomeotic distal 0.037
tau CG31057 gene product from transcript CG31057-RA 0.037
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD2 SMAD family member 2 0.999
SMAD7 SMAD family member 7 0.999
CCR5 chemokine (C-C motif) receptor 5 0.997
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.907
CCL4 chemokine (C-C motif) ligand 4 0.865
FKBP1A FK506 binding protein 1A, 12kDa 0.723
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.713
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.678
SMAD3 SMAD family member 3 0.514
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.494
CXCL9 chemokine (C-X-C motif) ligand 9 0.428
TGFB1 transforming growth factor, beta 1 0.398
CCR7 chemokine (C-C motif) receptor 7 0.352
ENG endoglin 0.340
CCL8 chemokine (C-C motif) ligand 8 0.327
TGFBR1 transforming growth factor, beta receptor 1 0.304
IFNG interferon, gamma 0.294
BMP2 bone morphogenetic protein 2 0.275
CCL5 chemokine (C-C motif) ligand 5 0.272
CCR4 chemokine (C-C motif) receptor 4 0.264
FSTL1 follistatin-like 1 0.221
CCL22 chemokine (C-C motif) ligand 22 0.212
CCL3 chemokine (C-C motif) ligand 3 0.209
SMAD1 SMAD family member 1 0.203
GDF5 growth differentiation factor 5 0.202
IL2RB interleukin 2 receptor, beta 0.193
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.190
ACVR1 activin A receptor, type I 0.161
IL1B interleukin 1, beta 0.127
CCL7 chemokine (C-C motif) ligand 7 0.114
SMAD5 SMAD family member 5 0.106
CCL19 chemokine (C-C motif) ligand 19 0.098
CCL13 chemokine (C-C motif) ligand 13 0.094
IL8 interleukin 8 0.087
TGFB3 transforming growth factor, beta 3 0.086
SMAD4 SMAD family member 4 0.085
ZNF148 zinc finger protein 148 0.081
CXCR6 chemokine (C-X-C motif) receptor 6 0.072
VEZF1 vascular endothelial zinc finger 1 0.069
CXCL13 chemokine (C-X-C motif) ligand 13 0.066
IRF4 interferon regulatory factor 4 0.062
PCGF2 polycomb group ring finger 2 0.057
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.056
CCL2 chemokine (C-C motif) ligand 2 0.055
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.054
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.053
CCR2 chemokine (C-C motif) receptor 2 0.049
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.048
RERE arginine-glutamic acid dipeptide (RE) repeats 0.047
CXXC5 CXXC finger protein 5 0.044
IL6 interleukin 6 (interferon, beta 2) 0.043
IL1R2 interleukin 1 receptor, type II 0.043
TNF tumor necrosis factor 0.042
PRRC2B proline-rich coiled-coil 2B 0.039
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.038
CCL11 chemokine (C-C motif) ligand 11 0.038
CD40LG CD40 ligand 0.035
SMAD6 SMAD family member 6 0.034
PRKG1 protein kinase, cGMP-dependent, type I 0.032
SLAMF7 SLAM family member 7 0.031
ACVR1B activin A receptor, type IB 0.028
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.025
SMO smoothened homolog (Drosophila) 0.025
RGS1 regulator of G-protein signaling 1 0.025
CXCL3 chemokine (C-X-C motif) ligand 3 0.025
CCL20 chemokine (C-C motif) ligand 20 0.024
CCR3 chemokine (C-C motif) receptor 3 0.024
CXCR3 chemokine (C-X-C motif) receptor 3 0.023
PUM1 pumilio homolog 1 (Drosophila) 0.023
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.022
CBX4 chromobox homolog 4 0.022
IDE insulin-degrading enzyme 0.020
CXCL11 chemokine (C-X-C motif) ligand 11 0.020
KLHL24 kelch-like 24 (Drosophila) 0.019
CAPRIN2 caprin family member 2 0.019
IL2RG interleukin 2 receptor, gamma 0.019
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.019
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.018
SC4MOL sterol-C4-methyl oxidase-like 0.018
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.017
FHL3 four and a half LIM domains 3 0.017
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.017
NRP1 neuropilin 1 0.016
INSIG1 insulin induced gene 1 0.016
CCR8 chemokine (C-C motif) receptor 8 0.015
CD83 CD83 molecule 0.015
IL21R interleukin 21 receptor 0.015
THBS1 thrombospondin 1 0.015
IL10 interleukin 10 0.015
EBI3 Epstein-Barr virus induced 3 0.014
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.014
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.014
SPIN1 spindlin 1 0.014
SOX7 SRY (sex determining region Y)-box 7 0.014
ACVR2B activin A receptor, type IIB 0.014
CCR6 chemokine (C-C motif) receptor 6 0.013
CD160 CD160 molecule 0.013
DPP4 dipeptidyl-peptidase 4 0.013
CCR1 chemokine (C-C motif) receptor 1 0.013
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
Sc4mol sterol-C4-methyl oxidase-like 0.473
Idi1 isopentenyl-diphosphate delta isomerase 1 0.412
Dbp D site of albumin promoter (albumin D-box) binding protein 0.139
Fdps farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) 0.127
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.117
Fdft1 farnesyl diphosphate farnesyl transferase 1 0.078
Sqle squalene epoxidase 0.060
Acat3 acetyl-Coenzyme A acetyltransferase 3 0.050
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.047
C1qc complement component 1, q subcomponent, C chain 0.041
Il1a interleukin 1 alpha 0.038
Il1b interleukin 1 beta 0.031
Tmem176b transmembrane protein 176B 0.029
Il2rb interleukin 2 receptor, beta 0.029
Cd86 CD86 molecule 0.025
Fcgrt Fc fragment of IgG, receptor, transporter, alpha 0.024
Stat6 signal transducer and activator of transcription 6 0.022
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.022
Cyp51 cytochrome P450, family 51 0.022
Cd14 CD14 molecule 0.022
Anpep alanyl (membrane) aminopeptidase 0.021
Ephx1 epoxide hydrolase 1, microsomal 0.020
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.020
Insig1 insulin induced gene 1 0.019
Il1rn interleukin 1 receptor antagonist 0.019
Cfd complement factor D (adipsin) 0.018
Cldn7 claudin 7 0.018
Cst3 cystatin C 0.017
Slc6a12 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 0.017
Mvd mevalonate (diphospho) decarboxylase 0.017
Aspg asparaginase homolog (S. cerevisiae) 0.017
Prf1 perforin 1 (pore forming protein) 0.016
Mmp3 matrix metallopeptidase 3 0.016
Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 0.016
Cd68 Cd68 molecule 0.015
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.015
Tcrb T-cell receptor beta chain 0.015
Il1r2 interleukin 1 receptor, type II 0.015
Masp2 mannan-binding lectin serine peptidase 2 0.015
Hpgds hematopoietic prostaglandin D synthase 0.015
Prrx1 paired related homeobox 1 0.014
Inmt indolethylamine N-methyltransferase 0.014
Mmp12 matrix metallopeptidase 12 0.013
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.013
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.013
Fut4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.013
Cd200r1 CD200 receptor 1 0.013
Cela1 chymotrypsin-like elastase family, member 1 0.012
Nox4 NADPH oxidase 4 0.012
Hebp1 heme binding protein 1 0.012
Sult1a1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.012
Ppap2b phosphatidic acid phosphatase type 2B 0.012
Man2b1 mannosidase, alpha, class 2B, member 1 0.012
Smad7 SMAD family member 7 0.011
Mpeg1 macrophage expressed 1 0.011
Cdh17 cadherin 17 0.011
Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0.011
Fcer1a Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 0.011
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.011
Nkg7 natural killer cell group 7 sequence 0.010
Pparg peroxisome proliferator-activated receptor gamma 0.010
Sell selectin L 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism