IMP

Process View

Mus musculus

15 genes annotated in mouse

negative regulation of microtubule polymerization or depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of microtubule polymerization or depolymerization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of microtubule polymerization or depolymerization" (in gray)

Name	Description	Probability	Func Analog Organism
Cdk1	cyclin-dependent kinase 1	0.996
Ccnb1	cyclin B1	0.989	Human
Macf1	microtubule-actin crosslinking factor 1	0.988	Fly
Ccna2	cyclin A2	0.986
Prc1	protein regulator of cytokinesis 1	0.978	Worm Fly
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.963
Ccnb2	cyclin B2	0.956
Kif20a	kinesin family member 20A	0.864
Plk1	polo-like kinase 1 (Drosophila)	0.864
Anln	anillin, actin binding protein	0.850
Birc5	baculoviral IAP repeat-containing 5	0.850
Ckap2	cytoskeleton associated protein 2	0.818
Dcx	doublecortin	0.750	Worm
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.738
Kif22	kinesin family member 22	0.710
Kif11	kinesin family member 11	0.689	Fly
Kif2c	kinesin family member 2C	0.612
Racgap1	Rac GTPase-activating protein 1	0.589
Kif4	kinesin family member 4	0.588
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.562
Cdca8	cell division cycle associated 8	0.511
Aurkb	aurora kinase B	0.474	Human
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.464
Cdca5	cell division cycle associated 5	0.429
Ncaph	non-SMC condensin I complex, subunit H	0.423
Top2a	topoisomerase (DNA) II alpha	0.418
Aurka	aurora kinase A	0.368	Human
Pax2	paired box gene 2	0.355
Dclk1	doublecortin-like kinase 1	0.354	Worm
Bdnf	brain derived neurotrophic factor	0.353
Braf	Braf transforming gene	0.325
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.308
Ube2c	ubiquitin-conjugating enzyme E2C	0.307
Clasp1	CLIP associating protein 1	0.294
Spag5	sperm associated antigen 5	0.285
Tbx10	T-box 10	0.283
Gtse1	G two S phase expressed protein 1	0.282
Trim55	tripartite motif-containing 55	0.272	Mouse
Ect2	ect2 oncogene	0.223
Fam64a	family with sequence similarity 64, member A	0.215
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.215
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.206
Trim63	tripartite motif-containing 63	0.206	Mouse
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.202
H2afx	H2A histone family, member X	0.193
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.191
Kif23	kinesin family member 23	0.186
Tuba1a	tubulin, alpha 1A	0.178
Cdkn3	cyclin-dependent kinase inhibitor 3	0.170
Sae1	SUMO1 activating enzyme subunit 1	0.169
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.168
Otx2	orthodenticle homolog 2 (Drosophila)	0.164
Lmnb1	lamin B1	0.161
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.155
Smc4	structural maintenance of chromosomes 4	0.153
Mki67	antigen identified by monoclonal antibody Ki 67	0.137
Cks2	CDC28 protein kinase regulatory subunit 2	0.126
Mis18bp1	MIS18 binding protein 1	0.125
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.125
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.123
Mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.123
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.117
Pcdhgb1	protocadherin gamma subfamily B, 1	0.115
Gsk3b	glycogen synthase kinase 3 beta	0.113
Mxd3	Max dimerization protein 3	0.110
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.097
Ccdc99	coiled-coil domain containing 99	0.092
Cenpa	centromere protein A	0.089
Pou3f4	POU domain, class 3, transcription factor 4	0.084
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.082
Vcp	valosin containing protein	0.079
Tacc3	transforming, acidic coiled-coil containing protein 3	0.075
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.075
Ttk	Ttk protein kinase	0.074
Foxm1	forkhead box M1	0.073
Ctnnb1	catenin (cadherin associated protein), beta 1	0.070
Nefl	neurofilament, light polypeptide	0.067
Cenpf	centromere protein F	0.065
Exoc3	exocyst complex component 3	0.065
Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.065
Trim59	tripartite motif-containing 59	0.064	Mouse
Ar	androgen receptor	0.062
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.061
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.060
Fam83d	family with sequence similarity 83, member D	0.060
Fgf10	fibroblast growth factor 10	0.057	Mouse
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.056
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.054
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.050
Nusap1	nucleolar and spindle associated protein 1	0.050
Nefm	neurofilament, medium polypeptide	0.050
Fgfbp1	fibroblast growth factor binding protein 1	0.050
Trp53	transformation related protein 53	0.049
Smc2	structural maintenance of chromosomes 2	0.049
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.049
Foxg1	forkhead box G1	0.048
Eya1	eyes absent 1 homolog (Drosophila)	0.048
Clasp2	CLIP associating protein 2	0.048
Ccnf	cyclin F	0.047
Cdca2	cell division cycle associated 2	0.047
Wdr1	WD repeat domain 1	0.046
Brca1	breast cancer 1	0.046
Plaa	phospholipase A2, activating protein	0.046
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	0.044
Pbk	PDZ binding kinase	0.044
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.043
Gbx2	gastrulation brain homeobox 2	0.043
Trp63	transformation related protein 63	0.042
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.042
Epas1	endothelial PAS domain protein 1	0.042
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.041
Plk4	polo-like kinase 4 (Drosophila)	0.041
Sox2	SRY-box containing gene 2	0.041
Apc	adenomatosis polyposis coli	0.039
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.038
Shc3	src homology 2 domain-containing transforming protein C3	0.038
Tcf21	transcription factor 21	0.038
Tcf19	transcription factor 19	0.038
Ina	internexin neuronal intermediate filament protein, alpha	0.038
Cenpn	centromere protein N	0.037
Emx1	empty spiracles homolog 1 (Drosophila)	0.037
2810417H13Rik	RIKEN cDNA 2810417H13 gene	0.037
Mastl	microtubule associated serine/threonine kinase-like	0.036
Pou4f3	POU domain, class 4, transcription factor 3	0.036
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.034
Hmgb3	high mobility group box 3	0.034
Spna2	spectrin alpha 2	0.033
Dync1h1	dynein cytoplasmic 1 heavy chain 1	0.033
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.031
Hmgb2	high mobility group box 2	0.031
Astn1	astrotactin 1	0.030
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.030
Gata3	GATA binding protein 3	0.030
Twist2	twist homolog 2 (Drosophila)	0.030
Clip1	CAP-GLY domain containing linker protein 1	0.029
Zfpm2	zinc finger protein, multitype 2	0.029
Diap3	diaphanous homolog 3 (Drosophila)	0.029
Rb1	retinoblastoma 1	0.029
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.028
Gap43	growth associated protein 43	0.028
Rxra	retinoid X receptor alpha	0.028
Btbd3	BTB (POZ) domain containing 3	0.027
Usp8	ubiquitin specific peptidase 8	0.027
Fgfr2	fibroblast growth factor receptor 2	0.026
Dtna	dystrobrevin alpha	0.026
Kif3b	kinesin family member 3B	0.025
Ddb1	damage specific DNA binding protein 1	0.025
Incenp	inner centromere protein	0.025
L1cam	L1 cell adhesion molecule	0.024
Tpx2	TPX2, microtubule-associated protein homolog (Xenopus laevis)	0.024
Ids	iduronate 2-sulfatase	0.024
Cplx1	complexin 1	0.024
Nkx2-1	NK2 homeobox 1	0.024
Rad51ap1	RAD51 associated protein 1	0.023
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.023
Shh	sonic hedgehog	0.023
Myef2	myelin basic protein expression factor 2, repressor	0.023
Tcf15	transcription factor 15	0.023
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.023
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.022
Smad3	MAD homolog 3 (Drosophila)	0.022
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.022
Bcl2	B-cell leukemia/lymphoma 2	0.021
Zic3	zinc finger protein of the cerebellum 3	0.021
Lmx1a	LIM homeobox transcription factor 1 alpha	0.021
Ube2t	ubiquitin-conjugating enzyme E2T (putative)	0.021
Ckap5	cytoskeleton associated protein 5	0.021
Cend1	cell cycle exit and neuronal differentiation 1	0.021
Stk11	serine/threonine kinase 11	0.021
Stx1a	syntaxin 1A (brain)	0.021
E2f8	E2F transcription factor 8	0.020
Cenpe	centromere protein E	0.020
Fgf8	fibroblast growth factor 8	0.020
Chd7	chromodomain helicase DNA binding protein 7	0.020
Slc6a15	solute carrier family 6 (neurotransmitter transporter), member 15	0.020
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.020
Zfp28	zinc finger protein 28	0.020
Pkia	protein kinase inhibitor, alpha	0.019
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.019
Egfr	epidermal growth factor receptor	0.019
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.018
Rgs7	regulator of G protein signaling 7	0.018
Gsg2	germ cell-specific gene 2	0.018
Rgs4	regulator of G-protein signaling 4	0.018
Tsc1	tuberous sclerosis 1	0.018
Cep55	centrosomal protein 55	0.018
Myo6	myosin VI	0.018
Mapk12	mitogen-activated protein kinase 12	0.018
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.018
Myo1c	myosin IC	0.017
Myo18a	myosin XVIIIA	0.017
Lrrk2	leucine-rich repeat kinase 2	0.017
Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.017
Adam22	a disintegrin and metallopeptidase domain 22	0.017
Mkl1	MKL (megakaryoblastic leukemia)/myocardin-like 1	0.017
Hpca	hippocalcin	0.017
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.017
Adra1a	adrenergic receptor, alpha 1a	0.017
Celf4	CUGBP, Elav-like family member 4	0.017
Hmx3	H6 homeobox 3	0.017
Plp1	proteolipid protein (myelin) 1	0.017
Napb	N-ethylmaleimide sensitive fusion protein attachment protein beta	0.016
Serpini1	serine (or cysteine) peptidase inhibitor, clade I, member 1	0.016
Glg1	golgi apparatus protein 1	0.016
Dpysl2	dihydropyrimidinase-like 2	0.016
Lamc1	laminin, gamma 1	0.016
Plcb1	phospholipase C, beta 1	0.016
Hoxa13	homeobox A13	0.016
Pvalb	parvalbumin	0.016
Eme1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.016
Syt11	synaptotagmin XI	0.016
Bai1	brain-specific angiogenesis inhibitor 1	0.016
Fgf3	fibroblast growth factor 3	0.016	Mouse
Ctcf	CCCTC-binding factor	0.016
Tbx15	T-box 15	0.016
Nf1	neurofibromatosis 1	0.016
Prkci	protein kinase C, iota	0.016
Cnn1	calponin 1	0.016
Prr11	proline rich 11	0.016
Jsrp1	junctional sarcoplasmic reticulum protein 1	0.016
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.016
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.016
Cckbr	cholecystokinin B receptor	0.016
Pola1	polymerase (DNA directed), alpha 1	0.015
Tlx1	T-cell leukemia, homeobox 1	0.015
Tmpo	thymopoietin	0.015
Kif3a	kinesin family member 3A	0.015
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.015
Tppp3	tubulin polymerization-promoting protein family member 3	0.015
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.015
Crmp1	collapsin response mediator protein 1	0.014
Depdc1a	DEP domain containing 1a	0.014
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.014
Oprl1	opioid receptor-like 1	0.014
Hmx2	H6 homeobox 2	0.014
Pgr	progesterone receptor	0.014
Gria3	glutamate receptor, ionotropic, AMPA3 (alpha 3)	0.014
Prkcz	protein kinase C, zeta	0.014
Zfp40	zinc finger protein 40	0.014
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.014
Cenpm	centromere protein M	0.014
Zik1	zinc finger protein interacting with K protein 1	0.014
Mapre2	microtubule-associated protein, RP/EB family, member 2	0.014
Reln	reelin	0.014
Dctn1	dynactin 1	0.014
Tubb5	tubulin, beta 5	0.014
Ube3b	ubiquitin protein ligase E3B	0.014
Fgf14	fibroblast growth factor 14	0.013	Mouse
Fgf4	fibroblast growth factor 4	0.013	Mouse
Rtn1	reticulon 1	0.013
Rhob	ras homolog gene family, member B	0.013
Snap25	synaptosomal-associated protein 25	0.013
Sult4a1	sulfotransferase family 4A, member 1	0.013
En1	engrailed 1	0.013
Mal	myelin and lymphocyte protein, T-cell differentiation protein	0.013
Ipo11	importin 11	0.013
Usp13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.013
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.013
Ckap2l	cytoskeleton associated protein 2-like	0.013	Mouse
Iqcb1	IQ calmodulin-binding motif containing 1	0.013
Lmna	lamin A	0.013
Pitpna	phosphatidylinositol transfer protein, alpha	0.013
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.013
Calm2	calmodulin 2	0.013
Calb1	calbindin 1	0.013
Mtap1b	microtubule-associated protein 1B	0.013
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.013
Invs	inversin	0.013
Tbx1	T-box 1	0.012
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.012
Kcnip2	Kv channel-interacting protein 2	0.012
P4htm	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	0.012
Egln1	EGL nine homolog 1 (C. elegans)	0.012
Lats1	large tumor suppressor	0.012
Exoc7	exocyst complex component 7	0.012
Psrc1	proline/serine-rich coiled-coil 1	0.012
Capn1	calpain 1	0.012
Utrn	utrophin	0.012
Casq2	calsequestrin 2	0.012
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.012
Nap1l2	nucleosome assembly protein 1-like 2	0.012
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.012
Etv1	ets variant gene 1	0.012
Rrm2	ribonucleotide reductase M2	0.012
Tgfbr3	transforming growth factor, beta receptor III	0.012
Ubp1	upstream binding protein 1	0.012
Ppp1r14c	protein phosphatase 1, regulatory (inhibitor) subunit 14c	0.012
Angpt1	angiopoietin 1	0.012
Mtap6	microtubule-associated protein 6	0.012
Slc4a2	solute carrier family 4 (anion exchanger), member 2	0.012
Atp8a1	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	0.012
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.012
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.012
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.011
Sry	sex determining region of Chr Y	0.011
Ccnd1	cyclin D1	0.011
Slc25a48	solute carrier family 25, member 48	0.011
Kit	kit oncogene	0.011
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.011
Depdc1b	DEP domain containing 1B	0.011
Gja3	gap junction protein, alpha 3	0.011
Maged2	melanoma antigen, family D, 2	0.011
Fgf9	fibroblast growth factor 9	0.011	Mouse
Socs5	suppressor of cytokine signaling 5	0.011
Cacna2d3	calcium channel, voltage-dependent, alpha2/delta subunit 3	0.011
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.011
Gpr83	G protein-coupled receptor 83	0.011
Nsd1	nuclear receptor-binding SET-domain protein 1	0.011
Usp22	ubiquitin specific peptidase 22	0.011
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.011
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.011
Sh3gl2	SH3-domain GRB2-like 2	0.011
Ryr2	ryanodine receptor 2, cardiac	0.011
D730040F13Rik	RIKEN cDNA D730040F13 gene	0.011
Park2	Parkinson disease (autosomal recessive, juvenile) 2, parkin	0.011
Ppp1r9b	protein phosphatase 1, regulatory subunit 9B	0.011
Scg3	secretogranin III	0.011
Mme	membrane metallo endopeptidase	0.011
Ndel1	nuclear distribution gene E-like homolog 1 (A. nidulans)	0.011
Rxrg	retinoid X receptor gamma	0.011
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.011
1700001O22Rik	RIKEN cDNA 1700001O22 gene	0.011
Flna	filamin, alpha	0.011
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.011
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.011
C77370	expressed sequence C77370	0.011
Sema3e	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	0.010
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.010
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.010
Smn1	survival motor neuron 1	0.010
Myl3	myosin, light polypeptide 3	0.010
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.010
BC018507	cDNA sequence BC018507	0.010
Gpr37	G protein-coupled receptor 37	0.010
2310044G17Rik	RIKEN cDNA 2310044G17 gene	0.010
Trpc1	transient receptor potential cation channel, subfamily C, member 1	0.010
Traf7	TNF receptor-associated factor 7	0.010
Bmp5	bone morphogenetic protein 5	0.010
Stmn3	stathmin-like 3	0.010
Amph	amphiphysin	0.010
Sass6	spindle assembly 6 homolog (C. elegans)	0.010
Kif2a	kinesin family member 2A	0.010
Cdc45	cell division cycle 45 homolog (S. cerevisiae)	0.010
Pif1	PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)	0.010
Stmn2	stathmin-like 2	0.010	Mouse
Zyx	zyxin	0.010
Uchl1	ubiquitin carboxy-terminal hydrolase L1	0.010
Ppp1r1a	protein phosphatase 1, regulatory (inhibitor) subunit 1A	0.010