The network for 'positive regulation of osteoblast differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of osteoblast differentiation

Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.994
Shh sonic hedgehog 0.994
Gli3 GLI-Kruppel family member GLI3 0.989
Foxc1 forkhead box C1 0.982
Tgfb2 transforming growth factor, beta 2 0.976
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.963
Fgfr1 fibroblast growth factor receptor 1 0.954
Sox9 SRY-box containing gene 9 0.943
Gli2 GLI-Kruppel family member GLI2 0.933
Pten phosphatase and tensin homolog 0.925
Fgf8 fibroblast growth factor 8 0.900
Smad4 MAD homolog 4 (Drosophila) 0.899
Runx2 runt related transcription factor 2 0.881
Notch1 Notch gene homolog 1 (Drosophila) 0.877
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.850
Prrx2 paired related homeobox 2 0.836
Pthlh parathyroid hormone-like peptide 0.834
Hand2 heart and neural crest derivatives expressed transcript 2 0.831
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.804
Trp53 transformation related protein 53 0.783
Gata4 GATA binding protein 4 0.774
Otx2 orthodenticle homolog 2 (Drosophila) 0.767
Pax2 paired box gene 2 0.765
Id3 inhibitor of DNA binding 3 0.754
Nodal nodal 0.744
Pax3 paired box gene 3 0.736
Dlx5 distal-less homeobox 5 0.735
Ctnnb1 catenin (cadherin associated protein), beta 1 0.682
Msx1 homeobox, msh-like 1 0.666
Csf1 colony stimulating factor 1 (macrophage) 0.652
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.636
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.622
Meox2 mesenchyme homeobox 2 0.618
Id1 inhibitor of DNA binding 1 0.617
Prrx1 paired related homeobox 1 0.610
Smad2 MAD homolog 2 (Drosophila) 0.610
Stat3 signal transducer and activator of transcription 3 0.610
Hes1 hairy and enhancer of split 1 (Drosophila) 0.594
Mndal myeloid nuclear differentiation antigen like 0.591
Bmpr1a bone morphogenetic protein receptor, type 1A 0.584
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.582
Zfpm2 zinc finger protein, multitype 2 0.577
Fos FBJ osteosarcoma oncogene 0.554
Rb1 retinoblastoma 1 0.540
Kl klotho 0.528
Hoxd13 homeobox D13 0.518
Gpc3 glypican 3 0.516
Efnb2 ephrin B2 0.515
Jun Jun oncogene 0.514
Smo smoothened homolog (Drosophila) 0.486
Pax8 paired box gene 8 0.463
Hand1 heart and neural crest derivatives expressed transcript 1 0.458
Pax6 paired box gene 6 0.451
Alx4 aristaless-like homeobox 4 0.441
Fgfr3 fibroblast growth factor receptor 3 0.432
Ntf3 neurotrophin 3 0.426
Emx2 empty spiracles homolog 2 (Drosophila) 0.425
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.420
Smad3 MAD homolog 3 (Drosophila) 0.395
Apc adenomatosis polyposis coli 0.388
Smad1 MAD homolog 1 (Drosophila) 0.379
Foxc2 forkhead box C2 0.378
Nos3 nitric oxide synthase 3, endothelial cell 0.374
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.370
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.369
Pitx2 paired-like homeodomain transcription factor 2 0.365
Foxh1 forkhead box H1 0.349
Mnda myeloid cell nuclear differentiation antigen 0.347
Tgfb1 transforming growth factor, beta 1 0.337
Jag1 jagged 1 0.332
Fgf10 fibroblast growth factor 10 0.332
Scn5a sodium channel, voltage-gated, type V, alpha 0.307
Sfrp2 secreted frizzled-related protein 2 0.286
Bmp4 bone morphogenetic protein 4 0.280
Gja1 gap junction protein, alpha 1 0.280
Pou3f3 POU domain, class 3, transcription factor 3 0.263
Twist2 twist homolog 2 (Drosophila) 0.256
Tbx2 T-box 2 0.253
Ifi203 interferon activated gene 203 0.251
Tbx5 T-box 5 0.251
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.241
Zic1 zinc finger protein of the cerebellum 1 0.238
Fgf3 fibroblast growth factor 3 0.227
Ptch1 patched homolog 1 0.224
Nog noggin 0.220
Tbx3 T-box 3 0.219
Tcf4 transcription factor 4 0.218
Wnt5a wingless-related MMTV integration site 5A 0.210
Hdac4 histone deacetylase 4 0.210
Pax9 paired box gene 9 0.209
Grb10 growth factor receptor bound protein 10 0.208
Neurog3 neurogenin 3 0.208
Thra thyroid hormone receptor alpha 0.207
Hoxd11 homeobox D11 0.200
Bmp2 bone morphogenetic protein 2 0.193
Gsc goosecoid homeobox 0.191
Rarg retinoic acid receptor, gamma 0.186
Smad6 MAD homolog 6 (Drosophila) 0.184
Fgf18 fibroblast growth factor 18 0.184
Vangl2 vang-like 2 (van gogh, Drosophila) 0.183
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD7 SMAD family member 7 1.000
BMPR1A bone morphogenetic protein receptor, type IA 0.999
SMAD4 SMAD family member 4 0.998
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.997
SMAD3 SMAD family member 3 0.996
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.995
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.995
SMAD2 SMAD family member 2 0.993
SMAD1 SMAD family member 1 0.986
PAX3 paired box 3 0.981
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.976
FKBP1A FK506 binding protein 1A, 12kDa 0.961
BMP2 bone morphogenetic protein 2 0.941
POU5F1 POU class 5 homeobox 1 0.941
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.934
FBLN1 fibulin 1 0.925
NOTCH1 notch 1 0.910
FGFR1 fibroblast growth factor receptor 1 0.846
SMAD5 SMAD family member 5 0.834
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.831
POU3F2 POU class 3 homeobox 2 0.821
SKIL SKI-like oncogene 0.818
GDF5 growth differentiation factor 5 0.816
BMPR1B bone morphogenetic protein receptor, type IB 0.813
JUP junction plakoglobin 0.805
NOTCH3 notch 3 0.799
TM4SF1 transmembrane 4 L six family member 1 0.798
CTGF connective tissue growth factor 0.791
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.750
FGFR2 fibroblast growth factor receptor 2 0.702
SP1 Sp1 transcription factor 0.636
FSTL1 follistatin-like 1 0.606
CXXC5 CXXC finger protein 5 0.583
ATF3 activating transcription factor 3 0.561
TCF4 transcription factor 4 0.555
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.521
EP300 E1A binding protein p300 0.490
SNX9 sorting nexin 9 0.478
TGFB3 transforming growth factor, beta 3 0.449
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.407
FGF1 fibroblast growth factor 1 (acidic) 0.405
HMGA1 high mobility group AT-hook 1 0.389
SKI v-ski sarcoma viral oncogene homolog (avian) 0.374
TGFB1 transforming growth factor, beta 1 0.330
ITGB1BP3 integrin beta 1 binding protein 3 0.304
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.302
SOCS3 suppressor of cytokine signaling 3 0.298
JUN jun proto-oncogene 0.274
EGR1 early growth response 1 0.245
CYR61 cysteine-rich, angiogenic inducer, 61 0.231
COL11A2 collagen, type XI, alpha 2 0.230
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.227
FOXD3 forkhead box D3 0.225
NOG noggin 0.225
MEOX2 mesenchyme homeobox 2 0.223
SATB2 SATB homeobox 2 0.210
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.204
FGF18 fibroblast growth factor 18 0.194
GFI1B growth factor independent 1B transcription repressor 0.190
HDAC4 histone deacetylase 4 0.182
FOS FBJ murine osteosarcoma viral oncogene homolog 0.180
ACVR1 activin A receptor, type I 0.176
MSX1 msh homeobox 1 0.176
YAP1 Yes-associated protein 1 0.167
BMP4 bone morphogenetic protein 4 0.164
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.162
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.162
ENG endoglin 0.161
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.161
AMOTL2 angiomotin like 2 0.159
IER2 immediate early response 2 0.157
PRKD2 protein kinase D2 0.150
SMAD6 SMAD family member 6 0.145
PRKG1 protein kinase, cGMP-dependent, type I 0.143
NAMPT nicotinamide phosphoribosyltransferase 0.143
KRT5 keratin 5 0.142
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.133
IGF2R insulin-like growth factor 2 receptor 0.129
LIMS1 LIM and senescent cell antigen-like domains 1 0.129
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.125
BST2 bone marrow stromal cell antigen 2 0.121
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.119
PIAS4 protein inhibitor of activated STAT, 4 0.116
JAG2 jagged 2 0.110
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.102
USP15 ubiquitin specific peptidase 15 0.099
ZFYVE9 zinc finger, FYVE domain containing 9 0.097
WWOX WW domain containing oxidoreductase 0.096
JUNB jun B proto-oncogene 0.096
INHBB inhibin, beta B 0.096
EPAS1 endothelial PAS domain protein 1 0.095
BMP7 bone morphogenetic protein 7 0.091
CDH5 cadherin 5, type 2 (vascular endothelium) 0.080
STAT4 signal transducer and activator of transcription 4 0.080
CABLES1 Cdk5 and Abl enzyme substrate 1 0.079
SFRP1 secreted frizzled-related protein 1 0.079
PARVA parvin, alpha 0.078
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.078
AXIN1 axin 1 0.076
LIF leukemia inhibitory factor (cholinergic differentiation factor) 0.075
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Rattus norvegicus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.015
Errfi1 ERBB receptor feedback inhibitor 1 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism