IMP

Process View

Homo sapiens

29 genes annotated in human

multicellular organismal macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "multicellular organismal macromolecule metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "multicellular organismal macromolecule metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
TEK	TEK tyrosine kinase, endothelial	0.966
COL1A1	collagen, type I, alpha 1	0.913
COL6A1	collagen, type VI, alpha 1	0.872
COL4A2	collagen, type IV, alpha 2	0.777
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.749	Human
COL1A2	collagen, type I, alpha 2	0.733	Human
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.656	Human
ENG	endoglin	0.650
FGA	fibrinogen alpha chain	0.529
COL6A2	collagen, type VI, alpha 2	0.465
FSTL1	follistatin-like 1	0.463
LOX	lysyl oxidase	0.457
COL3A1	collagen, type III, alpha 1	0.451	Human
POSTN	periostin, osteoblast specific factor	0.440
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.400
BGN	biglycan	0.388
COL5A2	collagen, type V, alpha 2	0.330	Human
PCOLCE	procollagen C-endopeptidase enhancer	0.319
DDR2	discoidin domain receptor tyrosine kinase 2	0.283
BMP1	bone morphogenetic protein 1	0.281
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.262	Mouse Rat
TIMP1	TIMP metallopeptidase inhibitor 1	0.233
BMPR1A	bone morphogenetic protein receptor, type IA	0.230
TMBIM6	transmembrane BAX inhibitor motif containing 6	0.218
TNC	tenascin C	0.205	Human
THBS2	thrombospondin 2	0.201
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.198
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.188
PXDN	peroxidasin homolog (Drosophila)	0.177
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.163
CYR61	cysteine-rich, angiogenic inducer, 61	0.158
FBN1	fibrillin 1	0.149
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.145	Human
CUL2	cullin 2	0.136
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.133
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.133
FBLN2	fibulin 2	0.130
LTBP2	latent transforming growth factor beta binding protein 2	0.124
COL6A3	collagen, type VI, alpha 3	0.121
PLEC	plectin	0.120
COL4A1	collagen, type IV, alpha 1	0.112
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.112
LAMB1	laminin, beta 1	0.111
NCF1	neutrophil cytosolic factor 1	0.105
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.101
CDCP1	CUB domain containing protein 1	0.100
TIMP2	TIMP metallopeptidase inhibitor 2	0.097
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.097
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.088	Rat
PRSS3	protease, serine, 3	0.086
CTSB	cathepsin B	0.084
C1R	complement component 1, r subcomponent	0.082
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.082	Human Mouse
ADAM12	ADAM metallopeptidase domain 12	0.081
MXRA5	matrix-remodelling associated 5	0.080
FGG	fibrinogen gamma chain	0.079
THY1	Thy-1 cell surface antigen	0.078
MRC2	mannose receptor, C type 2	0.077
PRKCB	protein kinase C, beta	0.074
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.073
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.073
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.072
COL5A1	collagen, type V, alpha 1	0.070
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.069
THBS1	thrombospondin 1	0.068
COL18A1	collagen, type XVIII, alpha 1	0.068
AMBP	alpha-1-microglobulin/bikunin precursor	0.066
MFAP2	microfibrillar-associated protein 2	0.065
CD63	CD63 molecule	0.064
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.063
NNMT	nicotinamide N-methyltransferase	0.062
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.062
CYTH1	cytohesin 1	0.061
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.061	Mouse
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.061
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.059	Human
FKBP10	FK506 binding protein 10, 65 kDa	0.058
ANGPTL2	angiopoietin-like 2	0.057	Human
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.057	Human
AEBP1	AE binding protein 1	0.055
LEPRE1	leucine proline-enriched proteoglycan (leprecan) 1	0.054	Human
COL11A1	collagen, type XI, alpha 1	0.052	Human
ALB	albumin	0.052
PLXDC1	plexin domain containing 1	0.052
IL6	interleukin 6 (interferon, beta 2)	0.052
BABAM1	BRISC and BRCA1 A complex member 1	0.049
COL16A1	collagen, type XVI, alpha 1	0.049
WISP1	WNT1 inducible signaling pathway protein 1	0.048
CXCL12	chemokine (C-X-C motif) ligand 12	0.047
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.047	Rat
FAP	fibroblast activation protein, alpha	0.047
GPNMB	glycoprotein (transmembrane) nmb	0.046
CD248	CD248 molecule, endosialin	0.046
EMILIN1	elastin microfibril interfacer 1	0.045
APOE	apolipoprotein E	0.044
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.043
PLOD1	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	0.043
LUM	lumican	0.042
IGFBP3	insulin-like growth factor binding protein 3	0.042
GLRX	glutaredoxin (thioltransferase)	0.041
FGF18	fibroblast growth factor 18	0.041
CCL7	chemokine (C-C motif) ligand 7	0.041
IL6R	interleukin 6 receptor	0.040
GLT8D2	glycosyltransferase 8 domain containing 2	0.039
SDC2	syndecan 2	0.038
MXRA8	matrix-remodelling associated 8	0.038
ACAN	aggrecan	0.038
GRB7	growth factor receptor-bound protein 7	0.037
COL7A1	collagen, type VII, alpha 1	0.036
HSPG2	heparan sulfate proteoglycan 2	0.036
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.035
CCND1	cyclin D1	0.035
CAV1	caveolin 1, caveolae protein, 22kDa	0.034
DCN	decorin	0.034
OLFML2B	olfactomedin-like 2B	0.034
SFRP4	secreted frizzled-related protein 4	0.033
STRA6	stimulated by retinoic acid gene 6 homolog (mouse)	0.033
FYN	FYN oncogene related to SRC, FGR, YES	0.032
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.031
VCAN	versican	0.031
SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	0.030	Mouse
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.030
LRRC17	leucine rich repeat containing 17	0.030
PLXND1	plexin D1	0.029
PTEN	phosphatase and tensin homolog	0.029
TGFBI	transforming growth factor, beta-induced, 68kDa	0.028
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.028
SPON2	spondin 2, extracellular matrix protein	0.028
SLC39A1	solute carrier family 39 (zinc transporter), member 1	0.028
COMP	cartilage oligomeric matrix protein	0.028
PDIA3	protein disulfide isomerase family A, member 3	0.027
EHD2	EH-domain containing 2	0.027
IGF1	insulin-like growth factor 1 (somatomedin C)	0.027
A1BG	alpha-1-B glycoprotein	0.026
SULF1	sulfatase 1	0.026
NID2	nidogen 2 (osteonidogen)	0.025
LOXL2	lysyl oxidase-like 2	0.025
CD68	CD68 molecule	0.024
COL4A5	collagen, type IV, alpha 5	0.024
TUBB2B	tubulin, beta 2B	0.024
F3	coagulation factor III (thromboplastin, tissue factor)	0.024
CCND2	cyclin D2	0.023
ITGA6	integrin, alpha 6	0.023
CTSD	cathepsin D	0.023
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.023
ISLR	immunoglobulin superfamily containing leucine-rich repeat	0.023
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.023
FN1	fibronectin 1	0.023	Human
CTSK	cathepsin K	0.022
PTHLH	parathyroid hormone-like hormone	0.022
COL10A1	collagen, type X, alpha 1	0.022
CST4	cystatin S	0.022	Human
WNT2	wingless-type MMTV integration site family member 2	0.022	Human
LRRC15	leucine rich repeat containing 15	0.022
MMP19	matrix metallopeptidase 19	0.021	Human
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.021
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.021
PRRX2	paired related homeobox 2	0.020
MYO10	myosin X	0.020
BTBD1	BTB (POZ) domain containing 1	0.020
CUL3	cullin 3	0.020	Worm
FBLN1	fibulin 1	0.020
GAS1	growth arrest-specific 1	0.020
LAMC2	laminin, gamma 2	0.020
CFD	complement factor D (adipsin)	0.019
CUL5	cullin 5	0.019
PLAU	plasminogen activator, urokinase	0.019
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.019	Human
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.019
MMP13	matrix metallopeptidase 13 (collagenase 3)	0.018
CAV2	caveolin 2	0.018
ELN	elastin	0.018
ECM1	extracellular matrix protein 1	0.018
TTR	transthyretin	0.018
C2	complement component 2	0.018
GGT5	gamma-glutamyltransferase 5	0.018
ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	0.017
COL13A1	collagen, type XIII, alpha 1	0.017
ZMYND11	zinc finger, MYND-type containing 11	0.017
PDPN	podoplanin	0.017
AXL	AXL receptor tyrosine kinase	0.017
CCL22	chemokine (C-C motif) ligand 22	0.017
GREM1	gremlin 1	0.017
ANGPTL4	angiopoietin-like 4	0.017
CD34	CD34 molecule	0.017
MSC	musculin	0.017
CCDC80	coiled-coil domain containing 80	0.017
INHBA	inhibin, beta A	0.017
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.017
CSTA	cystatin A (stefin A)	0.017
FNDC1	fibronectin type III domain containing 1	0.016
LTBP1	latent transforming growth factor beta binding protein 1	0.016
S100B	S100 calcium binding protein B	0.016
LAMA4	laminin, alpha 4	0.016
CTSL1	cathepsin L1	0.016
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.016
CTHRC1	collagen triple helix repeat containing 1	0.016
TGFB3	transforming growth factor, beta 3	0.016
MAN2B1	mannosidase, alpha, class 2B, member 1	0.016
EXT2	exostosin 2	0.016
KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.016
FBN3	fibrillin 3	0.016
HGFAC	HGF activator	0.016
FMOD	fibromodulin	0.016
CTGF	connective tissue growth factor	0.016	Rat
GLT25D1	glycosyltransferase 25 domain containing 1	0.016
KDELR3	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3	0.016
SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	0.015	Human
EPHB2	EPH receptor B2	0.015
CD14	CD14 molecule	0.015
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.015
HEXB	hexosaminidase B (beta polypeptide)	0.015
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.015
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.015
OSMR	oncostatin M receptor	0.015
CCL11	chemokine (C-C motif) ligand 11	0.015
ANTXR1	anthrax toxin receptor 1	0.015
DOCK7	dedicator of cytokinesis 7	0.015
AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)	0.015	Human
AHSG	alpha-2-HS-glycoprotein	0.015
GEM	GTP binding protein overexpressed in skeletal muscle	0.015
MEP1A	meprin A, alpha (PABA peptide hydrolase)	0.015
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.015	Human Mouse Rat
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.014
WNT1	wingless-type MMTV integration site family, member 1	0.014	Human
SYNPO	synaptopodin	0.014
OLFML3	olfactomedin-like 3	0.014
WNT4	wingless-type MMTV integration site family, member 4	0.014
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.014
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.014
CALD1	caldesmon 1	0.014
TWIST1	twist homolog 1 (Drosophila)	0.014
LOXL1	lysyl oxidase-like 1	0.014
CLEC4A	C-type lectin domain family 4, member A	0.014
CLIC4	chloride intracellular channel 4	0.014
FGF1	fibroblast growth factor 1 (acidic)	0.014
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.014
BMP4	bone morphogenetic protein 4	0.014
GPR124	G protein-coupled receptor 124	0.014
SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.014
PRKCDBP	protein kinase C, delta binding protein	0.014
P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	0.014
CCNE1	cyclin E1	0.014
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.013
WNT5A	wingless-type MMTV integration site family, member 5A	0.013
CST2	cystatin SA	0.013	Human
MOXD1	monooxygenase, DBH-like 1	0.013
PYY	peptide YY	0.013
IGFBP4	insulin-like growth factor binding protein 4	0.013
ZNF431	zinc finger protein 431	0.013
BMP2	bone morphogenetic protein 2	0.013	Human
GLI3	GLI family zinc finger 3	0.013
VEGFC	vascular endothelial growth factor C	0.013
WNT7A	wingless-type MMTV integration site family, member 7A	0.013	Human
ZFYVE9	zinc finger, FYVE domain containing 9	0.013
PLAUR	plasminogen activator, urokinase receptor	0.013
DAZAP2	DAZ associated protein 2	0.013
FILIP1L	filamin A interacting protein 1-like	0.013
PLG	plasminogen	0.013
LAMB3	laminin, beta 3	0.013
TECPR1	tectonin beta-propeller repeat containing 1	0.013
DIO2	deiodinase, iodothyronine, type II	0.013
PPIC	peptidylprolyl isomerase C (cyclophilin C)	0.013
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.013
BCAR1	breast cancer anti-estrogen resistance 1	0.013
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.013
CXCL2	chemokine (C-X-C motif) ligand 2	0.012
SMO	smoothened homolog (Drosophila)	0.012
FCGRT	Fc fragment of IgG, receptor, transporter, alpha	0.012
A2M	alpha-2-macroglobulin	0.012
FGFR3	fibroblast growth factor receptor 3	0.012
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.012
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.012
BMP8A	bone morphogenetic protein 8a	0.012
CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)	0.012
BRAP	BRCA1 associated protein	0.012
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.012
P4HA2	prolyl 4-hydroxylase, alpha polypeptide II	0.012
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	0.012
PTK7	PTK7 protein tyrosine kinase 7	0.012
PARVA	parvin, alpha	0.012
SFRP2	secreted frizzled-related protein 2	0.012
TMEM45A	transmembrane protein 45A	0.012
EEF2K	eukaryotic elongation factor-2 kinase	0.012
LAMB2	laminin, beta 2 (laminin S)	0.012
TMSB4X	thymosin beta 4, X-linked	0.012
HES1	hairy and enhancer of split 1, (Drosophila)	0.012
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.011
COL8A2	collagen, type VIII, alpha 2	0.011
CSF3	colony stimulating factor 3 (granulocyte)	0.011
CST1	cystatin SN	0.011	Human
IL32	interleukin 32	0.011
HEG1	HEG homolog 1 (zebrafish)	0.011
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.011
KIAA1199	KIAA1199	0.011
PDE4DIP	phosphodiesterase 4D interacting protein	0.011
COPZ2	coatomer protein complex, subunit zeta 2	0.011
FGFR2	fibroblast growth factor receptor 2	0.011
TSPAN9	tetraspanin 9	0.011
DMWD	dystrophia myotonica, WD repeat containing	0.011
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.011
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	0.011
HTRA1	HtrA serine peptidase 1	0.011
CCNA1	cyclin A1	0.011
EGLN1	egl nine homolog 1 (C. elegans)	0.011
LGMN	legumain	0.011
ITGB5	integrin, beta 5	0.011	Human
ANXA5	annexin A5	0.011
IHH	Indian hedgehog	0.011
WIF1	WNT inhibitory factor 1	0.011
ITIH3	inter-alpha (globulin) inhibitor H3	0.011
FGF4	fibroblast growth factor 4	0.011
C1S	complement component 1, s subcomponent	0.011
ARSE	arylsulfatase E (chondrodysplasia punctata 1)	0.011
TPSD1	tryptase delta 1	0.011
TF	transferrin	0.011
HRH1	histamine receptor H1	0.011
CRELD2	cysteine-rich with EGF-like domains 2	0.011
CSPG4	chondroitin sulfate proteoglycan 4	0.011
TMEM176B	transmembrane protein 176B	0.010
COL8A1	collagen, type VIII, alpha 1	0.010
PROCR	protein C receptor, endothelial	0.010
CXCL14	chemokine (C-X-C motif) ligand 14	0.010
PDCD1	programmed cell death 1	0.010
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.010
PRRX1	paired related homeobox 1	0.010
FBN2	fibrillin 2	0.010
PDLIM4	PDZ and LIM domain 4	0.010
COL12A1	collagen, type XII, alpha 1	0.010
DLC1	deleted in liver cancer 1	0.010
KRT17	keratin 17	0.010
PMEPA1	prostate transmembrane protein, androgen induced 1	0.010
ESM1	endothelial cell-specific molecule 1	0.010
EGLN3	egl nine homolog 3 (C. elegans)	0.010
NOG	noggin	0.010
CLDN1	claudin 1	0.010
NTM	neurotrimin	0.010
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.010
SLIT2	slit homolog 2 (Drosophila)	0.010