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Process View

Mus musculus

15 genes annotated in mouse

megakaryocyte development

The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "megakaryocyte development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "megakaryocyte development" (in gray)

Name	Description	Probability	Func Analog Organism
Hand2	heart and neural crest derivatives expressed transcript 2	0.928	Mouse
Pax3	paired box gene 3	0.902
Pax6	paired box gene 6	0.864
Otx2	orthodenticle homolog 2 (Drosophila)	0.831
Shh	sonic hedgehog	0.817
Gata4	GATA binding protein 4	0.803
Pbx1	pre B-cell leukemia transcription factor 1	0.772
Neurod1	neurogenic differentiation 1	0.748	Mouse
Msx1	homeobox, msh-like 1	0.734
Foxc2	forkhead box C2	0.725
Pitx2	paired-like homeodomain transcription factor 2	0.592
Tgfb2	transforming growth factor, beta 2	0.576
Isl1	ISL1 transcription factor, LIM/homeodomain	0.559
Gli3	GLI-Kruppel family member GLI3	0.530
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.523
Vegfa	vascular endothelial growth factor A	0.492
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.477
Tgfbr2	transforming growth factor, beta receptor II	0.468
Foxc1	forkhead box C1	0.346
Gli2	GLI-Kruppel family member GLI2	0.250
Neurod4	neurogenic differentiation 4	0.224	Mouse
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.200
Neurog2	neurogenin 2	0.198	Mouse
Tcfap2a	transcription factor AP-2, alpha	0.195
Ntf3	neurotrophin 3	0.194
Zeb1	zinc finger E-box binding homeobox 1	0.192
Fgf8	fibroblast growth factor 8	0.191
Gata1	GATA binding protein 1	0.186
Bmp4	bone morphogenetic protein 4	0.181
Cbl	Casitas B-lineage lymphoma	0.173
Kiss1	KiSS-1 metastasis-suppressor	0.170
Nos3	nitric oxide synthase 3, endothelial cell	0.165
Sox9	SRY-box containing gene 9	0.153
Gja1	gap junction protein, alpha 1	0.150
Trp53	transformation related protein 53	0.145
Tgfb1	transforming growth factor, beta 1	0.143
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.137
Ikzf1	IKAROS family zinc finger 1	0.131
Jag1	jagged 1	0.129
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.124
Ptf1a	pancreas specific transcription factor, 1a	0.123	Mouse
Runx1	runt related transcription factor 1	0.114
Meis2	Meis homeobox 2	0.108	Mouse
Meox2	mesenchyme homeobox 2	0.106
Csf1	colony stimulating factor 1 (macrophage)	0.105
Hoxd13	homeobox D13	0.101
Hand1	heart and neural crest derivatives expressed transcript 1	0.097	Mouse
Pbx3	pre B-cell leukemia transcription factor 3	0.090
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.086
Fgfr1	fibroblast growth factor receptor 1	0.085
Lhx3	LIM homeobox protein 3	0.084
Prrx1	paired related homeobox 1	0.080
Efna2	ephrin A2	0.080
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.079
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.079
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.078
Inpp5d	inositol polyphosphate-5-phosphatase D	0.073
Smo	smoothened homolog (Drosophila)	0.073
Eya1	eyes absent 1 homolog (Drosophila)	0.072
Foxg1	forkhead box G1	0.065
Hoxa9	homeobox A9	0.065
Hoxa1	homeobox A1	0.065
Setdb1	SET domain, bifurcated 1	0.064
Ldlr	low density lipoprotein receptor	0.061
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.061
Snai1	snail homolog 1 (Drosophila)	0.060
Meis1	Meis homeobox 1	0.056
Vegfc	vascular endothelial growth factor C	0.056
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.056
Pdx1	pancreatic and duodenal homeobox 1	0.054
Pten	phosphatase and tensin homolog	0.052
En1	engrailed 1	0.052
Gata6	GATA binding protein 6	0.052
Fgfr2	fibroblast growth factor receptor 2	0.051
Rxra	retinoid X receptor alpha	0.051
Apc	adenomatosis polyposis coli	0.050
Notch2	Notch gene homolog 2 (Drosophila)	0.050
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.050
Lhx9	LIM homeobox protein 9	0.049
Sox2	SRY-box containing gene 2	0.049
Insm1	insulinoma-associated 1	0.048
Acvr1	activin A receptor, type 1	0.048
Emx1	empty spiracles homolog 1 (Drosophila)	0.048
Nrp1	neuropilin 1	0.046
Gnrh1	gonadotropin releasing hormone 1	0.046
Adam17	a disintegrin and metallopeptidase domain 17	0.044
Sox11	SRY-box containing gene 11	0.044
Rara	retinoic acid receptor, alpha	0.044
Gbx2	gastrulation brain homeobox 2	0.043
Klf3	Kruppel-like factor 3 (basic)	0.042
Nhlh1	nescient helix loop helix 1	0.042	Mouse
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.042
Amhr2	anti-Mullerian hormone type 2 receptor	0.041
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.041
Cdh5	cadherin 5	0.041
Mecom	MDS1 and EVI1 complex locus	0.041
Lhx5	LIM homeobox protein 5	0.040
Pou4f2	POU domain, class 4, transcription factor 2	0.040
Ncoa3	nuclear receptor coactivator 3	0.036
Grb2	growth factor receptor bound protein 2	0.036
Gsc	goosecoid homeobox	0.035
Lepr	leptin receptor	0.033
Notch1	Notch gene homolog 1 (Drosophila)	0.033
Bmp2	bone morphogenetic protein 2	0.033
Onecut1	one cut domain, family member 1	0.033
Hoxa5	homeobox A5	0.033
Hoxa10	homeobox A10	0.033
Runx2	runt related transcription factor 2	0.032
Prrx2	paired related homeobox 2	0.031
Srebf2	sterol regulatory element binding factor 2	0.031
Lmo2	LIM domain only 2	0.031
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.031
Abi1	abl-interactor 1	0.030
Tlx3	T-cell leukemia, homeobox 3	0.030
Plcg2	phospholipase C, gamma 2	0.030
Epha3	Eph receptor A3	0.030
Lmx1b	LIM homeobox transcription factor 1 beta	0.029
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.029
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.029
Gdnf	glial cell line derived neurotrophic factor	0.029
Epor	erythropoietin receptor	0.029
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.028	Mouse
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.028
Dscaml1	Down syndrome cell adhesion molecule-like 1	0.028
Podxl	podocalyxin-like	0.027
Hoxa13	homeobox A13	0.026
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.026
Ebf3	early B-cell factor 3	0.025
Srrm4	serine/arginine repetitive matrix 4	0.025
Ednra	endothelin receptor type A	0.025
Vav1	vav 1 oncogene	0.025
Gpr50	G-protein-coupled receptor 50	0.025
Fgf15	fibroblast growth factor 15	0.023
Prph2	peripherin 2	0.023
Vhl	von Hippel-Lindau tumor suppressor	0.023
Plxnd1	plexin D1	0.023
Gabpb1	GA repeat binding protein, beta 1	0.023
Mab21l2	mab-21-like 2 (C. elegans)	0.023
Hic1	hypermethylated in cancer 1	0.023
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.023
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.023
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.023
Foxd3	forkhead box D3	0.022
Glra1	glycine receptor, alpha 1 subunit	0.022
Zfpm2	zinc finger protein, multitype 2	0.022	Mouse
Fbn2	fibrillin 2	0.022
Kdr	kinase insert domain protein receptor	0.022	Mouse
Zic1	zinc finger protein of the cerebellum 1	0.022
Hmx1	H6 homeobox 1	0.021
Smad6	MAD homolog 6 (Drosophila)	0.021
Pou4f3	POU domain, class 4, transcription factor 3	0.021
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.021
Pitx1	paired-like homeodomain transcription factor 1	0.021
Gnrhr	gonadotropin releasing hormone receptor	0.021
Plac1	placental specific protein 1	0.021
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.020
Sox4	SRY-box containing gene 4	0.020
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.020
Fes	feline sarcoma oncogene	0.019
Smad3	MAD homolog 3 (Drosophila)	0.019
Sgpl1	sphingosine phosphate lyase 1	0.019
Ptprb	protein tyrosine phosphatase, receptor type, B	0.019
Pax2	paired box gene 2	0.019
Tcf3	transcription factor 3	0.019
Scrt1	scratch homolog 1, zinc finger protein (Drosophila)	0.019
Fermt3	fermitin family homolog 3 (Drosophila)	0.019
Wt1	Wilms tumor 1 homolog	0.019
Mnx1	motor neuron and pancreas homeobox 1	0.019
Gdf11	growth differentiation factor 11	0.019
Tcf21	transcription factor 21	0.019
Alx3	aristaless-like homeobox 3	0.019
Ebf1	early B-cell factor 1	0.019
Myog	myogenin	0.018
Nkx6-1	NK6 homeobox 1	0.018
Hoxc5	homeobox C5	0.018
Shc1	src homology 2 domain-containing transforming protein C1	0.018
Phox2b	paired-like homeobox 2b	0.018
Prpf40a	PRP40 pre-mRNA processing factor 40 homolog A (yeast)	0.018
Ece1	endothelin converting enzyme 1	0.018
Sox18	SRY-box containing gene 18	0.018
Ptch1	patched homolog 1	0.018
Eya4	eyes absent 4 homolog (Drosophila)	0.017
Twist2	twist homolog 2 (Drosophila)	0.017	Mouse
Msx2	homeobox, msh-like 2	0.017
Tgfbr1	transforming growth factor, beta receptor I	0.017
Sh2b3	SH2B adaptor protein 3	0.017
Hoxd1	homeobox D1	0.017
Shox2	short stature homeobox 2	0.017
Ebf2	early B-cell factor 2	0.016
Sfpi1	SFFV proviral integration 1	0.016
Foxa2	forkhead box A2	0.016
Nynrin	NYN domain and retroviral integrase containing	0.016
Crlf3	cytokine receptor-like factor 3	0.016
Sox1	SRY-box containing gene 1	0.016
Hhex	hematopoietically expressed homeobox	0.016
Gab2	growth factor receptor bound protein 2-associated protein 2	0.016
Arx	aristaless related homeobox	0.016
Mapk8	mitogen-activated protein kinase 8	0.016
Eng	endoglin	0.016
Fyn	Fyn proto-oncogene	0.016
Wwox	WW domain-containing oxidoreductase	0.015
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.015
Hoxb4	homeobox B4	0.015
Cxcl12	chemokine (C-X-C motif) ligand 12	0.015
Smad4	MAD homolog 4 (Drosophila)	0.015
Obsl1	obscurin-like 1	0.015
Dlx5	distal-less homeobox 5	0.015
Tbx20	T-box 20	0.015
Wasf2	WAS protein family, member 2	0.015
Hes5	hairy and enhancer of split 5 (Drosophila)	0.015
She	src homology 2 domain-containing transforming protein E	0.015
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.015
Pbx2	pre B-cell leukemia transcription factor 2	0.015
H1fx	H1 histone family, member X	0.015
Ina	internexin neuronal intermediate filament protein, alpha	0.014
Ldb2	LIM domain binding 2	0.014
Tbx2	T-box 2	0.014
Apaf1	apoptotic peptidase activating factor 1	0.014
Neurog3	neurogenin 3	0.014	Mouse
Sos1	son of sevenless homolog 1 (Drosophila)	0.014
Hmha1	histocompatibility (minor) HA-1	0.014
Hoxa4	homeobox A4	0.014
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.014
Robo3	roundabout homolog 3 (Drosophila)	0.014
Lhx1	LIM homeobox protein 1	0.014
Egfr	epidermal growth factor receptor	0.014
Ephb2	Eph receptor B2	0.014
Sorbs3	sorbin and SH3 domain containing 3	0.014
Sox7	SRY-box containing gene 7	0.014
Tac2	tachykinin 2	0.014
Zbtb12	zinc finger and BTB domain containing 12	0.014
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.014
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.013
Dab1	disabled homolog 1 (Drosophila)	0.013
Stag1	stromal antigen 1	0.013
Lep	leptin	0.013
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.013
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.013
Fzd2	frizzled homolog 2 (Drosophila)	0.013
Mapk14	mitogen-activated protein kinase 14	0.013
Nos1	nitric oxide synthase 1, neuronal	0.013
Mta1	metastasis associated 1	0.013
Nkx3-2	NK3 homeobox 2	0.013
Smn1	survival motor neuron 1	0.013
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.013
Foxe3	forkhead box E3	0.013
Gcm1	glial cells missing homolog 1 (Drosophila)	0.013
Wipf1	WAS/WASL interacting protein family, member 1	0.013
Tyrobp	TYRO protein tyrosine kinase binding protein	0.013
Tead2	TEA domain family member 2	0.013
Kcnk3	potassium channel, subfamily K, member 3	0.013
Gata2	GATA binding protein 2	0.013
Tcf15	transcription factor 15	0.013	Mouse
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.013
Prph	peripherin	0.013
Hoxb1	homeobox B1	0.012
Aplnr	apelin receptor	0.012
Alx1	ALX homeobox 1	0.012
Zic3	zinc finger protein of the cerebellum 3	0.012
Foxf2	forkhead box F2	0.012
Dok1	docking protein 1	0.012
Foxd2	forkhead box D2	0.012
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.012
Mark4	MAP/microtubule affinity-regulating kinase 4	0.012
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.012
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.012
Igf1	insulin-like growth factor 1	0.012
Epx	eosinophil peroxidase	0.012
Efs	embryonal Fyn-associated substrate	0.012
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.012
Flt4	FMS-like tyrosine kinase 4	0.012	Mouse
Hoxb5	homeobox B5	0.012
Ncoa6	nuclear receptor coactivator 6	0.012
Dcc	deleted in colorectal carcinoma	0.012
Rbm38	RNA binding motif protein 38	0.012
Prox1	prospero-related homeobox 1	0.012
Myc	myelocytomatosis oncogene	0.012
Bcl2	B-cell leukemia/lymphoma 2	0.012
Fgf17	fibroblast growth factor 17	0.012
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.012
Lmo1	LIM domain only 1	0.012
Tek	endothelial-specific receptor tyrosine kinase	0.012
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.012
Tacr2	tachykinin receptor 2	0.012
Hoxb8	homeobox B8	0.012
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.012	Mouse
Dmpk	dystrophia myotonica-protein kinase	0.012
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.012
Prkd1	protein kinase D1	0.011
Ncf1	neutrophil cytosolic factor 1	0.011
Sirpa	signal-regulatory protein alpha	0.011
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.011
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.011
Evx1	even skipped homeotic gene 1 homolog	0.011
Dlk1	delta-like 1 homolog (Drosophila)	0.011
Hlx	H2.0-like homeobox	0.011
Csf3	colony stimulating factor 3 (granulocyte)	0.011
Hmga2	high mobility group AT-hook 2	0.011
Alx4	aristaless-like homeobox 4	0.011
Uncx	UNC homeobox	0.011
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.011
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.011
Zbtb7b	zinc finger and BTB domain containing 7B	0.011
Stat6	signal transducer and activator of transcription 6	0.011
Neurog1	neurogenin 1	0.011	Mouse
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.011
Bmp7	bone morphogenetic protein 7	0.011
Med1	mediator complex subunit 1	0.011
Kit	kit oncogene	0.011
Fzd4	frizzled homolog 4 (Drosophila)	0.010
Foxf1a	forkhead box F1a	0.010
Nfya	nuclear transcription factor-Y alpha	0.010
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.010
Eif4ebp2	eukaryotic translation initiation factor 4E binding protein 2	0.010
Hes1	hairy and enhancer of split 1 (Drosophila)	0.010
Ltbp1	latent transforming growth factor beta binding protein 1	0.010
Tbx1	T-box 1	0.010
Aif1l	allograft inflammatory factor 1-like	0.010
Tmem204	transmembrane protein 204	0.010
Grm1	glutamate receptor, metabotropic 1	0.010
4632428N05Rik	RIKEN cDNA 4632428N05 gene	0.010
Yap1	yes-associated protein 1	0.010
Zic2	zinc finger protein of the cerebellum 2	0.010
Hoxa11	homeobox A11	0.010