The network for 'regulation of response to dna damage stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of response to dna damage stimulus

Any process that modulates the frequency, rate or extent of response to DNA damage stimulus.

Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.999
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.970
Rb1 retinoblastoma 1 0.944
Mdm2 transformed mouse 3T3 cell double minute 2 0.928
Brca1 breast cancer 1 0.814
Clock circadian locomotor output cycles kaput 0.779
Per2 period homolog 2 (Drosophila) 0.756
Brca2 breast cancer 2 0.676
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.655
Cry1 cryptochrome 1 (photolyase-like) 0.596
Cdk4 cyclin-dependent kinase 4 0.573
Mdm4 transformed mouse 3T3 cell double minute 4 0.485
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.480
Pten phosphatase and tensin homolog 0.425
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.382
Pnp2 purine-nucleoside phosphorylase 2 0.318
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.285
2500003M10Rik RIKEN cDNA 2500003M10 gene 0.274
Nbn nibrin 0.258
Stag1 stromal antigen 1 0.256
Hbb-b1 hemoglobin, beta adult major chain 0.247
Igh immunoglobulin heavy chain complex 0.220
Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) 0.210
Pcna proliferating cell nuclear antigen 0.205
Atm ataxia telangiectasia mutated homolog (human) 0.198
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.197
Ncoa3 nuclear receptor coactivator 3 0.183
Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.168
Vasp vasodilator-stimulated phosphoprotein 0.162
Cry2 cryptochrome 2 (photolyase-like) 0.161
Trp73 transformation related protein 73 0.152
Huwe1 HECT, UBA and WWE domain containing 1 0.141
Qrich1 glutamine-rich 1 0.138
H2-Aa histocompatibility 2, class II antigen A, alpha 0.132
Daxx Fas death domain-associated protein 0.125
Arid1a AT rich interactive domain 1A (SWI-like) 0.122
Asxl1 additional sex combs like 1 (Drosophila) 0.122
Hdac1 histone deacetylase 1 0.118
Nfatc4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.117
Cul3 cullin 3 0.112
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.111
Trrap transformation/transcription domain-associated protein 0.110
Emx1 empty spiracles homolog 1 (Drosophila) 0.106
Wdr26 WD repeat domain 26 0.102
Raver2 ribonucleoprotein, PTB-binding 2 0.100
Hnrpdl heterogeneous nuclear ribonucleoprotein D-like 0.094
Abl2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) 0.092
Evl Ena-vasodilator stimulated phosphoprotein 0.091
Ewsr1 Ewing sarcoma breakpoint region 1 0.088
Enah enabled homolog (Drosophila) 0.085
Eif2c1 eukaryotic translation initiation factor 2C, 1 0.085
Smad4 MAD homolog 4 (Drosophila) 0.084
Skil SKI-like 0.083
Apaf1 apoptotic peptidase activating factor 1 0.079
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.079
Btg1 B-cell translocation gene 1, anti-proliferative 0.078
Fbxw7 F-box and WD-40 domain protein 7 0.077
Hprt hypoxanthine guanine phosphoribosyl transferase 0.076
Hnrnpd heterogeneous nuclear ribonucleoprotein D 0.075
Prim1 DNA primase, p49 subunit 0.073
Zfp362 zinc finger protein 362 0.073
Cxcr4 chemokine (C-X-C motif) receptor 4 0.072
Slc20a1 solute carrier family 20, member 1 0.072
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.072
Ccna2 cyclin A2 0.070
Srsf4 serine/arginine-rich splicing factor 4 0.069
En1 engrailed 1 0.069
Ccnd1 cyclin D1 0.068
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.068
Apc adenomatosis polyposis coli 0.066
Polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.066
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.065
Thbs1 thrombospondin 1 0.063
Smad7 MAD homolog 7 (Drosophila) 0.062
Nup37 nucleoporin 37 0.060
Rnf19a ring finger protein 19A 0.059
H2-Eb1 histocompatibility 2, class II antigen E beta 0.059
Ncoa6 nuclear receptor coactivator 6 0.057
Hdac2 histone deacetylase 2 0.057
Scaf11 SR-related CTD-associated factor 11 0.054
Hat1 histone aminotransferase 1 0.053
Myc myelocytomatosis oncogene 0.053
H2-DMa histocompatibility 2, class II, locus DMa 0.053
Kdm2b lysine (K)-specific demethylase 2B 0.053
Exoc6 exocyst complex component 6 0.051
Smad2 MAD homolog 2 (Drosophila) 0.050
Ikzf1 IKAROS family zinc finger 1 0.048
Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.047
Trp63 transformation related protein 63 0.046
Rfc3 replication factor C (activator 1) 3 0.046
Spnb1 spectrin beta 1 0.046
Trip12 thyroid hormone receptor interactor 12 0.045
Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform 0.045
Egr2 early growth response 2 0.044
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.043
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.043
Plagl2 pleiomorphic adenoma gene-like 2 0.043
Sox2 SRY-box containing gene 2 0.043
Sf3b1 splicing factor 3b, subunit 1 0.042
Msh2 mutS homolog 2 (E. coli) 0.041
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cxcr4b chemokine (C-X-C motif), receptor 4b 0.013
ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
E(spl) Enhancer of split 0.543
pan pangolin 0.354
lok loki 0.328
HLHmgamma E(spl) region transcript mgamma 0.302
HLHm7 E(spl) region transcript m7 0.272
HLHm3 E(spl) region transcript m3 0.245
CG31198 CG31198 gene product from transcript CG31198-RA 0.228
mus205 mutagen-sensitive 205 0.223
CG31343 CG31343 gene product from transcript CG31343-RA 0.218
HLHmdelta E(spl) region transcript mdelta 0.162
HLHmbeta E(spl) region transcript mbeta 0.152
rad50 CG6339 gene product from transcript CG6339-RD 0.144
Brca2 Breast cancer 2, early onset homolog 0.115
malpha E(spl) region transcript malpha 0.107
CG5524 CG5524 gene product from transcript CG5524-RA 0.096
hay haywire 0.088
CtBP C-terminal Binding Protein 0.088
l(1)dd4 lethal (1) discs degenerate 4 0.083
ago archipelago 0.079
CG15220 CG15220 gene product from transcript CG15220-RA 0.075
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.069
Smc5 CG32438 gene product from transcript CG32438-RE 0.064
mus308 mutagen-sensitive 308 0.061
CG2865 CG2865 gene product from transcript CG2865-RA 0.060
mip130 Myb-interacting protein 130 0.058
nuf nuclear fallout 0.057
sc scute 0.054
E(var)3-9 Enhancer of variegation 3-9 0.053
cpo couch potato 0.049
Cul-3 Cullin-3 0.045
CG14641 CG14641 gene product from transcript CG14641-RA 0.045
mle maleless 0.043
O-fut1 O-fucosyltransferase 1 0.042
Lrrk Leucine-rich repeat kinase 0.042
ebi CG4063 gene product from transcript CG4063-RA 0.042
Ncc69 sodium chloride cotransporter 69 0.042
shg shotgun 0.040
CG14814 CG14814 gene product from transcript CG14814-RA 0.039
Grip84 gamma-tubulin ring protein 84 0.037
HLHm5 E(spl) region transcript m5 0.037
CG5794 CG5794 gene product from transcript CG5794-RB 0.036
CG32473 CG32473 gene product from transcript CG32473-RA 0.036
alph alphabet 0.035
CG9894 CG9894 gene product from transcript CG9894-RB 0.034
bon bonus 0.034
CG5506 CG5506 gene product from transcript CG5506-RA 0.034
CG31716 CG31716 gene product from transcript CG31716-RH 0.034
Sema-2a CG4700 gene product from transcript CG4700-RC 0.033
CG10133 CG10133 gene product from transcript CG10133-RA 0.033
for foraging 0.033
NT1 Neurotrophin 1 0.033
pr-set7 CG3307 gene product from transcript CG3307-RC 0.032
cbt cabut 0.032
His2Av Histone H2A variant 0.032
l(2)dtl lethal-(2)-denticleless 0.031
CG18273 CG18273 gene product from transcript CG18273-RA 0.031
mus101 mutagen-sensitive 101 0.031
Caf1 Chromatin assembly factor 1 subunit 0.031
nopo no poles 0.030
esg escargot 0.028
Akap200 A kinase anchor protein 200 0.027
Smr Smrter 0.027
pyd polychaetoid 0.027
polo CG12306 gene product from transcript CG12306-RA 0.027
Chro Chromator 0.027
CG7376 CG7376 gene product from transcript CG7376-RA 0.027
Tom Twin of m4 0.026
CG32685 CG32685 gene product from transcript CG32685-RC 0.026
cdc16 CG6759 gene product from transcript CG6759-RA 0.025
Utx CG5640 gene product from transcript CG5640-RD 0.025
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.024
TORC CG6064 gene product from transcript CG6064-RA 0.024
dpn deadpan 0.024
Pat1 Protein interacting with APP tail-1 0.023
MED19 Mediator complex subunit 19 0.023
mof males absent on the first 0.023
kel kelch 0.023
h hairy 0.023
trbl tribbles 0.023
ed echinoid 0.022
egr eiger 0.022
Nup75 Nucleoporin 75 0.022
CG16826 CG16826 gene product from transcript CG16826-RA 0.022
CG2182 CG2182 gene product from transcript CG2182-RA 0.022
Eip63E Ecdysone-induced protein 63E 0.022
crc cryptocephal 0.022
fzy fizzy 0.021
CG10417 CG10417 gene product from transcript CG10417-RA 0.021
CTCF CG8591 gene product from transcript CG8591-RA 0.020
Rnp4F RNA-binding protein 4F 0.020
chif chiffon 0.020
Mcm3 Minichromosome maintenance 3 0.020
CG14614 CG14614 gene product from transcript CG14614-RA 0.020
ik2 IkappaB kinase-like 2 0.019
p53 CG33336 gene product from transcript CG33336-RB 0.019
Mnn1 Menin 1 0.019
18w 18 wheeler 0.019
tai taiman 0.019
rno rhinoceros 0.019
CG8486 CG8486 gene product from transcript CG8486-RE 0.019
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Homo sapiens
Name Description Probability Func Analog Organism
BRCA1 breast cancer 1, early onset 1.000
TP53 tumor protein p53 0.999
H2AFX H2A histone family, member X 0.995
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.941
NBN nibrin 0.934
RPA1 replication protein A1, 70kDa 0.924
FGFR2 fibroblast growth factor receptor 2 0.914
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.906
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.901
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.900
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.897
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.883
CREBBP CREB binding protein 0.873
RBBP8 retinoblastoma binding protein 8 0.872
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.807
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.798
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.795
MDC1 mediator of DNA-damage checkpoint 1 0.758
BAX BCL2-associated X protein 0.753
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.734
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.703
XIAP X-linked inhibitor of apoptosis 0.697
WRN Werner syndrome, RecQ helicase-like 0.669
BCL2L1 BCL2-like 1 0.652
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.640
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.633
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.630
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.628
CDK4 cyclin-dependent kinase 4 0.606
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 0.596
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.593
DAXX death-domain associated protein 0.549
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.546
THOC4 THO complex 4 0.539
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 0.528
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.528
VIM vimentin 0.523
TSC22D1 TSC22 domain family, member 1 0.521
EP300 E1A binding protein p300 0.517
BID BH3 interacting domain death agonist 0.517
CUL2 cullin 2 0.504
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.475
PCNA proliferating cell nuclear antigen 0.452
TOP1 topoisomerase (DNA) I 0.425
SMC6 structural maintenance of chromosomes 6 0.422
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.421
CDK6 cyclin-dependent kinase 6 0.420
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.407
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.407
TWIST1 twist homolog 1 (Drosophila) 0.405
H3F3C H3 histone, family 3C 0.390
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.372
HLA-DRA major histocompatibility complex, class II, DR alpha 0.371
CCND1 cyclin D1 0.370
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.354
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 0.349
RAD18 RAD18 homolog (S. cerevisiae) 0.344
PML promyelocytic leukemia 0.336
THOC2 THO complex 2 0.333
CCNE1 cyclin E1 0.330
PTPRC protein tyrosine phosphatase, receptor type, C 0.321
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.319
APAF1 apoptotic peptidase activating factor 1 0.317
ESR1 estrogen receptor 1 0.298
DDB1 damage-specific DNA binding protein 1, 127kDa 0.293
FGFR1 fibroblast growth factor receptor 1 0.292
BCAS2 breast carcinoma amplified sequence 2 0.291
RAD50 RAD50 homolog (S. cerevisiae) 0.290
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.286
PARP1 poly (ADP-ribose) polymerase 1 0.284
ATR ataxia telangiectasia and Rad3 related 0.282
FAS Fas (TNF receptor superfamily, member 6) 0.278
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.276
MAGEA2 melanoma antigen family A, 2 0.274
CCNT1 cyclin T1 0.271
POLH polymerase (DNA directed), eta 0.271
FANCD2 Fanconi anemia, complementation group D2 0.264
MEN1 multiple endocrine neoplasia I 0.263
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.260
RCC1 regulator of chromosome condensation 1 0.260
TMPO thymopoietin 0.253
SETD8 SET domain containing (lysine methyltransferase) 8 0.253
SMC2 structural maintenance of chromosomes 2 0.245
CDK9 cyclin-dependent kinase 9 0.243
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.242
CFLAR CASP8 and FADD-like apoptosis regulator 0.240
TOPBP1 topoisomerase (DNA) II binding protein 1 0.239
ZNF512B zinc finger protein 512B 0.238
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.233
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.229
CLSPN claspin 0.225
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.224
WDR5 WD repeat domain 5 0.222
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.221
FGF10 fibroblast growth factor 10 0.220
BAK1 BCL2-antagonist/killer 1 0.219
TP53BP1 tumor protein p53 binding protein 1 0.216
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.214
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.211
NCOA3 nuclear receptor coactivator 3 0.208
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SPT5 Spt5p 0.717
SPT16 Spt16p 0.635
RTF1 Rtf1p 0.625
CTR9 Ctr9p 0.591
PSY4 Psy4p 0.541
PAF1 Paf1p 0.429
TPD3 Tpd3p 0.318
CKA1 Cka1p 0.298
RAD23 Rad23p 0.224
RPO21 Rpo21p 0.153
CDC55 Cdc55p 0.139
DNA2 Dna2p 0.137
LEO1 Leo1p 0.133
CKS1 Cks1p 0.122
VPS64 Vps64p 0.110
RPN14 Rpn14p 0.107
PPH3 Pph3p 0.090
UBC13 Ubc13p 0.082
RFA1 Rfa1p 0.074
RPB3 Rpb3p 0.070
GBP2 Gbp2p 0.068
ROX1 Rox1p 0.065
TOP1 Top1p 0.056
RPT6 Rpt6p 0.052
POL30 Pol30p 0.047
SSN3 Ssn3p 0.046
FPK1 Fpk1p 0.046
PSY2 Psy2p 0.045
OPY2 Opy2p 0.044
TIP41 Tip41p 0.041
CKB1 Ckb1p 0.041
REV7 Rev7p 0.040
NRD1 Nrd1p 0.039
THP2 Thp2p 0.038
HAL5 Hal5p 0.038
RPS5 Rps5p 0.036
MEC1 Mec1p 0.036
MIG1 Mig1p 0.036
ESF1 Esf1p 0.035
HDA1 Hda1p 0.035
NRG1 Nrg1p 0.034
SGS1 Sgs1p 0.034
MYO5 Myo5p 0.034
MMS1 Mms1p 0.032
CAB3 Cab3p 0.032
RAD5 Rad5p 0.031
PRR2 Prr2p 0.031
GIP2 Gip2p 0.031
TBS1 Tbs1p 0.031
POB3 Pob3p 0.030
RAD55 Rad55p 0.030
SUB2 Sub2p 0.030
ECM2 Ecm2p 0.030
CUP9 Cup9p 0.030
NOP10 Nop10p 0.028
SPT6 Spt6p 0.028
RTG3 Rtg3p 0.028
AFT1 Aft1p 0.027
VPS41 Vps41p 0.026
HPR1 Hpr1p 0.026
AHP1 Ahp1p 0.026
CTK3 Ctk3p 0.026
HRB1 Hrb1p 0.025
SEM1 Sem1p 0.025
TSR1 Tsr1p 0.025
CTK1 Ctk1p 0.024
UBC4 Ubc4p 0.023
FSH1 Fsh1p 0.022
PRP45 Prp45p 0.021
PCM1 Pcm1p 0.021
YLR264C-A hypothetical protein 0.021
GLN3 Gln3p 0.020
CWC21 Cwc21p 0.020
FAR11 Far11p 0.019
CYC8 Cyc8p 0.019
RHO1 Rho1p 0.019
RIM13 Rim13p 0.019
HSF1 Hsf1p 0.019
RMI1 Rmi1p 0.019
CAK1 Cak1p 0.019
SRD1 Srd1p 0.019
RPN2 Rpn2p 0.018
SIZ1 Siz1p 0.018
PCL7 Pcl7p 0.018
CKB2 Ckb2p 0.018
LEU2 Leu2p 0.018
SUB1 Sub1p 0.018
TRX2 Trx2p 0.018
STP2 Stp2p 0.018
YNL234W hypothetical protein 0.017
ARP10 Arp10p 0.017
CDC73 Cdc73p 0.017
CET1 Cet1p 0.017
SWI6 Swi6p 0.017
SAK1 Sak1p 0.017
REB1 Reb1p 0.016
YIR035C hypothetical protein 0.016
ATG21 Atg21p 0.016
DST1 Dst1p 0.016
PRS2 Prs2p 0.016