IMP

Process View

Mus musculus

19 genes annotated in mouse

negative regulation of nuclear division

Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of nuclear division"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of nuclear division" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.987
Trp53	transformation related protein 53	0.982
Gli3	GLI-Kruppel family member GLI3	0.612
Bmp4	bone morphogenetic protein 4	0.600	Human
Fgfr2	fibroblast growth factor receptor 2	0.564
Brca1	breast cancer 1	0.536
Sox9	SRY-box containing gene 9	0.516
Ctnnb1	catenin (cadherin associated protein), beta 1	0.451
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.412
Lin9	lin-9 homolog (C. elegans)	0.405
Cdk4	cyclin-dependent kinase 4	0.342
Cdk2	cyclin-dependent kinase 2	0.329
Ccnb1	cyclin B1	0.252
Cenpe	centromere protein E	0.247
Atf4	activating transcription factor 4	0.230
Brca2	breast cancer 2	0.229
Hells	helicase, lymphoid specific	0.221
Trim59	tripartite motif-containing 59	0.221
Sgol1	shugoshin-like 1 (S. pombe)	0.213
Ccne2	cyclin E2	0.211	Fly
Ncoa3	nuclear receptor coactivator 3	0.210
Pthlh	parathyroid hormone-like peptide	0.198
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.189
Plk4	polo-like kinase 4 (Drosophila)	0.158
Rb1	retinoblastoma 1	0.151
Rpa3	replication protein A3	0.151
Trp63	transformation related protein 63	0.150
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.147
Chek1	checkpoint kinase 1 homolog (S. pombe)	0.140	Human
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.140
Sgol2	shugoshin-like 2 (S. pombe)	0.137
Msx1	homeobox, msh-like 1	0.130
Mdm2	transformed mouse 3T3 cell double minute 2	0.126
Erg	avian erythroblastosis virus E-26 (v-ets) oncogene related	0.124
Mastl	microtubule associated serine/threonine kinase-like	0.121
Rara	retinoic acid receptor, alpha	0.117
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.116
Ptch1	patched homolog 1	0.116
Cenpk	centromere protein K	0.112
Runx2	runt related transcription factor 2	0.111
Spag5	sperm associated antigen 5	0.109
Cbx1	chromobox homolog 1 (Drosophila HP1 beta)	0.106
Anln	anillin, actin binding protein	0.106
Dtl	denticleless homolog (Drosophila)	0.102
Otx2	orthodenticle homolog 2 (Drosophila)	0.098
Blm	Bloom syndrome, RecQ helicase-like	0.098
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.096
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.094
Mdm4	transformed mouse 3T3 cell double minute 4	0.092
4632434I11Rik	RIKEN cDNA 4632434I11 gene	0.092
Dbf4	DBF4 homolog (S. cerevisiae)	0.087
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.086
Cenpj	centromere protein J	0.082
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.082
Recql	RecQ protein-like	0.079
Mis18bp1	MIS18 binding protein 1	0.079
Foxc1	forkhead box C1	0.079
Ooep	oocyte expressed protein homolog (dog)	0.077
Nlrp5	NLR family, pyrin domain containing 5	0.074
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.073	Yeast
Lrrk2	leucine-rich repeat kinase 2	0.068
Sae1	SUMO1 activating enzyme subunit 1	0.067
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.065
Prrx1	paired related homeobox 1	0.064
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.063	Yeast
Hand1	heart and neural crest derivatives expressed transcript 1	0.061
Cdk1	cyclin-dependent kinase 1	0.058
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.058	Yeast
Ncapg	non-SMC condensin I complex, subunit G	0.057
Trip13	thyroid hormone receptor interactor 13	0.055
Haus6	HAUS augmin-like complex, subunit 6	0.055
Aurka	aurora kinase A	0.053
Ncapg2	non-SMC condensin II complex, subunit G2	0.053
Rbl1	retinoblastoma-like 1 (p107)	0.049
Tsc2	tuberous sclerosis 2	0.049
Kif20a	kinesin family member 20A	0.049
Kif23	kinesin family member 23	0.048
Ect2	ect2 oncogene	0.048
Fbxo5	F-box protein 5	0.048
Tsc1	tuberous sclerosis 1	0.047
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.047
Bmp7	bone morphogenetic protein 7	0.046	Human
Ccna2	cyclin A2	0.044
Kif2c	kinesin family member 2C	0.044
Prrx2	paired related homeobox 2	0.044
Ccne1	cyclin E1	0.043	Fly
Smc2	structural maintenance of chromosomes 2	0.043	Yeast
E2f8	E2F transcription factor 8	0.042
Ccnf	cyclin F	0.042
Cdca8	cell division cycle associated 8	0.041
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.041	Fly
Rpgrip1l	Rpgrip1-like	0.040
Ncapd3	non-SMC condensin II complex, subunit D3	0.040
Arl6ip6	ADP-ribosylation factor-like 6 interacting protein 6	0.039
Suv39h2	suppressor of variegation 3-9 homolog 2 (Drosophila)	0.038
Smc4	structural maintenance of chromosomes 4	0.038
Hmgb2	high mobility group box 2	0.038
Mns1	meiosis-specific nuclear structural protein 1	0.037
Fgfr1	fibroblast growth factor receptor 1	0.037	Mouse
Alx1	ALX homeobox 1	0.037
Arfrp1	ADP-ribosylation factor related protein 1	0.036
Esco2	establishment of cohesion 1 homolog 2 (S. cerevisiae)	0.036
Kif11	kinesin family member 11	0.035
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.035
Nedd1	neural precursor cell expressed, developmentally down-regulated gene 1	0.034
Kif22	kinesin family member 22	0.033
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.033
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.033
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.033
Dlx5	distal-less homeobox 5	0.033
Fignl1	fidgetin-like 1	0.032
Nog	noggin	0.032
Dsn1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.032
Fbxo43	F-box protein 43	0.031
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.029
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.029
Zp3	zona pellucida glycoprotein 3	0.029
Gsg2	germ cell-specific gene 2	0.029
Fgfr3	fibroblast growth factor receptor 3	0.028
Bmp2	bone morphogenetic protein 2	0.028
Neurog2	neurogenin 2	0.027
Mcm8	minichromosome maintenance deficient 8 (S. cerevisiae)	0.027
Zeb1	zinc finger E-box binding homeobox 1	0.027
Igbp1	immunoglobulin (CD79A) binding protein 1	0.026
Hist2h4	histone cluster 2, H4	0.026
Lrp6	low density lipoprotein receptor-related protein 6	0.026
Hist1h2bm	histone cluster 1, H2bm	0.025
Pms2	postmeiotic segregation increased 2 (S. cerevisiae)	0.025
2610039C10Rik	RIKEN cDNA 2610039C10 gene	0.025
Skp1a	S-phase kinase-associated protein 1A	0.025
Pot1a	protection of telomeres 1A	0.025
Casc5	cancer susceptibility candidate 5	0.024
Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.024
Cenpf	centromere protein F	0.023
Hist1h2aa	histone cluster 1, H2aa	0.023
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.023
Pola1	polymerase (DNA directed), alpha 1	0.023
Naa11	N(alpha)-acetyltransferase 11, NatA catalytic subunit	0.021
Eri2	exoribonuclease 2	0.021
Nasp	nuclear autoantigenic sperm protein (histone-binding)	0.021
Shcbp1	Shc SH2-domain binding protein 1	0.021
Trp73	transformation related protein 73	0.021
Atad2	ATPase family, AAA domain containing 2	0.021
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.021
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.021
Gtse1	G two S phase expressed protein 1	0.021
Prc1	protein regulator of cytokinesis 1	0.021
Skil	SKI-like	0.021
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.021
Hand2	heart and neural crest derivatives expressed transcript 2	0.020
Prim2	DNA primase, p58 subunit	0.020
Lig4	ligase IV, DNA, ATP-dependent	0.020
Aicda	activation-induced cytidine deaminase	0.020
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.020
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.020
Acd	adrenocortical dysplasia	0.020
Pcna	proliferating cell nuclear antigen	0.020
Cdkn2aipnl	CDKN2A interacting protein N-terminal like	0.019
Mki67	antigen identified by monoclonal antibody Ki 67	0.019
Rbbp8	retinoblastoma binding protein 8	0.019
Apc	adenomatosis polyposis coli	0.019	Human
Gabpb1	GA repeat binding protein, beta 1	0.019
Ccdc77	coiled-coil domain containing 77	0.019
Fancm	Fanconi anemia, complementation group M	0.019
Lmnb1	lamin B1	0.018
6720463M24Rik	RIKEN cDNA 6720463M24 gene	0.018
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.018
Cenpq	centromere protein Q	0.018
G2e3	G2/M-phase specific E3 ubiquitin ligase	0.017
Ccnb2	cyclin B2	0.017
Ccdc99	coiled-coil domain containing 99	0.017
Nf2	neurofibromatosis 2	0.017
Sufu	suppressor of fused homolog (Drosophila)	0.017
Lmna	lamin A	0.017
Etaa1	Ewing's tumor-associated antigen 1	0.017
Melk	maternal embryonic leucine zipper kinase	0.016
Tmpo	thymopoietin	0.016
Hus1	Hus1 homolog (S. pombe)	0.016
Rbmxl2	RNA binding motif protein, X-linked-like 2	0.016
Ube2t	ubiquitin-conjugating enzyme E2T (putative)	0.016
Gli2	GLI-Kruppel family member GLI2	0.016
Cdc6	cell division cycle 6 homolog (S. cerevisiae)	0.016
Irf6	interferon regulatory factor 6	0.016
Hes1	hairy and enhancer of split 1 (Drosophila)	0.016
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.016
Zfp101	zinc finger protein 101	0.016
Ripk4	receptor-interacting serine-threonine kinase 4	0.015
Kif20b	kinesin family member 20B	0.015
Hist2h3c2-ps	histone cluster 2, H3c2, pseudogene	0.015
Smad3	MAD homolog 3 (Drosophila)	0.015
Ckap2	cytoskeleton associated protein 2	0.015
Atr	ataxia telangiectasia and Rad3 related	0.015
Chek2	CHK2 checkpoint homolog (S. pombe)	0.015
Birc5	baculoviral IAP repeat-containing 5	0.014
Chtf18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.014
Fgfrl1	fibroblast growth factor receptor-like 1	0.014
Ppih	peptidyl prolyl isomerase H	0.014
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.014
Cbx5	chromobox homolog 5 (Drosophila HP1a)	0.014
Tbc1d4	TBC1 domain family, member 4	0.014
Terf1	telomeric repeat binding factor 1	0.014	Human
Gsc	goosecoid homeobox	0.014
Rrm1	ribonucleotide reductase M1	0.013
Polr1a	polymerase (RNA) I polypeptide A	0.013
Dna2	DNA replication helicase 2 homolog (yeast)	0.013
Mbnl3	muscleblind-like 3 (Drosophila)	0.013
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.013
Raf1	v-raf-leukemia viral oncogene 1	0.013
Mybl1	myeloblastosis oncogene-like 1	0.013
Nf1	neurofibromatosis 1	0.013
H2afz	H2A histone family, member Z	0.012
Prmt3	protein arginine N-methyltransferase 3	0.012
Pask	PAS domain containing serine/threonine kinase	0.012
Cenpi	centromere protein I	0.012
Ercc6l	excision repair cross-complementing rodent repair deficiency complementation group 6 - like	0.012
Cdc45	cell division cycle 45 homolog (S. cerevisiae)	0.012
Zik1	zinc finger protein interacting with K protein 1	0.012
Polh	polymerase (DNA directed), eta (RAD 30 related)	0.012
Atf6b	activating transcription factor 6 beta	0.012
Bmp5	bone morphogenetic protein 5	0.012
Piwil2	piwi-like homolog 2 (Drosophila)	0.012
Rad18	RAD18 homolog (S. cerevisiae)	0.012
Lsm2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.012
Tbx1	T-box 1	0.012
Rbl2	retinoblastoma-like 2	0.012
Msh2	mutS homolog 2 (E. coli)	0.012
Fancb	Fanconi anemia, complementation group B	0.012
Orc1	origin recognition complex, subunit 1	0.012
Cul4a	cullin 4A	0.011
H1	histocompatibility 1	0.011
Banf1	barrier to autointegration factor 1	0.011
Sox2	SRY-box containing gene 2	0.011
Eif4ebp1	eukaryotic translation initiation factor 4E binding protein 1	0.011
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.011
Palb2	partner and localizer of BRCA2	0.011
Neurod1	neurogenic differentiation 1	0.011
Phospho1	phosphatase, orphan 1	0.011
Mtf2	metal response element binding transcription factor 2	0.011
Cenpn	centromere protein N	0.011
Notch1	Notch gene homolog 1 (Drosophila)	0.011
Ckap2l	cytoskeleton associated protein 2-like	0.011
Ptk2	PTK2 protein tyrosine kinase 2	0.011
Polr3k	polymerase (RNA) III (DNA directed) polypeptide K	0.011
Clspn	claspin homolog (Xenopus laevis)	0.011
Racgap1	Rac GTPase-activating protein 1	0.011
Wrn	Werner syndrome homolog (human)	0.011
Cstf2	cleavage stimulation factor, 3' pre-RNA subunit 2	0.011
Kif4	kinesin family member 4	0.010
Bard1	BRCA1 associated RING domain 1	0.010
Cdca2	cell division cycle associated 2	0.010
Mapk13	mitogen-activated protein kinase 13	0.010
Ttk	Ttk protein kinase	0.010	Yeast Fly
Arhgap11a	Rho GTPase activating protein 11A	0.010
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.010
Eya1	eyes absent 1 homolog (Drosophila)	0.010