IMP

Process View

Homo sapiens

20 genes annotated in human

interleukin 2 production

The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "interleukin 2 production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "interleukin 2 production" (in gray)

Name	Description	Probability	Func Analog Organism
BIRC3	baculoviral IAP repeat containing 3	0.997
IL1B	interleukin 1, beta	0.984
TRAF6	TNF receptor-associated factor 6	0.974
TRAF1	TNF receptor-associated factor 1	0.963	Human
CCL4	chemokine (C-C motif) ligand 4	0.935	Human
TRAF3	TNF receptor-associated factor 3	0.933	Human
IL1R1	interleukin 1 receptor, type I	0.932
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.879
HDAC7	histone deacetylase 7	0.862
CD80	CD80 molecule	0.815
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.814
CD40	CD40 molecule, TNF receptor superfamily member 5	0.763
TRAF2	TNF receptor-associated factor 2	0.742
CCR5	chemokine (C-C motif) receptor 5	0.695
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.498
CD86	CD86 molecule	0.469
IL2RB	interleukin 2 receptor, beta	0.395
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.394
IL1R2	interleukin 1 receptor, type II	0.328
CXCL9	chemokine (C-X-C motif) ligand 9	0.317
TNF	tumor necrosis factor	0.313
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.306
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.273
IL6	interleukin 6 (interferon, beta 2)	0.268
RIPK2	receptor-interacting serine-threonine kinase 2	0.222	Mouse
TANK	TRAF family member-associated NFKB activator	0.211
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.208
CCR7	chemokine (C-C motif) receptor 7	0.206
IL8	interleukin 8	0.203
PRKD2	protein kinase D2	0.185	Mouse
CXCL10	chemokine (C-X-C motif) ligand 10	0.165
BCL10	B-cell CLL/lymphoma 10	0.163
ZMYND11	zinc finger, MYND-type containing 11	0.153
CCL2	chemokine (C-C motif) ligand 2	0.153	Human
CCL8	chemokine (C-C motif) ligand 8	0.152	Human
TRIM21	tripartite motif containing 21	0.116	Human
MED15	mediator complex subunit 15	0.114
BCAR1	breast cancer anti-estrogen resistance 1	0.112
ICAM1	intercellular adhesion molecule 1	0.109
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.105
INSR	insulin receptor	0.101
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.101
TRIM39	tripartite motif containing 39	0.101	Human
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.100
IRF9	interferon regulatory factor 9	0.100
FOXP3	forkhead box P3	0.099
SOD2	superoxide dismutase 2, mitochondrial	0.096
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.095
BIRC2	baculoviral IAP repeat containing 2	0.089
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.085
NCOR1	nuclear receptor corepressor 1	0.085
CCL20	chemokine (C-C motif) ligand 20	0.081	Human
PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like	0.080
CD2	CD2 molecule	0.079
CD69	CD69 molecule	0.078
DAXX	death-domain associated protein	0.075
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.073
TICAM2	toll-like receptor adaptor molecule 2	0.071
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.070
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.067
MEF2C	myocyte enhancer factor 2C	0.066
CD83	CD83 molecule	0.062	Mouse
PML	promyelocytic leukemia	0.062
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.061
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.060	Human
CCL22	chemokine (C-C motif) ligand 22	0.054	Human
LAT	linker for activation of T cells	0.053
IDE	insulin-degrading enzyme	0.051
HDAC9	histone deacetylase 9	0.051	Human
IL7R	interleukin 7 receptor	0.051
ZNF263	zinc finger protein 263	0.048
CCL13	chemokine (C-C motif) ligand 13	0.048	Human
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.047
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.045
ARIH2	ariadne homolog 2 (Drosophila)	0.044
GRAP2	GRB2-related adaptor protein 2	0.044
CCL5	chemokine (C-C motif) ligand 5	0.044	Human
CXCL3	chemokine (C-X-C motif) ligand 3	0.044
TICAM1	toll-like receptor adaptor molecule 1	0.042
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.041
CXCL2	chemokine (C-X-C motif) ligand 2	0.039
IRF1	interferon regulatory factor 1	0.039	Human
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.039
RIPK3	receptor-interacting serine-threonine kinase 3	0.038
IL10	interleukin 10	0.038
TRADD	TNFRSF1A-associated via death domain	0.038
IL10RA	interleukin 10 receptor, alpha	0.036
BCL6	B-cell CLL/lymphoma 6	0.036
CCL3	chemokine (C-C motif) ligand 3	0.034	Human
ATXN1	ataxin 1	0.033
TRIM32	tripartite motif containing 32	0.033
CCR4	chemokine (C-C motif) receptor 4	0.033
IFNG	interferon, gamma	0.032
DPP4	dipeptidyl-peptidase 4	0.030
CXCL13	chemokine (C-X-C motif) ligand 13	0.030
TRIM26	tripartite motif containing 26	0.030
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.029
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.029	Human
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.029
CD28	CD28 molecule	0.028
TRIM17	tripartite motif containing 17	0.028	Human
HECTD1	HECT domain containing 1	0.027
XIAP	X-linked inhibitor of apoptosis	0.027
CXCL11	chemokine (C-X-C motif) ligand 11	0.027
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.026
MAPK8	mitogen-activated protein kinase 8	0.026
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.026
GHR	growth hormone receptor	0.025
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.025
KAT5	K(lysine) acetyltransferase 5	0.024
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.024
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.024
IRF8	interferon regulatory factor 8	0.024	Human
STAP2	signal transducing adaptor family member 2	0.024
TRIM43	tripartite motif containing 43	0.024
NUMBL	numb homolog (Drosophila)-like	0.023
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.023
IL1RN	interleukin 1 receptor antagonist	0.022	Human
JAK2	Janus kinase 2	0.021
WDR5	WD repeat domain 5	0.021
TNFRSF4	tumor necrosis factor receptor superfamily, member 4	0.021
IRAK2	interleukin-1 receptor-associated kinase 2	0.020
CXCL5	chemokine (C-X-C motif) ligand 5	0.020
SLAMF7	SLAM family member 7	0.020
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.020
CCL7	chemokine (C-C motif) ligand 7	0.020	Human
CD247	CD247 molecule	0.020
SFN	stratifin	0.020
CD48	CD48 molecule	0.019
CDK11B	cyclin-dependent kinase 11B	0.019
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.019
TRIM5	tripartite motif containing 5	0.019	Human
PIAS4	protein inhibitor of activated STAT, 4	0.019
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.018
IRF2BP2	interferon regulatory factor 2 binding protein 2	0.017
SLAMF1	signaling lymphocytic activation molecule family member 1	0.017
IRF4	interferon regulatory factor 4	0.017
MEF2A	myocyte enhancer factor 2A	0.017
SMAD1	SMAD family member 1	0.017
ZNF473	zinc finger protein 473	0.017
TRIM34	tripartite motif containing 34	0.017
SQSTM1	sequestosome 1	0.016
LCK	lymphocyte-specific protein tyrosine kinase	0.016
FPR3	formyl peptide receptor 3	0.015
C9orf89	chromosome 9 open reading frame 89	0.015
EGFR	epidermal growth factor receptor	0.015
STAT4	signal transducer and activator of transcription 4	0.015
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.015
STRN	striatin, calmodulin binding protein	0.015
RUNX3	runt-related transcription factor 3	0.015
TRAF3IP2	TRAF3 interacting protein 2	0.015
RGS1	regulator of G-protein signaling 1	0.015
CCR1	chemokine (C-C motif) receptor 1	0.015
ADAMDEC1	ADAM-like, decysin 1	0.014
NCOR2	nuclear receptor corepressor 2	0.014
TRAF5	TNF receptor-associated factor 5	0.014	Human
RIN1	Ras and Rab interactor 1	0.014
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.014
FAS	Fas (TNF receptor superfamily, member 6)	0.014
CCL19	chemokine (C-C motif) ligand 19	0.013	Human
IL15RA	interleukin 15 receptor, alpha	0.013
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.013
SELE	selectin E	0.013
LY86	lymphocyte antigen 86	0.013
ING1	inhibitor of growth family, member 1	0.012
CCL1	chemokine (C-C motif) ligand 1	0.012	Human
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.012
CXCR4	chemokine (C-X-C motif) receptor 4	0.012
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.012
HIPK2	homeodomain interacting protein kinase 2	0.012
CSF1	colony stimulating factor 1 (macrophage)	0.012
LAMP3	lysosomal-associated membrane protein 3	0.012
CCL11	chemokine (C-C motif) ligand 11	0.012	Human
SNAPIN	SNAP-associated protein	0.011
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.011
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.011
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.011
IRAK1	interleukin-1 receptor-associated kinase 1	0.011
CCR3	chemokine (C-C motif) receptor 3	0.011
GLRX3	glutaredoxin 3	0.011
IFI16	interferon, gamma-inducible protein 16	0.011
UBD	ubiquitin D	0.010
CH25H	cholesterol 25-hydroxylase	0.010
DARC	Duffy blood group, chemokine receptor	0.010
RRBP1	ribosome binding protein 1 homolog 180kDa (dog)	0.010
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.010
RNASE6	ribonuclease, RNase A family, k6	0.010
PRDM1	PR domain containing 1, with ZNF domain	0.010
PPIE	peptidylprolyl isomerase E (cyclophilin E)	0.010
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.010
TRAT1	T cell receptor associated transmembrane adaptor 1	0.010