IMP

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Mus musculus

17 genes annotated in mouse

Multi-species View

regulation of the force of heart contraction

GO:0002026

Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of the force of heart contraction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of the force of heart contraction" (in gray)

Name	Description	Probability	Func Analog Organism
Ldb3	LIM domain binding 3	0.998
Nos3	nitric oxide synthase 3, endothelial cell	0.983
Lepr	leptin receptor	0.968
Actn2	actinin alpha 2	0.967
Pnpla2	patatin-like phospholipase domain containing 2	0.951
Nos1	nitric oxide synthase 1, neuronal	0.938
Pparg	peroxisome proliferator activated receptor gamma	0.920
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.757
Cav1	caveolin 1, caveolae protein	0.640
Lep	leptin	0.567
Adrb1	adrenergic receptor, beta 1	0.494
Kl	klotho	0.481
Ar	androgen receptor	0.431
Prkcc	protein kinase C, gamma	0.419
Esr1	estrogen receptor 1 (alpha)	0.410
Hrc	histidine rich calcium binding protein	0.383
Ckmt2	creatine kinase, mitochondrial 2	0.358
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.336
Vegfa	vascular endothelial growth factor A	0.310
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.287	Human Mouse
Tnnt3	troponin T3, skeletal, fast	0.265
Cox8b	cytochrome c oxidase, subunit VIIIb	0.255
Esr2	estrogen receptor 2 (beta)	0.251
Myl3	myosin, light polypeptide 3	0.240	Human
Pgr	progesterone receptor	0.238
Kcnk3	potassium channel, subfamily K, member 3	0.230
Ttn	titin	0.226
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.165
Cox6a2	cytochrome c oxidase, subunit VI a, polypeptide 2	0.165
Shc3	src homology 2 domain-containing transforming protein C3	0.159
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.158
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.156
Vamp2	vesicle-associated membrane protein 2	0.153
Cckbr	cholecystokinin B receptor	0.153
Csrp3	cysteine and glycine-rich protein 3	0.147
Prkce	protein kinase C, epsilon	0.143	Mouse
Myom2	myomesin 2	0.140
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.140
Slc12a1	solute carrier family 12, member 1	0.133
Ckm	creatine kinase, muscle	0.126
Snta1	syntrophin, acidic 1	0.126
Drd2	dopamine receptor D2	0.124
Sstr4	somatostatin receptor 4	0.122
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.118
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.113
Sgcg	sarcoglycan, gamma (dystrophin-associated glycoprotein)	0.111
Rasgrf2	RAS protein-specific guanine nucleotide-releasing factor 2	0.111
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.109
Ptgs2	prostaglandin-endoperoxide synthase 2	0.103
Ghr	growth hormone receptor	0.102
Des	desmin	0.102
Cacng1	calcium channel, voltage-dependent, gamma subunit 1	0.098
Pgam2	phosphoglycerate mutase 2	0.089
Epas1	endothelial PAS domain protein 1	0.088
Tcap	titin-cap	0.085
Phkg1	phosphorylase kinase gamma 1	0.085
Adra2c	adrenergic receptor, alpha 2c	0.084	Mouse
Rasgrp2	RAS, guanyl releasing protein 2	0.079
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.077	Mouse
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.071
Adrb2	adrenergic receptor, beta 2	0.071	Mouse Rat
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.070
Vdr	vitamin D receptor	0.069
Insr	insulin receptor	0.069
Wdr1	WD repeat domain 1	0.066
Dmd	dystrophin, muscular dystrophy	0.065
Col4a3	collagen, type IV, alpha 3	0.064
Myoz1	myozenin 1	0.064
Art1	ADP-ribosyltransferase 1	0.063
Rasgrp1	RAS guanyl releasing protein 1	0.063
Ank1	ankyrin 1, erythroid	0.061
Actc1	actin, alpha, cardiac muscle 1	0.060
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.060
Rxrg	retinoid X receptor gamma	0.057
Tnni2	troponin I, skeletal, fast 2	0.056
Srpk3	serine/arginine-rich protein specific kinase 3	0.053
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.052
Nrap	nebulin-related anchoring protein	0.051	Mouse
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.051
Krtap5-1	keratin associated protein 5-1	0.049
Sstr1	somatostatin receptor 1	0.048
Apobec2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2	0.048
Myh4	myosin, heavy polypeptide 4, skeletal muscle	0.048	Mouse
Hrh1	histamine receptor H1	0.048
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.047
Gja5	gap junction protein, alpha 5	0.046
Coro1a	coronin, actin binding protein 1A	0.045
Kcne2	potassium voltage-gated channel, Isk-related subfamily, gene 2	0.044
Ptrf	polymerase I and transcript release factor	0.044
Pygm	muscle glycogen phosphorylase	0.044
Src	Rous sarcoma oncogene	0.044
Nppa	natriuretic peptide type A	0.042
Syn2	synapsin II	0.042
Pvalb	parvalbumin	0.042
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.040
Myom1	myomesin 1	0.039
Edn3	endothelin 3	0.039
Tgfb1	transforming growth factor, beta 1	0.039
Galr2	galanin receptor 2	0.039
Casq1	calsequestrin 1	0.038
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.038	Mouse
Pcdh12	protocadherin 12	0.037
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.037
Gast	gastrin	0.036
Crhr2	corticotropin releasing hormone receptor 2	0.034
Sebox	SEBOX homeobox	0.034
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.033	Mouse
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.033
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.032
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.032
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.031
Mybpc3	myosin binding protein C, cardiac	0.031
Smyd1	SET and MYND domain containing 1	0.031
Timp4	tissue inhibitor of metalloproteinase 4	0.031
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.030
Bglap	bone gamma carboxyglutamate protein	0.030
Myl1	myosin, light polypeptide 1	0.030
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.030
Pspn	persephin	0.030
Myoz2	myozenin 2	0.029
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.029	Mouse
Ptprb	protein tyrosine phosphatase, receptor type, B	0.028
Fxyd1	FXYD domain-containing ion transport regulator 1	0.028
ND6	NADH dehydrogenase subunit 6	0.028
Mb	myoglobin	0.028
Cacna1e	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.028
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.028
Col25a1	collagen, type XXV, alpha 1	0.027
Rgs6	regulator of G-protein signaling 6	0.027
Icam2	intercellular adhesion molecule 2	0.026
Tnnc2	troponin C2, fast	0.026
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.026	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.026
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.026	Mouse
Cnn2	calponin 2	0.026
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	0.026
Fam164c	family with sequence similarity 164, member C	0.026
Actn3	actinin alpha 3	0.025
Fndc7	fibronectin type III domain containing 7	0.025
Thbd	thrombomodulin	0.025
Cdh13	cadherin 13	0.025
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.025
Trh	thyrotropin releasing hormone	0.025
Alx3	aristaless-like homeobox 3	0.024
Plcd1	phospholipase C, delta 1	0.024
Sstr5	somatostatin receptor 5	0.024
Hcrt	hypocretin	0.024
Clcnka	chloride channel Ka	0.024
Fezf2	Fez family zinc finger 2	0.024
Tgfbr3	transforming growth factor, beta receptor III	0.023
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.023
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.023
Ucp1	uncoupling protein 1 (mitochondrial, proton carrier)	0.023
A530016L24Rik	RIKEN cDNA A530016L24 gene	0.023
Txlnb	taxilin beta	0.022
Mas1	MAS1 oncogene	0.022
Xirp1	xin actin-binding repeat containing 1	0.022
Tnnt2	troponin T2, cardiac	0.022
Clock	circadian locomotor output cycles kaput	0.022
Lag3	lymphocyte-activation gene 3	0.022
Vcl	vinculin	0.021
Plcg1	phospholipase C, gamma 1	0.021
Akt1	thymoma viral proto-oncogene 1	0.021
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.021
Cav3	caveolin 3	0.021	Mouse
Krt86	keratin 86	0.021
Gnrh1	gonadotropin releasing hormone 1	0.021
Pdgfb	platelet derived growth factor, B polypeptide	0.021
Pde6a	phosphodiesterase 6A, cGMP-specific, rod, alpha	0.021
Cntnap1	contactin associated protein-like 1	0.021
Zfr2	zinc finger RNA binding protein 2	0.021
Grm2	glutamate receptor, metabotropic 2	0.021
Tnnc1	troponin C, cardiac/slow skeletal	0.021
Popdc3	popeye domain containing 3	0.020
Ryr1	ryanodine receptor 1, skeletal muscle	0.020
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.020
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.020
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.020	Mouse
Sipa1	signal-induced proliferation associated gene 1	0.020
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.020
Hrh2	histamine receptor H2	0.020	Mouse
Apoe	apolipoprotein E	0.019
Prox1	prospero-related homeobox 1	0.019
Oprd1	opioid receptor, delta 1	0.019
Adipoq	adiponectin, C1Q and collagen domain containing	0.019
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.019
Fut2	fucosyltransferase 2	0.019
Adora2a	adenosine A2a receptor	0.019
Syt7	synaptotagmin VII	0.019
Dlg2	discs, large homolog 2 (Drosophila)	0.019
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.019
Acr	acrosin prepropeptide	0.018
Lhx6	LIM homeobox protein 6	0.018
Adrb3	adrenergic receptor, beta 3	0.018	Mouse
Cd151	CD151 antigen	0.018
Lmna	lamin A	0.018
Grm1	glutamate receptor, metabotropic 1	0.018
Krtap5-4	keratin associated protein 5-4	0.018
Otog	otogelin	0.018
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.017
Gh	growth hormone	0.017
Fgf1	fibroblast growth factor 1	0.017
Flt1	FMS-like tyrosine kinase 1	0.017
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.017
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.017
Gja8	gap junction protein, alpha 8	0.017
Acta1	actin, alpha 1, skeletal muscle	0.017
L1cam	L1 cell adhesion molecule	0.017
Chia	chitinase, acidic	0.017
Prkcb	protein kinase C, beta	0.016	Mouse
Myh8	myosin, heavy polypeptide 8, skeletal muscle, perinatal	0.016
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.016
Itgb3	integrin beta 3	0.016
Arpc4	actin related protein 2/3 complex, subunit 4	0.016
Sult4a1	sulfotransferase family 4A, member 1	0.016
Adra2a	adrenergic receptor, alpha 2a	0.016	Mouse
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.016
S100a6	S100 calcium binding protein A6 (calcyclin)	0.016
Kdr	kinase insert domain protein receptor	0.016
Homer1	homer homolog 1 (Drosophila)	0.016
Lmod2	leiomodin 2 (cardiac)	0.016
Ldlr	low density lipoprotein receptor	0.016
Npy5r	neuropeptide Y receptor Y5	0.016
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.016
Agtr2	angiotensin II receptor, type 2	0.016
Sln	sarcolipin	0.016
Inhbc	inhibin beta-C	0.015
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.015
Grm8	glutamate receptor, metabotropic 8	0.015
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.015
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.015
Kifc2	kinesin family member C2	0.015
Oprk1	opioid receptor, kappa 1	0.015
Sstr3	somatostatin receptor 3	0.015
Arhgef1	Rho guanine nucleotide exchange factor (GEF) 1	0.015
Odf3	outer dense fiber of sperm tails 3	0.015
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.015
Hspb2	heat shock protein 2	0.015
Kcnd1	potassium voltage-gated channel, Shal-related family, member 1	0.015
Mog	myelin oligodendrocyte glycoprotein	0.015
Il10	interleukin 10	0.015
Vars	valyl-tRNA synthetase	0.015
Tlr4	toll-like receptor 4	0.015
Cabp7	calcium binding protein 7	0.015
Neto1	neuropilin (NRP) and tolloid (TLL)-like 1	0.014
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.014
Musk	muscle, skeletal, receptor tyrosine kinase	0.014
Clec3b	C-type lectin domain family 3, member b	0.014
Npy6r	neuropeptide Y receptor Y6	0.014
Alox12b	arachidonate 12-lipoxygenase, 12R type	0.014
Myoc	myocilin	0.014
Usp13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.014
Pitpnm1	phosphatidylinositol transfer protein, membrane-associated 1	0.014
Acvr1c	activin A receptor, type IC	0.014
Lif	leukemia inhibitory factor	0.014
Ryr3	ryanodine receptor 3	0.014
Kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.014
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.014
Crhr1	corticotropin releasing hormone receptor 1	0.014
Prkca	protein kinase C, alpha	0.014
Csf1	colony stimulating factor 1 (macrophage)	0.014
Krt4	keratin 4	0.014
Arrb2	arrestin, beta 2	0.014
Ptafr	platelet-activating factor receptor	0.014
Cfl1	cofilin 1, non-muscle	0.014
Capn1	calpain 1	0.013
Hrh3	histamine receptor H3	0.013
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.013
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.013
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.013
Myl4	myosin, light polypeptide 4	0.013
Hoxb1	homeobox B1	0.013
Prkg1	protein kinase, cGMP-dependent, type I	0.013
Nt5e	5' nucleotidase, ecto	0.013
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.013
Cnih3	cornichon homolog 3 (Drosophila)	0.013
Egln1	EGL nine homolog 1 (C. elegans)	0.013
U46068	cDNA sequence U46068	0.013
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.013
Col19a1	collagen, type XIX, alpha 1	0.013
Gab2	growth factor receptor bound protein 2-associated protein 2	0.013
Rps6ka4	ribosomal protein S6 kinase, polypeptide 4	0.013
Smpx	small muscle protein, X-linked	0.013
Arrb1	arrestin, beta 1	0.013
Ilk	integrin linked kinase	0.013
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.013
Fgf4	fibroblast growth factor 4	0.013
Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.012
Wnt7a	wingless-related MMTV integration site 7A	0.012
Il1r1	interleukin 1 receptor, type I	0.012
Trim54	tripartite motif-containing 54	0.012
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.012
Glra1	glycine receptor, alpha 1 subunit	0.012
Mapk3	mitogen-activated protein kinase 3	0.012
Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.012
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.012
Syt3	synaptotagmin III	0.012
Gata5	GATA binding protein 5	0.012
Ren1	renin 1 structural	0.012
Syt6	synaptotagmin VI	0.012
Calcr	calcitonin receptor	0.012
Arhgap1	Rho GTPase activating protein 1	0.012
Cntn3	contactin 3	0.012
Aff2	AF4/FMR2 family, member 2	0.012
Thrb	thyroid hormone receptor beta	0.012
Mybph	myosin binding protein H	0.012
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.012
Elk1	ELK1, member of ETS oncogene family	0.012
Kcna5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.012
Gucy2e	guanylate cyclase 2e	0.012
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.012
Npy1r	neuropeptide Y receptor Y1	0.011
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.011
Dpep3	dipeptidase 3	0.011
Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	0.011
Cbln3	cerebellin 3 precursor protein	0.011
Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	0.011
Trp63	transformation related protein 63	0.011
Nppb	natriuretic peptide type B	0.011
Tomm7	translocase of outer mitochondrial membrane 7 homolog (yeast)	0.011
Hr	hairless	0.011
Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	0.011
Myh11	myosin, heavy polypeptide 11, smooth muscle	0.011
Tnni1	troponin I, skeletal, slow 1	0.011
Bcan	brevican	0.011
S100a11	S100 calcium binding protein A11 (calgizzarin)	0.011
Sox1	SRY-box containing gene 1	0.011
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.011
Scn10a	sodium channel, voltage-gated, type X, alpha	0.011
Hsf4	heat shock transcription factor 4	0.011
Galr1	galanin receptor 1	0.011
Nrp1	neuropilin 1	0.011
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.011
Actb	actin, beta	0.011
Mkl1	MKL (megakaryoblastic leukemia)/myocardin-like 1	0.011
Tpm1	tropomyosin 1, alpha	0.011
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.010
Plekho1	pleckstrin homology domain containing, family O member 1	0.010
Glycam1	glycosylation dependent cell adhesion molecule 1	0.010
Tacr1	tachykinin receptor 1	0.010
Arpp21	cyclic AMP-regulated phosphoprotein, 21	0.010
Sncg	synuclein, gamma	0.010
Npas1	neuronal PAS domain protein 1	0.010
Rasa3	RAS p21 protein activator 3	0.010
Plin4	perilipin 4	0.010
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.010
Krt36	keratin 36	0.010
Hamp	hepcidin antimicrobial peptide	0.010
Cfd	complement factor D (adipsin)	0.010
Agtr1a	angiotensin II receptor, type 1a	0.010
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.010
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.010
Vhl	von Hippel-Lindau tumor suppressor	0.010