IMP

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Danio rerio

4 genes annotated in zebrafish

negative regulation of neuron projection regeneration

Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of neuron projection regeneration"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of neuron projection regeneration" (in gray)

Name	Description	Probability	Func Analog Organism
gro1	groucho 1	0.835
epha4a	eph receptor A4a	0.815
ephb4b	eph receptor B4b	0.658	Zebrafish
atf3	activating transcription factor 3	0.643
cdh2	cadherin 2, neuronal	0.641
socs3a	suppressor of cytokine signaling 3a	0.615
efnb3b	ephrin B3b	0.575
dbx1a	developing brain homeobox 1a	0.484
gro2	groucho 2	0.452
prickle2	prickle-like 2 (Drosophila)	0.446
otx1b	orthodenticle homolog 1b	0.440
junb	jun B proto-oncogene	0.423
her8a	hairy-related 8a	0.416
ephb3a	eph receptor B3a	0.398	Zebrafish
dla	deltaA	0.376
znf503	zinc finger protein 503	0.370
otx1a	orthodenticle homolog 1a	0.351
notch3	notch homolog 3	0.341
fzd5	frizzled homolog 5	0.310
gli1	GLI-Kruppel family member 1	0.308
dlc	deltaC	0.288
efnb2a	ephrin B2a	0.244
boc	brother of CDO	0.234
six3b	sine oculis homeobox homolog 3b	0.233
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.228
neurog1	neurogenin 1	0.221
fosl2	fos-like antigen 2	0.217
ptprk	protein tyrosine phosphatase, receptor type, K	0.211
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.208
fgfr1b	fibroblast growth factor receptor 1b	0.205
sfrp5	secreted frizzled-related protein 5	0.201
efnb1	ephrin B1	0.200
fzd8a	frizzled homolog 8a	0.196
fgf3	fibroblast growth factor 3	0.193
LOC100000687	signal peptide, CUB and EGF-like domain-containing protein 3-like	0.189
flh	floating head	0.174
ptpro	protein tyrosine phosphatase, receptor type, O	0.160
atoh1a	atonal homolog 1a	0.144
copeb	core promoter element binding protein	0.141
dusp2	dual specificity phosphatase 2	0.141
zbtb16a	zinc finger and BTB domain containing 16a	0.140
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.139
prickle1a	prickle-like 1 (Drosophila) a	0.134
srsf4	serine/arginine-rich splicing factor 4	0.133
irx3b	iroquois homeobox protein 3b	0.123
ntn2	netrin 2	0.121
sox2	SRY-box containing gene 2	0.118
dld	deltaD	0.112
irx1b	iroquois homeobox protein 1, b	0.111
esrrga	estrogen-related receptor gamma a	0.111
sema3aa	semaphorin 3aa	0.102
junbl	jun B proto-oncogene, like	0.100
pcdh10b	protocadherin 10b	0.097
ext1a	exostoses (multiple) 1a	0.096
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.095
ctsl1b	cathepsin L, 1 b	0.094
hoxb1a	homeo box B1a	0.092
pax3a	paired box gene 3a	0.092
hoxb2a	homeo box B2a	0.090
ephb4a	eph receptor B4a	0.087	Zebrafish
smad1	MAD homolog 1 (Drosophila)	0.087
pax6b	paired box gene 6b	0.086
lfng	lunatic fringe homolog	0.085
pax2a	paired box gene 2a	0.084
col14a1	collagen, type XIV, alpha 1	0.083
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.083
LOC797832	similar to signal peptide, CUB domain, EGF-like 1	0.081
nova2	neuro-oncological ventral antigen 2	0.079
sox19b	SRY-box containing gene 19b	0.079
irx5a	iroquois homeobox protein 5a	0.077
scube2	signal peptide, CUB domain, EGF-like 2	0.075
mmp9	matrix metalloproteinase 9	0.075
stat3	signal transduction and activation of transcription 3	0.072
ckap5	cytoskeleton associated protein 5	0.071
meis2.2	myeloid ecotropic viral integration site 2.2	0.071
grcc10	gene rich cluster, C10 gene	0.070
tbx2b	T-box 2b	0.064
foxn4	forkhead box N4	0.062
lhx1b	LIM homeobox 1b	0.062
olig3	oligodendrocyte transcription factor 3	0.062
cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.059
efna5a	ephrin A5a	0.059
sb:cb81	sb:cb81	0.058
epb4.1l4	erythrocyte protein band 4.1-like 4	0.058
gbx2	gastrulation brain homeo box 2	0.057
wnt3a	wingless-type MMTV integration site family, member 3A	0.056
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.056
btg2	B-cell translocation gene 2	0.055
pbx4	pre-B-cell leukemia transcription factor 4	0.055
zgc:92851	zgc:92851	0.055
cdc25	cell division cycle 25 homolog	0.054
smarce1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.054
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.054
hesx1	homeo box (expressed in ES cells) 1	0.052
jun	jun proto-oncogene	0.051
foxb1.2	forkhead box B1.2	0.051
emx1	empty spiracles homeobox 1	0.050
wnt8b	wingless-type MMTV integration site family, member 8b	0.049
met	met proto-oncogene (hepatocyte growth factor receptor)	0.048
pou3f3a	POU class 3 homeobox 3a	0.048
ndr2	nodal-related 2	0.047
gbx1	gastrulation brain homeobox 1	0.046
ptf1a	pancreas specific transcription factor, 1a	0.045
rbm4.3	RNA binding motif protein 4.3	0.044
fgf8b	fibroblast growth factor 8 b	0.044
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.043
nog1	noggin 1	0.043
hnrnpl2	heterogeneous nuclear ribonucleoprotein L2	0.042
sox1a	SRY-box containing gene 1a	0.041
ncam1b	neural cell adhesion molecule 1b	0.041
mcl1a	myeloid cell leukemia sequence 1a	0.040
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.040
magi2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.040
chst10	carbohydrate sulfotransferase 10	0.039
emx3	empty spiracles homeobox 3	0.038
wnt1	wingless-type MMTV integration site family, member 1	0.038
elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.037
irf11	interferon regulatory factor 11	0.037
barhl2	BarH-like 2	0.036
dag1	dystroglycan 1	0.036
fstl1b	follistatin-like 1b	0.035
sdcbp	syndecan binding protein (syntenin)	0.035
kirrel3l	kin of IRRE like 3 like	0.034
cul1a	cullin 1a	0.033
smarcc1a	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a	0.033
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.033
extl3	exostoses (multiple)-like 3	0.033
socs3b	suppressor of cytokine signaling 3b	0.032	Zebrafish
fgfr1a	fibroblast growth factor receptor 1a	0.032
arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.031
zgc:153997	zgc:153997	0.031
tada3l	transcriptional adaptor 3 (NGG1 homolog, yeast)-like	0.031
fzd8b	frizzled homolog 8b	0.031
neurod4	neurogenic differentiation 4	0.031
rarab	retinoic acid receptor, alpha b	0.031
fn1	fibronectin 1	0.030
irf9	interferon regulatory factor 9	0.030
LOC100000332	e3 ubiquitin-protein ligase RNF182-like	0.030
sox3	SRY-box containing gene 3	0.030
kif20bb	kinesin family member 20Bb	0.029
LOC100331732	rap guanine nucleotide exchange factor 5-like	0.029
elof1	elongation factor 1 homolog (S. cerevisiae)	0.029
per2	period homolog 2 (Drosophila)	0.029
axin2	axin 2 (conductin, axil)	0.028
sox21a	SRY-box containing gene 21a	0.028
otpb	orthopedia homolog b	0.028
irx1a	iroquois homeobox protein 1, a	0.028
pitx3	paired-like homeodomain transcription factor 3	0.028
lztfl1	leucine zipper transcription factor-like 1	0.028
irx4b	iroquois homeobox protein 4b	0.028
foxa2	forkhead box A2	0.028
pax7a	paired box gene 7a	0.028
bactin1	bactin1	0.026
seh1l	SEH1-like (S. cerevisiae)	0.026
ek1	eph-like kinase 1	0.026	Zebrafish
dab1a	disabled homolog 1a (Drosophila)	0.026
celf2	cugbp, Elav-like family member 2	0.026
odc1	ornithine decarboxylase 1	0.026
irx4a	iroquois homeobox protein 4a	0.026
hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.026
vax2	ventral anterior homeobox 2	0.025
thop1	thimet oligopeptidase 1	0.025
atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.025
epha7	eph receptor A7	0.025	Zebrafish
supt3h	suppressor of Ty 3 homolog (S. cerevisiae)	0.025
uba2	ubiquitin-like modifier activating enzyme 2	0.025
gsc	goosecoid	0.024
dbx1b	developing brain homeobox 1b	0.024
elmo1	engulfment and cell motility 1 (ced-12 homolog, C. elegans)	0.024
gadd45bb	growth arrest and DNA-damage-inducible, beta b	0.024
irx7	iroquois homeobox protein 7	0.023
rcc2	regulator of chromosome condensation 2	0.023
xbp1	X-box binding protein 1	0.023
dram2	DNA-damage regulated autophagy modulator 2	0.023
egr2a	early growth response 2a	0.023
jak1	Janus kinase 1	0.023
supt5h	suppressor of Ty 5 homolog (S. cerevisiae)	0.023
lrrtm1	leucine rich repeat transmembrane neuronal 1	0.022
hoxd3a	homeo box D3a	0.022
si:dkeyp-63d11.7	si:dkeyp-63d11.7	0.022
traf4a	tnf receptor-associated factor 4a	0.022
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.022
arid4a	AT rich interactive domain 4A (RBP1-like)	0.021
nrg2a	neuregulin 2a	0.021
smoc1	SPARC related modular calcium binding 1	0.021
sfrp1a	secreted frizzled-related protein 1a	0.021
mpped2	metallophosphoesterase domain containing 2	0.021
epha4b	eph receptor A4b	0.020
pax8	paired box gene 8	0.020
si:ch211-59d15.5	si:ch211-59d15.5	0.020
arx	aristaless related homeobox	0.020
ilf2	interleukin enhancer binding factor 2	0.020
cln6	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	0.020
sap30bp	SAP30 binding protein and SAP30 binding protein	0.020
zgc:158363	zgc:158363	0.019
pcdh2ac	protocadherin 2 alpha c	0.019
fzd7b	frizzled homolog 7b	0.019
chst11	carbohydrate (chondroitin 4) sulfotransferase 11	0.019
pcdh10a	protocadherin 10a	0.019
h1m	linker histone H1M	0.019
fars2	phenylalanyl-tRNA synthetase 2, mitochondrial	0.019
atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.019
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.019
ctnnd2b	catenin (cadherin-associated protein), delta 2b	0.019
gtf2h4	general transcription factor IIH, polypeptide 4	0.019
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.019
rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.019
zgc:123194	zgc:123194	0.019
ppil4	peptidylprolyl isomerase (cyclophilin)-like 4	0.018
zdhhc8b	zinc finger, DHHC-type containing 8b	0.018
nudcd2	NudC domain containing 2	0.018
nrarpb	notch-regulated ankyrin repeat protein b	0.018
hdac6	histone deacetylase 6	0.018
hdac8	histone deacetylase 8	0.018
amotl2a	angiomotin like 2a	0.018
fzd7a	frizzled homolog 7a	0.017
map3k4	mitogen activated protein kinase kinase kinase 4	0.017
cpsf5	cleavage and polyadenylation specific factor 5	0.017
ints7	integrator complex subunit 7	0.017
ube2na	ubiquitin-conjugating enzyme E2Na	0.017
slit3	slit (Drosophila) homolog 3	0.017
smo	smoothened homolog (Drosophila)	0.017
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.017
pax6a	paired box gene 6a	0.017
taf8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.017
lmo1	LIM domain only 1	0.017
pak2b	p21 (CDKN1A)-activated kinase 2b	0.017
srp68	signal recognition particle 68	0.017
dnaja2l	DnaJ (Hsp40) homolog, subfamily A, member 2, like	0.017
pou3f1	POU class 3 homeobox 1	0.017
nrarpa	notch-regulated ankyrin repeat protein a	0.017
hoxa2b	homeo box A2b	0.017
zgc:162213	zgc:162213	0.016
mta2	metastasis associated 1 family, member 2	0.016
otub1	OTU domain, ubiquitin aldehyde binding 1	0.016
ntn1a	netrin 1a	0.016
igfbp3	insulin-like growth factor binding protein 3	0.016
hspa12b	heat shock protein 12B	0.016
hoxb6a	homeo box B6a	0.016
im:7137555	im:7137555	0.016
lmnb1	lamin B1	0.016
fam60al	family with sequence similarity 60, member A, like	0.016
pcdh18a	protocadherin 18a	0.016
lhx2b	LIM homeobox 2b	0.016
mapk1	mitogen-activated protein kinase 1	0.016
LOC100331431	hypothetical protein LOC100331431	0.016
epn1	epsin 1	0.016
LOC100004261	mitogen-activated protein kinase kinase kinase 14-like	0.016
znf207a	zinc finger protein 207, a	0.016
card9	caspase recruitment domain family, member 9	0.016
six1b	sine oculis homeobox homolog 1b	0.016
zgc:92664	zgc:92664	0.016
LOC100332237	thrombospondin-1-like	0.015
her5	hairy-related 5	0.015
fmr1	fragile X mental retardation 1	0.015
casp8	caspase 8, apoptosis-related cysteine peptidase	0.015
ncam1a	neural cell adhesion molecule 1a	0.015
marcksb	myristoylated alanine rich protein kinase C substrate b	0.015
ncor1	nuclear receptor co-repressor 1	0.015
atat1	alpha tubulin acetyltransferase 1	0.015
hnrnpa1	heterogeneous nuclear ribonucleoprotein A1	0.015
prkcbp1l	protein kinase C binding protein 1, like	0.015
sephs1	selenophosphate synthetase 1	0.014
zgc:66030	zgc:66030	0.014
rap1a	RAP1A, member of RAS oncogene family	0.014
nog2	noggin 2	0.014
hp1bp3	heterochromatin protein 1, binding protein 3	0.014
nrp2b	neuropilin 2b	0.014
cirbp	cold inducible RNA binding protein	0.014
her1	hairy-related 1	0.014
hbbe3	hemoglobin beta embryonic-3	0.014
rasgef1bb	RasGEF domain family, member 1Bb	0.014
rab11fip4a	RAB11 family interacting protein 4 (class II) a	0.014
gli3	GLI-Kruppel family member GLI3	0.014
nr2f1b	nuclear receptor subfamily 2, group F, member 1b	0.014
ptpra	protein tyrosine phosphatase, receptor type, A	0.014
igfbp1a	insulin-like growth factor binding protein 1a	0.014
celf4	CUGBP, Elav-like family member 4	0.014
im:7156396	im:7156396	0.014
meis2.1	myeloid ecotropic viral integration site 2.1	0.014
evx1	even-skipped homeobox 1	0.014
sf3a3	splicing factor 3a, subunit 3	0.014
h3f3d	H3 histone, family 3D	0.014
lzic	leucine zipper and CTNNBIP1 domain containing	0.013
dynlrb1	dynein, light chain, roadblock-type 1	0.013
skia	nuclear oncoprotein skia	0.013
dpm3	dolichyl-phosphate mannosyltransferase polypeptide 3	0.013
uvrag	UV radiation resistance associated gene	0.013
zbtb4	zinc finger and BTB domain containing 4	0.013
LOC557062	hypothetical protein LOC557062	0.013
coro1a	coronin, actin binding protein, 1A	0.013
rbfox1l	RNA binding protein, fox-1 homolog (C. elegans) 1-like	0.013
wu:fb78c02	wu:fb78c02	0.013
LOC100331484	hypothetical protein LOC100331484	0.013
mxi1	max interacting protein	0.013
gli2a	GLI-Kruppel family member GLI2a	0.013
hs6st1a	heparan sulfate 6-O-sulfotransferase 1a	0.013
btg1	B-cell translocation gene 1	0.013
homez	homeodomain leucine zipper gene	0.013
robo2	roundabout homolog 2	0.013
nkx2.1a	NK2 homeobox 1a	0.013
ncor2	nuclear receptor co-repressor 2	0.013
foxg1a	forkhead box G1a	0.013
chd	chordin	0.013
hmg20b	high-mobility group 20B	0.013
eng2b	engrailed 2b	0.013
plp1a	proteolipid protein 1a	0.013
pfn2l	profilin 2 like	0.013
sema3fb	semaphorin 3fb	0.013
snx27	sorting nexin family member 27	0.013
rxrga	retinoid x receptor, gamma a	0.013
lmx1b.2	LIM homeobox transcription factor 1, beta 2	0.013
top2a	topoisomerase (DNA) II alpha	0.013
ndor1	NADPH dependent diflavin oxidoreductase 1	0.012
wars	tryptophanyl-tRNA synthetase	0.012
wnt5b	wingless-type MMTV integration site family, member 5b	0.012
her3	hairy-related 3	0.012
stk17b	serine/threonine kinase 17b (apoptosis-inducing)	0.012
zfp36l1b	zinc finger protein 36, C3H type-like 1b	0.012
pfdn2	prefoldin subunit 2	0.012
gyltl1b	glycosyltransferase-like 1b	0.012
grhl2b	grainyhead-like 2b (Drosophila)	0.012
sp4	sp4 transcription factor	0.012
pigp	phosphatidylinositol glycan, class P	0.012
sat1a	spermidine/spermine N1-acetyltransferase 1a	0.012
chd7	chromodomain helicase DNA binding protein 7	0.012
LOC793701	growth arrest-specific protein 7-like	0.012
LOC100332470	uncharacterized protein KIAA0586-like	0.012
nrxn1a	neurexin 1a	0.012
pcdh19	protocadherin 19	0.012
tfg	trk-fused gene	0.012
tbx16	T-box gene 16	0.012
huwe1	HECT, UBA and WWE domain containing 1	0.012
tuba8l4	tubulin, alpha 8 like 4	0.012
rfng	radical fringe homolog (Drosophila)	0.012
ntn1b	netrin 1b	0.012
lrrn1	leucine rich repeat neuronal 1	0.012
marcksa	myristoylated alanine rich protein kinase C substrate a	0.012
eya2	eyes absent homolog 2 (Drosophila)	0.012
tmpoa	thymopoietin a	0.012
otx2	orthodenticle homolog 2	0.012
LOC100537698	kinesin-like protein KIF21A-like	0.012
pnpo	pyridoxine 5'-phosphate oxidase	0.011
pdk2	pyruvate dehydrogenase kinase, isoenzyme 2	0.011
si:dkey-21c19.3	si:dkey-21c19.3	0.011
nr2f5	nuclear receptor subfamily 2, group F, member 5	0.011
insm1b	insulinoma-associated 1b	0.011
efcab11	EF-hand calcium binding domain 11	0.011
nxn	nucleoredoxin	0.011
ngly1	N-glycanase 1	0.011
c1qc	complement component 1, q subcomponent, C chain	0.011
si:ch1073-268b21.1	si:ch1073-268b21.1	0.011
pacsin3	protein kinase C and casein kinase substrate in neurons 3	0.011
stac3	SH3 and cysteine rich domain 3	0.011
cnp	2',3'-cyclic nucleotide 3' phosphodiesterase	0.011
zgc:175096	zgc:175096	0.011
aven	apoptosis, caspase activation inhibitor	0.011
zgc:100787	zgc:100787	0.011
wnt4a	wingless-type MMTV integration site family, member 4a	0.011
spry1	sprouty homolog 1 (Drosophila)	0.011
zgc:158292	zgc:158292	0.011
traf7	TNF receptor-associated factor 7	0.011
bmpr1ba	bone morphogenetic protein receptor, type 1ba	0.011
cdk8	cyclin-dependent kinase 8	0.011
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.011
ube2g2	ubiquitin-conjugating enzyme E2G 2	0.011
ccz1	CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)	0.011
pcdh8	protocadherin 8	0.011
nrp1a	neuropilin 1a	0.011
sb:cb1008	sb:cb1008	0.011
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.011
bon	bonnie and clyde	0.011
hnrnpu	heterogeneous nuclear ribonucleoprotein U	0.011
hhip	hedgehog interacting protein	0.011
trappc5	trafficking protein particle complex 5	0.011
klf4	Kruppel-like factor 4	0.011
lft1	lefty1	0.011
ssbp3b	single stranded DNA binding protein 3b	0.011
hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.011
fgf17	fibroblast growth factor 17	0.011
gdi2	GDP dissociation inhibitor 2	0.011
elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.011
srsf1a	serine/arginine-rich splicing factor 1a	0.011
LOC562939	ER degradation-enhancing alpha-mannosidase-like 3-like	0.010
agk	acylglycerol kinase	0.010
ppip5k1	diphosphoinositol pentakisphosphate kinase 1	0.010
tert	telomerase reverse transcriptase	0.010
hnrnph1l	heterogeneous nuclear ribonucleoprotein H1, like	0.010
ociad1	OCIA domain containing 1	0.010
sox11b	SRY-box containing gene 11b	0.010
six3a	sine oculis homeobox homolog 3a	0.010
hnrnpa0l	heterogeneous nuclear ribonucleoprotein A0, like	0.010
srp19	signal recognition particle 19	0.010
thsd7a	thrombospondin, type I, domain containing 7A	0.010
appl1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.010
clic4	chloride intracellular channel 4	0.010
actr1	ARP1 actin-related protein 1, centractin (yeast)	0.010
asb11	ankyrin repeat and SOCS box-containing 11	0.010
lbx2	ladybird homeobox homolog 2 (Drosophila)	0.010
ewsr1b	Ewing sarcoma breakpoint region 1b	0.010
pknox1.2	pbx/knotted 1 homeobox 1.2	0.010
sim2	single-minded homolog 2 (Drosophila)	0.010
cdx4	caudal type homeo box transcription factor 4	0.010
jag1a	jagged 1a	0.010
notch1a	notch homolog 1a	0.010
sema3d	semaphorin 3d	0.010
aars	alanyl-tRNA synthetase	0.010
sema3ab	semaphorin 3ab	0.010