The network for 'immune system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

immune system development

The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

Homo sapiens
Name Description Probability Func Analog Organism
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 1.000
EGFR epidermal growth factor receptor 1.000
GRB2 growth factor receptor-bound protein 2 0.999
TRAF1 TNF receptor-associated factor 1 0.999
BRCA1 breast cancer 1, early onset 0.997
SMAD2 SMAD family member 2 0.997
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.996
RUNX1 runt-related transcription factor 1 0.995
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.994
BIRC3 baculoviral IAP repeat containing 3 0.993
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.992
SH3KBP1 SH3-domain kinase binding protein 1 0.991
JUN jun proto-oncogene 0.989
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.987
NCOR2 nuclear receptor corepressor 2 0.984
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.979
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.977
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.977
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.975
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.973
CCR5 chemokine (C-C motif) receptor 5 0.970
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.964
LCK lymphocyte-specific protein tyrosine kinase 0.961
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.961
TAL1 T-cell acute lymphocytic leukemia 1 0.959
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.959
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.959
ICAM1 intercellular adhesion molecule 1 0.957
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.947
CFLAR CASP8 and FADD-like apoptosis regulator 0.944
AR androgen receptor 0.943
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.939
HDAC3 histone deacetylase 3 0.939
ESR1 estrogen receptor 1 0.926
SYK spleen tyrosine kinase 0.926
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.922
CD40 CD40 molecule, TNF receptor superfamily member 5 0.920
DDIT3 DNA-damage-inducible transcript 3 0.918
CCL5 chemokine (C-C motif) ligand 5 0.917
PARP1 poly (ADP-ribose) polymerase 1 0.915
NOTCH1 notch 1 0.914
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.914
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.913
IL8 interleukin 8 0.912
CCL4 chemokine (C-C motif) ligand 4 0.909
FGFR1 fibroblast growth factor receptor 1 0.907
FGFR2 fibroblast growth factor receptor 2 0.904
UBC ubiquitin C 0.900
IRF1 interferon regulatory factor 1 0.895
DAXX death-domain associated protein 0.894
IL4R interleukin 4 receptor 0.891
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.887
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.883
FAS Fas (TNF receptor superfamily, member 6) 0.882
CREBBP CREB binding protein 0.878
IL2RB interleukin 2 receptor, beta 0.875
IL10RA interleukin 10 receptor, alpha 0.872
HLA-C major histocompatibility complex, class I, C 0.859
CXCL10 chemokine (C-X-C motif) ligand 10 0.857
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.854
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.852
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.851
SP1 Sp1 transcription factor 0.848
NCOR1 nuclear receptor corepressor 1 0.843
TNF tumor necrosis factor 0.840
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.831
EP300 E1A binding protein p300 0.824
VEGFA vascular endothelial growth factor A 0.816
CD86 CD86 molecule 0.814
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.810
CAV1 caveolin 1, caveolae protein, 22kDa 0.806
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.804
CCR7 chemokine (C-C motif) receptor 7 0.803
PBX1 pre-B-cell leukemia homeobox 1 0.794
SMAD3 SMAD family member 3 0.793
PML promyelocytic leukemia 0.778
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.775
HLA-B major histocompatibility complex, class I, B 0.774
SOCS3 suppressor of cytokine signaling 3 0.772
TGIF1 TGFB-induced factor homeobox 1 0.770
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.767
B2M beta-2-microglobulin 0.762
AXL AXL receptor tyrosine kinase 0.761
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.755
TCF12 transcription factor 12 0.743
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.742
XIAP X-linked inhibitor of apoptosis 0.731
ZNF43 zinc finger protein 43 0.718
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.710
TGFB1 transforming growth factor, beta 1 0.708
CXCL9 chemokine (C-X-C motif) ligand 9 0.700
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.697
WDR5 WD repeat domain 5 0.685
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.684
CXCL2 chemokine (C-X-C motif) ligand 2 0.684
KLF4 Kruppel-like factor 4 (gut) 0.684
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.683
STAT1 signal transducer and activator of transcription 1, 91kDa 0.681
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.680
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.675
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cmyb transcription factor cmyb 0.999
spns2 spinster homolog 2 (Drosophila) 0.998
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.988
tfr1a transferrin receptor 1a 0.988
plcg1 phospholipase C, gamma 1 0.985
rag1 recombination activating gene 1 0.984
bmp4 bone morphogenetic protein 4 0.983
cdh5 cadherin 5 0.982
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.980
mib mind bomb 0.980
runx1 runt-related transcription factor 1 0.978
alas2 aminolevulinate, delta-, synthetase 2 0.975
gdf6a growth differentiation factor 6a 0.973
tp53 tumor protein p53 0.967
etv2 ets variant gene 2 0.962
trim33 tripartite motif-containing 33 0.959
gata6 GATA-binding protein 6 0.958
dlb deltaB 0.950
bmp2b bone morphogenetic protein 2b 0.948
notch3 notch homolog 3 0.925
hhip hedgehog interacting protein 0.918
fn1 fibronectin 1 0.916
gata3 GATA-binding protein 3 0.908
tie1 endothelium-specific receptor tyrosine kinase 1 0.872
hhex hematopoietically expressed homeobox 0.869
prdm1a PR domain containing 1a, with ZNF domain 0.868
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.867
kita kit receptor a 0.851
mych myelocytomatosis oncogene homolog 0.851
osr1 odd-skipped related 1 (Drosophila) 0.832
tbx5a T-box 5a 0.821
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.820
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.807
jag1b jagged 1b 0.803
pax2a paired box gene 2a 0.793
LOC566708 FL cytokine receptor-like 0.791
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.784
ndr2 nodal-related 2 0.762
cdx4 caudal type homeo box transcription factor 4 0.761
fgfr4 fibroblast growth factor receptor 4 0.756
unc45a unc-45 homolog A (C. elegans) 0.754
tbx1 T-box 1 0.753
wnt9a wingless-type MMTV integration site family, member 9A 0.753
pcdh18b protocadherin 18b 0.751
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.743
rpl11 ribosomal protein L11 0.742
hoxd4a homeo box D4a 0.736
tpm4 tropomyosin 4 0.735
dlc deltaC 0.729
acvr1l activin A receptor, type I like 0.727
socs1 suppressor of cytokine signaling 1 0.707
il7r interleukin 7 receptor 0.703
ldb2a LIM-domain binding factor 2a 0.700
aplnrb apelin receptor b 0.695
gata5 GATA-binding protein 5 0.694
foxi1 forkhead box I1 0.688
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.686
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.681
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.680
notch1a notch homolog 1a 0.678
csf1ra colony stimulating factor 1 receptor, a 0.676
met met proto-oncogene (hepatocyte growth factor receptor) 0.672
sox9b SRY-box containing gene 9b 0.667
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.661
vegfc vascular endothelial growth factor c 0.658
chd chordin 0.648
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.646
pdlim3b PDZ and LIM domain 3b 0.638
eomesa eomesodermin homolog a 0.636
ptch2 patched 2 0.631
npm1 nucleophosmin 1 0.630
pdcd2 programmed cell death 2 0.629
cbfb core-binding factor, beta subunit 0.616
csnk1a1 casein kinase 1, alpha 1 0.613
gata1a GATA binding protein 1a 0.611
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.611
tbx24 T-box 24 0.610
gro1 groucho 1 0.596
cdh6 cadherin 6 0.591
lhx2b LIM homeobox 2b 0.590
ephb4a eph receptor B4a 0.589
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.585
traf4a tnf receptor-associated factor 4a 0.584
znfl2a zinc finger-like gene 2a 0.581
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.580
efnb2a ephrin B2a 0.577
msh6 mutS homolog 6 (E. coli) 0.576
osr2 odd-skipped related 2 (Drosophila) 0.575
sgk1 serum/glucocorticoid regulated kinase 1 0.570
ephb4b eph receptor B4b 0.569
gata2a GATA-binding protein 2a 0.569
cdh1 cadherin 1, epithelial 0.567
hand2 heart and neural crest derivatives expressed transcript 2 0.562
pkd2 polycystic kidney disease 2 0.558
tfec transcription factor EC 0.554
pitx3 paired-like homeodomain transcription factor 3 0.549
tp63 tumor protein p63 0.542
cxcr4b chemokine (C-X-C motif), receptor 4b 0.538
pea3 ETS-domain transcription factor pea3 0.538
hbbe3 hemoglobin beta embryonic-3 0.533
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Egfr Epidermal growth factor receptor 0.949
pan pangolin 0.858
os outstretched 0.827
N Notch 0.815
wg wingless 0.796
nmo nemo 0.742
shn schnurri 0.702
csw corkscrew 0.695
rap retina aberrant in pattern 0.669
put punt 0.660
Src64B Src oncogene at 64B 0.623
corto CG2530 gene product from transcript CG2530-RA 0.622
ct cut 0.600
da daughterless 0.596
rl rolled 0.592
hth homothorax 0.559
twi twist 0.525
Smox Smad on X 0.517
dom domino 0.510
Ras85D Ras oncogene at 85D 0.503
drk downstream of receptor kinase 0.502
dpp decapentaplegic 0.495
Pvr PDGF- and VEGF-receptor related 0.482
Rac1 CG2248 gene product from transcript CG2248-RA 0.472
l(2)gl lethal (2) giant larvae 0.454
Dcr-2 Dicer-2 0.448
aop anterior open 0.402
Rac2 CG8556 gene product from transcript CG8556-RA 0.387
emc extra macrochaetae 0.384
east enhanced adult sensory threshold 0.381
ush u-shaped 0.365
fu fused 0.352
rho rhomboid 0.350
Ser Serrate 0.347
zfh1 Zn finger homeodomain 1 0.345
Tl Toll 0.343
Dsor1 Downstream of raf1 0.341
E(spl) Enhancer of split 0.317
Moe Moesin 0.314
rin rasputin 0.309
mbc myoblast city 0.306
srp serpent 0.296
ci cubitus interruptus 0.294
Rel Relish 0.293
Dad Daughters against dpp 0.286
dco discs overgrown 0.278
ena enabled 0.278
Su(H) Suppressor of Hairless 0.265
CtBP C-terminal Binding Protein 0.254
phl pole hole 0.249
hipk homeodomain interacting protein kinase 0.239
Imp IGF-II mRNA-binding protein 0.234
insc inscuteable 0.225
bsk basket 0.220
tsr twinstar 0.208
betaInt-nu beta[nu] integrin 0.207
G-oalpha47A G protein oalpha 47A 0.201
px plexus 0.201
elav embryonic lethal abnormal vision 0.201
Jra Jun-related antigen 0.191
cta concertina 0.191
tin tinman 0.186
tws twins 0.182
Atg1 Autophagy-specific gene 1 0.182
ss spineless 0.178
hep hemipterous 0.176
RpS6 Ribosomal protein S6 0.176
babo baboon 0.174
norpA no receptor potential A 0.170
Dlic Dynein light intermediate chain 0.169
scny scrawny 0.167
Sam-S S-adenosylmethionine Synthetase 0.161
MED19 Mediator complex subunit 19 0.161
fog folded gastrulation 0.158
Mef2 Myocyte enhancer factor 2 0.155
Sema-1a CG18405 gene product from transcript CG18405-RD 0.153
vg vestigial 0.151
fng fringe 0.148
shot short stop 0.147
HLHm7 E(spl) region transcript m7 0.143
CkIIalpha Casein kinase II alpha subunit 0.138
p120ctn Adherens junction protein p120 0.137
InR Insulin-like receptor 0.135
S6k RPS6-p70-protein kinase 0.135
puc puckered 0.134
fl(2)d female lethal d 0.130
Adgf-A Adenosine deaminase-related growth factor A 0.130
Gug Grunge 0.128
HLHm3 E(spl) region transcript m3 0.128
slmb supernumerary limbs 0.127
Cat Catalase 0.123
Wnk CG7177 gene product from transcript CG7177-RA 0.123
ap apterous 0.122
psidin phagocyte signaling impaired 0.120
nau nautilus 0.119
klu klumpfuss 0.114
dac dachshund 0.113
polo CG12306 gene product from transcript CG12306-RA 0.112
AGO1 Argonaute-1 0.112
unc-13 CG2999 gene product from transcript CG2999-RA 0.109
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd37 CD37 molecule 0.465
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.397
Junb jun B proto-oncogene 0.277
Fos FBJ osteosarcoma oncogene 0.277
Dusp1 dual specificity phosphatase 1 0.273
Calcr calcitonin receptor 0.255
Bmp6 bone morphogenetic protein 6 0.223
Ccr5 chemokine (C-C motif) receptor 5 0.199
Prrx1 paired related homeobox 1 0.191
LOC100134871 beta globin minor gene 0.182
Cd247 Cd247 molecule 0.176
Alas2 aminolevulinate, delta-, synthase 2 0.172
RT1-EC2 RT1 class Ib, locus EC2 0.172
Cd2 Cd2 molecule 0.166
Bcl2 B-cell CLL/lymphoma 2 0.166
C1qa complement component 1, q subcomponent, A chain 0.163
Tgfbr2 transforming growth factor, beta receptor II 0.160
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.151
Ctrc chymotrypsin C (caldecrin) 0.150
Slfn2 schlafen 2 0.148
Zfp36 zinc finger protein 36 0.142
Cfp complement factor properdin 0.138
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.138
Cd5 Cd5 molecule 0.132
Ccl5 chemokine (C-C motif) ligand 5 0.130
Jak1 Janus kinase 1 0.129
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.120
RT1-Da RT1 class II, locus Da 0.119
Tcrb T-cell receptor beta chain 0.119
LOC287167 globin, alpha 0.117
Flt4 fms-related tyrosine kinase 4 0.117
Sec14l3 SEC14-like 3 (S. cerevisiae) 0.107
Mylk2 myosin light chain kinase 2 0.103
Gna15 guanine nucleotide binding protein, alpha 15 0.102
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.100
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.097
Ccl3 chemokine (C-C motif) ligand 3 0.095
Hck hemopoietic cell kinase 0.095
Cfb complement factor B 0.092
Cd4 Cd4 molecule 0.091
LOC689064 beta-globin 0.085
Tgfbr3 transforming growth factor, beta receptor III 0.082
Cxcr4 chemokine (C-X-C motif) receptor 4 0.081
Arhgap4 Rho GTPase activating protein 4 0.078
Nfya nuclear transcription factor-Y alpha 0.076
Il8rb interleukin 8 receptor, beta 0.076
Smad7 SMAD family member 7 0.074
Prl prolactin 0.072
Btg2 BTG family, member 2 0.071
Olr837 olfactory receptor 837 0.069
Prf1 perforin 1 (pore forming protein) 0.069
Barhl2 BarH-like homeobox 2 0.069
Ier2 immediate early response 2 0.068
Jak2 Janus kinase 2 0.068
Akap1 A kinase (PRKA) anchor protein 1 0.065
Foxd3 forkhead box D3 0.064
Man2b1 mannosidase, alpha, class 2B, member 1 0.064
RT1-A3 RT1 class I, locus A3 0.062
Tnr tenascin R 0.062
Rara retinoic acid receptor, alpha 0.060
Stat4 signal transducer and activator of transcription 4 0.060
Sell selectin L 0.060
Apol3 apolipoprotein L, 3 0.060
Aif1 allograft inflammatory factor 1 0.059
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.059
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.058
Smek2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 0.058
Itgam integrin, alpha M 0.058
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.058
Rt1.aa MHC class I RT1.Aa alpha-chain 0.058
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.057
Ctsj cathepsin J 0.055
Cd3g CD3 molecule, gamma 0.054
Brd4 bromodomain containing 4 0.053
Il1rn interleukin 1 receptor antagonist 0.053
Neurog3 neurogenin 3 0.052
Ntn1 netrin 1 0.050
Lifr leukemia inhibitory factor receptor alpha 0.050
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.050
Egr1 early growth response 1 0.050
Napsa napsin A aspartic peptidase 0.049
Il2rb interleukin 2 receptor, beta 0.049
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.048
Rhob ras homolog gene family, member B 0.048
Klf4 Kruppel-like factor 4 (gut) 0.048
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.048
Hbe1 hemoglobin, epsilon 1 0.048
Ccr2 chemokine (C-C motif) receptor 2 0.047
Slco1a5 solute carrier organic anion transporter family, member 1a5 0.047
Acacb acetyl-Coenzyme A carboxylase beta 0.047
RGD1564664 similar to LOC387763 protein 0.046
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.045
Adora2a adenosine A2a receptor 0.045
Cmklr1 chemokine-like receptor 1 0.045
LOC687711 similar to small nuclear ribonucleoprotein D3 0.045
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.044
Il6 interleukin 6 0.044
Tmem176b transmembrane protein 176B 0.043
Cd40lg CD40 ligand 0.043
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.043
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism