IMP

Process View

Mus musculus

2 genes annotated in mouse

syncytiotrophoblast cell differentiation involved in labyrinthine layer development

The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "syncytiotrophoblast cell differentiation involved in labyrinthine layer development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "syncytiotrophoblast cell differentiation involved in labyrinthine layer development" (in gray)

Name	Description	Probability	Func Analog Organism
Gopc	golgi associated PDZ and coiled-coil motif containing	0.997
Gli3	GLI-Kruppel family member GLI3	0.991
Wnt5a	wingless-related MMTV integration site 5A	0.929
Fzd1	frizzled homolog 1 (Drosophila)	0.881	Mouse
Fgfr2	fibroblast growth factor receptor 2	0.861
Gpc3	glypican 3	0.835
Fzd8	frizzled homolog 8 (Drosophila)	0.707	Mouse
Bmp4	bone morphogenetic protein 4	0.667
Smad6	MAD homolog 6 (Drosophila)	0.656
Dlg4	discs, large homolog 4 (Drosophila)	0.638
Grb10	growth factor receptor bound protein 10	0.602
Prrx1	paired related homeobox 1	0.511
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.476
Gas1	growth arrest specific 1	0.474
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.472
Acvr1	activin A receptor, type 1	0.470
Emp2	epithelial membrane protein 2	0.440
Zfhx4	zinc finger homeodomain 4	0.378
Gli2	GLI-Kruppel family member GLI2	0.335
Fzd7	frizzled homolog 7 (Drosophila)	0.333	Mouse
Col4a5	collagen, type IV, alpha 5	0.332
Pbx1	pre B-cell leukemia transcription factor 1	0.319
Fzd2	frizzled homolog 2 (Drosophila)	0.317	Mouse
Sfrp1	secreted frizzled-related protein 1	0.310
Hes1	hairy and enhancer of split 1 (Drosophila)	0.309
Npr3	natriuretic peptide receptor 3	0.299
Smo	smoothened homolog (Drosophila)	0.298
Hoxb6	homeobox B6	0.273
Fbln1	fibulin 1	0.257
Zfp185	zinc finger protein 185	0.242
Foxc1	forkhead box C1	0.236
Tgfb2	transforming growth factor, beta 2	0.226
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.225
Capn6	calpain 6	0.222
Vegfa	vascular endothelial growth factor A	0.221
Dlg2	discs, large homolog 2 (Drosophila)	0.220
Tgfbr3	transforming growth factor, beta receptor III	0.212
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.211
Krtap5-1	keratin associated protein 5-1	0.201
Mrc2	mannose receptor, C type 2	0.200
Efna2	ephrin A2	0.179
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.176
Ptk7	PTK7 protein tyrosine kinase 7	0.168
Efnb1	ephrin B1	0.160
Hoxd9	homeobox D9	0.159
Socs5	suppressor of cytokine signaling 5	0.158
Dlg1	discs, large homolog 1 (Drosophila)	0.158
Ddr2	discoidin domain receptor family, member 2	0.157
Tead2	TEA domain family member 2	0.151
Tbx2	T-box 2	0.150
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.148
Irs1	insulin receptor substrate 1	0.147
Smad3	MAD homolog 3 (Drosophila)	0.141
Sstr4	somatostatin receptor 4	0.133
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.130
Eya1	eyes absent 1 homolog (Drosophila)	0.130
Sfrp2	secreted frizzled-related protein 2	0.129
Fzd4	frizzled homolog 4 (Drosophila)	0.129	Mouse
Bmp7	bone morphogenetic protein 7	0.113
Plxna1	plexin A1	0.113
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.112
Fgf10	fibroblast growth factor 10	0.107
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.105
Cdh6	cadherin 6	0.102
Cachd1	cache domain containing 1	0.100
Tpbg	trophoblast glycoprotein	0.098
Hoxa2	homeobox A2	0.096
Jag1	jagged 1	0.095
Efs	embryonal Fyn-associated substrate	0.094
Gdf10	growth differentiation factor 10	0.092
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.091
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.086
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.083
Amotl2	angiomotin-like 2	0.082
Btbd3	BTB (POZ) domain containing 3	0.080
Neo1	neogenin	0.080
Podxl	podocalyxin-like	0.078
Hoxd8	homeobox D8	0.077
Hs3st3a1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.077
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.077
Zfp503	zinc finger protein 503	0.075
Fgfr1	fibroblast growth factor receptor 1	0.073
Ctnnal1	catenin (cadherin associated protein), alpha-like 1	0.072
Ephb3	Eph receptor B3	0.072
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.072
Hoxb3	homeobox B3	0.065
Gata6	GATA binding protein 6	0.065
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.063
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.063
Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.061
Tbx3	T-box 3	0.059
Smoc2	SPARC related modular calcium binding 2	0.057
Hoxa9	homeobox A9	0.057
Mfap2	microfibrillar-associated protein 2	0.057
Sult5a1	sulfotransferase family 5A, member 1	0.056
Sardh	sarcosine dehydrogenase	0.053
Rarg	retinoic acid receptor, gamma	0.052
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.051
Wnt7b	wingless-related MMTV integration site 7B	0.051
Bmp5	bone morphogenetic protein 5	0.050
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.050
Foxc2	forkhead box C2	0.049
S1pr3	sphingosine-1-phosphate receptor 3	0.049
Ptrf	polymerase I and transcript release factor	0.048
Sh3rf1	SH3 domain containing ring finger 1	0.048
Ephb2	Eph receptor B2	0.047
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.046
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.046
Itga8	integrin alpha 8	0.046
Fgfr3	fibroblast growth factor receptor 3	0.045
Per3	period homolog 3 (Drosophila)	0.045
Msx1	homeobox, msh-like 1	0.044
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.044
Sh3d19	SH3 domain protein D19	0.044
Fjx1	four jointed box 1 (Drosophila)	0.044
Gjc1	gap junction protein, gamma 1	0.043
Sox4	SRY-box containing gene 4	0.042
Yap1	yes-associated protein 1	0.042
Igfbp2	insulin-like growth factor binding protein 2	0.041
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.041
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.040
Ptprk	protein tyrosine phosphatase, receptor type, K	0.040
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.040
Angpt1	angiopoietin 1	0.039
Vangl2	vang-like 2 (van gogh, Drosophila)	0.038
Meis2	Meis homeobox 2	0.038
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.038
Zfhx3	zinc finger homeobox 3	0.038
Sox9	SRY-box containing gene 9	0.038
Ednrb	endothelin receptor type B	0.037
Efna4	ephrin A4	0.037
Smad5	MAD homolog 5 (Drosophila)	0.037
Mmp11	matrix metallopeptidase 11	0.037
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.036
Sox2	SRY-box containing gene 2	0.036
Col11a1	collagen, type XI, alpha 1	0.035
Ltbp3	latent transforming growth factor beta binding protein 3	0.035
Ntn1	netrin 1	0.035
Twist1	twist homolog 1 (Drosophila)	0.035
Prkd1	protein kinase D1	0.035
Epha4	Eph receptor A4	0.034
Atxn1	ataxin 1	0.034
Lrig1	leucine-rich repeats and immunoglobulin-like domains 1	0.034
Irx3	Iroquois related homeobox 3 (Drosophila)	0.033
Wnt5b	wingless-related MMTV integration site 5B	0.033
Myo10	myosin X	0.032
Arhgap29	Rho GTPase activating protein 29	0.032
Hoxd4	homeobox D4	0.031
Ddah2	dimethylarginine dimethylaminohydrolase 2	0.031
Matn4	matrilin 4	0.031
Prrx2	paired related homeobox 2	0.031
Nfia	nuclear factor I/A	0.030
Lrp2	low density lipoprotein receptor-related protein 2	0.030
Rarb	retinoic acid receptor, beta	0.030
Ptgfr	prostaglandin F receptor	0.030
Gli1	GLI-Kruppel family member GLI1	0.030
She	src homology 2 domain-containing transforming protein E	0.029
Prx	periaxin	0.029
Rcn3	reticulocalbin 3, EF-hand calcium binding domain	0.028
Id4	inhibitor of DNA binding 4	0.028
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.028
Tcf15	transcription factor 15	0.028
Ptgfrn	prostaglandin F2 receptor negative regulator	0.027
Trp63	transformation related protein 63	0.027
Egfr	epidermal growth factor receptor	0.027
Ptch2	patched homolog 2	0.027
Efna1	ephrin A1	0.026
Cmtm8	CKLF-like MARVEL transmembrane domain containing 8	0.026
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.025
Tprgl	transformation related protein 63 regulated like	0.025
Ehd2	EH-domain containing 2	0.025
Foxd1	forkhead box D1	0.025
Plagl1	pleiomorphic adenoma gene-like 1	0.025
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.025
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.025
Fzd5	frizzled homolog 5 (Drosophila)	0.025
Hoxd10	homeobox D10	0.025
Aplnr	apelin receptor	0.024
Met	met proto-oncogene	0.024
Hoxa11	homeobox A11	0.024
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.024
Plxna3	plexin A3	0.024
Fat4	FAT tumor suppressor homolog 4 (Drosophila)	0.024
Fndc1	fibronectin type III domain containing 1	0.023
Ptprg	protein tyrosine phosphatase, receptor type, G	0.023
Creb3l1	cAMP responsive element binding protein 3-like 1	0.023
Wwtr1	WW domain containing transcription regulator 1	0.023
Tead3	TEA domain family member 3	0.023
Pcdh18	protocadherin 18	0.023
Ptpru	protein tyrosine phosphatase, receptor type, U	0.023
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.023
Spry4	sprouty homolog 4 (Drosophila)	0.023
Bmp6	bone morphogenetic protein 6	0.022
Wnt1	wingless-related MMTV integration site 1	0.022
Efna5	ephrin A5	0.022
Tbx15	T-box 15	0.022
Col12a1	collagen, type XII, alpha 1	0.022
Wwc2	WW, C2 and coiled-coil domain containing 2	0.022
Npnt	nephronectin	0.021
Dpysl2	dihydropyrimidinase-like 2	0.021
Becn1	beclin 1, autophagy related	0.021
Twist2	twist homolog 2 (Drosophila)	0.021
Hoxc8	homeobox C8	0.021
Tex19.1	testis expressed gene 19.1	0.020
Nxn	nucleoredoxin	0.020
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.020
Ebf3	early B-cell factor 3	0.020
Dll1	delta-like 1 (Drosophila)	0.020
Ntf3	neurotrophin 3	0.019
Ptch1	patched homolog 1	0.019
Epha3	Eph receptor A3	0.019
Axin2	axin2	0.019
Mtap1b	microtubule-associated protein 1B	0.019
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.019
Dnajb1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.019
Osr1	odd-skipped related 1 (Drosophila)	0.019
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.018
Wnt3a	wingless-related MMTV integration site 3A	0.018
Lama5	laminin, alpha 5	0.018
Nfib	nuclear factor I/B	0.018
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.018
Hic1	hypermethylated in cancer 1	0.018
Folr1	folate receptor 1 (adult)	0.018
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.018
Hoxb5	homeobox B5	0.018
Gab1	growth factor receptor bound protein 2-associated protein 1	0.018
Ube2h	ubiquitin-conjugating enzyme E2H	0.017
Smtn	smoothelin	0.017
Dach1	dachshund 1 (Drosophila)	0.017
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.017
Timp2	tissue inhibitor of metalloproteinase 2	0.017
Epn2	epsin 2	0.017
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.017
Ocln	occludin	0.017
Dlx5	distal-less homeobox 5	0.017
Tcf21	transcription factor 21	0.017
Efna3	ephrin A3	0.017
Pdgfb	platelet derived growth factor, B polypeptide	0.017
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.016
Bcam	basal cell adhesion molecule	0.016
Hipk3	homeodomain interacting protein kinase 3	0.016
Pcsk6	proprotein convertase subtilisin/kexin type 6	0.016
Prkci	protein kinase C, iota	0.016
Nat6	N-acetyltransferase 6	0.016
Vcan	versican	0.016
Hoxa3	homeobox A3	0.016
Mid2	midline 2	0.016
Sox7	SRY-box containing gene 7	0.016
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.015
Zfp358	zinc finger protein 358	0.015
Gpc4	glypican 4	0.015
Stra6	stimulated by retinoic acid gene 6	0.015
Ptpn13	protein tyrosine phosphatase, non-receptor type 13	0.015
Ephb4	Eph receptor B4	0.015
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.015
Vhl	von Hippel-Lindau tumor suppressor	0.015
Rara	retinoic acid receptor, alpha	0.015
Clec11a	C-type lectin domain family 11, member a	0.015
Epas1	endothelial PAS domain protein 1	0.015
Aff1	AF4/FMR2 family, member 1	0.015
Ghr	growth hormone receptor	0.015
Adcy6	adenylate cyclase 6	0.015
Slc2a5	solute carrier family 2 (facilitated glucose transporter), member 5	0.015
Fign	fidgetin	0.014
Fgf7	fibroblast growth factor 7	0.014
Mpdz	multiple PDZ domain protein	0.014
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.014
Ihh	Indian hedgehog	0.014
Tspan9	tetraspanin 9	0.014
Ryk	receptor-like tyrosine kinase	0.014
Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.014
Dnaja4	DnaJ (Hsp40) homolog, subfamily A, member 4	0.014
Ids	iduronate 2-sulfatase	0.014
Notch3	Notch gene homolog 3 (Drosophila)	0.014
Mtap2	microtubule-associated protein 2	0.014
Wnt4	wingless-related MMTV integration site 4	0.014
Hspa1a	heat shock protein 1A	0.014
Efnb2	ephrin B2	0.014
Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.013
Col4a4	collagen, type IV, alpha 4	0.013
Tgfbr1	transforming growth factor, beta receptor I	0.013
Art1	ADP-ribosyltransferase 1	0.013
Ctnnb1	catenin (cadherin associated protein), beta 1	0.013
Eya4	eyes absent 4 homolog (Drosophila)	0.013
Pdlim3	PDZ and LIM domain 3	0.013
Fgfrl1	fibroblast growth factor receptor-like 1	0.013
Grem1	gremlin 1	0.013
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.013
Hoxb4	homeobox B4	0.013
Efhd1	EF hand domain containing 1	0.013
Thbs1	thrombospondin 1	0.013
Ptprf	protein tyrosine phosphatase, receptor type, F	0.013
Hspb2	heat shock protein 2	0.013
Ppara	peroxisome proliferator activated receptor alpha	0.013
Mmp15	matrix metallopeptidase 15	0.013
Fgf2	fibroblast growth factor 2	0.012
Sox13	SRY-box containing gene 13	0.012
Adipor1	adiponectin receptor 1	0.012
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.012
Dtna	dystrobrevin alpha	0.012
Dppa5a	developmental pluripotency associated 5A	0.012
Lrig3	leucine-rich repeats and immunoglobulin-like domains 3	0.012
Mmp16	matrix metallopeptidase 16	0.012
Pitx2	paired-like homeodomain transcription factor 2	0.012
Cul7	cullin 7	0.012
Csrp1	cysteine and glycine-rich protein 1	0.012
Lpar1	lysophosphatidic acid receptor 1	0.012
Cntfr	ciliary neurotrophic factor receptor	0.012
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.012
Cldn8	claudin 8	0.012
Slc22a5	solute carrier family 22 (organic cation transporter), member 5	0.012
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.012
C1qtnf3	C1q and tumor necrosis factor related protein 3	0.012
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.012
Rgs5	regulator of G-protein signaling 5	0.012
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.012
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.012
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.012
Usp22	ubiquitin specific peptidase 22	0.012
Zfp532	zinc finger protein 532	0.012
Nog	noggin	0.012
Repin1	replication initiator 1	0.011
Ndp	Norrie disease (pseudoglioma) (human)	0.011
Klf12	Kruppel-like factor 12	0.011
Cxadr	coxsackie virus and adenovirus receptor	0.011
Upk3b	uroplakin 3B	0.011
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.011
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.011
Gpr27	G protein-coupled receptor 27	0.011
Epb4.1l4a	erythrocyte protein band 4.1-like 4a	0.011
Zcchc14	zinc finger, CCHC domain containing 14	0.011
Rab5b	RAB5B, member RAS oncogene family	0.011
Igfbp3	insulin-like growth factor binding protein 3	0.011
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.011
Fhdc1	FH2 domain containing 1	0.011
Gabarapl1	gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1	0.011
Ptges	prostaglandin E synthase	0.011
Phka1	phosphorylase kinase alpha 1	0.011
Epb4.1l4b	erythrocyte protein band 4.1-like 4b	0.010
Lama1	laminin, alpha 1	0.010
Nsd1	nuclear receptor-binding SET-domain protein 1	0.010
Shh	sonic hedgehog	0.010
Dnajb4	DnaJ (Hsp40) homolog, subfamily B, member 4	0.010
Scx	scleraxis	0.010
Thrb	thyroid hormone receptor beta	0.010
Angptl7	angiopoietin-like 7	0.010
Fgd1	FYVE, RhoGEF and PH domain containing 1	0.010
Itga2	integrin alpha 2	0.010
Fam84a	family with sequence similarity 84, member A	0.010
Pvrl3	poliovirus receptor-related 3	0.010
Ret	ret proto-oncogene	0.010