The network for 'osteoblast differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.

Homo sapiens
Name Description Probability Func Analog Organism
FHL2 four and a half LIM domains 2 0.996
SKIL SKI-like oncogene 0.996
FN1 fibronectin 1 0.995
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.985
SMAD2 SMAD family member 2 0.979
FBLN1 fibulin 1 0.977
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.974
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.967
SMAD7 SMAD family member 7 0.963
SMAD3 SMAD family member 3 0.962
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.962
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.944
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.929
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.919
SMAD4 SMAD family member 4 0.888
RUNX1 runt-related transcription factor 1 0.822
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.815
HIPK2 homeodomain interacting protein kinase 2 0.788
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.772
ATF3 activating transcription factor 3 0.762
JUN jun proto-oncogene 0.736
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.735
PRKD2 protein kinase D2 0.734
EGFR epidermal growth factor receptor 0.727
FOS FBJ murine osteosarcoma viral oncogene homolog 0.726
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.725
BMP2 bone morphogenetic protein 2 0.723
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.720
CAV1 caveolin 1, caveolae protein, 22kDa 0.707
BMPR1A bone morphogenetic protein receptor, type IA 0.689
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.686
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.659
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.655
ENG endoglin 0.635
SOCS3 suppressor of cytokine signaling 3 0.628
PTPRC protein tyrosine phosphatase, receptor type, C 0.615
COL6A1 collagen, type VI, alpha 1 0.604
COL1A1 collagen, type I, alpha 1 0.600
JAG1 jagged 1 0.599
NOTCH3 notch 3 0.587
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.582
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.582
SMAD5 SMAD family member 5 0.577
AR androgen receptor 0.573
BMP1 bone morphogenetic protein 1 0.552
CTGF connective tissue growth factor 0.542
PAX3 paired box 3 0.522
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.522
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.499
POU5F1 POU class 5 homeobox 1 0.497
NCOR1 nuclear receptor corepressor 1 0.480
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.471
FKBP1A FK506 binding protein 1A, 12kDa 0.470
HNRNPF heterogeneous nuclear ribonucleoprotein F 0.469
SUFU suppressor of fused homolog (Drosophila) 0.466
CCR5 chemokine (C-C motif) receptor 5 0.453
LTBP4 latent transforming growth factor beta binding protein 4 0.442
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.437
BCAR1 breast cancer anti-estrogen resistance 1 0.437
POU3F2 POU class 3 homeobox 2 0.419
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.414
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.410
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.407
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.401
BMP7 bone morphogenetic protein 7 0.394
DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 0.388
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.379
AXIN1 axin 1 0.372
WNT3A wingless-type MMTV integration site family, member 3A 0.372
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.372
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.369
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.369
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.360
COL6A2 collagen, type VI, alpha 2 0.359
NOTCH1 notch 1 0.357
TP53 tumor protein p53 0.356
DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0.351
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.329
TCF4 transcription factor 4 0.321
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.320
FOXF2 forkhead box F2 0.318
TP63 tumor protein p63 0.313
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.310
YBX1 Y box binding protein 1 0.307
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.301
SFRP1 secreted frizzled-related protein 1 0.294
MSX1 msh homeobox 1 0.289
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.287
EGR1 early growth response 1 0.286
TAL1 T-cell acute lymphocytic leukemia 1 0.272
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.270
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.268
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.267
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.263
FSTL1 follistatin-like 1 0.261
SP1 Sp1 transcription factor 0.253
HIC1 hypermethylated in cancer 1 0.251
PARVA parvin, alpha 0.250
PXN paxillin 0.244
CXXC5 CXXC finger protein 5 0.242
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
shha sonic hedgehog a 0.961
bmp2b bone morphogenetic protein 2b 0.948
sox9b SRY-box containing gene 9b 0.793
sox9a SRY-box containing gene 9a 0.718
col1a1a collagen, type I, alpha 1a 0.577
runx2b runt-related transcription factor 2b 0.520
wnt5b wingless-type MMTV integration site family, member 5b 0.515
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.495
ptch2 patched 2 0.374
fgf3 fibroblast growth factor 3 0.251
nf1a neurofibromin 1a 0.212
tbx1 T-box 1 0.209
fn1 fibronectin 1 0.155
dusp6 dual specificity phosphatase 6 0.134
sulf1 sulfatase 1 0.106
fgfr1a fibroblast growth factor receptor 1a 0.103
has2 hyaluronan synthase 2 0.102
col1a2 collagen, type I, alpha 2 0.088
notch2 notch homolog 2 0.087
smo smoothened homolog (Drosophila) 0.084
mef2ca myocyte enhancer factor 2ca 0.078
rargb retinoic acid receptor, gamma b 0.076
ptch1 patched 1 0.075
runx2a runt-related transcription factor 2a 0.074
twist1a twist1a 0.074
twist3 twist3 0.066
jag1b jagged 1b 0.065
dlx3b distal-less homeobox gene 3b 0.059
dlx2a distal-less homeobox gene 2a 0.059
col5a1 procollagen, type V, alpha 1 0.057
wnt3 wingless-type MMTV integration site family, member 3 0.053
apoeb apolipoprotein Eb 0.052
msxc muscle segment homeobox C 0.051
boc brother of CDO 0.050
bmp4 bone morphogenetic protein 4 0.050
kita kit receptor a 0.043
zgc:158603 zgc:158603 0.042
chd chordin 0.042
sfrp1a secreted frizzled-related protein 1a 0.041
spry4 sprouty (Drosophila) homolog 4 0.041
disp1 dispatched homolog 1 (Drosophila) 0.039
myod1 myogenic differentiation 1 0.038
wnt10a wingless-type MMTV integration site family, member 10a 0.037
pcdh8 protocadherin 8 0.036
ihha Indian hedgehog homolog a 0.034
igfbp3 insulin-like growth factor binding protein 3 0.034
gli2a GLI-Kruppel family member GLI2a 0.033
pax7a paired box gene 7a 0.032
dag1 dystroglycan 1 0.032
dacha dachshund a 0.031
fstl1b follistatin-like 1b 0.031
igfbp1b insulin-like growth factor binding protein 1b 0.029
gli3 GLI-Kruppel family member GLI3 0.026
foxp1b forkhead box P1b 0.024
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.023
col10a1 collagen, type X, alpha 1 0.022
notch3 notch homolog 3 0.022
tp63 tumor protein p63 0.022
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.022
ctgf connective tissue growth factor 0.021
arl4ab ADP-ribosylation factor-like 4ab 0.021
gdf6a growth differentiation factor 6a 0.020
efnb1 ephrin B1 0.020
acvr2a activin receptor IIa 0.019
wnt11r wingless-type MMTV integration site family, member 11, related 0.018
crabp2b cellular retinoic acid binding protein 2, b 0.018
loxl3b lysyl oxidase-like 3b 0.018
gpib glucose phosphate isomerase b 0.017
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.016
msxb muscle segment homeobox B 0.016
tgfb1a transforming growth factor, beta 1a 0.016
hsp47 heat shock protein 47 0.015
smad5 MAD homolog 5 (Drosophila) 0.015
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.015
smad3b MAD, mothers against decapentaplegic homolog 3b (Drosophila) 0.014
sufu suppressor of fused homolog (Drosophila) 0.014
extl3 exostoses (multiple)-like 3 0.013
plagl2 pleiomorphic adenoma gene-like 2 0.013
wu:fv91b12 wu:fv91b12 0.013
frem3 Fras1 related extracellular matrix 3 0.013
foxa3 forkhead box A3 0.013
lfng lunatic fringe homolog 0.013
matn4 matrilin 4 0.013
hspa5 heat shock protein 5 0.013
smyhc1 slow myosin heavy chain 1 0.012
gpc4 glypican 4 0.012
foxo3b forkhead box O3b 0.012
tpm4 tropomyosin 4 0.011
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.011
nrg2a neuregulin 2a 0.011
rag1 recombination activating gene 1 0.011
wif1 wnt inhibitory factor 1 0.011
rplp0 ribosomal protein, large, P0 0.011
il6r interleukin 6 receptor 0.010
fzd7b frizzled homolog 7b 0.010
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.010
btg1 B-cell translocation gene 1 0.010
ldb2a LIM-domain binding factor 2a 0.010
mych myelocytomatosis oncogene homolog 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.584
Id3 inhibitor of DNA binding 3 0.183
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.146
Fgfr2 fibroblast growth factor receptor 2 0.144
Tpt1 tumor protein, translationally-controlled 1 0.123
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.120
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.093
Crtap cartilage associated protein 0.086
Id1 inhibitor of DNA binding 1 0.076
Bcl2 B-cell CLL/lymphoma 2 0.074
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.064
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.062
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.061
Tcfe2a transcription factor E2a 0.061
Col12a1 collagen, type XII, alpha 1 0.057
Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.055
Mmp23 matrix metallopeptidase 23 0.052
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.051
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.050
S100a11 S100 calcium binding protein A11 (calizzarin) 0.048
Vim vimentin 0.047
Twist2 twist homolog 2 (Drosophila) 0.045
Capn6 calpain 6 0.043
Smad7 SMAD family member 7 0.042
Acta1 actin, alpha 1, skeletal muscle 0.040
Wnt5a wingless-type MMTV integration site family, member 5A 0.040
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.039
Calb2 calbindin 2 0.039
Nfia nuclear factor I/A 0.038
Col3a1 collagen, type III, alpha 1 0.038
Bmp3 bone morphogenetic protein 3 0.037
Hapln1 hyaluronan and proteoglycan link protein 1 0.036
Nradd neurotrophin receptor associated death domain 0.036
Jub jub, ajuba homolog (Xenopus laevis) 0.036
Foxd1 forkhead box D1 0.035
Dcn decorin 0.035
Bmp4 bone morphogenetic protein 4 0.035
Shox2 short stature homeobox 2 0.035
Col14a1 collagen, type XIV, alpha 1 0.035
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.034
Cpxm2 carboxypeptidase X (M14 family), member 2 0.033
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.032
Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 0.030
Actb actin, beta 0.030
Lect1 leukocyte cell derived chemotaxin 1 0.030
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.030
Efemp2 EGF-containing fibulin-like extracellular matrix protein 2 0.029
Prdm12 PR domain containing 12 0.029
Irs1 insulin receptor substrate 1 0.029
Gja6 gap junction protein, alpha 6 0.028
Gja1 gap junction protein, alpha 1 0.028
Sgk1 serum/glucocorticoid regulated kinase 1 0.028
Fth1 ferritin, heavy polypeptide 1 0.028
Igf2 insulin-like growth factor 2 0.028
Adrb1 adrenergic, beta-1-, receptor 0.028
Vcan versican 0.027
Prrx2 paired related homeobox 2 0.027
Cand1 cullin-associated and neddylation-dissociated 1 0.027
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.026
Dchs1 dachsous 1 (Drosophila) 0.025
Fam69b family with sequence similarity 69, member B 0.025
Rpl19 ribosomal protein L19 0.025
Igfbp5 insulin-like growth factor binding protein 5 0.025
Irs3 insulin receptor substrate 3 0.024
Spta1 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) 0.024
Fgfr1 Fibroblast growth factor receptor 1 0.024
Col1a2 collagen, type I, alpha 2 0.024
Prrx1 paired related homeobox 1 0.024
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.023
Paics phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.022
Olah oleoyl-ACP hydrolase 0.022
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.022
Hist1h2ba histone cluster 1, H2ba 0.022
Sod3 superoxide dismutase 3, extracellular 0.022
Galntl1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 0.022
Kctd15 potassium channel tetramerisation domain containing 15 0.022
Tgfb2 transforming growth factor, beta 2 0.022
Mid1 midline 1 0.022
Timp3 TIMP metallopeptidase inhibitor 3 0.022
Mafb v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) 0.022
Tagln transgelin 0.021
Cxcl2 chemokine (C-X-C motif) ligand 2 0.021
Znf503 zinc finger protein 503 0.021
Tardbp TAR DNA binding protein 0.021
Aif1 allograft inflammatory factor 1 0.021
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.021
Fgf10 fibroblast growth factor 10 0.021
Foxc2 forkhead box C2 0.020
Prdm2 PR domain containing 2, with ZNF domain 0.020
Tcp1 t-complex 1 0.020
Ednrb endothelin receptor type B 0.020
Aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.020
RGD1311307 similar to 1300014I06Rik protein 0.020
Lepr leptin receptor 0.020
Acvr1 activin A receptor, type I 0.020
Unc5b unc-5 homolog B (C. elegans) 0.020
Glg1 golgi apparatus protein 1 0.020
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.020
Actg1 actin, gamma 1 0.020
Syn1 synapsin I 0.019
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism