IMP

Process View

Mus musculus

15 genes annotated in mouse

negative regulation of nf kappab transcription factor activity

GO:0032088

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of nf kappab transcription factor activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of nf kappab transcription factor activity" (in gray)

Name	Description	Probability	Func Analog Organism
Traf6	TNF receptor-associated factor 6	0.999	Mouse
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.825	Human
Itch	itchy, E3 ubiquitin protein ligase	0.740
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.521
Myd88	myeloid differentiation primary response gene 88	0.481
Arrb2	arrestin, beta 2	0.341	Human
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.317
Stat3	signal transducer and activator of transcription 3	0.258
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.253
Igh	immunoglobulin heavy chain complex	0.215
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.209
Rnf11	ring finger protein 11	0.182
Arrb1	arrestin, beta 1	0.144	Human
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.142
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.119
Ikbkb	inhibitor of kappaB kinase beta	0.110
Cd44	CD44 antigen	0.109
Mavs	mitochondrial antiviral signaling protein	0.099
Rnf19a	ring finger protein 19A	0.092
Fos	FBJ osteosarcoma oncogene	0.091
Stat1	signal transducer and activator of transcription 1	0.089
Fam96a	family with sequence similarity 96, member A	0.083
Pycard	PYD and CARD domain containing	0.079	Human
Egr2	early growth response 2	0.075
Zfp36	zinc finger protein 36	0.067
Map3k3	mitogen-activated protein kinase kinase kinase 3	0.066
Birc3	baculoviral IAP repeat-containing 3	0.065
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.063
Cd40	CD40 antigen	0.062
Socs3	suppressor of cytokine signaling 3	0.058
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.058
Tnf	tumor necrosis factor	0.056
Gbp5	guanylate binding protein 5	0.054
Ncoa3	nuclear receptor coactivator 3	0.053
Cyld	cylindromatosis (turban tumor syndrome)	0.053	Human
Casp1	caspase 1	0.053
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.044
Smad6	MAD homolog 6 (Drosophila)	0.044
Irak3	interleukin-1 receptor-associated kinase 3	0.043	Human
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.043
Sharpin	SHANK-associated RH domain interacting protein	0.042
Ikbkg	inhibitor of kappaB kinase gamma	0.042
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.038
Hbb-b1	hemoglobin, beta adult major chain	0.038
Skil	SKI-like	0.038
Bcl3	B-cell leukemia/lymphoma 3	0.037
Fas	Fas (TNF receptor superfamily member 6)	0.036
Junb	Jun-B oncogene	0.034
Card11	caspase recruitment domain family, member 11	0.034
Traf2	TNF receptor-associated factor 2	0.033	Mouse
Rb1	retinoblastoma 1	0.032
Irf1	interferon regulatory factor 1	0.032
Jun	Jun oncogene	0.032
Nlrp3	NLR family, pyrin domain containing 3	0.031	Human Mouse
Il6st	interleukin 6 signal transducer	0.031
Trafd1	TRAF type zinc finger domain containing 1	0.030
Tmem64	transmembrane protein 64	0.030
Irf7	interferon regulatory factor 7	0.030
Rnf31	ring finger protein 31	0.030
Ubc	ubiquitin C	0.029
Lyz2	lysozyme 2	0.029
Dusp1	dual specificity phosphatase 1	0.029
Rac1	RAS-related C3 botulinum substrate 1	0.028
Aim2	absent in melanoma 2	0.028
Plagl2	pleiomorphic adenoma gene-like 2	0.027
Egr1	early growth response 1	0.026
Cxcl2	chemokine (C-X-C motif) ligand 2	0.026
Klf6	Kruppel-like factor 6	0.026
Mcl1	myeloid cell leukemia sequence 1	0.023
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.022
Btg2	B-cell translocation gene 2, anti-proliferative	0.022
Kif19a	kinesin family member 19A	0.021
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.021
Grxcr1	glutaredoxin, cysteine rich 1	0.021
Il1r1	interleukin 1 receptor, type I	0.020
Anapc2	anaphase promoting complex subunit 2	0.020
Sufu	suppressor of fused homolog (Drosophila)	0.019
Sap18	Sin3-associated polypeptide 18	0.019
Tbk1	TANK-binding kinase 1	0.019
Mdm2	transformed mouse 3T3 cell double minute 2	0.019
Rel	reticuloendotheliosis oncogene	0.017
Tifa	TRAF-interacting protein with forkhead-associated domain	0.017
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.017	Mouse
Errfi1	ERBB receptor feedback inhibitor 1	0.017
Whrn	whirlin	0.017
Noto	notochord homolog (Xenopus laevis)	0.016
Bcl6	B-cell leukemia/lymphoma 6	0.016
Erbb2ip	Erbb2 interacting protein	0.016
Atf3	activating transcription factor 3	0.016
Odf2	outer dense fiber of sperm tails 2	0.015
Irak4	interleukin-1 receptor-associated kinase 4	0.015
Tnip1	TNFAIP3 interacting protein 1	0.015
Add1	adducin 1 (alpha)	0.015
Hpd	4-hydroxyphenylpyruvic acid dioxygenase	0.015
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.014
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.014
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.014
Trp53bp1	transformation related protein 53 binding protein 1	0.013
BC006779	cDNA sequence BC006779	0.013
Axin1	axin 1	0.013
Trp53	transformation related protein 53	0.013
Cyb5	cytochrome b-5	0.013
Ush1g	Usher syndrome 1G homolog (human)	0.012
Stx11	syntaxin 11	0.012
Ripk2	receptor (TNFRSF)-interacting serine-threonine kinase 2	0.012
Nkd2	naked cuticle 2 homolog (Drosophila)	0.012
Ahsg	alpha-2-HS-glycoprotein	0.012
Smad7	MAD homolog 7 (Drosophila)	0.012
Ube2n	ubiquitin-conjugating enzyme E2N	0.012
Prkcd	protein kinase C, delta	0.012
Hspa1b	heat shock protein 1B	0.012
Cdk4	cyclin-dependent kinase 4	0.011
H2-Q6	histocompatibility 2, Q region locus 6	0.011
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.011
Pim1	proviral integration site 1	0.011
Prdx6	peroxiredoxin 6	0.011
Stat6	signal transducer and activator of transcription 6	0.011
Tlr4	toll-like receptor 4	0.011
Ooep	oocyte expressed protein homolog (dog)	0.011
Setdb1	SET domain, bifurcated 1	0.011
Nfil3	nuclear factor, interleukin 3, regulated	0.011
Icos	inducible T-cell co-stimulator	0.011
Chuk	conserved helix-loop-helix ubiquitous kinase	0.011
Scp2	sterol carrier protein 2, liver	0.011
Irf9	interferon regulatory factor 9	0.011
Mx2	myxovirus (influenza virus) resistance 2	0.010
Hspa1a	heat shock protein 1A	0.010
Btg1	B-cell translocation gene 1, anti-proliferative	0.010
Il1b	interleukin 1 beta	0.010
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.010
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.010
Dnahc11	dynein, axonemal, heavy chain 11	0.010