The network for 'positive regulation of leukocyte mediated cytotoxicity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of leukocyte mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.

Mus musculus
Name Description Probability Func Analog Organism
B2m beta-2 microglobulin 1.000
H2-D1 histocompatibility 2, D region locus 1 1.000
H2-K1 histocompatibility 2, K1, K region 1.000
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.998
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.998
Slamf1 signaling lymphocytic activation molecule family member 1 0.997
Tapbp TAP binding protein 0.996
H2-Q7 histocompatibility 2, Q region locus 7 0.986
Fyn Fyn proto-oncogene 0.986
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.984
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.983
Gzmk granzyme K 0.977
Xcl1 chemokine (C motif) ligand 1 0.964
Stat5b signal transducer and activator of transcription 5B 0.959
Fasl Fas ligand (TNF superfamily, member 6) 0.951
Stat5a signal transducer and activator of transcription 5A 0.924
Stat1 signal transducer and activator of transcription 1 0.911
Il2rg interleukin 2 receptor, gamma chain 0.909
Pnp2 purine-nucleoside phosphorylase 2 0.904
Gzma granzyme A 0.856
Gzmb granzyme B 0.856
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.787
Cd244 CD244 natural killer cell receptor 2B4 0.745
Stat3 signal transducer and activator of transcription 3 0.743
Il12b interleukin 12b 0.727
Il2 interleukin 2 0.694
Itk IL2-inducible T-cell kinase 0.690
Ctsw cathepsin W 0.676
Il2rb interleukin 2 receptor, beta chain 0.663
Ncr1 natural cytotoxicity triggering receptor 1 0.658
Il6 interleukin 6 0.641
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.611
Icos inducible T-cell co-stimulator 0.560
Cxcl2 chemokine (C-X-C motif) ligand 2 0.551
Il18rap interleukin 18 receptor accessory protein 0.511
Irf9 interferon regulatory factor 9 0.504
Klrb1a killer cell lectin-like receptor subfamily B member 1A 0.497
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.479
Itm2b integral membrane protein 2B 0.465
Prf1 perforin 1 (pore forming protein) 0.435
Spna1 spectrin alpha 1 0.431
H2-Q8 histocompatibility 2, Q region locus 8 0.413
Zfp36 zinc finger protein 36 0.401
Ccr3 chemokine (C-C motif) receptor 3 0.399
Ccl4 chemokine (C-C motif) ligand 4 0.384
Sh2d2a SH2 domain protein 2A 0.365
Irg1 immunoresponsive gene 1 0.354
Il1rn interleukin 1 receptor antagonist 0.352
Il10 interleukin 10 0.346
Cd28 CD28 antigen 0.344
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.336
Ctsb cathepsin B 0.321
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.290
Il2ra interleukin 2 receptor, alpha chain 0.289
Lck lymphocyte protein tyrosine kinase 0.287
H2-Q6 histocompatibility 2, Q region locus 6 0.282
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.264
Sh2d1a SH2 domain protein 1A 0.247
Dnase1l3 deoxyribonuclease 1-like 3 0.237
Ciita class II transactivator 0.232
BC147527 cDNA sequence BC147527 0.229
Xcr1 chemokine (C motif) receptor 1 0.222
Klre1 killer cell lectin-like receptor family E member 1 0.220
H2-Q5 histocompatibility 2, Q region locus 5 0.214
Ccl7 chemokine (C-C motif) ligand 7 0.212
Il18r1 interleukin 18 receptor 1 0.204
Klrb1f killer cell lectin-like receptor subfamily B member 1F 0.199
Bex6 brain expressed gene 6 0.191
Klra7 killer cell lectin-like receptor, subfamily A, member 7 0.189
Il7r interleukin 7 receptor 0.187
Junb Jun-B oncogene 0.179
Cd180 CD180 antigen 0.169
Cd160 CD160 antigen 0.168
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.167
H2-M9 histocompatibility 2, M region locus 9 0.167
Tbx21 T-box 21 0.163
Gcet2 germinal center expressed transcript 2 0.160
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.159
Ptgs2 prostaglandin-endoperoxide synthase 2 0.157
Slamf7 SLAM family member 7 0.156
Ccl5 chemokine (C-C motif) ligand 5 0.151
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.144
Ccr9 chemokine (C-C motif) receptor 9 0.139
Il4ra interleukin 4 receptor, alpha 0.137
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.131
Ifng interferon gamma 0.130
Cxcl10 chemokine (C-X-C motif) ligand 10 0.129
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.127
Ccr5 chemokine (C-C motif) receptor 5 0.126
Ccl3 chemokine (C-C motif) ligand 3 0.122
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.122
Gdf15 growth differentiation factor 15 0.119
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.114
Nkg7 natural killer cell group 7 sequence 0.114
Mx2 myxovirus (influenza virus) resistance 2 0.113
Ccrl2 chemokine (C-C motif) receptor-like 2 0.112
Il6st interleukin 6 signal transducer 0.112
Gbp1 guanylate binding protein 1 0.110
Lair1 leukocyte-associated Ig-like receptor 1 0.110
Ppbp pro-platelet basic protein 0.103
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
zgc:64115 zgc:64115 0.672
syngr1a synaptogyrin 1a 0.228
hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.141
coro1a coronin, actin binding protein, 1A 0.109
styk1 serine/threonine/tyrosine kinase 1 0.107
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.090
zgc:64161 zgc:64161 0.086
itln1 intelectin 1 0.084
zgc:174863 zgc:174863 0.077
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.075
itln3 intelectin 3 0.070
defbl3 defensin, beta-like 3 0.069
trim25 tripartite motif-containing 25 0.067
dmrt1 doublesex and mab-3 related transcription factor 1 0.062
c1qc complement component 1, q subcomponent, C chain 0.061
col5a3 collagen, type V, alpha 3 0.060
cx34.4 connexin 34.4 0.055
pkz protein kinase containing Z-DNA binding domains 0.054
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.052
illr1 immune-related, lectin-like receptor 1 0.052
pcsk2 proprotein convertase subtilisin/kexin type 2 0.050
pcsk1 proprotein convertase subtilisin/kexin type 1 0.049
b2m beta-2-microglobulin 0.048
cul1b cullin 1b 0.044
gsk3b glycogen synthase kinase 3 beta 0.043
zgc:101598 zgc:101598 0.042
foxp3a forkhead box P3a 0.042
tlr22 toll-like receptor 22 0.042
pcsk7 proprotein convertase subtilisin/kexin type 7 0.038
pigu phosphatidylinositol glycan anchor biosynthesis, class U 0.038
gch2 GTP cyclohydrolase 2 0.038
illr3 immune-related, lectin-like receptor 3 0.036
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.036
psmb9a proteasome (prosome, macropain) subunit, beta type, 9a 0.036
zgc:63831 zgc:63831 0.034
zgc:162329 zgc:162329 0.033
trpm6 transient receptor potential cation channel, subfamily M, member 6 0.032
cd40lg CD40 ligand 0.032
nitr8 novel immune-type receptor 8 0.032
mitfa microphthalmia-associated transcription factor a 0.032
irf11 interferon regulatory factor 11 0.031
ifnphi1 interferon phi 1 0.031
nitr5 novel immune-type receptor 5 and immune-type receptor 5-like 0.031
slc12a10.1 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.1 0.031
tnfrsf18 tumor necrosis factor receptor superfamily, member 18 0.030
asah1b N-acylsphingosine amidohydrolase (acid ceramidase) 1b 0.030
npy7r neuropeptide Y receptor Y7 0.030
zgc:112072 zgc:112072 0.030
arpc1b actin related protein 2/3 complex, subunit 1B 0.029
stat1a signal transduction and activation of transcription 1a 0.029
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.029
zgc:64051 zgc:64051 0.028
nitr4a novel immune-type receptor 4a 0.028
ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a 0.028
lrrc33 leucine rich repeat containing 33 0.028
pcsk9 proprotein convertase subtilisin/kexin type 9 0.028
eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.027
nitr12 novel immune-type receptor 12 0.027
gmfg glia maturation factor, gamma 0.027
sdcbp syndecan binding protein (syntenin) 0.027
c3c complement component c3c 0.027
LOC567441 interferon-induced protein with tetratricopeptide repeats 5-like 0.027
tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 0.027
psme1 proteasome activator subunit 1 0.026
g6pd glucose-6-phosphate dehydrogenase 0.026
clica chloride intracellular channel a 0.026
waca WW domain containing adaptor with coiled-coil a 0.026
gpr22 G protein-coupled receptor 22 0.026
igfbp6a insulin-like growth factor binding protein 6a 0.026
zgc:112018 zgc:112018 0.025
zgc:162337 zgc:162337 0.025
tec tec protein tyrosine kinase 0.025
jak3 Janus kinase 3 (a protein tyrosine kinase, leukocyte) 0.025
ugt5c2 UDP glucuronosyltransferase 5 family, polypeptide C2 0.025
ptk6a PTK6 protein tyrosine kinase 6a 0.025
si:ch211-140f21.1 si:ch211-140f21.1 0.025
c1qb complement component 1, q subcomponent, B chain 0.025
ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.024
defbl1 defensin, beta-like 1 0.024
c3b complement component c3b 0.024
tlr21 toll-like receptor 21 0.024
sec31b Sec31 homolog B (S. cerevisiae) 0.024
dock8 dedicator of cytokinesis 8 0.024
LOC555739 serine/threonine-protein kinase LMTK1-like 0.024
npy4r neuropeptide Y receptor Y4 0.023
LOC793458 peptide Y-like 0.023
LOC100538108 tissue-type plasminogen activator-like 0.023
nitr9 novel immune-type receptor 9 0.023
tlr9 toll-like receptor 9 0.023
si:ch211-244b2.4 si:ch211-244b2.4 0.023
LOC794786 interferon-induced protein with tetratricopeptide repeats 1-like 0.022
adipor2 adiponectin receptor 2 0.022
sqstm1 sequestosome 1 0.022
cxc46 CXC chemokine 46 0.022
illr4 immune-related, lectin-like receptor 4 0.021
fgf23 fibroblast growth factor 23 0.021
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.021
tbx21 T-box 21 0.021
nitr13 novel immune-type receptor 13 0.021
zgc:171538 zgc:171538 0.020
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
B2M beta-2-microglobulin 0.998
HLA-A major histocompatibility complex, class I, A 0.993
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.939
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.913
HLA-C major histocompatibility complex, class I, C 0.867
TAPBP TAP binding protein (tapasin) 0.661
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.657
IL8 interleukin 8 0.623
CD84 CD84 molecule 0.562
HLA-E major histocompatibility complex, class I, E 0.485
HLA-B major histocompatibility complex, class I, B 0.452
CCL5 chemokine (C-C motif) ligand 5 0.407
CCL4 chemokine (C-C motif) ligand 4 0.407
CXCL3 chemokine (C-X-C motif) ligand 3 0.392
HLA-G major histocompatibility complex, class I, G 0.316
CCR5 chemokine (C-C motif) receptor 5 0.257
HLA-F major histocompatibility complex, class I, F 0.218
CXCL2 chemokine (C-X-C motif) ligand 2 0.145
CXCL9 chemokine (C-X-C motif) ligand 9 0.119
IL2RB interleukin 2 receptor, beta 0.111
GBA glucosidase, beta, acid 0.102
IL6 interleukin 6 (interferon, beta 2) 0.098
IFNG interferon, gamma 0.096
IL23A interleukin 23, alpha subunit p19 0.095
CCL20 chemokine (C-C motif) ligand 20 0.085
SLAMF1 signaling lymphocytic activation molecule family member 1 0.076
DPP4 dipeptidyl-peptidase 4 0.074
CCL8 chemokine (C-C motif) ligand 8 0.068
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.066
PVRL3 poliovirus receptor-related 3 0.064
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.061
PVRL4 poliovirus receptor-related 4 0.057
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.054
CCL2 chemokine (C-C motif) ligand 2 0.054
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.050
ITM2B integral membrane protein 2B 0.047
CXCL10 chemokine (C-X-C motif) ligand 10 0.040
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.039
ICAM1 intercellular adhesion molecule 1 0.039
IL1B interleukin 1, beta 0.036
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.035
ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5 0.033
CCL13 chemokine (C-C motif) ligand 13 0.033
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.030
IDE insulin-degrading enzyme 0.029
CXCL5 chemokine (C-X-C motif) ligand 5 0.029
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.028
CCR7 chemokine (C-C motif) receptor 7 0.027
GZMK granzyme K (granzyme 3; tryptase II) 0.027
UBD ubiquitin D 0.026
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.025
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.025
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.024
TJP1 tight junction protein 1 (zona occludens 1) 0.023
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.022
CXCL13 chemokine (C-X-C motif) ligand 13 0.021
CXCL11 chemokine (C-X-C motif) ligand 11 0.020
TLR2 toll-like receptor 2 0.020
CCL3 chemokine (C-C motif) ligand 3 0.020
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.020
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.018
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.018
CCL7 chemokine (C-C motif) ligand 7 0.017
CD8A CD8a molecule 0.017
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.015
IL7R interleukin 7 receptor 0.015
CAV1 caveolin 1, caveolae protein, 22kDa 0.015
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.015
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.014
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.014
VCAM1 vascular cell adhesion molecule 1 0.014
CCL19 chemokine (C-C motif) ligand 19 0.014
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.014
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.014
CCR4 chemokine (C-C motif) receptor 4 0.014
SRGN serglycin 0.014
STAP2 signal transducing adaptor family member 2 0.013
CCL22 chemokine (C-C motif) ligand 22 0.013
KLRF1 killer cell lectin-like receptor subfamily F, member 1 0.013
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) 0.013
NSF N-ethylmaleimide-sensitive factor 0.013
NCSTN nicastrin 0.013
BCR breakpoint cluster region 0.013
CH25H cholesterol 25-hydroxylase 0.012
HCST hematopoietic cell signal transducer 0.012
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.012
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.012
SELE selectin E 0.012
GPR171 G protein-coupled receptor 171 0.012
CD83 CD83 molecule 0.012
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.011
IL18RAP interleukin 18 receptor accessory protein 0.011
CD2 CD2 molecule 0.011
CCR1 chemokine (C-C motif) receptor 1 0.011
FASLG Fas ligand (TNF superfamily, member 6) 0.011
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.010
IL10RA interleukin 10 receptor, alpha 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.997
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.930
RT1-CE12 RT1 class I, locus CE12 0.749
Casp1 caspase 1 0.626
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.256
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.252
RT1-S3 RT1 class Ib, locus S3 0.172
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.146
RT1-Cl RT1 class Ib, locus Cl 0.094
RT1-M3-1 RT1 class Ib, locus M3, gene 1 0.085
Cxcl10 chemokine (C-X-C motif) ligand 10 0.084
Gbp2 guanylate binding protein 2 0.083
Hsph1 heat shock 105/110 protein 1 0.070
Irf1 interferon regulatory factor 1 0.051
RT1-N3 RT1 class Ib, locus N3 0.046
Ripk3 receptor-interacting serine-threonine kinase 3 0.042
Ccl5 chemokine (C-C motif) ligand 5 0.034
Nkg7 natural killer cell group 7 sequence 0.034
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.033
Rt1.aa MHC class I RT1.Aa alpha-chain 0.033
LOC100364500 RT1 class I, locus CE11-like 0.028
Gzmb granzyme B 0.027
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.026
Atf3 activating transcription factor 3 0.025
Gzmk granzyme K 0.024
Cxcl9 chemokine (C-X-C motif) ligand 9 0.022
RT1-CE16 RT1 class I, locus CE16 0.022
Cd2 Cd2 molecule 0.018
LOC100364485 mCG1051031-like 0.017
Nmi N-myc (and STAT) interactor 0.015
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.015
Ccl7 chemokine (C-C motif) ligand 7 0.015
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.013
Ly6c Ly6-C antigen 0.013
Slc22a18 solute carrier family 22, member 18 0.013
RT1-CE5 RT1 class I, locus CE5 0.013
Tpt1 tumor protein, translationally-controlled 1 0.013
Dcaf7 DDB1 and CUL4 associated factor 7 0.013
Mrgprf MAS-related GPR, member F 0.012
Ifi35 interferon-induced protein 35 0.012
Prf1 perforin 1 (pore forming protein) 0.012
Mcpt8 mast cell protease 8 0.012
RT1-Ba RT1 class II, locus Ba 0.011
Apol3 apolipoprotein L, 3 0.011
Cxcl16 chemokine (C-X-C motif) ligand 16 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism