IMP
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negative regulation of protein tyrosine kinase activity
Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein tyrosine kinase activity"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Egfr | epidermal growth factor receptor | 0.933 | ||
| Cbl | Casitas B-lineage lymphoma | 0.927 | Fly | |
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.854 | ||
| Arrb1 | arrestin, beta 1 | 0.849 | Fly | |
| Arrb2 | arrestin, beta 2 | 0.814 | Fly | |
| Gab2 | growth factor receptor bound protein 2-associated protein 2 | 0.789 | ||
| Grb2 | growth factor receptor bound protein 2 | 0.723 | Fly | |
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.715 | ||
| Shc1 | src homology 2 domain-containing transforming protein C1 | 0.614 | ||
| Psen1 | presenilin 1 | 0.499 | ||
| Ncstn | nicastrin | 0.494 | ||
| Erlin2 | ER lipid raft associated 2 | 0.494 | ||
| Sos1 | son of sevenless homolog 1 (Drosophila) | 0.431 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.391 | ||
| Aph1a | anterior pharynx defective 1a homolog (C. elegans) | 0.287 | ||
| Pten | phosphatase and tensin homolog | 0.282 | ||
| Psen2 | presenilin 2 | 0.244 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.211 | ||
| Frs2 | fibroblast growth factor receptor substrate 2 | 0.202 | ||
| Sh3kbp1 | SH3-domain kinase binding protein 1 | 0.190 | ||
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.185 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.173 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.161 | ||
| Fyn | Fyn proto-oncogene | 0.156 | ||
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.146 | ||
| Itsn1 | intersectin 1 (SH3 domain protein 1A) | 0.123 | ||
| Numb | numb gene homolog (Drosophila) | 0.122 | ||
| Pik3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | 0.119 | ||
| Map4k1 | mitogen-activated protein kinase kinase kinase kinase 1 | 0.107 | ||
| Braf | Braf transforming gene | 0.100 | ||
| Ptpra | protein tyrosine phosphatase, receptor type, A | 0.098 | ||
| 4732456N10Rik | RIKEN cDNA 4732456N10 gene | 0.091 | ||
| Rps3 | ribosomal protein S3 | 0.090 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.087 | ||
| Gab1 | growth factor receptor bound protein 2-associated protein 1 | 0.085 | ||
| Blnk | B-cell linker | 0.079 | ||
| Lrrk1 | leucine-rich repeat kinase 1 | 0.079 | ||
| Pxn | paxillin | 0.072 | ||
| Src | Rous sarcoma oncogene | 0.070 | ||
| Rapgef1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.068 | ||
| Trp73 | transformation related protein 73 | 0.064 | ||
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.063 | ||
| Dll1 | delta-like 1 (Drosophila) | 0.056 | ||
| App | amyloid beta (A4) precursor protein | 0.049 | ||
| Trp53 | transformation related protein 53 | 0.045 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.041 | ||
| Cpne2 | copine II | 0.041 | ||
| Rxra | retinoid X receptor alpha | 0.040 | ||
| Foxm1 | forkhead box M1 | 0.039 | ||
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.039 | ||
| Ndst1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.039 | ||
| Cd22 | CD22 antigen | 0.036 | ||
| Sipa1 | signal-induced proliferation associated gene 1 | 0.034 | ||
| Tek | endothelial-specific receptor tyrosine kinase | 0.033 | ||
| Foxo1 | forkhead box O1 | 0.032 | ||
| Plekho1 | pleckstrin homology domain containing, family O member 1 | 0.032 | ||
| Flii | flightless I homolog (Drosophila) | 0.031 | ||
| Ticam1 | toll-like receptor adaptor molecule 1 | 0.030 | ||
| Vegfa | vascular endothelial growth factor A | 0.030 | ||
| Pik3ap1 | phosphoinositide-3-kinase adaptor protein 1 | 0.030 | ||
| Sh2b2 | SH2B adaptor protein 2 | 0.030 | ||
| Crkl | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.028 | ||
| Pdcd6ip | programmed cell death 6 interacting protein | 0.028 | ||
| Efhd2 | EF hand domain containing 2 | 0.027 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.027 | ||
| Psenen | presenilin enhancer 2 homolog (C. elegans) | 0.027 | ||
| Crk | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.027 | ||
| Cd2ap | CD2-associated protein | 0.026 | ||
| Apc | adenomatosis polyposis coli | 0.026 | ||
| Kit | kit oncogene | 0.026 | ||
| Pde6g | phosphodiesterase 6G, cGMP-specific, rod, gamma | 0.025 | ||
| Ptch1 | patched homolog 1 | 0.025 | ||
| Tlr4 | toll-like receptor 4 | 0.024 | ||
| Flt1 | FMS-like tyrosine kinase 1 | 0.023 | ||
| Csk | c-src tyrosine kinase | 0.023 | ||
| Dok1 | docking protein 1 | 0.023 | ||
| Syvn1 | synovial apoptosis inhibitor 1, synoviolin | 0.023 | ||
| Rb1 | retinoblastoma 1 | 0.023 | ||
| Itk | IL2-inducible T-cell kinase | 0.022 | ||
| Fam3b | family with sequence similarity 3, member B | 0.022 | ||
| Gabrr2 | gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 | 0.022 | ||
| Meox2 | mesenchyme homeobox 2 | 0.021 | ||
| Met | met proto-oncogene | 0.021 | ||
| Zfp36 | zinc finger protein 36 | 0.020 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.020 | ||
| Dnm2 | dynamin 2 | 0.020 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.020 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.019 | ||
| Dbnl | drebrin-like | 0.019 | ||
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.019 | ||
| Calr | calreticulin | 0.019 | ||
| Klraq1 | KLRAQ motif containing 1 | 0.019 | ||
| Eml3 | echinoderm microtubule associated protein like 3 | 0.018 | ||
| Elmo2 | engulfment and cell motility 2, ced-12 homolog (C. elegans) | 0.018 | ||
| Chuk | conserved helix-loop-helix ubiquitous kinase | 0.018 | ||
| Cblb | Casitas B-lineage lymphoma b | 0.018 | Fly | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.018 | ||
| Foxc1 | forkhead box C1 | 0.018 | ||
| Pip4k2a | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.018 | ||
| Prr13 | proline rich 13 | 0.018 | ||
| Lfng | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.017 | ||
| Gsk3b | glycogen synthase kinase 3 beta | 0.017 | ||
| Bdnf | brain derived neurotrophic factor | 0.017 | ||
| Vav2 | vav 2 oncogene | 0.017 | ||
| Errfi1 | ERBB receptor feedback inhibitor 1 | 0.017 | ||
| Nfatc1 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | 0.016 | ||
| Fyb | FYN binding protein | 0.016 | ||
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.016 | ||
| Cebpd | CCAAT/enhancer binding protein (C/EBP), delta | 0.016 | ||
| Anxa7 | annexin A7 | 0.016 | ||
| Smap2 | stromal membrane-associated GTPase-activating protein 2 | 0.016 | ||
| Sh3bp2 | SH3-domain binding protein 2 | 0.016 | ||
| Coro1a | coronin, actin binding protein 1A | 0.015 | ||
| Rab17 | RAB17, member RAS oncogene family | 0.015 | ||
| Mesp2 | mesoderm posterior 2 | 0.015 | ||
| Psap | prosaposin | 0.014 | ||
| Cerk | ceramide kinase | 0.014 | ||
| Gramd1a | GRAM domain containing 1A | 0.014 | ||
| Dsg4 | desmoglein 4 | 0.014 | ||
| Usp8 | ubiquitin specific peptidase 8 | 0.014 | ||
| Plcg1 | phospholipase C, gamma 1 | 0.014 | ||
| Prnp | prion protein | 0.014 | ||
| Dlgap3 | discs, large (Drosophila) homolog-associated protein 3 | 0.014 | ||
| Stat6 | signal transducer and activator of transcription 6 | 0.013 | ||
| Akt1 | thymoma viral proto-oncogene 1 | 0.013 | ||
| Efnb2 | ephrin B2 | 0.013 | ||
| Sgpl1 | sphingosine phosphate lyase 1 | 0.013 | ||
| Bcar1 | breast cancer anti-estrogen resistance 1 | 0.013 | ||
| Tyk2 | tyrosine kinase 2 | 0.013 | ||
| Rab13 | RAB13, member RAS oncogene family | 0.013 | ||
| Nck1 | non-catalytic region of tyrosine kinase adaptor protein 1 | 0.013 | ||
| Pias2 | protein inhibitor of activated STAT 2 | 0.013 | ||
| Kitl | kit ligand | 0.013 | ||
| Cdk5r1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 0.013 | ||
| Cldn3 | claudin 3 | 0.013 | ||
| Lmna | lamin A | 0.013 | ||
| Kcnh3 | potassium voltage-gated channel, subfamily H (eag-related), member 3 | 0.013 | ||
| Pppde2 | PPPDE peptidase domain containing 2 | 0.012 | ||
| Tmem79 | transmembrane protein 79 | 0.012 | ||
| Gnat1 | guanine nucleotide binding protein, alpha transducing 1 | 0.012 | ||
| Mfsd6l | major facilitator superfamily domain containing 6-like | 0.012 | ||
| Aipl1 | aryl hydrocarbon receptor-interacting protein-like 1 | 0.012 | ||
| Drd4 | dopamine receptor D4 | 0.012 | ||
| Tjp3 | tight junction protein 3 | 0.012 | ||
| Grin1 | glutamate receptor, ionotropic, NMDA1 (zeta 1) | 0.012 | ||
| Id1 | inhibitor of DNA binding 1 | 0.012 | ||
| Ppm1m | protein phosphatase 1M | 0.012 | ||
| Arf3 | ADP-ribosylation factor 3 | 0.012 | ||
| Tgm2 | transglutaminase 2, C polypeptide | 0.012 | ||
| Tmem115 | transmembrane protein 115 | 0.012 | ||
| Sirt7 | sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae) | 0.012 | ||
| Prkd2 | protein kinase D2 | 0.012 | ||
| Zap70 | zeta-chain (TCR) associated protein kinase | 0.012 | ||
| Lad1 | ladinin | 0.011 | ||
| Cd8b1 | CD8 antigen, beta chain 1 | 0.011 | ||
| Tcirg1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 | 0.011 | ||
| Myo15 | myosin XV | 0.011 | ||
| Rab35 | RAB35, member RAS oncogene family | 0.011 | ||
| Grb7 | growth factor receptor bound protein 7 | 0.011 | ||
| Grk6 | G protein-coupled receptor kinase 6 | 0.011 | ||
| Ankrd34a | ankyrin repeat domain 34A | 0.011 | ||
| Snta1 | syntrophin, acidic 1 | 0.011 | ||
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.011 | ||
| Rps6ka1 | ribosomal protein S6 kinase polypeptide 1 | 0.011 | ||
| Stam2 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 0.011 | ||
| Gadd45g | growth arrest and DNA-damage-inducible 45 gamma | 0.011 | ||
| Dusp1 | dual specificity phosphatase 1 | 0.011 | ||
| Sorbs1 | sorbin and SH3 domain containing 1 | 0.011 | ||
| Cdh1 | cadherin 1 | 0.011 | ||
| Rab25 | RAB25, member RAS oncogene family | 0.011 | ||
| Cacna2d4 | calcium channel, voltage-dependent, alpha 2/delta subunit 4 | 0.011 | ||
| Rasa3 | RAS p21 protein activator 3 | 0.011 | ||
| Twf2 | twinfilin, actin-binding protein, homolog 2 (Drosophila) | 0.011 | ||
| Tgfa | transforming growth factor alpha | 0.011 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.011 | ||
| Crb3 | crumbs homolog 3 (Drosophila) | 0.011 | ||
| Ripply2 | ripply2 homolog (zebrafish) | 0.010 | ||
| Cotl1 | coactosin-like 1 (Dictyostelium) | 0.010 | ||
| Tbc1d10b | TBC1 domain family, member 10b | 0.010 | ||
| Ets2 | E26 avian leukemia oncogene 2, 3' domain | 0.010 | ||
| Prex1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.010 | ||
| Vav3 | vav 3 oncogene | 0.010 | ||
| Tmc6 | transmembrane channel-like gene family 6 | 0.010 | ||
| Rasgrp1 | RAS guanyl releasing protein 1 | 0.010 | ||
| Cd19 | CD19 antigen | 0.010 | ||
| Stk4 | serine/threonine kinase 4 | 0.010 | ||
| Npc1 | Niemann Pick type C1 | 0.010 | ||
| Adam12 | a disintegrin and metallopeptidase domain 12 (meltrin alpha) | 0.010 | ||
| Rnf19b | ring finger protein 19B | 0.010 | ||
| Ikbkb | inhibitor of kappaB kinase beta | 0.010 | ||
| Tradd | TNFRSF1A-associated via death domain | 0.010 |