The network for 'fibroblast proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

fibroblast proliferation

The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.

Homo sapiens
Name Description Probability Func Analog Organism
RING1 ring finger protein 1 0.998
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.997
VEGFA vascular endothelial growth factor A 0.994
RNF2 ring finger protein 2 0.981
RB1 retinoblastoma 1 0.916
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.914
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.895
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.842
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.797
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.737
CBX7 chromobox homolog 7 0.729
CBX8 chromobox homolog 8 0.703
FTL ferritin, light polypeptide 0.636
APLF aprataxin and PNKP like factor 0.630
RYBP RING1 and YY1 binding protein 0.620
PLAU plasminogen activator, urokinase 0.601
NAMPT nicotinamide phosphoribosyltransferase 0.581
CCND1 cyclin D1 0.571
CBX6 chromobox homolog 6 0.546
DTX3L deltex 3-like (Drosophila) 0.520
RBL2 retinoblastoma-like 2 (p130) 0.501
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.456
PARP9 poly (ADP-ribose) polymerase family, member 9 0.436
PCGF2 polycomb group ring finger 2 0.422
USP11 ubiquitin specific peptidase 11 0.417
FTH1 ferritin, heavy polypeptide 1 0.417
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.407
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.400
AXL AXL receptor tyrosine kinase 0.397
TFDP1 transcription factor Dp-1 0.384
CDK2 cyclin-dependent kinase 2 0.357
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.348
PARP14 poly (ADP-ribose) polymerase family, member 14 0.339
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.334
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.327
BMI1 BMI1 polycomb ring finger oncogene 0.312
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.283
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.282
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.280
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.276
E2F1 E2F transcription factor 1 0.256
NRP1 neuropilin 1 0.242
LIG4 ligase IV, DNA, ATP-dependent 0.237
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.212
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.210
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.204
PDGFA platelet-derived growth factor alpha polypeptide 0.188
CCND3 cyclin D3 0.183
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.172
CBX4 chromobox homolog 4 0.163
TFF1 trefoil factor 1 0.142
CDK6 cyclin-dependent kinase 6 0.139
MAX MYC associated factor X 0.135
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.132
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.129
CDH5 cadherin 5, type 2 (vascular endothelium) 0.128
RNF144B ring finger protein 144B 0.126
NFIL3 nuclear factor, interleukin 3 regulated 0.117
BHLHE40 basic helix-loop-helix family, member e40 0.113
PCGF5 polycomb group ring finger 5 0.108
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.105
TP53 tumor protein p53 0.105
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.099
BCOR BCL6 corepressor 0.098
CTSB cathepsin B 0.095
E2F4 E2F transcription factor 4, p107/p130-binding 0.092
E2F2 E2F transcription factor 2 0.089
BAD BCL2-associated agonist of cell death 0.088
S100B S100 calcium binding protein B 0.087
E2F6 E2F transcription factor 6 0.082
CUX1 cut-like homeobox 1 0.082
RXRA retinoid X receptor, alpha 0.081
E2F3 E2F transcription factor 3 0.078
CCND2 cyclin D2 0.074
PDGFC platelet derived growth factor C 0.073
COL6A1 collagen, type VI, alpha 1 0.065
CCNE1 cyclin E1 0.065
ATF2 activating transcription factor 2 0.065
AHR aryl hydrocarbon receptor 0.064
UQCRB ubiquinol-cytochrome c reductase binding protein 0.062
CXCR4 chemokine (C-X-C motif) receptor 4 0.061
HLA-DMB major histocompatibility complex, class II, DM beta 0.059
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.059
CKS1B CDC28 protein kinase regulatory subunit 1B 0.058
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.057
JUNB jun B proto-oncogene 0.057
SIRT1 sirtuin 1 0.055
COPS6 COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) 0.053
IGF2R insulin-like growth factor 2 receptor 0.052
IGFBP5 insulin-like growth factor binding protein 5 0.052
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.051
FOSL1 FOS-like antigen 1 0.050
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.050
STMN2 stathmin-like 2 0.047
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.047
COL11A2 collagen, type XI, alpha 2 0.046
CABLES1 Cdk5 and Abl enzyme substrate 1 0.045
BAK1 BCL2-antagonist/killer 1 0.045
ITGB1BP3 integrin beta 1 binding protein 3 0.045
LGALS8 lectin, galactoside-binding, soluble, 8 0.044
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Pten phosphatase and tensin homolog 0.989
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.952
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.941
Rara retinoic acid receptor, alpha 0.894
Pbx1 pre B-cell leukemia transcription factor 1 0.855
Tgfb1 transforming growth factor, beta 1 0.756
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.643
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.639
Gli3 GLI-Kruppel family member GLI3 0.638
Fos FBJ osteosarcoma oncogene 0.609
Jun Jun oncogene 0.595
Fgfr1 fibroblast growth factor receptor 1 0.571
Lepr leptin receptor 0.508
C1qa complement component 1, q subcomponent, alpha polypeptide 0.505
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.498
Sp1 trans-acting transcription factor 1 0.487
Stat3 signal transducer and activator of transcription 3 0.446
Mdm4 transformed mouse 3T3 cell double minute 4 0.434
Apc adenomatosis polyposis coli 0.430
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.414
Shh sonic hedgehog 0.406
Mcl1 myeloid cell leukemia sequence 1 0.392
Fgfr2 fibroblast growth factor receptor 2 0.348
Ret ret proto-oncogene 0.338
Trp63 transformation related protein 63 0.336
Nrg1 neuregulin 1 0.327
Fgf8 fibroblast growth factor 8 0.315
Rxra retinoid X receptor alpha 0.312
Mdm2 transformed mouse 3T3 cell double minute 2 0.302
C1qc complement component 1, q subcomponent, C chain 0.301
Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) 0.300
Kit kit oncogene 0.293
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.291
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.291
H2-Aa histocompatibility 2, class II antigen A, alpha 0.272
Csf1 colony stimulating factor 1 (macrophage) 0.271
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.263
Ar androgen receptor 0.259
Cic capicua homolog (Drosophila) 0.258
Notch2 Notch gene homolog 2 (Drosophila) 0.252
Polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.244
Smad3 MAD homolog 3 (Drosophila) 0.232
Skil SKI-like 0.225
Egr1 early growth response 1 0.213
Bcl2 B-cell leukemia/lymphoma 2 0.208
Ccnd2 cyclin D2 0.208
Spry4 sprouty homolog 4 (Drosophila) 0.198
Hoxa9 homeobox A9 0.198
Ccnd1 cyclin D1 0.193
Mapk14 mitogen-activated protein kinase 14 0.184
Bdnf brain derived neurotrophic factor 0.182
Rarb retinoic acid receptor, beta 0.175
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.172
Isl1 ISL1 transcription factor, LIM/homeodomain 0.168
Tyrobp TYRO protein tyrosine kinase binding protein 0.165
Pax3 paired box gene 3 0.164
Atf3 activating transcription factor 3 0.160
Pax6 paired box gene 6 0.158
Prrx1 paired related homeobox 1 0.158
Nf1 neurofibromatosis 1 0.154
Cdk1 cyclin-dependent kinase 1 0.150
Mapk8 mitogen-activated protein kinase 8 0.149
Wnt5a wingless-related MMTV integration site 5A 0.146
Egr2 early growth response 2 0.142
Ptgs2 prostaglandin-endoperoxide synthase 2 0.138
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.134
Sox9 SRY-box containing gene 9 0.130
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.129
Ntf3 neurotrophin 3 0.129
Runx1 runt related transcription factor 1 0.127
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.120
H2-Eb1 histocompatibility 2, class II antigen E beta 0.110
Wt1 Wilms tumor 1 homolog 0.109
Ftl1 ferritin light chain 1 0.109
Max Max protein 0.108
Ep300 E1A binding protein p300 0.108
Lif leukemia inhibitory factor 0.107
Csf1r colony stimulating factor 1 receptor 0.105
Sfrp2 secreted frizzled-related protein 2 0.103
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.102
Hbegf heparin-binding EGF-like growth factor 0.101
Kiss1 KiSS-1 metastasis-suppressor 0.099
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.098
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.096
Btg2 B-cell translocation gene 2, anti-proliferative 0.094
Nos3 nitric oxide synthase 3, endothelial cell 0.094
Trp73 transformation related protein 73 0.093
Pparg peroxisome proliferator activated receptor gamma 0.093
Dst dystonin 0.092
Zfp36 zinc finger protein 36 0.092
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.092
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.088
Lmna lamin A 0.087
Zfp830 zinc finger protein 830 0.086
Rbl1 retinoblastoma-like 1 (p107) 0.085
Vdr vitamin D receptor 0.084
Tcf21 transcription factor 21 0.084
Apoe apolipoprotein E 0.084
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.083
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Rattus norvegicus
Name Description Probability Func Analog Organism
Anxa5 annexin A5 0.078
Lgals3 lectin, galactoside-binding, soluble, 3 0.033
Vim vimentin 0.028
Gja5 gap junction protein, alpha 5 0.026
Cps1 carbamoyl-phosphate synthetase 1 0.025
Gja1 gap junction protein, alpha 1 0.024
Ctsj cathepsin J 0.020
Calcb calcitonin-related polypeptide, beta 0.019
Ctsb cathepsin B 0.018
Il1a interleukin 1 alpha 0.018
RT1-Ba RT1 class II, locus Ba 0.017
Apoa5 apolipoprotein A-V 0.016
Mbl1 mannose-binding lectin (protein A) 1 0.016
S1pr2 sphingosine-1-phosphate receptor 2 0.015
Esr1 estrogen receptor 1 0.015
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.015
Nrg1 neuregulin 1 0.015
RT1-Da RT1 class II, locus Da 0.015
Cxcl2 chemokine (C-X-C motif) ligand 2 0.015
Cp ceruloplasmin 0.015
S100a10 S100 calcium binding protein A10 0.014
A3galt2 alpha 1,3-galactosyltransferase 2 0.014
Ahsg alpha-2-HS-glycoprotein 0.014
Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 0.013
Hspb1 heat shock protein 1 0.013
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.013
Dars aspartyl-tRNA synthetase 0.013
Trim47 tripartite motif-containing 47 0.013
LOC100364500 RT1 class I, locus CE11-like 0.012
Asgr1 asialoglycoprotein receptor 1 0.012
Il1rl1 interleukin 1 receptor-like 1 0.012
Cd80 Cd80 molecule 0.012
Dhdpsl dihydrodipicolinate synthase-like, mitochondrial 0.012
P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 0.012
Hspa1a heat shock 70kD protein 1A 0.012
Il8rb interleukin 8 receptor, beta 0.012
Psgb1 pregnancy-specific beta 1-glycoprotein 0.012
Foxo3 forkhead box O3 0.012
Tshb thyroid stimulating hormone, beta 0.011
Nradd neurotrophin receptor associated death domain 0.011
Pik3ip1 phosphoinositide-3-kinase interacting protein 1 0.011
Tbxa2r thromboxane A2 receptor 0.011
Fga fibrinogen alpha chain 0.011
Mmp10 matrix metallopeptidase 10 0.011
Nos3 nitric oxide synthase 3, endothelial cell 0.011
Igfbp5 insulin-like growth factor binding protein 5 0.011
Orm1 orosomucoid 1 0.011
Igfals insulin-like growth factor binding protein, acid labile subunit 0.011
Ubb ubiquitin B 0.011
Cebpe CCAAT/enhancer binding protein (C/EBP), epsilon 0.011
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.011
Cd151 CD151 molecule (Raph blood group) 0.011
Cox4i2 cytochrome c oxidase subunit IV isoform 2 0.010
Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 0.010
Ptgfr prostaglandin F receptor 0.010
Cd9 CD9 molecule 0.010
Arpc1b actin related protein 2/3 complex, subunit 1B 0.010
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.010
Selp selectin P 0.010
Il9r interleukin 9 receptor 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism