The network for 'tissue regeneration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tissue regeneration

The regrowth of lost or destroyed tissues.

Homo sapiens
Name Description Probability Func Analog Organism
HDAC2 histone deacetylase 2 0.979
JAG1 jagged 1 0.969
HDAC1 histone deacetylase 1 0.964
FGFR2 fibroblast growth factor receptor 2 0.938
EGFR epidermal growth factor receptor 0.921
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.910
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.734
ESR1 estrogen receptor 1 0.731
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.653
FN1 fibronectin 1 0.632
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.580
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.575
TP63 tumor protein p63 0.564
PLAU plasminogen activator, urokinase 0.557
FGB fibrinogen beta chain 0.534
KRT17 keratin 17 0.528
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.484
ALB albumin 0.462
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.461
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.453
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.446
LAT linker for activation of T cells 0.429
KDM1A lysine (K)-specific demethylase 1A 0.421
VDAC1 voltage-dependent anion channel 1 0.415
FKBP1A FK506 binding protein 1A, 12kDa 0.408
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.400
CHD4 chromodomain helicase DNA binding protein 4 0.393
PLAT plasminogen activator, tissue 0.367
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.355
KRT18 keratin 18 0.349
RBBP4 retinoblastoma binding protein 4 0.332
EED embryonic ectoderm development 0.330
KRT14 keratin 14 0.326
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.317
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.310
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.298
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.297
KRT19 keratin 19 0.257
TTN titin 0.251
IGFBP3 insulin-like growth factor binding protein 3 0.246
S100A10 S100 calcium binding protein A10 0.234
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.231
MTA3 metastasis associated 1 family, member 3 0.231
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.230
TERF2 telomeric repeat binding factor 2 0.227
MAPK1 mitogen-activated protein kinase 1 0.227
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.214
FANCA Fanconi anemia, complementation group A 0.208
RBBP7 retinoblastoma binding protein 7 0.207
COL1A2 collagen, type I, alpha 2 0.200
GRB10 growth factor receptor-bound protein 10 0.196
SMAD7 SMAD family member 7 0.190
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.189
FRS2 fibroblast growth factor receptor substrate 2 0.187
FGA fibrinogen alpha chain 0.181
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.178
JAK2 Janus kinase 2 0.175
IGF2R insulin-like growth factor 2 receptor 0.173
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.173
APOA1 apolipoprotein A-I 0.167
THBS1 thrombospondin 1 0.164
ZHX1 zinc fingers and homeoboxes 1 0.162
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.162
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.159
FYN FYN oncogene related to SRC, FGR, YES 0.148
FAS Fas (TNF receptor superfamily, member 6) 0.146
PPL periplakin 0.145
POU5F1 POU class 5 homeobox 1 0.138
FGF2 fibroblast growth factor 2 (basic) 0.135
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.133
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.130
FGF1 fibroblast growth factor 1 (acidic) 0.130
TGFB3 transforming growth factor, beta 3 0.129
CSK c-src tyrosine kinase 0.129
DDR2 discoidin domain receptor tyrosine kinase 2 0.127
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.127
INSR insulin receptor 0.127
NSF N-ethylmaleimide-sensitive factor 0.126
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.125
MBD3 methyl-CpG binding domain protein 3 0.124
IQGAP1 IQ motif containing GTPase activating protein 1 0.122
ITGB1BP3 integrin beta 1 binding protein 3 0.121
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.121
TJP1 tight junction protein 1 (zona occludens 1) 0.120
KRT6A keratin 6A 0.120
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.120
FAM162A family with sequence similarity 162, member A 0.119
GATAD2B GATA zinc finger domain containing 2B 0.117
FBLN1 fibulin 1 0.113
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.112
CAV1 caveolin 1, caveolae protein, 22kDa 0.111
GADD45A growth arrest and DNA-damage-inducible, alpha 0.111
FAF1 Fas (TNFRSF6) associated factor 1 0.110
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.109
FGG fibrinogen gamma chain 0.107
APOC3 apolipoprotein C-III 0.106
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.104
BLM Bloom syndrome, RecQ helicase-like 0.101
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.101
CSTA cystatin A (stefin A) 0.100
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
sox10 SRY-box containing gene 10 0.989
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.981
eya1 eyes absent homolog 1 0.912
fgfr1a fibroblast growth factor receptor 1a 0.792
evx1 even-skipped homeobox 1 0.761
tbx1 T-box 1 0.690
col1a1a collagen, type I, alpha 1a 0.680
egr2b early growth response 2b 0.655
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.647
cxcr4b chemokine (C-X-C motif), receptor 4b 0.610
wnt5b wingless-type MMTV integration site family, member 5b 0.592
wnt10a wingless-type MMTV integration site family, member 10a 0.586
kdrl kinase insert domain receptor like 0.581
lef1 lymphocyte enhancer binding factor 1 0.563
emx3 empty spiracles homeobox 3 0.546
wnt11r wingless-type MMTV integration site family, member 11, related 0.538
dkk1b dickkopf 1b 0.527
mmp2 matrix metalloproteinase 2 0.515
col2a1a collagen type II, alpha-1a 0.484
runx1 runt-related transcription factor 1 0.474
foxd3 forkhead box D3 0.469
anxa1a annexin A1a 0.466
snai1b snail homolog 1b (Drosophila) 0.451
hmx4 H6 family homeobox 4 0.437
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.410
mib mind bomb 0.405
efnb3b ephrin B3b 0.352
sox11a SRY-box containing gene 11a 0.343
twist3 twist3 0.342
runx2b runt-related transcription factor 2b 0.341
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.339
robo3 roundabout homolog 3 0.333
mbp myelin basic protein 0.329
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.328
tyr tyrosinase 0.316
dbx1a developing brain homeobox 1a 0.301
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.301
ptf1a pancreas specific transcription factor, 1a 0.297
csnk1a1 casein kinase 1, alpha 1 0.296
krit1 KRIT1, ankyrin repeat containing 0.288
nkx2.2a NK2 transcription factor related 2a 0.288
anxa1b annexin A1b 0.274
cdh1 cadherin 1, epithelial 0.271
pitx3 paired-like homeodomain transcription factor 3 0.269
wnt4a wingless-type MMTV integration site family, member 4a 0.267
col1a2 collagen, type I, alpha 2 0.258
gata3 GATA-binding protein 3 0.254
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.253
wnt9b wingless-type MMTV integration site family, member 9B 0.240
atoh1a atonal homolog 1a 0.235
vcana versican a 0.234
pitx2 paired-like homeodomain transcription factor 2 0.223
sox11b SRY-box containing gene 11b 0.221
gata4 GATA-binding protein 4 0.221
sfrp1a secreted frizzled-related protein 1a 0.217
tbx5a T-box 5a 0.210
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.210
fbn2b fibrillin 2b 0.205
gsc goosecoid 0.205
nanos3 nanos homolog 3 0.205
tagln2 transgelin 2 0.204
dld deltaD 0.197
spns2 spinster homolog 2 (Drosophila) 0.190
dcn decorin 0.185
postn periostin, osteoblast specific factor 0.184
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.180
bmp1a bone morphogenetic protein 1a 0.179
id1 inhibitor of DNA binding 1 0.177
foxg1a forkhead box G1a 0.177
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.176
ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.172
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.171
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.171
junb jun B proto-oncogene 0.170
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.169
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.169
tnc tenascin C 0.169
foxn4 forkhead box N4 0.169
ctsk cathepsin K 0.168
fn1b fibronectin 1b 0.167
hdac1 histone deacetylase 1 0.167
ripk2 receptor-interacting serine-threonine kinase 2 0.166
fzd7a frizzled homolog 7a 0.164
zgc:92533 zgc:92533 0.161
pkp1 plakophilin 1 0.161
krt4 keratin 4 0.160
grhl2b grainyhead-like 2b (Drosophila) 0.157
tgfb1a transforming growth factor, beta 1a 0.154
alpi alkaline phosphatase, intestinal 0.152
nrg2a neuregulin 2a 0.152
lhx2b LIM homeobox 2b 0.150
tll1 tolloid-like 1 0.150
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.148
odz4 odd Oz/ten-m homolog 4 0.145
crybb1 crystallin, beta B1 0.143
col19a1 collagen, type XIX, alpha 1 0.143
gli2a GLI-Kruppel family member GLI2a 0.142
hnf1ba HNF1 homeobox Ba 0.142
cx39.9 connexin 39.9 0.142
neurog1 neurogenin 1 0.142
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Drosophila melanogaster
Name Description Probability Func Analog Organism
wg wingless 0.011
gsb gooseberry 0.011
Abd-B Abdominal B 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.931
Fst follistatin 0.768
Fgfr2 fibroblast growth factor receptor 2 0.762
Ctnnb1 catenin (cadherin associated protein), beta 1 0.733
Mapk14 mitogen-activated protein kinase 14 0.717
Rxra retinoid X receptor alpha 0.694
Trp63 transformation related protein 63 0.658
Egfr epidermal growth factor receptor 0.643
Krt17 keratin 17 0.641
Shh sonic hedgehog 0.628
Tbx1 T-box 1 0.549
Smad3 MAD homolog 3 (Drosophila) 0.547
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.529
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.515
Rarg retinoic acid receptor, gamma 0.500
Foxn1 forkhead box N1 0.457
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.395
Gopc golgi associated PDZ and coiled-coil motif containing 0.381
Ret ret proto-oncogene 0.365
Ptgs2 prostaglandin-endoperoxide synthase 2 0.356
Fgf10 fibroblast growth factor 10 0.322
Pax3 paired box gene 3 0.318
Pitx2 paired-like homeodomain transcription factor 2 0.315
Gli3 GLI-Kruppel family member GLI3 0.315
Krt6a keratin 6A 0.300
Hes1 hairy and enhancer of split 1 (Drosophila) 0.298
Grb10 growth factor receptor bound protein 10 0.287
Fgf8 fibroblast growth factor 8 0.274
Mybph myosin binding protein H 0.258
Jarid2 jumonji, AT rich interactive domain 2 0.250
Pax1 paired box gene 1 0.248
Ntf3 neurotrophin 3 0.242
Foxc1 forkhead box C1 0.231
Wnt3a wingless-related MMTV integration site 3A 0.223
Krt5 keratin 5 0.218
Krt14 keratin 14 0.213
Sox2 SRY-box containing gene 2 0.205
Smad6 MAD homolog 6 (Drosophila) 0.188
Ppl periplakin 0.188
Efnb2 ephrin B2 0.186
Krt35 keratin 35 0.185
Ptk7 PTK7 protein tyrosine kinase 7 0.182
Krt72-ps keratin 72, pseudogene 0.179
Gpc3 glypican 3 0.176
Fzd1 frizzled homolog 1 (Drosophila) 0.170
Atoh7 atonal homolog 7 (Drosophila) 0.170
Nos3 nitric oxide synthase 3, endothelial cell 0.169
Pax7 paired box gene 7 0.167
Psapl1 prosaposin-like 1 0.167
Tgfb2 transforming growth factor, beta 2 0.164
Pkp1 plakophilin 1 0.158
Sfn stratifin 0.147
Tbx3 T-box 3 0.140
Wnt5a wingless-related MMTV integration site 5A 0.137
Fbln1 fibulin 1 0.136
Barx2 BarH-like homeobox 2 0.136
Wnt7a wingless-related MMTV integration site 7A 0.133
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.130
Efna4 ephrin A4 0.125
Ctsd cathepsin D 0.122
Neurog2 neurogenin 2 0.121
Isl1 ISL1 transcription factor, LIM/homeodomain 0.118
Pax2 paired box gene 2 0.118
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.116
Shc1 src homology 2 domain-containing transforming protein C1 0.115
Vegfa vascular endothelial growth factor A 0.114
Krtdap keratinocyte differentiation associated protein 0.113
Hspa9 heat shock protein 9 0.112
Nodal nodal 0.112
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.111
Hoxd13 homeobox D13 0.110
Cldn3 claudin 3 0.108
Gdnf glial cell line derived neurotrophic factor 0.108
Sox4 SRY-box containing gene 4 0.106
Tcfap2c transcription factor AP-2, gamma 0.106
Hdac1 histone deacetylase 1 0.103
Hoxa2 homeobox A2 0.103
Esr1 estrogen receptor 1 (alpha) 0.103
Sprr1a small proline-rich protein 1A 0.101
Lrp2 low density lipoprotein receptor-related protein 2 0.101
Emx1 empty spiracles homolog 1 (Drosophila) 0.100
Tgfa transforming growth factor alpha 0.100
Gli2 GLI-Kruppel family member GLI2 0.100
Pax8 paired box gene 8 0.098
Krt33b keratin 33B 0.096
Apoe apolipoprotein E 0.092
Pax6 paired box gene 6 0.091
Mta2 metastasis-associated gene family, member 2 0.089
Myf5 myogenic factor 5 0.088
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.087
Fgf5 fibroblast growth factor 5 0.086
Ptch2 patched homolog 2 0.086
Sfrp2 secreted frizzled-related protein 2 0.086
Phox2b paired-like homeobox 2b 0.085
Bmp4 bone morphogenetic protein 4 0.085
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.085
Twist1 twist homolog 1 (Drosophila) 0.084
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.084
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.084
Sox9 SRY-box containing gene 9 0.082
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Rattus norvegicus
Name Description Probability Func Analog Organism
Anxa2 annexin A2 0.535
Nefm neurofilament, medium polypeptide 0.408
Aebp1 AE binding protein 1 0.372
Nefl neurofilament, light polypeptide 0.323
Fgfr2 fibroblast growth factor receptor 2 0.275
Krt18 keratin 18 0.246
Hmox1 heme oxygenase (decycling) 1 0.211
Anxa5 annexin A5 0.203
Igfbp5 insulin-like growth factor binding protein 5 0.177
Pzp pregnancy-zone protein 0.161
Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi 0.141
Aldoa aldolase A, fructose-bisphosphate 0.141
Runx1 runt-related transcription factor 1 0.134
Emp1 epithelial membrane protein 1 0.132
Smad7 SMAD family member 7 0.130
Anxa1 annexin A1 0.129
Tgm1 transglutaminase 1, K polypeptide 0.122
Pkm2 pyruvate kinase, muscle 0.120
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.119
Timp3 TIMP metallopeptidase inhibitor 3 0.112
Gja1 gap junction protein, alpha 1 0.112
Nbl1 neuroblastoma, suppression of tumorigenicity 1 0.111
S1pr2 sphingosine-1-phosphate receptor 2 0.109
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.105
Ccl2 chemokine (C-C motif) ligand 2 0.098
Plau plasminogen activator, urokinase 0.098
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.097
Spp1 secreted phosphoprotein 1 0.096
Mgp matrix Gla protein 0.096
Icam1 intercellular adhesion molecule 1 0.093
Cd44 Cd44 molecule 0.091
Acta2 smooth muscle alpha-actin 0.091
Thbd thrombomodulin 0.091
Cd9 CD9 molecule 0.090
Fgfr1 Fibroblast growth factor receptor 1 0.086
Col12a1 collagen, type XII, alpha 1 0.084
Hspb1 heat shock protein 1 0.083
Nab1 Ngfi-A binding protein 1 0.082
Eln elastin 0.078
Socs3 suppressor of cytokine signaling 3 0.077
Olfml2b olfactomedin-like 2B 0.074
Prrx1 paired related homeobox 1 0.074
Cd37 CD37 molecule 0.073
Nefh neurofilament, heavy polypeptide 0.073
Cd14 CD14 molecule 0.072
Tgfbr2 transforming growth factor, beta receptor II 0.069
Stxbp1 syntaxin binding protein 1 0.067
Ldha lactate dehydrogenase A 0.065
Ednrb endothelin receptor type B 0.064
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.063
Sod3 superoxide dismutase 3, extracellular 0.063
Col3a1 collagen, type III, alpha 1 0.060
Myh9 myosin, heavy chain 9, non-muscle 0.059
Tgfb1 transforming growth factor, beta 1 0.058
Bgn biglycan 0.057
Pecam1 platelet/endothelial cell adhesion molecule 1 0.056
Hpx hemopexin 0.056
Lgals3 lectin, galactoside-binding, soluble, 3 0.056
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.055
RT1-M5 RT1 class Ib, locus M5 0.054
Phkg1 phosphorylase kinase, gamma 1 0.054
Prkch protein kinase C, eta 0.053
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.053
Lamc1 laminin, gamma 1 0.052
Kif2c kinesin family member 2C 0.051
Pdpn podoplanin 0.051
Ccdc80 coiled-coil domain containing 80 0.051
Tgfb3 transforming growth factor, beta 3 0.050
Notch2 Notch homolog 2 (Drosophila) 0.049
Jak2 Janus kinase 2 0.049
Gja4 gap junction protein, alpha 4 0.049
Itgb4 integrin, beta 4 0.049
Pygm phosphorylase, glycogen, muscle 0.049
Jak1 Janus kinase 1 0.048
Irs1 insulin receptor substrate 1 0.047
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.047
Tagln transgelin 0.046
Soat1 sterol O-acyltransferase 1 0.046
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.045
Fn1 fibronectin 1 0.045
Ccr5 chemokine (C-C motif) receptor 5 0.044
Egr3 early growth response 3 0.044
Cdh6 cadherin 6 0.044
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.044
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.043
C2cd4d C2 calcium-dependent domain containing 4D 0.043
Calcb calcitonin-related polypeptide, beta 0.042
Pax8 paired box 8 0.041
Ptprc protein tyrosine phosphatase, receptor type, C 0.041
Flt1 FMS-related tyrosine kinase 1 0.040
Lcn2 lipocalin 2 0.040
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.040
Smad1 SMAD family member 1 0.040
Rrm2 ribonucleotide reductase M2 0.039
Dusp7 dual specificity phosphatase 7 0.039
Ednra endothelin receptor type A 0.038
Olr737 olfactory receptor 737 0.038
Tcp11 t-complex protein 11 0.038
Mfap4 microfibrillar-associated protein 4 0.038
Casq1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.038
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism