The network for 'positive regulation of rac gtpase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of rac gtpase activity

Any process that activates or increases the activity of a GTPase of the Rac family.

Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 1.000
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.999
S100A6 S100 calcium binding protein A6 0.998
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.996
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.996
EGFR epidermal growth factor receptor 0.995
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.992
S100B S100 calcium binding protein B 0.986
SOS1 son of sevenless homolog 1 (Drosophila) 0.980
S100A8 S100 calcium binding protein A8 0.976
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.969
PTK2 PTK2 protein tyrosine kinase 2 0.959
DOCK1 dedicator of cytokinesis 1 0.947
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.944
S100A11 S100 calcium binding protein A11 0.942
SFN stratifin 0.933
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.928
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.924
ABI1 abl-interactor 1 0.917
S100A9 S100 calcium binding protein A9 0.894
NCF2 neutrophil cytosolic factor 2 0.883
BAIAP2 BAI1-associated protein 2 0.844
GRB2 growth factor receptor-bound protein 2 0.828
CCR5 chemokine (C-C motif) receptor 5 0.816
TRAF5 TNF receptor-associated factor 5 0.804
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.755
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.749
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.746
S100A1 S100 calcium binding protein A1 0.711
RHOC ras homolog gene family, member C 0.694
BBS10 Bardet-Biedl syndrome 10 0.690
VAV1 vav 1 guanine nucleotide exchange factor 0.677
PLCG1 phospholipase C, gamma 1 0.658
SH3RF3 SH3 domain containing ring finger 3 0.657
LAT linker for activation of T cells 0.649
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.620
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.616
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.598
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.588
CCL4 chemokine (C-C motif) ligand 4 0.574
GRB7 growth factor receptor-bound protein 7 0.564
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.538
S100A4 S100 calcium binding protein A4 0.538
SH3KBP1 SH3-domain kinase binding protein 1 0.521
SH3BP2 SH3-domain binding protein 2 0.500
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.466
NCKAP1 NCK-associated protein 1 0.447
IQGAP1 IQ motif containing GTPase activating protein 1 0.446
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.439
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.425
RHOA ras homolog gene family, member A 0.416
EMP3 epithelial membrane protein 3 0.407
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.392
SH3RF1 SH3 domain containing ring finger 1 0.384
LY6G6F lymphocyte antigen 6 complex, locus G6F 0.383
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.378
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.368
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.364
NCK1 NCK adaptor protein 1 0.343
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.326
LGALS1 lectin, galactoside-binding, soluble, 1 0.319
RALBP1 ralA binding protein 1 0.319
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.319
NAV1 neuron navigator 1 0.255
ANXA2 annexin A2 0.251
WIPF1 WAS/WASL interacting protein family, member 1 0.243
S100A10 S100 calcium binding protein A10 0.240
DPP4 dipeptidyl-peptidase 4 0.239
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.232
MARK2 MAP/microtubule affinity-regulating kinase 2 0.227
CXCL9 chemokine (C-X-C motif) ligand 9 0.223
CHN2 chimerin (chimaerin) 2 0.214
CAPG capping protein (actin filament), gelsolin-like 0.209
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.208
TNF tumor necrosis factor 0.207
BCAR1 breast cancer anti-estrogen resistance 1 0.203
CCL2 chemokine (C-C motif) ligand 2 0.201
GSK3B glycogen synthase kinase 3 beta 0.193
SH2D1A SH2 domain containing 1A 0.190
EFNA1 ephrin-A1 0.190
ZNF746 zinc finger protein 746 0.187
GAS7 growth arrest-specific 7 0.181
TRAF3 TNF receptor-associated factor 3 0.178
RHOU ras homolog gene family, member U 0.173
CCL3 chemokine (C-C motif) ligand 3 0.154
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.146
KIAA1377 KIAA1377 0.143
EFNA5 ephrin-A5 0.136
VAV3 vav 3 guanine nucleotide exchange factor 0.134
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.134
IL1B interleukin 1, beta 0.130
CCL8 chemokine (C-C motif) ligand 8 0.127
ARHGAP15 Rho GTPase activating protein 15 0.126
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.122
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.120
PVRL3 poliovirus receptor-related 3 0.118
ZMYND11 zinc finger, MYND-type containing 11 0.117
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.110
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
mbc myoblast city 0.902
plexB plexin B 0.458
pod1 CG4532 gene product from transcript CG4532-RF 0.452
Abi Abelson interacting protein 0.411
Sos Son of sevenless 0.388
Hem HEM-protein 0.344
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.321
neuroligin CG13772 gene product from transcript CG13772-RA 0.297
Dab Disabled 0.207
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.206
gek genghis khan 0.163
rok Rho-kinase 0.140
ena enabled 0.122
CG11033 CG11033 gene product from transcript CG11033-RB 0.112
l(2)k16918 lethal (2) k16918 0.106
Eph Eph receptor tyrosine kinase 0.070
synj synaptojanin 0.066
CG31224 CG31224 gene product from transcript CG31224-RA 0.061
vav CG7893 gene product from transcript CG7893-RB 0.059
dock dreadlocks 0.053
baz bazooka 0.050
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.045
Ephrin CG1862 gene product from transcript CG1862-RA 0.044
alpha-Man-IIb CG4606 gene product from transcript CG4606-RA 0.044
su(s) suppressor of sable 0.040
dia diaphanous 0.040
CG6734 CG6734 gene product from transcript CG6734-RA 0.038
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.036
stg string 0.036
bin3 bicoid-interacting protein 3 0.035
phl pole hole 0.033
LIMK1 LIM-kinase1 0.031
Pak3 CG14895 gene product from transcript CG14895-RA 0.031
CG15099 CG15099 gene product from transcript CG15099-RA 0.029
drk downstream of receptor kinase 0.026
enok enoki mushroom 0.025
Ank2 Ankyrin 2 0.024
nwk nervous wreck 0.024
pcx pecanex 0.022
Wnt5 Wnt oncogene analog 5 0.021
stai stathmin 0.021
betaInt-nu beta[nu] integrin 0.021
lap like-AP180 0.019
XNP CG4548 gene product from transcript CG4548-RA 0.019
RanBPM Ran-binding protein M 0.019
Flo-2 flotillin 2 0.019
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.018
Mtl Mig-2-like 0.017
CG10631 CG10631 gene product from transcript CG10631-RA 0.017
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.017
tomosyn CG17762 gene product from transcript CG17762-RB 0.016
fbl6 CG13213 gene product from transcript CG13213-RB 0.015
Hip14 Huntingtin-interacting protein 14 0.014
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.014
CG11486 CG11486 gene product from transcript CG11486-RG 0.014
exex extra-extra 0.014
DAAM Dishevelled Associated Activator of Morphogenesis 0.014
CG3632 CG3632 gene product from transcript CG3632-RH 0.013
lmd lame duck 0.013
tay tay bridge 0.013
CG12734 CG12734 gene product from transcript CG12734-RA 0.013
htl heartless 0.013
Nak Numb-associated kinase 0.013
Sra-1 specifically Rac1-associated protein 1 0.013
CG7518 CG7518 gene product from transcript CG7518-RD 0.012
CG11138 CG11138 gene product from transcript CG11138-RC 0.012
CG9425 CG9425 gene product from transcript CG9425-RB 0.012
SCAR CG4636 gene product from transcript CG4636-RA 0.012
CG8155 CG8155 gene product from transcript CG8155-RA 0.012
Eps-15 Epidermal growth factor receptor pathway substrate clone 15 0.011
CG12187 CG12187 gene product from transcript CG12187-RA 0.011
CG12207 CG12207 gene product from transcript CG12207-RB 0.011
Rheb CG1081 gene product from transcript CG1081-RA 0.011
CG14442 CG14442 gene product from transcript CG14442-RB 0.011
CG10188 CG10188 gene product from transcript CG10188-RB 0.011
CG3125 CG3125 gene product from transcript CG3125-RA 0.010
Graf CG8948 gene product from transcript CG8948-RB 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Grb2 growth factor receptor bound protein 2 1.000
Itsn1 intersectin 1 (SH3 domain protein 1A) 1.000
Vav1 vav 1 oncogene 0.997
Git1 G protein-coupled receptor kinase-interactor 1 0.980
Dlg4 discs, large homolog 4 (Drosophila) 0.972
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.943
Cbl Casitas B-lineage lymphoma 0.942
Rac1 RAS-related C3 botulinum substrate 1 0.887
Dnm1 dynamin 1 0.885
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.819
Prkcd protein kinase C, delta 0.745
Bcr breakpoint cluster region 0.739
Anxa2 annexin A2 0.698
Shc1 src homology 2 domain-containing transforming protein C1 0.683
Efnb2 ephrin B2 0.655
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.648
Braf Braf transforming gene 0.620
Nf1 neurofibromatosis 1 0.457
Ncf1 neutrophil cytosolic factor 1 0.451
Pxn paxillin 0.440
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.439
Elmo1 engulfment and cell motility 1, ced-12 homolog (C. elegans) 0.401
Efna1 ephrin A1 0.393
Tgfb1 transforming growth factor, beta 1 0.365
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.352
Lrrk2 leucine-rich repeat kinase 2 0.348
Nckap1l NCK associated protein 1 like 0.334
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.272
Inpp5d inositol polyphosphate-5-phosphatase D 0.221
Frs2 fibroblast growth factor receptor substrate 2 0.220
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.206
Apc adenomatosis polyposis coli 0.204
Cxcr4 chemokine (C-X-C motif) receptor 4 0.197
Axin1 axin 1 0.183
Traf6 TNF receptor-associated factor 6 0.178
Cep55 centrosomal protein 55 0.177
Atp8b2 ATPase, class I, type 8B, member 2 0.171
Prkce protein kinase C, epsilon 0.147
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 0.146
Dock2 dedicator of cyto-kinesis 2 0.144
Vav2 vav 2 oncogene 0.138
Arhgap21 Rho GTPase activating protein 21 0.137
Ptk2 PTK2 protein tyrosine kinase 2 0.131
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.127
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.126
Abr active BCR-related gene 0.121
Btk Bruton agammaglobulinemia tyrosine kinase 0.121
Psen1 presenilin 1 0.107
Zfyve16 zinc finger, FYVE domain containing 16 0.105
Necap2 NECAP endocytosis associated 2 0.103
Itga3 integrin alpha 3 0.100
Sh3bgrl3 SH3 domain binding glutamic acid-rich protein-like 3 0.097
Sh3kbp1 SH3-domain kinase binding protein 1 0.096
Rasgrp1 RAS guanyl releasing protein 1 0.095
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.095
Elmo2 engulfment and cell motility 2, ced-12 homolog (C. elegans) 0.094
Eps15 epidermal growth factor receptor pathway substrate 15 0.094
Dlg2 discs, large homolog 2 (Drosophila) 0.093
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.091
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.088
Cd37 CD37 antigen 0.085
Irf5 interferon regulatory factor 5 0.084
Pdcd6ip programmed cell death 6 interacting protein 0.083
Ptpra protein tyrosine phosphatase, receptor type, A 0.083
S100a6 S100 calcium binding protein A6 (calcyclin) 0.083
Ptpre protein tyrosine phosphatase, receptor type, E 0.081
Sirpa signal-regulatory protein alpha 0.080
Srgap2 SLIT-ROBO Rho GTPase activating protein 2 0.074
Crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.072
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.072
Kit kit oncogene 0.071
Ctnnb1 catenin (cadherin associated protein), beta 1 0.068
Itga4 integrin alpha 4 0.068
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.068
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.067
Prkcb protein kinase C, beta 0.067
Htt huntingtin 0.065
Dck deoxycytidine kinase 0.065
Src Rous sarcoma oncogene 0.063
Selplg selectin, platelet (p-selectin) ligand 0.061
Itch itchy, E3 ubiquitin protein ligase 0.061
Ccnb2 cyclin B2 0.060
Ncoa3 nuclear receptor coactivator 3 0.058
Usp12 ubiquitin specific peptidase 12 0.057
Arf3 ADP-ribosylation factor 3 0.056
Rad21 RAD21 homolog (S. pombe) 0.056
Smad3 MAD homolog 3 (Drosophila) 0.056
Coro1c coronin, actin binding protein 1C 0.055
Fbxo11 F-box protein 11 0.053
Plp2 proteolipid protein 2 0.053
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.053
Apaf1 apoptotic peptidase activating factor 1 0.051
Gsk3a glycogen synthase kinase 3 alpha 0.051
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.051
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.049
Plcb1 phospholipase C, beta 1 0.046
Arhgap30 Rho GTPase activating protein 30 0.045
4732456N10Rik RIKEN cDNA 4732456N10 gene 0.044
Plaur plasminogen activator, urokinase receptor 0.044
Blnk B-cell linker 0.043
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Rattus norvegicus
Name Description Probability Func Analog Organism
S100a4 S100 calcium-binding protein A4 0.170
Anxa2 annexin A2 0.146
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.114
Dlg3 discs, large homolog 3 (Drosophila) 0.062
Capn2 calpain 2 0.053
S100a11 S100 calcium binding protein A11 (calizzarin) 0.035
Bap1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 0.026
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.026
Fmnl1 formin-like 1 0.025
Snx4 sorting nexin 4 0.022
Wdfy1 WD repeat and FYVE domain containing 1 0.022
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.020
Becn1 beclin 1, autophagy related 0.019
Anxa1 annexin A1 0.018
Lcp2 lymphocyte cytosolic protein 2 0.016
S100a6 S100 calcium binding protein A6 0.015
Bin2 bridging integrator 2 0.015
Mlf2 myeloid leukemia factor 2 0.014
Mbtps1 membrane-bound transcription factor peptidase, site 1 0.014
Shank2 SH3 and multiple ankyrin repeat domains 2 0.013
Zmym4 zinc finger, MYM-type 4 0.013
Lgals3 lectin, galactoside-binding, soluble, 3 0.012
Zfp91 zinc finger protein 91 0.012
Tmprss2 transmembrane protease, serine 2 0.011
Rnf10 ring finger protein 10 0.011
RGD1563106 similar to novel protein 0.011
Dlgap4 discs, large homolog-associated protein 4 (Drosophila) 0.011
Matk megakaryocyte-associated tyrosine kinase 0.010
Prr13 proline rich 13 0.010
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism