IMP

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Homo sapiens

3 genes annotated in human

bmp signaling pathway involved in heart development

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "bmp signaling pathway involved in heart development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "bmp signaling pathway involved in heart development" (in gray)

Name	Description	Probability	Func Analog Organism
FOXD3	forkhead box D3	1.000
SP1	Sp1 transcription factor	1.000
BMPR1A	bone morphogenetic protein receptor, type IA	1.000
WWP2	WW domain containing E3 ubiquitin protein ligase 2	1.000
PAX3	paired box 3	1.000
SOX10	SRY (sex determining region Y)-box 10	1.000
SOX2	SRY (sex determining region Y)-box 2	1.000
FSTL1	follistatin-like 1	0.999
HTT	huntingtin	0.997
HCFC1	host cell factor C1 (VP16-accessory protein)	0.987
SMAD3	SMAD family member 3	0.984
ESR1	estrogen receptor 1	0.961
HMGA1	high mobility group AT-hook 1	0.950
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.935
MSX1	msh homeobox 1	0.929	Mouse
MSX2	msh homeobox 2	0.904	Mouse
SMAD7	SMAD family member 7	0.898
EP300	E1A binding protein p300	0.847
MEOX2	mesenchyme homeobox 2	0.795
ZFYVE9	zinc finger, FYVE domain containing 9	0.770
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.581
POU3F3	POU class 3 homeobox 3	0.554	Human
SOX1	SRY (sex determining region Y)-box 1	0.492
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.488
POU3F2	POU class 3 homeobox 2	0.468	Human
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.467
SOX11	SRY (sex determining region Y)-box 11	0.459
NOG	noggin	0.454
OTP	orthopedia homeobox	0.453
DLX2	distal-less homeobox 2	0.439
NOVA2	neuro-oncological ventral antigen 2	0.301
ATN1	atrophin 1	0.300
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.289
SOX21	SRY (sex determining region Y)-box 21	0.265
DLX5	distal-less homeobox 5	0.217
POU3F1	POU class 3 homeobox 1	0.208	Human
LHX1	LIM homeobox 1	0.198
SMAD4	SMAD family member 4	0.193
ADARB1	adenosine deaminase, RNA-specific, B1	0.186
BMP2	bone morphogenetic protein 2	0.181
NEUROG3	neurogenin 3	0.172
TP73	tumor protein p73	0.160
SFRP5	secreted frizzled-related protein 5	0.156
TBX2	T-box 2	0.147
ATF7IP	activating transcription factor 7 interacting protein	0.146
NKX2-1	NK2 homeobox 1	0.136
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.128
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.121
ELF1	E74-like factor 1 (ets domain transcription factor)	0.114
HOXD12	homeobox D12	0.110
POU4F1	POU class 4 homeobox 1	0.108	Human
BMPR1B	bone morphogenetic protein receptor, type IB	0.107
NKX6-1	NK6 homeobox 1	0.101
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.098
FOXA2	forkhead box A2	0.097
TGFB1	transforming growth factor, beta 1	0.087
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.085
ESR2	estrogen receptor 2 (ER beta)	0.085
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.084
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.082
UTF1	undifferentiated embryonic cell transcription factor 1	0.080
PAX6	paired box 6	0.080
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.078
LHX2	LIM homeobox 2	0.077
BMP7	bone morphogenetic protein 7	0.074	Zebrafish
GBX2	gastrulation brain homeobox 2	0.072
VSX1	visual system homeobox 1	0.070
OLIG2	oligodendrocyte lineage transcription factor 2	0.070
LHX5	LIM homeobox 5	0.066
PITX2	paired-like homeodomain 2	0.065
NPAS1	neuronal PAS domain protein 1	0.063
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.063
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.063
HOXC8	homeobox C8	0.062
NKX2-8	NK2 homeobox 8	0.061
NEUROG1	neurogenin 1	0.056
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.056
NCOA1	nuclear receptor coactivator 1	0.055
FOXB1	forkhead box B1	0.054
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.052
CDH4	cadherin 4, type 1, R-cadherin (retinal)	0.052
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.051
POU4F2	POU class 4 homeobox 2	0.050	Human
SIX6	SIX homeobox 6	0.049
FBXL15	F-box and leucine-rich repeat protein 15	0.049
FGF3	fibroblast growth factor 3	0.049
NFYA	nuclear transcription factor Y, alpha	0.047
SOX18	SRY (sex determining region Y)-box 18	0.047
LBX1	ladybird homeobox 1	0.046
SMAD2	SMAD family member 2	0.046
ALX1	ALX homeobox 1	0.046
HOXD3	homeobox D3	0.045
SREBF2	sterol regulatory element binding transcription factor 2	0.044
PDX1	pancreatic and duodenal homeobox 1	0.044
GRIP1	glutamate receptor interacting protein 1	0.044
BMP4	bone morphogenetic protein 4	0.044
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.042
HOXB13	homeobox B13	0.042
PGR	progesterone receptor	0.041
CRLF1	cytokine receptor-like factor 1	0.040
NHLH2	nescient helix loop helix 2	0.039
COL2A1	collagen, type II, alpha 1	0.039
SALL2	sal-like 2 (Drosophila)	0.039
DRD4	dopamine receptor D4	0.039
SIX2	SIX homeobox 2	0.038
VASP	vasodilator-stimulated phosphoprotein	0.038
PAX2	paired box 2	0.037
NCOR2	nuclear receptor corepressor 2	0.037
RBP3	retinol binding protein 3, interstitial	0.036
HOXC4	homeobox C4	0.036
HOXD9	homeobox D9	0.036
ZNF143	zinc finger protein 143	0.035
ACAN	aggrecan	0.035
AMN	amnionless homolog (mouse)	0.035
FGF8	fibroblast growth factor 8 (androgen-induced)	0.035
CRHR2	corticotropin releasing hormone receptor 2	0.034
NFYC	nuclear transcription factor Y, gamma	0.034
NELL1	NEL-like 1 (chicken)	0.033
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.033
DIO3	deiodinase, iodothyronine, type III	0.033
RUNX2	runt-related transcription factor 2	0.033
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.033
WT1	Wilms tumor 1	0.032
ISL1	ISL LIM homeobox 1	0.032
DLX4	distal-less homeobox 4	0.032
TBX5	T-box 5	0.031
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.031
DIDO1	death inducer-obliterator 1	0.031
GSC2	goosecoid homeobox 2	0.031
ONECUT2	one cut homeobox 2	0.030
VAX2	ventral anterior homeobox 2	0.030
CALCA	calcitonin-related polypeptide alpha	0.030
HAP1	huntingtin-associated protein 1	0.030
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.030
BAP1	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	0.030
MTA2	metastasis associated 1 family, member 2	0.029
PAX7	paired box 7	0.029
HES2	hairy and enhancer of split 2 (Drosophila)	0.029
TLX1	T-cell leukemia homeobox 1	0.029
FOXG1	forkhead box G1	0.029
BHLHE23	basic helix-loop-helix family, member e23	0.029
MYOD1	myogenic differentiation 1	0.029
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.028
BCL6	B-cell CLL/lymphoma 6	0.028
IL11	interleukin 11	0.028
DCX	doublecortin	0.028
PDLIM7	PDZ and LIM domain 7 (enigma)	0.028
SIM2	single-minded homolog 2 (Drosophila)	0.028
CIITA	class II, major histocompatibility complex, transactivator	0.028
L1TD1	LINE-1 type transposase domain containing 1	0.027
GALR1	galanin receptor 1	0.027
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.027
HOXD13	homeobox D13	0.026
NPTX1	neuronal pentraxin I	0.026
BARX1	BARX homeobox 1	0.026
POU3F4	POU class 3 homeobox 4	0.026	Human
FOXL1	forkhead box L1	0.026
SALL1	sal-like 1 (Drosophila)	0.025
NEUROD2	neurogenic differentiation 2	0.025
POU4F3	POU class 4 homeobox 3	0.025	Human
SOX17	SRY (sex determining region Y)-box 17	0.024
SALL3	sal-like 3 (Drosophila)	0.024
NKX2-2	NK2 homeobox 2	0.024
HAND2	heart and neural crest derivatives expressed 2	0.024
HOXD11	homeobox D11	0.024
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.024
ALX3	ALX homeobox 3	0.023
FST	follistatin	0.023
AATF	apoptosis antagonizing transcription factor	0.023
PAX5	paired box 5	0.023
EYA2	eyes absent homolog 2 (Drosophila)	0.023
SOX3	SRY (sex determining region Y)-box 3	0.023
NCOA2	nuclear receptor coactivator 2	0.023
MNX1	motor neuron and pancreas homeobox 1	0.023
EVX1	even-skipped homeobox 1	0.022
ZNF281	zinc finger protein 281	0.022
LPAR4	lysophosphatidic acid receptor 4	0.022
PAX8	paired box 8	0.022
HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	0.021
DPPA4	developmental pluripotency associated 4	0.021
PRDM13	PR domain containing 13	0.021
SSTR5	somatostatin receptor 5	0.021
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.021
CDX2	caudal type homeobox 2	0.020
VRTN	vertebrae development homolog (pig)	0.020
DOHH	deoxyhypusine hydroxylase/monooxygenase	0.020
HOXA11	homeobox A11	0.020
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.020
TBX1	T-box 1	0.020
POMC	proopiomelanocortin	0.020
FOXF2	forkhead box F2	0.020
TGFB2	transforming growth factor, beta 2	0.020
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.020
HOXD10	homeobox D10	0.020
GABRG3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	0.020
FOXO1	forkhead box O1	0.019
NHLH1	nescient helix loop helix 1	0.019
FZD8	frizzled homolog 8 (Drosophila)	0.019
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.019
LMX1B	LIM homeobox transcription factor 1, beta	0.019
SALL4	sal-like 4 (Drosophila)	0.019
GATA5	GATA binding protein 5	0.019
ACTA1	actin, alpha 1, skeletal muscle	0.019
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.019
SETD1A	SET domain containing 1A	0.018
HOXA2	homeobox A2	0.018
EN2	engrailed homeobox 2	0.018
TCF15	transcription factor 15 (basic helix-loop-helix)	0.018
PRDM8	PR domain containing 8	0.018
C10orf46	chromosome 10 open reading frame 46	0.018
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.018
EPAS1	endothelial PAS domain protein 1	0.018
AMELX	amelogenin, X-linked	0.018
KCNAB3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.018
FOXD2	forkhead box D2	0.018
GJD2	gap junction protein, delta 2, 36kDa	0.017
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.017
NKD1	naked cuticle homolog 1 (Drosophila)	0.017
FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.017
HIPK2	homeodomain interacting protein kinase 2	0.017
BMP6	bone morphogenetic protein 6	0.017
COL13A1	collagen, type XIII, alpha 1	0.017
HNF1A	HNF1 homeobox A	0.017
HOXB8	homeobox B8	0.017
DMRT1	doublesex and mab-3 related transcription factor 1	0.017
PYY	peptide YY	0.016
HIC1	hypermethylated in cancer 1	0.016
PURA	purine-rich element binding protein A	0.016
EGR1	early growth response 1	0.016
HOXC5	homeobox C5	0.016
PNRC2	proline-rich nuclear receptor coactivator 2	0.016
ZNF157	zinc finger protein 157	0.016
EN1	engrailed homeobox 1	0.016
PNOC	prepronociceptin	0.016
MTA3	metastasis associated 1 family, member 3	0.016
KLF5	Kruppel-like factor 5 (intestinal)	0.016
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.016
NPAS3	neuronal PAS domain protein 3	0.016
PRMT2	protein arginine methyltransferase 2	0.016
POU2F3	POU class 2 homeobox 3	0.016	Human
ARNT	aryl hydrocarbon receptor nuclear translocator	0.016
MSC	musculin	0.016
RARA	retinoic acid receptor, alpha	0.016
PITX1	paired-like homeodomain 1	0.016
SIX3	SIX homeobox 3	0.015
TIGD3	tigger transposable element derived 3	0.015
BCOR	BCL6 corepressor	0.015
THAP11	THAP domain containing 11	0.015
HOXC13	homeobox C13	0.015
FOXF1	forkhead box F1	0.015
STAT5A	signal transducer and activator of transcription 5A	0.015
BMP8B	bone morphogenetic protein 8b	0.015
BCL2L10	BCL2-like 10 (apoptosis facilitator)	0.015
RAX	retina and anterior neural fold homeobox	0.015
HOXC6	homeobox C6	0.015
SHOX2	short stature homeobox 2	0.015
C16orf53	chromosome 16 open reading frame 53	0.015
KISS1	KiSS-1 metastasis-suppressor	0.015
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.015
FOXE3	forkhead box E3	0.014
GAL	galanin prepropeptide	0.014
NDP	Norrie disease (pseudoglioma)	0.014
HOXA6	homeobox A6	0.014
WNT1	wingless-type MMTV integration site family, member 1	0.014
HOXC10	homeobox C10	0.014
CDR1	cerebellar degeneration-related protein 1, 34kDa	0.014
SLC35D3	solute carrier family 35, member D3	0.014
CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.014
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	0.014
EPHX3	epoxide hydrolase 3	0.014
GLI3	GLI family zinc finger 3	0.014
MLL2	myeloid/lymphoid or mixed-lineage leukemia 2	0.014
TLX2	T-cell leukemia homeobox 2	0.014
PTCH1	patched 1	0.014
HIST1H1T	histone cluster 1, H1t	0.014
IRX5	iroquois homeobox 5	0.014
IL17B	interleukin 17B	0.013
NRG2	neuregulin 2	0.013
GP5	glycoprotein V (platelet)	0.013
SIM1	single-minded homolog 1 (Drosophila)	0.013
ASCL2	achaete-scute complex homolog 2 (Drosophila)	0.013
SP5	Sp5 transcription factor	0.013
GATA4	GATA binding protein 4	0.013
FUT9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	0.013
HOXD1	homeobox D1	0.013
KLF4	Kruppel-like factor 4 (gut)	0.013
GATA2	GATA binding protein 2	0.013
GALR2	galanin receptor 2	0.013
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.013
IRX4	iroquois homeobox 4	0.013
NEUROG2	neurogenin 2	0.013
NKX3-2	NK3 homeobox 2	0.013
KRT33A	keratin 33A	0.013
CD70	CD70 molecule	0.013
TLE2	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	0.013
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.013
SCT	secretin	0.013
FOXA1	forkhead box A1	0.013
TF	transferrin	0.013
FOXC1	forkhead box C1	0.013
SIX1	SIX homeobox 1	0.013
HOXB6	homeobox B6	0.013
LASS1	LAG1 homolog, ceramide synthase 1	0.013
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.013
HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.013
DSPP	dentin sialophosphoprotein	0.013
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.013
EBF3	early B-cell factor 3	0.012
IL1F9	interleukin 1 family, member 9	0.012
KRT19	keratin 19	0.012
NRTN	neurturin	0.012
ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	0.012
SUMF2	sulfatase modifying factor 2	0.012
LEP	leptin	0.012
RFX4	regulatory factor X, 4 (influences HLA class II expression)	0.012
EFNA1	ephrin-A1	0.012
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.012
NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	0.012
GTF2A1	general transcription factor IIA, 1, 19/37kDa	0.012
PCDH10	protocadherin 10	0.012
TULP1	tubby like protein 1	0.012
NR2E1	nuclear receptor subfamily 2, group E, member 1	0.012
ZBTB7A	zinc finger and BTB domain containing 7A	0.012
ROR1	receptor tyrosine kinase-like orphan receptor 1	0.012
AKAP13	A kinase (PRKA) anchor protein 13	0.012
S1PR2	sphingosine-1-phosphate receptor 2	0.012
HOXB3	homeobox B3	0.012
HOXB9	homeobox B9	0.012
CALCR	calcitonin receptor	0.012
PNMT	phenylethanolamine N-methyltransferase	0.012
CEMP1	cementum protein 1	0.012
FOXL2	forkhead box L2	0.012
ESPN	espin	0.012
EDN1	endothelin 1	0.012
MAGEC1	melanoma antigen family C, 1	0.012
C3orf17	chromosome 3 open reading frame 17	0.012
DPPA2	developmental pluripotency associated 2	0.012
PHOX2A	paired-like homeobox 2a	0.012
FBN2	fibrillin 2	0.011
TBX3	T-box 3	0.011
PROX1	prospero homeobox 1	0.011
TNXB	tenascin XB	0.011
HIST1H4G	histone cluster 1, H4g	0.011
EMX1	empty spiracles homeobox 1	0.011
CRYBA2	crystallin, beta A2	0.011
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	0.011
EYA1	eyes absent homolog 1 (Drosophila)	0.011
GRP	gastrin-releasing peptide	0.011
CHD6	chromodomain helicase DNA binding protein 6	0.011
FOXD1	forkhead box D1	0.011
NEUROD1	neurogenic differentiation 1	0.011
PITX3	paired-like homeodomain 3	0.011
GRIK3	glutamate receptor, ionotropic, kainate 3	0.011
TWIST1	twist homolog 1 (Drosophila)	0.011
HOXC9	homeobox C9	0.011
HOXA10	homeobox A10	0.011
FGF20	fibroblast growth factor 20	0.011
BARX2	BARX homeobox 2	0.011
CD22	CD22 molecule	0.011
CADM4	cell adhesion molecule 4	0.011
APOC4	apolipoprotein C-IV	0.011
INSM1	insulinoma-associated 1	0.011
GPR1	G protein-coupled receptor 1	0.011
CD72	CD72 molecule	0.011
SNTG2	syntrophin, gamma 2	0.011
AHSG	alpha-2-HS-glycoprotein	0.011
MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	0.011
GPR17	G protein-coupled receptor 17	0.011
TACR1	tachykinin receptor 1	0.011
MED19	mediator complex subunit 19	0.011
KCNJ14	potassium inwardly-rectifying channel, subfamily J, member 14	0.011
OSR2	odd-skipped related 2 (Drosophila)	0.011
ZIC2	Zic family member 2 (odd-paired homolog, Drosophila)	0.011
IL26	interleukin 26	0.011
HS3ST1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	0.011
GRAP	GRB2-related adaptor protein	0.011
KLHL35	kelch-like 35 (Drosophila)	0.011
FGFR4	fibroblast growth factor receptor 4	0.011
RIT2	Ras-like without CAAX 2	0.010
SLC32A1	solute carrier family 32 (GABA vesicular transporter), member 1	0.010
KLHL1	kelch-like 1 (Drosophila)	0.010
NMNAT1	nicotinamide nucleotide adenylyltransferase 1	0.010
NCOA6	nuclear receptor coactivator 6	0.010
PCDHA2	protocadherin alpha 2	0.010
DLX3	distal-less homeobox 3	0.010
SLC18A3	solute carrier family 18 (vesicular acetylcholine), member 3	0.010
ARC	activity-regulated cytoskeleton-associated protein	0.010
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.010
NGFR	nerve growth factor receptor	0.010
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.010
RUNX1	runt-related transcription factor 1	0.010
HOXA4	homeobox A4	0.010
MEOX1	mesenchyme homeobox 1	0.010
GSTT1	glutathione S-transferase theta 1	0.010
C1orf183	chromosome 1 open reading frame 183	0.010
ALX4	ALX homeobox 4	0.010
CADM3	cell adhesion molecule 3	0.010
CST1	cystatin SN	0.010
RXRA	retinoid X receptor, alpha	0.010
IL1F7	interleukin 1 family, member 7 (zeta)	0.010
ZNF335	zinc finger protein 335	0.010
MAGEB3	melanoma antigen family B, 3	0.010
INHBB	inhibin, beta B	0.010
KCNS2	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	0.010
CREBBP	CREB binding protein	0.010
PTHLH	parathyroid hormone-like hormone	0.010