IMP

Process View

Homo sapiens

29 genes annotated in human

Multi-species View

negative regulation of dna replication

GO:0008156

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of dna replication"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of dna replication" (in gray)

Name	Description	Probability	Func Analog Organism
SMC1A	structural maintenance of chromosomes 1A	0.985
STAG2	stromal antigen 2	0.982
STAG1	stromal antigen 1	0.980	Human
WAPAL	wings apart-like homolog (Drosophila)	0.976
RAD21	RAD21 homolog (S. pombe)	0.952
SMC3	structural maintenance of chromosomes 3	0.952
NBN	nibrin	0.892
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.863
RBL2	retinoblastoma-like 2 (p130)	0.861	Fly
RAD50	RAD50 homolog (S. cerevisiae)	0.719
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.702
PDS5A	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.680
PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.655	Human
BRCA1	breast cancer 1, early onset	0.594
RB1	retinoblastoma 1	0.554
TERF2	telomeric repeat binding factor 2	0.532	Human
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.474
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.431
ATM	ataxia telangiectasia mutated	0.347
CDK2	cyclin-dependent kinase 2	0.345
TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	0.334
RFC1	replication factor C (activator 1) 1, 145kDa	0.306
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.296
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.246
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.235
ENG	endoglin	0.190
RBBP8	retinoblastoma binding protein 8	0.176
RBL1	retinoblastoma-like 1 (p107)	0.161	Fly
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.147
CNOT2	CCR4-NOT transcription complex, subunit 2	0.126
CCNE1	cyclin E1	0.122
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.116
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.115
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.115
EZR	ezrin	0.112	Human
C17orf28	chromosome 17 open reading frame 28	0.110
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.099
MMS22L	MMS22-like, DNA repair protein	0.094
INSR	insulin receptor	0.093
SCHIP1	schwannomin interacting protein 1	0.092
TBC1D10A	TBC1 domain family, member 10A	0.079
E2F5	E2F transcription factor 5, p130-binding	0.079	Fly
WRN	Werner syndrome, RecQ helicase-like	0.075
CNOT7	CCR4-NOT transcription complex, subunit 7	0.074
INO80B	INO80 complex subunit B	0.074
LIN9	lin-9 homolog (C. elegans)	0.068
ACD	adrenocortical dysplasia homolog (mouse)	0.068
SKP2	S-phase kinase-associated protein 2 (p45)	0.064
ORC2	origin recognition complex, subunit 2	0.061
CCDC6	coiled-coil domain containing 6	0.060
CNOT1	CCR4-NOT transcription complex, subunit 1	0.059
FSTL1	follistatin-like 1	0.057
LARP7	La ribonucleoprotein domain family, member 7	0.056
LIN54	lin-54 homolog (C. elegans)	0.055
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.054
SSU72	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0.053
RAD9A	RAD9 homolog A (S. pombe)	0.053
EP300	E1A binding protein p300	0.052
TGFB1	transforming growth factor, beta 1	0.049
JUB	jub, ajuba homolog (Xenopus laevis)	0.048
SORBS1	sorbin and SH3 domain containing 1	0.048
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.043
BLM	Bloom syndrome, RecQ helicase-like	0.042
FANCD2	Fanconi anemia, complementation group D2	0.040
NUP153	nucleoporin 153kDa	0.039
HIPK2	homeodomain interacting protein kinase 2	0.038
DEK	DEK oncogene	0.036
BTRC	beta-transducin repeat containing	0.036
CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit	0.034
E2F1	E2F transcription factor 1	0.034
TGFB3	transforming growth factor, beta 3	0.034
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.034
RIF1	RAP1 interacting factor homolog (yeast)	0.033
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.033
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.033
MYH9	myosin, heavy chain 9, non-muscle	0.032
CUL1	cullin 1	0.031
RAD1	RAD1 homolog (S. pombe)	0.030
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.030
AFF1	AF4/FMR2 family, member 1	0.030
AFF4	AF4/FMR2 family, member 4	0.030
NRP1	neuropilin 1	0.029
RAD17	RAD17 homolog (S. pombe)	0.029
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.029
CNOT8	CCR4-NOT transcription complex, subunit 8	0.028
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.027
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.026
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.026
DAXX	death-domain associated protein	0.025
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.025
RHOA	ras homolog gene family, member A	0.025
MSN	moesin	0.025	Human
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.024
CCNT1	cyclin T1	0.024
CKS2	CDC28 protein kinase regulatory subunit 2	0.023
TAF1A	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	0.023
BANP	BTG3 associated nuclear protein	0.023
E2F4	E2F transcription factor 4, p107/p130-binding	0.023	Fly
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.022
ANAPC4	anaphase promoting complex subunit 4	0.022
TAF1B	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	0.022
EGR1	early growth response 1	0.021
TGFBR3	transforming growth factor, beta receptor III	0.021
RHOG	ras homolog gene family, member G (rho G)	0.020
ENPP5	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	0.020	Human
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.020
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.020
DDX21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	0.019
BRCA2	breast cancer 2, early onset	0.019	Mouse
TP53BP1	tumor protein p53 binding protein 1	0.019
TONSL	tonsoku-like, DNA repair protein	0.018
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.018
HDAC1	histone deacetylase 1	0.018
LIN52	lin-52 homolog (C. elegans)	0.018
EIF3A	eukaryotic translation initiation factor 3, subunit A	0.017
BTG2	BTG family, member 2	0.017
POT1	protection of telomeres 1 homolog (S. pombe)	0.017
SETD7	SET domain containing (lysine methyltransferase) 7	0.017
TOP3A	topoisomerase (DNA) III alpha	0.017
FBXW11	F-box and WD repeat domain containing 11	0.017
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.016
TOPBP1	topoisomerase (DNA) II binding protein 1	0.016
SORBS3	sorbin and SH3 domain containing 3	0.016
IPO4	importin 4	0.016
HEXIM1	hexamethylene bis-acetamide inducible 1	0.016
IQGAP1	IQ motif containing GTPase activating protein 1	0.016
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.016
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.015
NF2	neurofibromin 2 (merlin)	0.015
FBXW2	F-box and WD repeat domain containing 2	0.015
THBS1	thrombospondin 1	0.015
RRN3	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	0.014
E2F2	E2F transcription factor 2	0.014
SH2B1	SH2B adaptor protein 1	0.014
ADRB2	adrenergic, beta-2-, receptor, surface	0.014
RHOC	ras homolog gene family, member C	0.013
ENPP4	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)	0.013	Human
S100A2	S100 calcium binding protein A2	0.013
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.013
FBXO4	F-box protein 4	0.013
MYST1	MYST histone acetyltransferase 1	0.013
NCL	nucleolin	0.012
CASP8AP2	caspase 8 associated protein 2	0.012
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.012
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.012
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.012
MAPK12	mitogen-activated protein kinase 12	0.012
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.012
RINT1	RAD50 interactor 1	0.012
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.012
ACTN1	actinin, alpha 1	0.011
ZNF217	zinc finger protein 217	0.011
AMOT	angiomotin	0.011
ATR	ataxia telangiectasia and Rad3 related	0.011
CD44	CD44 molecule (Indian blood group)	0.011
RBBP4	retinoblastoma binding protein 4	0.011
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.011
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.011
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.011
YRDC	yrdC domain containing (E. coli)	0.011
EDC4	enhancer of mRNA decapping 4	0.010
CNOT10	CCR4-NOT transcription complex, subunit 10	0.010
MSH3	mutS homolog 3 (E. coli)	0.010
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.010
LIN37	lin-37 homolog (C. elegans)	0.010
DCLRE1A	DNA cross-link repair 1A	0.010
S100B	S100 calcium binding protein B	0.010