The network for 'regulation of ligase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of ligase activity

Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.

Homo sapiens
Name Description Probability Func Analog Organism
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.996
RNF2 ring finger protein 2 0.990
RING1 ring finger protein 1 0.985
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.946
SMAD7 SMAD family member 7 0.911
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.900
SMAD1 SMAD family member 1 0.856
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.843
CBX7 chromobox homolog 7 0.729
USP11 ubiquitin specific peptidase 11 0.679
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.656
RNF11 ring finger protein 11 0.644
SIRT2 sirtuin 2 0.624
MAGEA3 melanoma antigen family A, 3 0.603
SPRY4 sprouty homolog 4 (Drosophila) 0.601
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.542
ARIH2 ariadne homolog 2 (Drosophila) 0.505
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.468
CBX8 chromobox homolog 8 0.425
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.423
MAGEA12 melanoma antigen family A, 12 0.414
PSEN1 presenilin 1 0.413
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.388
NAP1L5 nucleosome assembly protein 1-like 5 0.385
CTAG1B cancer/testis antigen 1B 0.375
TEKT4 tektin 4 0.366
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.362
CUL2 cullin 2 0.354
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.338
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 0.326
SMAD2 SMAD family member 2 0.323
MAGEA6 melanoma antigen family A, 6 0.308
SMAD5 SMAD family member 5 0.293
YY1 YY1 transcription factor 0.250
RYBP RING1 and YY1 binding protein 0.249
FLNB filamin B, beta 0.238
EID2 EP300 interacting inhibitor of differentiation 2 0.220
FHL1 four and a half LIM domains 1 0.216
CBX6 chromobox homolog 6 0.204
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.169
VHL von Hippel-Lindau tumor suppressor 0.155
GCLC glutamate-cysteine ligase, catalytic subunit 0.149
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.149
CDK2 cyclin-dependent kinase 2 0.145
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 0.140
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 0.133
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.127
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.124
PML promyelocytic leukemia 0.121
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.120
ANAPC11 anaphase promoting complex subunit 11 0.119
EID2B EP300 interacting inhibitor of differentiation 2B 0.115
MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E) 0.110
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.106
SUFU suppressor of fused homolog (Drosophila) 0.105
FHL2 four and a half LIM domains 2 0.102
CCNB1 cyclin B1 0.100
CFL1 cofilin 1 (non-muscle) 0.098
KAT5 K(lysine) acetyltransferase 5 0.097
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.091
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 0.091
PIAS4 protein inhibitor of activated STAT, 4 0.090
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.088
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.087
BCOR BCL6 corepressor 0.087
CBX4 chromobox homolog 4 0.085
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.082
PJA1 praja ring finger 1 0.082
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.082
CKS1B CDC28 protein kinase regulatory subunit 1B 0.081
HSF1 heat shock transcription factor 1 0.078
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.075
AR androgen receptor 0.075
GSK3B glycogen synthase kinase 3 beta 0.074
APLF aprataxin and PNKP like factor 0.074
SFN stratifin 0.073
SOD1 superoxide dismutase 1, soluble 0.072
CLSPN claspin 0.071
TUBB2C tubulin, beta 2C 0.070
EID3 EP300 interacting inhibitor of differentiation 3 0.069
EID1 EP300 interacting inhibitor of differentiation 1 0.067
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.067
PRNP prion protein 0.066
ANKRD52 ankyrin repeat domain 52 0.065
MAGEA5 melanoma antigen family A, 5 0.062
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.062
CCDC6 coiled-coil domain containing 6 0.061
ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) 0.060
PSEN2 presenilin 2 (Alzheimer disease 4) 0.059
FBXO5 F-box protein 5 0.057
TP53 tumor protein p53 0.056
FBXL15 F-box and leucine-rich repeat protein 15 0.056
BST2 bone marrow stromal cell antigen 2 0.054
SNIP1 Smad nuclear interacting protein 1 0.053
MAGEA4 melanoma antigen family A, 4 0.052
YAF2 YY1 associated factor 2 0.052
CCNA2 cyclin A2 0.052
TRIM69 tripartite motif containing 69 0.051
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.051
HERC2 hect domain and RLD 2 0.046
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
atn-1 Protein ATN-1 0.015
K09G1.1 Protein K09G1.1 0.013
CELE_R102.2 Protein R102.2 0.010
gas-1 Protein GAS-1 0.010
sucg-1 Protein SUCG-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.916
Notch1 Notch gene homolog 1 (Drosophila) 0.626
Atf4 activating transcription factor 4 0.602
Lrrk2 leucine-rich repeat kinase 2 0.602
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.540
Psen1 presenilin 1 0.536
Axin1 axin 1 0.427
Ctnnb1 catenin (cadherin associated protein), beta 1 0.338
Gclc glutamate-cysteine ligase, catalytic subunit 0.208
Cdca8 cell division cycle associated 8 0.174
Gsk3b glycogen synthase kinase 3 beta 0.159
Apc adenomatosis polyposis coli 0.159
Smad7 MAD homolog 7 (Drosophila) 0.144
Cdk2 cyclin-dependent kinase 2 0.135
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.115
Rnf111 ring finger 111 0.107
Notch2 Notch gene homolog 2 (Drosophila) 0.094
Ccnb1 cyclin B1 0.083
Traf6 TNF receptor-associated factor 6 0.080
Rpgrip1l Rpgrip1-like 0.074
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.074
Ncstn nicastrin 0.069
Dohh deoxyhypusine hydroxylase/monooxygenase 0.067
Abl2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) 0.066
Cdk1 cyclin-dependent kinase 1 0.051
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.050
Mybl2 myeloblastosis oncogene-like 2 0.047
Dok1 docking protein 1 0.046
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.044
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.043
Irf6 interferon regulatory factor 6 0.035
Mdm2 transformed mouse 3T3 cell double minute 2 0.034
Kif22 kinesin family member 22 0.034
Smad4 MAD homolog 4 (Drosophila) 0.032
Skp1a S-phase kinase-associated protein 1A 0.032
Ccne1 cyclin E1 0.031
Ccnb2 cyclin B2 0.029
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.028
Casp8 caspase 8 0.027
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.027
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.026
Sfn stratifin 0.025
Tbcb tubulin folding cofactor B 0.025
Cops6 COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) 0.024
Ptch1 patched homolog 1 0.023
Ube2c ubiquitin-conjugating enzyme E2C 0.023
Smurf1 SMAD specific E3 ubiquitin protein ligase 1 0.023
Ccna2 cyclin A2 0.022
Skil SKI-like 0.021
Traf2 TNF receptor-associated factor 2 0.020
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.020
Sgol2 shugoshin-like 2 (S. pombe) 0.020
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.020
Aph1a anterior pharynx defective 1a homolog (C. elegans) 0.019
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.019
Mbd3 methyl-CpG binding domain protein 3 0.019
Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like 0.018
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.018
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.018
Zbtb7a zinc finger and BTB domain containing 7a 0.017
Aurka aurora kinase A 0.017
Birc5 baculoviral IAP repeat-containing 5 0.016
Rnf2 ring finger protein 2 0.015
Map2k3 mitogen-activated protein kinase kinase 3 0.015
Akt1 thymoma viral proto-oncogene 1 0.014
Dok2 docking protein 2 0.014
Lef1 lymphoid enhancer binding factor 1 0.014
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.014
Gtse1 G two S phase expressed protein 1 0.013
Rfwd2 ring finger and WD repeat domain 2 0.013
Ube2v2 ubiquitin-conjugating enzyme E2 variant 2 0.013
Runx1 runt related transcription factor 1 0.013
Kif20a kinesin family member 20A 0.013
Ripk4 receptor-interacting serine-threonine kinase 4 0.013
Smad6 MAD homolog 6 (Drosophila) 0.013
Psen2 presenilin 2 0.012
Efnb2 ephrin B2 0.012
Drap1 Dr1 associated protein 1 (negative cofactor 2 alpha) 0.012
Prkce protein kinase C, epsilon 0.011
Acot7 acyl-CoA thioesterase 7 0.011
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.011
Ric8 resistance to inhibitors of cholinesterase 8 homolog (C. elegans) 0.011
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.010
Trp73 transformation related protein 73 0.010
Dll1 delta-like 1 (Drosophila) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.015
Dad1 defender against cell death 1 0.015
Pttg1 pituitary tumor-transforming 1 0.014
Dynlrb1 dynein light chain roadblock-type 1 0.013
Kifc1 kinesin family member C1 0.012
March5 membrane-associated ring finger (C3HC4) 5 0.012
Top2a topoisomerase (DNA) II alpha 0.012
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.011
Tceb1 transcription elongation factor B (SIII), polypeptide 1 0.011
Ubl5 ubiquitin-like 5 0.011
Dynll1 dynein light chain LC8-type 1 0.011
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC20 Cdc20p 0.013
BMH1 Bmh1p 0.012