IMP

Process View

Mus musculus

21 genes annotated in mouse

antigen processing and presentation of exogenous peptide antigen

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "antigen processing and presentation of exogenous peptide antigen"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "antigen processing and presentation of exogenous peptide antigen" (in gray)

Name	Description	Probability	Func Analog Organism
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	1.000
H2-Aa	histocompatibility 2, class II antigen A, alpha	1.000
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	1.000
H2-Eb1	histocompatibility 2, class II antigen E beta	0.999
B2m	beta-2 microglobulin	0.998
H2-K1	histocompatibility 2, K1, K region	0.998
H2-D1	histocompatibility 2, D region locus 1	0.987	Mouse
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.979
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.977
H2-DMa	histocompatibility 2, class II, locus DMa	0.911
Tapbp	TAP binding protein	0.898
Lyz2	lysozyme 2	0.847
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.826	Mouse
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.740
Cd40	CD40 antigen	0.732
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.728
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.664
Ptprc	protein tyrosine phosphatase, receptor type, C	0.588
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.582
C1qc	complement component 1, q subcomponent, C chain	0.579
H2-Q7	histocompatibility 2, Q region locus 7	0.575
Tyrobp	TYRO protein tyrosine kinase binding protein	0.515
Mavs	mitochondrial antiviral signaling protein	0.442
Ciita	class II transactivator	0.402
Gm2a	GM2 ganglioside activator protein	0.342
H2-Q6	histocompatibility 2, Q region locus 6	0.291
Ly86	lymphocyte antigen 86	0.262
Lck	lymphocyte protein tyrosine kinase	0.243
Tcra	T-cell receptor alpha chain	0.229
Lat	linker for activation of T cells	0.222
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.216
C1qb	complement component 1, q subcomponent, beta polypeptide	0.208
Il2rg	interleukin 2 receptor, gamma chain	0.197
Unc93b1	unc-93 homolog B1 (C. elegans)	0.180
Ctsb	cathepsin B	0.177
Irf8	interferon regulatory factor 8	0.176
Ccl5	chemokine (C-C motif) ligand 5	0.165
H2-Q8	histocompatibility 2, Q region locus 8	0.159
Cd247	CD247 antigen	0.139	Mouse
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.127
H2-Ob	histocompatibility 2, O region beta locus	0.119	Mouse
Psap	prosaposin	0.118
Birc3	baculoviral IAP repeat-containing 3	0.106
C920025E04Rik	RIKEN cDNA C920025E04 gene	0.104
Aif1	allograft inflammatory factor 1	0.103
Tgfb1	transforming growth factor, beta 1	0.102
Plbd1	phospholipase B domain containing 1	0.086
Cp	ceruloplasmin	0.082
Cd3g	CD3 antigen, gamma polypeptide	0.080
AF251705	cDNA sequence AF251705	0.080
Gbp2	guanylate binding protein 2	0.067
Blk	B lymphoid kinase	0.062
Gabarap	gamma-aminobutyric acid receptor associated protein	0.061
Cxcl9	chemokine (C-X-C motif) ligand 9	0.060
Csf1r	colony stimulating factor 1 receptor	0.055
Ptpn18	protein tyrosine phosphatase, non-receptor type 18	0.051
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.046
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.044
Hexa	hexosaminidase A	0.042
Tbxas1	thromboxane A synthase 1, platelet	0.041
Cd52	CD52 antigen	0.040
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.039
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.039
Agtr1a	angiotensin II receptor, type 1a	0.038
Pld4	phospholipase D family, member 4	0.038
Cd2	CD2 antigen	0.036
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.035
Lyz1	lysozyme 1	0.034
AW112010	expressed sequence AW112010	0.033
Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein	0.032
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.031
Cyba	cytochrome b-245, alpha polypeptide	0.031
Calcrl	calcitonin receptor-like	0.030
Ctsh	cathepsin H	0.027
S1pr4	sphingosine-1-phosphate receptor 4	0.027
Fcna	ficolin A	0.026
Sh2d2a	SH2 domain protein 2A	0.026
Clec4n	C-type lectin domain family 4, member n	0.025
Shisa5	shisa homolog 5 (Xenopus laevis)	0.025
Ccl6	chemokine (C-C motif) ligand 6	0.024
Ccr7	chemokine (C-C motif) receptor 7	0.024
Ccr9	chemokine (C-C motif) receptor 9	0.023
Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	0.023
Ly6d	lymphocyte antigen 6 complex, locus D	0.022
H2-Oa	histocompatibility 2, O region alpha locus	0.021
Hcst	hematopoietic cell signal transducer	0.021
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.021
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.021
Irf5	interferon regulatory factor 5	0.021
Fasl	Fas ligand (TNF superfamily, member 6)	0.021
Ifngr1	interferon gamma receptor 1	0.021
Cd27	CD27 antigen	0.020
Napsa	napsin A aspartic peptidase	0.020	Mouse
Cd6	CD6 antigen	0.020
Cxcr3	chemokine (C-X-C motif) receptor 3	0.020
Rhoh	ras homolog gene family, member H	0.019
Glis2	GLIS family zinc finger 2	0.019
Bst2	bone marrow stromal cell antigen 2	0.019
Ctsw	cathepsin W	0.019
Il2	interleukin 2	0.018
Il15ra	interleukin 15 receptor, alpha chain	0.018
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.018
C3	complement component 3	0.018
Ccl22	chemokine (C-C motif) ligand 22	0.018
Lgals9	lectin, galactose binding, soluble 9	0.018
Pacsin1	protein kinase C and casein kinase substrate in neurons 1	0.018
Folr2	folate receptor 2 (fetal)	0.018
Parp14	poly (ADP-ribose) polymerase family, member 14	0.017
Inpp5d	inositol polyphosphate-5-phosphatase D	0.017
Ifi27l2a	interferon, alpha-inducible protein 27 like 2A	0.017
Xcl1	chemokine (C motif) ligand 1	0.017
H2-Q5	histocompatibility 2, Q region locus 5	0.017
Il15	interleukin 15	0.017
Fgd2	FYVE, RhoGEF and PH domain containing 2	0.017
Tcn2	transcobalamin 2	0.016
Il10	interleukin 10	0.016
Syngr2	synaptogyrin 2	0.016
Lgals3bp	lectin, galactoside-binding, soluble, 3 binding protein	0.015
Ly6e	lymphocyte antigen 6 complex, locus E	0.015
Cd19	CD19 antigen	0.015
Ikbkg	inhibitor of kappaB kinase gamma	0.015
Gimap3	GTPase, IMAP family member 3	0.015
Trafd1	TRAF type zinc finger domain containing 1	0.015
Trim21	tripartite motif-containing 21	0.015
Fuca1	fucosidase, alpha-L- 1, tissue	0.015
Uba7	ubiquitin-like modifier activating enzyme 7	0.015
Il2rb	interleukin 2 receptor, beta chain	0.014
Ccr6	chemokine (C-C motif) receptor 6	0.014
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.014
Dnase1l3	deoxyribonuclease 1-like 3	0.014
Ctsz	cathepsin Z	0.014
Itgax	integrin alpha X	0.014
Rarg	retinoic acid receptor, gamma	0.014
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.014
Irf1	interferon regulatory factor 1	0.013
H2-DMb1	histocompatibility 2, class II, locus Mb1	0.013
Epsti1	epithelial stromal interaction 1 (breast)	0.013
Grap2	GRB2-related adaptor protein 2	0.013
Itk	IL2-inducible T-cell kinase	0.013
Gzma	granzyme A	0.013
Rag2	recombination activating gene 2	0.013
H2-M3	histocompatibility 2, M region locus 3	0.012
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.012
Slamf9	SLAM family member 9	0.012
Il7r	interleukin 7 receptor	0.012
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.012
Ly9	lymphocyte antigen 9	0.011
Elane	elastase, neutrophil expressed	0.011
Cd86	CD86 antigen	0.011
Cd3e	CD3 antigen, epsilon polypeptide	0.011
Ggt5	gamma-glutamyltransferase 5	0.011
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.011
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.011
Ubd	ubiquitin D	0.011
Itgb7	integrin beta 7	0.011
Irf7	interferon regulatory factor 7	0.011
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.011
Lamp1	lysosomal-associated membrane protein 1	0.010
Cd96	CD96 antigen	0.010
P2rx4	purinergic receptor P2X, ligand-gated ion channel 4	0.010
Tnip1	TNFAIP3 interacting protein 1	0.010
Itgae	integrin alpha E, epithelial-associated	0.010