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Process View

Mus musculus

3 genes annotated in mouse

sinoatrial node cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "sinoatrial node cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "sinoatrial node cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Pitx2	paired-like homeodomain transcription factor 2	1.000
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	1.000
Shh	sonic hedgehog	1.000
Hand2	heart and neural crest derivatives expressed transcript 2	1.000
Fgfr2	fibroblast growth factor receptor 2	1.000
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	1.000
Tbx3	T-box 3	1.000
Tcfap2a	transcription factor AP-2, alpha	1.000
Hoxa1	homeobox A1	0.999
Foxc1	forkhead box C1	0.999
Pax3	paired box gene 3	0.999
Chd7	chromodomain helicase DNA binding protein 7	0.999
Fgf8	fibroblast growth factor 8	0.999
Prrx1	paired related homeobox 1	0.999
Foxg1	forkhead box G1	0.998
Foxc2	forkhead box C2	0.998
Eya1	eyes absent 1 homolog (Drosophila)	0.998
Sox9	SRY-box containing gene 9	0.997
Dlx5	distal-less homeobox 5	0.995
Msx1	homeobox, msh-like 1	0.995
Tbx5	T-box 5	0.995	Mouse
Pitx1	paired-like homeodomain transcription factor 1	0.994
Hand1	heart and neural crest derivatives expressed transcript 1	0.993
Scn5a	sodium channel, voltage-gated, type V, alpha	0.991
Tbx1	T-box 1	0.990	Mouse
Bmp4	bone morphogenetic protein 4	0.989
Chrd	chordin	0.988
Otx2	orthodenticle homolog 2 (Drosophila)	0.978
Jag1	jagged 1	0.968
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.960
Isl1	ISL1 transcription factor, LIM/homeodomain	0.958
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.954
Tgfb2	transforming growth factor, beta 2	0.946
Pax2	paired box gene 2	0.946
Hoxa3	homeobox A3	0.942
Ednra	endothelin receptor type A	0.941
Gli3	GLI-Kruppel family member GLI3	0.931
Gsc	goosecoid homeobox	0.927
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.923
Gata4	GATA binding protein 4	0.905
Smo	smoothened homolog (Drosophila)	0.833
Rarb	retinoic acid receptor, beta	0.833
Gja5	gap junction protein, alpha 5	0.791
Runx2	runt related transcription factor 2	0.754
Bmp7	bone morphogenetic protein 7	0.741
Rarg	retinoic acid receptor, gamma	0.738
Tbx4	T-box 4	0.725	Mouse
Rxra	retinoid X receptor alpha	0.722
Vangl2	vang-like 2 (van gogh, Drosophila)	0.718
Fgf10	fibroblast growth factor 10	0.660
Alx1	ALX homeobox 1	0.642
Pax9	paired box gene 9	0.611
Zeb1	zinc finger E-box binding homeobox 1	0.606
Vegfa	vascular endothelial growth factor A	0.539
Efnb2	ephrin B2	0.536
Gbx2	gastrulation brain homeobox 2	0.505
Acvr1	activin A receptor, type 1	0.489
Ntf3	neurotrophin 3	0.480
Lef1	lymphoid enhancer binding factor 1	0.479
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.474
Msx2	homeobox, msh-like 2	0.460
Ece1	endothelin converting enzyme 1	0.456
Fgfr1	fibroblast growth factor receptor 1	0.430
Lrp6	low density lipoprotein receptor-related protein 6	0.422
Wnt3a	wingless-related MMTV integration site 3A	0.397
Dlx2	distal-less homeobox 2	0.396
Sall4	sal-like 4 (Drosophila)	0.378
Mn1	meningioma 1	0.344
Hoxa2	homeobox A2	0.321
Fgfr3	fibroblast growth factor receptor 3	0.314
Rara	retinoic acid receptor, alpha	0.311
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.304
Zic3	zinc finger protein of the cerebellum 3	0.298
Sox11	SRY-box containing gene 11	0.296
Gata3	GATA binding protein 3	0.296
Gata6	GATA binding protein 6	0.295
Tcf21	transcription factor 21	0.279
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.274
Prrx2	paired related homeobox 2	0.251
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.248
Sox2	SRY-box containing gene 2	0.247
Bmp2	bone morphogenetic protein 2	0.209
Ighmbp2	immunoglobulin mu binding protein 2	0.196
Lmx1a	LIM homeobox transcription factor 1 alpha	0.189
Zfpm2	zinc finger protein, multitype 2	0.171
Bdnf	brain derived neurotrophic factor	0.154
Bmp5	bone morphogenetic protein 5	0.150
Tbx20	T-box 20	0.148	Mouse
Hoxa13	homeobox A13	0.148
Hmx3	H6 homeobox 3	0.147
Otx1	orthodenticle homolog 1 (Drosophila)	0.144
Xirp1	xin actin-binding repeat containing 1	0.135
Pou5f1	POU domain, class 5, transcription factor 1	0.130
Nkx3-2	NK3 homeobox 2	0.126
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.120
Nodal	nodal	0.120
Rnf2	ring finger protein 2	0.119
Mecom	MDS1 and EVI1 complex locus	0.115
Foxi3	forkhead box I3	0.112
Dlx6	distal-less homeobox 6	0.110
Nog	noggin	0.110
Hoxb3	homeobox B3	0.106
Ryr2	ryanodine receptor 2, cardiac	0.099
Irx3	Iroquois related homeobox 3 (Drosophila)	0.091
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.089
Wt1	Wilms tumor 1 homolog	0.088
Myf5	myogenic factor 5	0.086
Smad6	MAD homolog 6 (Drosophila)	0.083
Tgfbr2	transforming growth factor, beta receptor II	0.073
Bves	blood vessel epicardial substance	0.072
Gata5	GATA binding protein 5	0.069
Tnfrsf25	tumor necrosis factor receptor superfamily, member 25	0.067
Dll4	delta-like 4 (Drosophila)	0.065
Des	desmin	0.061
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.060
Rdh10	retinol dehydrogenase 10 (all-trans)	0.059
Cxadr	coxsackie virus and adenovirus receptor	0.058
Meox2	mesenchyme homeobox 2	0.058
Nanog	Nanog homeobox	0.057
Noto	notochord homolog (Xenopus laevis)	0.055
Foxf1a	forkhead box F1a	0.054
T	brachyury	0.054	Mouse
Pbx1	pre B-cell leukemia transcription factor 1	0.054
Irx4	Iroquois related homeobox 4 (Drosophila)	0.052
Hoxb4	homeobox B4	0.051
Trp63	transformation related protein 63	0.049
Wnt5a	wingless-related MMTV integration site 5A	0.049
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.047
Shox2	short stature homeobox 2	0.046
Fgf3	fibroblast growth factor 3	0.046
Lrp5	low density lipoprotein receptor-related protein 5	0.045
Col13a1	collagen, type XIII, alpha 1	0.045
Gata2	GATA binding protein 2	0.043
Prdm6	PR domain containing 6	0.043
Alx4	aristaless-like homeobox 4	0.042
Asb12	ankyrin repeat and SOCS box-containing 12	0.041
Hoxa10	homeobox A10	0.041
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.040
Ltbp1	latent transforming growth factor beta binding protein 1	0.039
Msc	musculin	0.039
Hoxd1	homeobox D1	0.039
Casq1	calsequestrin 1	0.039
Rybp	RING1 and YY1 binding protein	0.037
Gja1	gap junction protein, alpha 1	0.037
Myf6	myogenic factor 6	0.036
Fgfrl1	fibroblast growth factor receptor-like 1	0.036
Satb2	special AT-rich sequence binding protein 2	0.035
Htt	huntingtin	0.034
Gli2	GLI-Kruppel family member GLI2	0.034
Dnahc11	dynein, axonemal, heavy chain 11	0.034
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.034
Emx2	empty spiracles homolog 2 (Drosophila)	0.033
Nrg1	neuregulin 1	0.032
Asb10	ankyrin repeat and SOCS box-containing 10	0.032
Foxf2	forkhead box F2	0.031
Ripply3	ripply3 homolog (zebrafish)	0.031
Irx5	Iroquois related homeobox 5 (Drosophila)	0.031
Bmper	BMP-binding endothelial regulator	0.030
Sox4	SRY-box containing gene 4	0.030
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.030
Mesp1	mesoderm posterior 1	0.029	Human
Sall1	sal-like 1 (Drosophila)	0.029
Atoh8	atonal homolog 8 (Drosophila)	0.029
Pou4f2	POU domain, class 4, transcription factor 2	0.029
Myl7	myosin, light polypeptide 7, regulatory	0.028
Lhx9	LIM homeobox protein 9	0.028
Alx3	aristaless-like homeobox 3	0.028
Hoxd3	homeobox D3	0.027
Hmx2	H6 homeobox 2	0.025
Tcfcp2l1	transcription factor CP2-like 1	0.025
Bcl6	B-cell leukemia/lymphoma 6	0.025
Efna1	ephrin A1	0.025
Wdr19	WD repeat domain 19	0.024
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.024
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.024
Myl3	myosin, light polypeptide 3	0.024
Hoxb1	homeobox B1	0.024
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.022
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.022
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.022
Alpk3	alpha-kinase 3	0.021
Ldb3	LIM domain binding 3	0.021
Hoxb2	homeobox B2	0.021
Foxi1	forkhead box I1	0.021
Popdc2	popeye domain containing 2	0.021
Myoz2	myozenin 2	0.020
Vstm2b	V-set and transmembrane domain containing 2B	0.020
Cdx2	caudal type homeobox 2	0.020
Cd274	CD274 antigen	0.020
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.020
Lhx1	LIM homeobox protein 1	0.020
Flnc	filamin C, gamma	0.019
Prdm1	PR domain containing 1, with ZNF domain	0.019
Foxh1	forkhead box H1	0.019
Pax7	paired box gene 7	0.019
Popdc3	popeye domain containing 3	0.019	Mouse
Hoxa4	homeobox A4	0.018
Emx1	empty spiracles homolog 1 (Drosophila)	0.018
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.017
Tal1	T-cell acute lymphocytic leukemia 1	0.017
Mkl2	MKL/myocardin-like 2	0.017
Hoxd9	homeobox D9	0.017
Dlx1	distal-less homeobox 1	0.017
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.017
Tlx3	T-cell leukemia, homeobox 3	0.017
Isl2	insulin related protein 2 (islet 2)	0.017
Myocd	myocardin	0.017
Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	0.017
Tead1	TEA domain family member 1	0.017
Egfr	epidermal growth factor receptor	0.017
Tshz1	teashirt zinc finger family member 1	0.017
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.016
Hspb2	heat shock protein 2	0.016
Nkd2	naked cuticle 2 homolog (Drosophila)	0.016
Osr1	odd-skipped related 1 (Drosophila)	0.016
Runx3	runt related transcription factor 3	0.016
Nos3	nitric oxide synthase 3, endothelial cell	0.016
Lmod2	leiomodin 2 (cardiac)	0.015
Lao1	L-amino acid oxidase 1	0.015
Pax6	paired box gene 6	0.015
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.015
Hspb3	heat shock protein 3	0.015
Mll2	myeloid/lymphoid or mixed-lineage leukemia 2	0.015
Lmod1	leiomodin 1 (smooth muscle)	0.015
Sp8	trans-acting transcription factor 8	0.015
Bnc1	basonuclin 1	0.015
Fign	fidgetin	0.015
Foxe3	forkhead box E3	0.015
Nkd1	naked cuticle 1 homolog (Drosophila)	0.015
Foxa1	forkhead box A1	0.014
Fuz	fuzzy homolog (Drosophila)	0.014
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.014
Nkx6-1	NK6 homeobox 1	0.014
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.014
Pln	phospholamban	0.014
Tbx15	T-box 15	0.014	Mouse
Synpo2l	synaptopodin 2-like	0.014
Jph2	junctophilin 2	0.014
Tcf15	transcription factor 15	0.014
Csrp3	cysteine and glycine-rich protein 3	0.014
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.014
Twist2	twist homolog 2 (Drosophila)	0.013
Mks1	Meckel syndrome, type 1	0.013
Myo6	myosin VI	0.013
Rag2	recombination activating gene 2	0.013
Wnt11	wingless-related MMTV integration site 11	0.013
Tnnt3	troponin T3, skeletal, fast	0.013
Defb10	defensin beta 10	0.013
Cd5	CD5 antigen	0.013
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.013
Tcf7	transcription factor 7, T-cell specific	0.013
Fgf18	fibroblast growth factor 18	0.012
Cxcr5	chemokine (C-X-C motif) receptor 5	0.012
Thsd1	thrombospondin, type I, domain 1	0.012
S1pr4	sphingosine-1-phosphate receptor 4	0.012
Neurog2	neurogenin 2	0.012
Apobec2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2	0.012
Pds5a	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.012
Dmrt3	doublesex and mab-3 related transcription factor 3	0.012
Aldh1a3	aldehyde dehydrogenase family 1, subfamily A3	0.012
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.012
Fzd6	frizzled homolog 6 (Drosophila)	0.012
Fzd8	frizzled homolog 8 (Drosophila)	0.012
Tnnc1	troponin C, cardiac/slow skeletal	0.012
Zic1	zinc finger protein of the cerebellum 1	0.012
Npr2	natriuretic peptide receptor 2	0.012
BC020535	cDNA sequence BC020535	0.012
Igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	0.012
Cap2	CAP, adenylate cyclase-associated protein, 2 (yeast)	0.012
Gdf3	growth differentiation factor 3	0.012
Cd28	CD28 antigen	0.011
Hoxd8	homeobox D8	0.011
Zbtb33	zinc finger and BTB domain containing 33	0.011
Hoxd11	homeobox D11	0.011
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.011
Hopx	HOP homeobox	0.011
Scube2	signal peptide, CUB domain, EGF-like 2	0.011
Dnase1l2	deoxyribonuclease 1-like 2	0.011
Nkg7	natural killer cell group 7 sequence	0.011
Itgb1bp2	integrin beta 1 binding protein 2	0.011
Sync	syncoilin	0.011
Adamts8	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8	0.011
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.011
Rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.011
Hoxd13	homeobox D13	0.011
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.011
Klf14	Kruppel-like factor 14	0.011
Axin2	axin2	0.011
Hmga2	high mobility group AT-hook 2	0.011
Pou4f3	POU domain, class 4, transcription factor 3	0.011
Cd8b1	CD8 antigen, beta chain 1	0.011
Klf3	Kruppel-like factor 3 (basic)	0.010
Csnk2a1	casein kinase 2, alpha 1 polypeptide	0.010
Acvr2b	activin receptor IIB	0.010
Ppp1r3a	protein phosphatase 1, regulatory (inhibitor) subunit 3A	0.010
Zbtb16	zinc finger and BTB domain containing 16	0.010
Synpo2	synaptopodin 2	0.010
Prkg2	protein kinase, cGMP-dependent, type II	0.010
Adam28	a disintegrin and metallopeptidase domain 28	0.010
Kremen1	kringle containing transmembrane protein 1	0.010
Has2	hyaluronan synthase 2	0.010
Aif1l	allograft inflammatory factor 1-like	0.010
Pou2af1	POU domain, class 2, associating factor 1	0.010
Lrrc56	leucine rich repeat containing 56	0.010
Lrp4	low density lipoprotein receptor-related protein 4	0.010
Asb14	ankyrin repeat and SOCS box-containing 14	0.010
Gdnf	glial cell line derived neurotrophic factor	0.010
Atp1b4	ATPase, (Na+)/K+ transporting, beta 4 polypeptide	0.010
Prtg	protogenin homolog (Gallus gallus)	0.010
Actn2	actinin alpha 2	0.010
Pax1	paired box gene 1	0.010