IMP

Process View

Homo sapiens

26 genes annotated in human

endothelial cell apoptotic process

Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endothelial cell apoptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endothelial cell apoptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
TEK	TEK tyrosine kinase, endothelial	0.973	Mouse
TAL1	T-cell acute lymphocytic leukemia 1	0.936
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.929
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.794	Human
SQSTM1	sequestosome 1	0.786
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.685
FAS	Fas (TNF receptor superfamily, member 6)	0.652
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.634
CFLAR	CASP8 and FADD-like apoptosis regulator	0.589
CDH5	cadherin 5, type 2 (vascular endothelium)	0.589
FGB	fibrinogen beta chain	0.551
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.531	Human
TRADD	TNFRSF1A-associated via death domain	0.479
COL4A2	collagen, type IV, alpha 2	0.469	Human
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.423
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.396
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.392
COL4A1	collagen, type IV, alpha 1	0.382	Human
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.349
TRAF1	TNF receptor-associated factor 1	0.347
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.330
FGA	fibrinogen alpha chain	0.316
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.303
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.276
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.233
ANGPT2	angiopoietin 2	0.229	Human
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.225
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.220
PLAU	plasminogen activator, urokinase	0.204
TRAF6	TNF receptor-associated factor 6	0.197
KEAP1	kelch-like ECH-associated protein 1	0.194
TRAF5	TNF receptor-associated factor 5	0.190
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.183
TRAF3	TNF receptor-associated factor 3	0.183
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.179
NOXA1	NADPH oxidase activator 1	0.177
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.163
AXL	AXL receptor tyrosine kinase	0.158
PRKCZ	protein kinase C, zeta	0.153	Human
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.138
PLAT	plasminogen activator, tissue	0.135
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.132
PML	promyelocytic leukemia	0.128
BIRC3	baculoviral IAP repeat containing 3	0.121
FADD	Fas (TNFRSF6)-associated via death domain	0.114
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.112
TRAF2	TNF receptor-associated factor 2	0.104
FGG	fibrinogen gamma chain	0.103
TNF	tumor necrosis factor	0.102
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.098
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.097
COL4A4	collagen, type IV, alpha 4	0.084	Human
PTPRB	protein tyrosine phosphatase, receptor type, B	0.082
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.080
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.074
MAP2K5	mitogen-activated protein kinase kinase 5	0.072
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.071
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.071
FYB	FYN binding protein	0.066
S100B	S100 calcium binding protein B	0.066
TNIP1	TNFAIP3 interacting protein 1	0.065
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.064
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.061
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.061
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.061
VIM	vimentin	0.056
ZMYND11	zinc finger, MYND-type containing 11	0.054
CRP	C-reactive protein, pentraxin-related	0.050
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.049
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.049
TOX4	TOX high mobility group box family member 4	0.047
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.047	Human
PGF	placental growth factor	0.046
COL4A5	collagen, type IV, alpha 5	0.045	Human
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.045
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.045
NUMB	numb homolog (Drosophila)	0.045
PLAUR	plasminogen activator, urokinase receptor	0.044
ZNF71	zinc finger protein 71	0.043
ANGPT1	angiopoietin 1	0.042
TNIP2	TNFAIP3 interacting protein 2	0.040
VEGFA	vascular endothelial growth factor A	0.040
PDGFA	platelet-derived growth factor alpha polypeptide	0.039
COL5A1	collagen, type V, alpha 1	0.039
FGFR1	fibroblast growth factor receptor 1	0.038
VEGFC	vascular endothelial growth factor C	0.038
LIMD1	LIM domains containing 1	0.037
SPHK1	sphingosine kinase 1	0.036
SMAD3	SMAD family member 3	0.034
SIAH1	seven in absentia homolog 1 (Drosophila)	0.034
BCAR1	breast cancer anti-estrogen resistance 1	0.033
LRP1	low density lipoprotein receptor-related protein 1	0.033
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.032
RUNX1	runt-related transcription factor 1	0.031
CDCP1	CUB domain containing protein 1	0.030
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.030
NID1	nidogen 1	0.029
NID2	nidogen 2 (osteonidogen)	0.028
KITLG	KIT ligand	0.028
TBX5	T-box 5	0.028
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.028
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.028
A2M	alpha-2-macroglobulin	0.027
TTR	transthyretin	0.027
CCDC115	coiled-coil domain containing 115	0.027
BGN	biglycan	0.027
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.027
KIAA1377	KIAA1377	0.027
KLF13	Kruppel-like factor 13	0.027
SH3RF1	SH3 domain containing ring finger 1	0.026
ZHX1	zinc fingers and homeoboxes 1	0.026
PECAM1	platelet/endothelial cell adhesion molecule	0.025
VHL	von Hippel-Lindau tumor suppressor	0.025
RIPK2	receptor-interacting serine-threonine kinase 2	0.025
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.024	Human
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.024	Human
LAT	linker for activation of T cells	0.024
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.024
PRKCE	protein kinase C, epsilon	0.024
COL4A6	collagen, type IV, alpha 6	0.023	Human
CD40	CD40 molecule, TNF receptor superfamily member 5	0.023
SMG1	SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)	0.023
FLT4	fms-related tyrosine kinase 4	0.023	Human
DAXX	death-domain associated protein	0.023
IL32	interleukin 32	0.023
RARA	retinoic acid receptor, alpha	0.023
NMT2	N-myristoyltransferase 2	0.023
CALCRL	calcitonin receptor-like	0.023
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.022
DCAF7	DDB1 and CUL4 associated factor 7	0.021
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.021
CD34	CD34 molecule	0.021
BHLHE40	basic helix-loop-helix family, member e40	0.021
IRF1	interferon regulatory factor 1	0.021
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.021
PCOLCE	procollagen C-endopeptidase enhancer	0.021
COL6A2	collagen, type VI, alpha 2	0.020
ORM1	orosomucoid 1	0.020
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.020
XIAP	X-linked inhibitor of apoptosis	0.020
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.020
PDGFC	platelet derived growth factor C	0.019
FYN	FYN oncogene related to SRC, FGR, YES	0.019
C1orf93	chromosome 1 open reading frame 93	0.019
LAPTM5	lysosomal protein transmembrane 5	0.018
PXDN	peroxidasin homolog (Drosophila)	0.018
PRKCA	protein kinase C, alpha	0.017
THBS1	thrombospondin 1	0.017
CAV1	caveolin 1, caveolae protein, 22kDa	0.017
APOA1	apolipoprotein A-I	0.017
CYBA	cytochrome b-245, alpha polypeptide	0.017
CCL14	chemokine (C-C motif) ligand 14	0.017
GLUL	glutamate-ammonia ligase	0.016
FABP4	fatty acid binding protein 4, adipocyte	0.016
OSMR	oncostatin M receptor	0.016
TIMP3	TIMP metallopeptidase inhibitor 3	0.016
ACTB	actin, beta	0.016
FRZB	frizzled-related protein	0.016
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.016
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.016	Human
MCAM	melanoma cell adhesion molecule	0.016
TECPR1	tectonin beta-propeller repeat containing 1	0.016
COL16A1	collagen, type XVI, alpha 1	0.016
LIMK2	LIM domain kinase 2	0.016
PLXDC1	plexin domain containing 1	0.015
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.015
TBX2	T-box 2	0.015
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.015
FBN1	fibrillin 1	0.015
STK10	serine/threonine kinase 10	0.014
PICK1	protein interacting with PRKCA 1	0.014
KSR1	kinase suppressor of ras 1	0.014
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.013
RIN1	Ras and Rab interactor 1	0.013
VTN	vitronectin	0.013
F2	coagulation factor II (thrombin)	0.013
COL1A2	collagen, type I, alpha 2	0.013
MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)	0.013
ZC3H12A	zinc finger CCCH-type containing 12A	0.013
F11R	F11 receptor	0.013
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.013
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.013
PDPK1	3-phosphoinositide dependent protein kinase-1	0.013
MSN	moesin	0.012
COL6A1	collagen, type VI, alpha 1	0.012
ALB	albumin	0.012
SPRR2A	small proline-rich protein 2A	0.012
TICAM1	toll-like receptor adaptor molecule 1	0.012
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.012
CD44	CD44 molecule (Indian blood group)	0.012
GJA4	gap junction protein, alpha 4, 37kDa	0.012
ZBTB16	zinc finger and BTB domain containing 16	0.012
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.012
SIAH2	seven in absentia homolog 2 (Drosophila)	0.012
PLXND1	plexin D1	0.012
RYBP	RING1 and YY1 binding protein	0.012
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.012
STK11	serine/threonine kinase 11	0.011
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.011
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.011
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.011
AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	0.011	Human
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.011
BCL3	B-cell CLL/lymphoma 3	0.011
CD14	CD14 molecule	0.011
ACTN1	actinin, alpha 1	0.011
PLCG1	phospholipase C, gamma 1	0.011
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.011
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.011	Human
ACVRL1	activin A receptor type II-like 1	0.011
ICAM1	intercellular adhesion molecule 1	0.011
CD97	CD97 molecule	0.011
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.011
LMO4	LIM domain only 4	0.011
AEBP1	AE binding protein 1	0.011
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.011
TRMT2A	TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)	0.011
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.011
PCDH12	protocadherin 12	0.011
IGFBP5	insulin-like growth factor binding protein 5	0.011
SORBS2	sorbin and SH3 domain containing 2	0.011
BAG1	BCL2-associated athanogene	0.010
CLDN5	claudin 5	0.010
COL3A1	collagen, type III, alpha 1	0.010
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.010
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.010
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.010
SLA	Src-like-adaptor	0.010
TFPI2	tissue factor pathway inhibitor 2	0.010
MYH9	myosin, heavy chain 9, non-muscle	0.010
SHANK3	SH3 and multiple ankyrin repeat domains 3	0.010