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Process View

Homo sapiens

2 genes annotated in human

lens morphogenesis in camera type eye

GO:0002089

The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lens morphogenesis in camera type eye"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lens morphogenesis in camera type eye" (in gray)

Name	Description	Probability	Func Analog Organism
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.988
SP1	Sp1 transcription factor	0.985
SMAD4	SMAD family member 4	0.974
SMAD3	SMAD family member 3	0.934
CREBBP	CREB binding protein	0.889
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.888
EP300	E1A binding protein p300	0.877
ENG	endoglin	0.835
PBX1	pre-B-cell leukemia homeobox 1	0.800
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.742	Mouse
PVRL4	poliovirus receptor-related 4	0.567
SKIL	SKI-like oncogene	0.551
HNF4A	hepatocyte nuclear factor 4, alpha	0.524
PXN	paxillin	0.514
CTGF	connective tissue growth factor	0.507
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.467
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.451
DCAF7	DDB1 and CUL4 associated factor 7	0.420
RUNX1	runt-related transcription factor 1	0.396
HCFC1	host cell factor C1 (VP16-accessory protein)	0.381
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.357
EFNA1	ephrin-A1	0.333
SMAD2	SMAD family member 2	0.333
SMAD1	SMAD family member 1	0.249
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.231
TACC1	transforming, acidic coiled-coil containing protein 1	0.194
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.160	Mouse
ZFYVE9	zinc finger, FYVE domain containing 9	0.159
BTRC	beta-transducin repeat containing	0.159
FBLN1	fibulin 1	0.150
FGF1	fibroblast growth factor 1 (acidic)	0.147
POU5F1	POU class 5 homeobox 1	0.140
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.122
MEIS2	Meis homeobox 2	0.122
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.118
SREBF2	sterol regulatory element binding transcription factor 2	0.116
SH3BP4	SH3-domain binding protein 4	0.108
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.107
TCF4	transcription factor 4	0.107
HTT	huntingtin	0.100
KCTD1	potassium channel tetramerisation domain containing 1	0.098
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.096	Mouse
PVRL3	poliovirus receptor-related 3	0.093	Mouse
APC	adenomatous polyposis coli	0.088
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.088
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.085
VCL	vinculin	0.081
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.079
PDLIM5	PDZ and LIM domain 5	0.077
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.074
HIPK2	homeodomain interacting protein kinase 2	0.074	Mouse
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.073
FHL2	four and a half LIM domains 2	0.066
BCAR1	breast cancer anti-estrogen resistance 1	0.066
TRIM33	tripartite motif containing 33	0.064
PML	promyelocytic leukemia	0.063
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.062
ZYX	zyxin	0.061
SALL2	sal-like 2 (Drosophila)	0.060
ACTN1	actinin, alpha 1	0.059
FGFR2	fibroblast growth factor receptor 2	0.059
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.052
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.050
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.050
IGFBP3	insulin-like growth factor binding protein 3	0.048
EPAS1	endothelial PAS domain protein 1	0.048
FOXD3	forkhead box D3	0.043
FLNA	filamin A, alpha	0.041
IPO13	importin 13	0.040
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.038
FERMT2	fermitin family member 2	0.038
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.037
TGFB1	transforming growth factor, beta 1	0.036
BCR	breakpoint cluster region	0.034
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.034
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.034
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.034
TP53	tumor protein p53	0.033
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.032
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.032
CSNK1D	casein kinase 1, delta	0.031
CYR61	cysteine-rich, angiogenic inducer, 61	0.028
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.028
GLIS2	GLIS family zinc finger 2	0.028
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.027
LHX2	LIM homeobox 2	0.027
EPHB3	EPH receptor B3	0.027
YY1	YY1 transcription factor	0.027
PAX6	paired box 6	0.026	Zebrafish
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.026
HSPG2	heparan sulfate proteoglycan 2	0.026
PTK2	PTK2 protein tyrosine kinase 2	0.026	Zebrafish
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.025
SOX2	SRY (sex determining region Y)-box 2	0.025	Mouse
FBXW11	F-box and WD repeat domain containing 11	0.025
TJP1	tight junction protein 1 (zona occludens 1)	0.024
THBS1	thrombospondin 1	0.023
EPHB2	EPH receptor B2	0.023
MYH10	myosin, heavy chain 10, non-muscle	0.023
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.023
EGR1	early growth response 1	0.023
EPHA7	EPH receptor A7	0.022
LMO2	LIM domain only 2 (rhombotin-like 1)	0.022
TLN1	talin 1	0.022
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.022
CNOT4	CCR4-NOT transcription complex, subunit 4	0.021
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.021
MRAS	muscle RAS oncogene homolog	0.021
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.020
AHNAK	AHNAK nucleoprotein	0.020
GLUL	glutamate-ammonia ligase	0.020
CREB1	cAMP responsive element binding protein 1	0.020
CTBP2	C-terminal binding protein 2	0.020
TGFBR1	transforming growth factor, beta receptor 1	0.020
CXXC5	CXXC finger protein 5	0.020
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.020
AR	androgen receptor	0.019
POU3F2	POU class 3 homeobox 2	0.019
GLI3	GLI family zinc finger 3	0.019
ITGA6	integrin, alpha 6	0.019
ATF7IP	activating transcription factor 7 interacting protein	0.019
CDX2	caudal type homeobox 2	0.018
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.018
ZBTB4	zinc finger and BTB domain containing 4	0.018
PPL	periplakin	0.018
KRT8	keratin 8	0.018
CD63	CD63 molecule	0.017
SDC2	syndecan 2	0.017
ITGB5	integrin, beta 5	0.017
DEDD	death effector domain containing	0.017
HEMGN	hemogen	0.017
DIAPH1	diaphanous homolog 1 (Drosophila)	0.017
PKP4	plakophilin 4	0.017
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.016
CUL9	cullin 9	0.016
GSK3B	glycogen synthase kinase 3 beta	0.016
PIAS1	protein inhibitor of activated STAT, 1	0.016
NKAP	NFKB activating protein	0.016
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.016
LEF1	lymphoid enhancer-binding factor 1	0.016
PCBP2	poly(rC) binding protein 2	0.015
YAP1	Yes-associated protein 1	0.015
TP73	tumor protein p73	0.015
FSTL1	follistatin-like 1	0.015
USP42	ubiquitin specific peptidase 42	0.015
ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	0.015
FOSL1	FOS-like antigen 1	0.015
BMP2	bone morphogenetic protein 2	0.015
CHERP	calcium homeostasis endoplasmic reticulum protein	0.014
CD9	CD9 molecule	0.014
HES1	hairy and enhancer of split 1, (Drosophila)	0.014
DACH1	dachshund homolog 1 (Drosophila)	0.014
CHMP4B	chromatin modifying protein 4B	0.014
FLNB	filamin B, beta	0.014
ZNF331	zinc finger protein 331	0.014
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.014
ITGB1BP1	integrin beta 1 binding protein 1	0.014
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.014
MCM3AP	minichromosome maintenance complex component 3 associated protein	0.014
JUP	junction plakoglobin	0.014
ELF4	E74-like factor 4 (ets domain transcription factor)	0.014
HOXA9	homeobox A9	0.013
TAL1	T-cell acute lymphocytic leukemia 1	0.013
FOXO3	forkhead box O3	0.013
NOTCH1	notch 1	0.013
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.013
SMAD7	SMAD family member 7	0.013
AMOTL2	angiomotin like 2	0.013
GAB1	GRB2-associated binding protein 1	0.013
PHF12	PHD finger protein 12	0.013
ANXA1	annexin A1	0.013
NLK	nemo-like kinase	0.013
EPHB6	EPH receptor B6	0.013
PIAS2	protein inhibitor of activated STAT, 2	0.013
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.013
SOX9	SRY (sex determining region Y)-box 9	0.013
HNF1A	HNF1 homeobox A	0.013
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.013
PIAS3	protein inhibitor of activated STAT, 3	0.012
LRP6	low density lipoprotein receptor-related protein 6	0.012
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.012
FOXG1	forkhead box G1	0.012
ZFP106	zinc finger protein 106 homolog (mouse)	0.012
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.012
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.012
TGFB2	transforming growth factor, beta 2	0.012
SERTAD1	SERTA domain containing 1	0.012
PSEN1	presenilin 1	0.012
FMNL2	formin-like 2	0.011
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.011
MEF2C	myocyte enhancer factor 2C	0.011
LGALS1	lectin, galactoside-binding, soluble, 1	0.011
POU3F1	POU class 3 homeobox 1	0.011
BMP7	bone morphogenetic protein 7	0.011
TNC	tenascin C	0.011
ATXN2	ataxin 2	0.011
HOXB7	homeobox B7	0.011
FGFR1	fibroblast growth factor receptor 1	0.011
PLAGL1	pleiomorphic adenoma gene-like 1	0.011
PTPRF	protein tyrosine phosphatase, receptor type, F	0.011
SALL1	sal-like 1 (Drosophila)	0.011
BRD4	bromodomain containing 4	0.011
FGF9	fibroblast growth factor 9 (glia-activating factor)	0.011
NKX2-2	NK2 homeobox 2	0.011
JMY	junction mediating and regulatory protein, p53 cofactor	0.011
SIX3	SIX homeobox 3	0.011
MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	0.011
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.011
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.011
GLI2	GLI family zinc finger 2	0.011
TNIK	TRAF2 and NCK interacting kinase	0.011
HIC1	hypermethylated in cancer 1	0.011
DUSP10	dual specificity phosphatase 10	0.010
ERRFI1	ERBB receptor feedback inhibitor 1	0.010
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.010
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.010
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.010
NCOA6	nuclear receptor coactivator 6	0.010
PTK7	PTK7 protein tyrosine kinase 7	0.010
CCDC17	coiled-coil domain containing 17	0.010
MACF1	microtubule-actin crosslinking factor 1	0.010
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.010
PROX1	prospero homeobox 1	0.010
ING2	inhibitor of growth family, member 2	0.010
ZBED5	zinc finger, BED-type containing 5	0.010
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.010
FOXC1	forkhead box C1	0.010
MYST1	MYST histone acetyltransferase 1	0.010