The network for 'positive regulation of leukocyte proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of leukocyte proliferation

Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.

Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.998
LCK lymphocyte-specific protein tyrosine kinase 0.993
GRB2 growth factor receptor-bound protein 2 0.992
CD80 CD80 molecule 0.991
FGFR2 fibroblast growth factor receptor 2 0.985
BCL2 B-cell CLL/lymphoma 2 0.981
ICAM1 intercellular adhesion molecule 1 0.979
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.973
IL1B interleukin 1, beta 0.963
TRAF1 TNF receptor-associated factor 1 0.953
SYK spleen tyrosine kinase 0.920
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.904
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.901
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.890
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.873
SOCS3 suppressor of cytokine signaling 3 0.869
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.847
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.842
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.811
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.797
BCL2L1 BCL2-like 1 0.761
CCL4 chemokine (C-C motif) ligand 4 0.748
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.734
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.712
CD86 CD86 molecule 0.712
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.710
HLA-DRA major histocompatibility complex, class II, DR alpha 0.705
IL2RG interleukin 2 receptor, gamma 0.689
BTN3A2 butyrophilin, subfamily 3, member A2 0.683
CXCL9 chemokine (C-X-C motif) ligand 9 0.668
BTN3A3 butyrophilin, subfamily 3, member A3 0.663
IL2RB interleukin 2 receptor, beta 0.632
CCR5 chemokine (C-C motif) receptor 5 0.620
IL8 interleukin 8 0.589
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.561
PTPRC protein tyrosine phosphatase, receptor type, C 0.555
BID BH3 interacting domain death agonist 0.554
IRAK1 interleukin-1 receptor-associated kinase 1 0.551
PLCG1 phospholipase C, gamma 1 0.544
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.538
CCR7 chemokine (C-C motif) receptor 7 0.535
BTN3A1 butyrophilin, subfamily 3, member A1 0.532
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.499
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.498
CD247 CD247 molecule 0.495
IL1R1 interleukin 1 receptor, type I 0.472
VAV1 vav 1 guanine nucleotide exchange factor 0.471
LAT linker for activation of T cells 0.449
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.447
JAK1 Janus kinase 1 0.420
IL10 interleukin 10 0.417
IFNG interferon, gamma 0.414
CCL20 chemokine (C-C motif) ligand 20 0.411
CXCL10 chemokine (C-X-C motif) ligand 10 0.402
BAX BCL2-associated X protein 0.385
HLA-DMA major histocompatibility complex, class II, DM alpha 0.377
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.375
CCL2 chemokine (C-C motif) ligand 2 0.370
CXCL2 chemokine (C-X-C motif) ligand 2 0.367
NCOA3 nuclear receptor coactivator 3 0.366
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.364
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.355
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.352
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.352
IL6 interleukin 6 (interferon, beta 2) 0.350
CCL22 chemokine (C-C motif) ligand 22 0.336
GRB7 growth factor receptor-bound protein 7 0.334
IRF4 interferon regulatory factor 4 0.330
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.309
TAL1 T-cell acute lymphocytic leukemia 1 0.290
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.288
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.282
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.281
BCL2A1 BCL2-related protein A1 0.274
SH3BP2 SH3-domain binding protein 2 0.271
STAT4 signal transducer and activator of transcription 4 0.270
SLA Src-like-adaptor 0.269
TLR2 toll-like receptor 2 0.267
HDAC9 histone deacetylase 9 0.261
CXCR6 chemokine (C-X-C motif) receptor 6 0.251
FGF10 fibroblast growth factor 10 0.239
IRAK2 interleukin-1 receptor-associated kinase 2 0.232
FGFR1 fibroblast growth factor receptor 1 0.227
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.227
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.225
LIF leukemia inhibitory factor (cholinergic differentiation factor) 0.218
BTN2A2 butyrophilin, subfamily 2, member A2 0.215
CCR1 chemokine (C-C motif) receptor 1 0.213
FGF1 fibroblast growth factor 1 (acidic) 0.212
SIGLEC7 sialic acid binding Ig-like lectin 7 0.210
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.207
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.204
CCL5 chemokine (C-C motif) ligand 5 0.200
GRAP2 GRB2-related adaptor protein 2 0.196
IL7R interleukin 7 receptor 0.193
INSR insulin receptor 0.190
MEFV Mediterranean fever 0.189
CCL8 chemokine (C-C motif) ligand 8 0.189
IGF2 insulin-like growth factor 2 (somatomedin A) 0.186
TNF tumor necrosis factor 0.184
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Lyz2 lysozyme 2 1.000
Tnf tumor necrosis factor 0.997
Icos inducible T-cell co-stimulator 0.987
Cd28 CD28 antigen 0.987
Tlr4 toll-like receptor 4 0.980
Lta lymphotoxin A 0.977
Ifng interferon gamma 0.974
Ikzf1 IKAROS family zinc finger 1 0.970
Lepr leptin receptor 0.968
Cd40 CD40 antigen 0.966
Igh immunoglobulin heavy chain complex 0.965
Ccl2 chemokine (C-C motif) ligand 2 0.945
Myd88 myeloid differentiation primary response gene 88 0.938
Tgfb1 transforming growth factor, beta 1 0.937
Ccr2 chemokine (C-C motif) receptor 2 0.934
Tlr2 toll-like receptor 2 0.934
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.925
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.924
Il10 interleukin 10 0.886
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.875
Il4 interleukin 4 0.870
Ltb lymphotoxin B 0.868
Nos3 nitric oxide synthase 3, endothelial cell 0.864
Pdcd1 programmed cell death 1 0.856
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.840
Rybp RING1 and YY1 binding protein 0.834
Ccr7 chemokine (C-C motif) receptor 7 0.830
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.828
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.827
Stat3 signal transducer and activator of transcription 3 0.806
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.802
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.798
Socs1 suppressor of cytokine signaling 1 0.794
Stat5b signal transducer and activator of transcription 5B 0.777
Fas Fas (TNF receptor superfamily member 6) 0.767
Nos2 nitric oxide synthase 2, inducible 0.742
Irf4 interferon regulatory factor 4 0.735
Gli2 GLI-Kruppel family member GLI2 0.720
Batf basic leucine zipper transcription factor, ATF-like 0.711
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.704
Fasl Fas ligand (TNF superfamily, member 6) 0.694
Sh2d2a SH2 domain protein 2A 0.685
Il2rb interleukin 2 receptor, beta chain 0.673
Rarg retinoic acid receptor, gamma 0.668
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.660
Ccr1 chemokine (C-C motif) receptor 1 0.651
Ccl3 chemokine (C-C motif) ligand 3 0.642
Pten phosphatase and tensin homolog 0.638
Cd6 CD6 antigen 0.630
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.604
Btk Bruton agammaglobulinemia tyrosine kinase 0.596
Sfpi1 SFFV proviral integration 1 0.592
Col1a1 collagen, type I, alpha 1 0.583
Cxcl13 chemokine (C-X-C motif) ligand 13 0.577
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.574
Fgfr2 fibroblast growth factor receptor 2 0.571
Pax2 paired box gene 2 0.565
Cxcr5 chemokine (C-X-C motif) receptor 5 0.553
Cd44 CD44 antigen 0.552
Sykb spleen tyrosine kinase 0.551
Pparg peroxisome proliferator activated receptor gamma 0.551
Vhl von Hippel-Lindau tumor suppressor 0.547
Efnb2 ephrin B2 0.527
Cd80 CD80 antigen 0.521
Il1r1 interleukin 1 receptor, type I 0.516
Il2rg interleukin 2 receptor, gamma chain 0.505
Clec4n C-type lectin domain family 4, member n 0.502
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.496
Lag3 lymphocyte-activation gene 3 0.495
Cd4 CD4 antigen 0.493
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.491
Traf2 TNF receptor-associated factor 2 0.473
Drd2 dopamine receptor D2 0.469
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.464
Mmp9 matrix metallopeptidase 9 0.463
Ccl4 chemokine (C-C motif) ligand 4 0.460
C3ar1 complement component 3a receptor 1 0.458
Stat5a signal transducer and activator of transcription 5A 0.445
Ccl7 chemokine (C-C motif) ligand 7 0.434
Gli3 GLI-Kruppel family member GLI3 0.432
Ccl12 chemokine (C-C motif) ligand 12 0.430
Bcl2 B-cell leukemia/lymphoma 2 0.417
Nog noggin 0.417
Rel reticuloendotheliosis oncogene 0.415
Itgax integrin alpha X 0.413
Gpr132 G protein-coupled receptor 132 0.410
Fyn Fyn proto-oncogene 0.389
Card11 caspase recruitment domain family, member 11 0.371
Runx1 runt related transcription factor 1 0.371
Pax8 paired box gene 8 0.370
Foxn1 forkhead box N1 0.361
Casp1 caspase 1 0.357
Casp8 caspase 8 0.355
Bcl3 B-cell leukemia/lymphoma 3 0.349
Ephb2 Eph receptor B2 0.347
Snai1 snail homolog 1 (Drosophila) 0.345
Tbx21 T-box 21 0.341
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.338
Irf8 interferon regulatory factor 8 0.337
Nos1 nitric oxide synthase 1, neuronal 0.332
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Ba RT1 class II, locus Ba 0.319
Ptprc protein tyrosine phosphatase, receptor type, C 0.178
Cd247 Cd247 molecule 0.158
Itgb7 integrin, beta 7 0.147
Lcp1 lymphocyte cytosolic protein 1 0.127
Cd37 CD37 molecule 0.126
Srd5a2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.094
Casp1 caspase 1 0.090
Kl Klotho 0.084
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.082
Il10 interleukin 10 0.077
Ccr5 chemokine (C-C motif) receptor 5 0.072
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.069
Cd53 Cd53 molecule 0.069
Hck hemopoietic cell kinase 0.067
Cd5 Cd5 molecule 0.058
Reg3b regenerating islet-derived 3 beta 0.056
Prol1 proline rich, lacrimal 1 0.053
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.052
Gzmk granzyme K 0.051
RT1-Db1 RT1 class II, locus Db1 0.049
Cd2 Cd2 molecule 0.048
Spn sialophorin 0.045
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.044
Zbp1 Z-DNA binding protein 1 0.044
Scn11a sodium channel, voltage-gated, type XI, alpha 0.043
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.043
Prpg1 proline-rich proteoglycan 1 0.042
Cfp complement factor properdin 0.042
Il1rl1 interleukin 1 receptor-like 1 0.039
Nkg7 natural killer cell group 7 sequence 0.038
Napsa napsin A aspartic peptidase 0.035
Chat choline acetyltransferase 0.034
Olr1078 olfactory receptor 1078 0.033
Gfra2 GDNF family receptor alpha 2 0.033
Il1r1 interleukin 1 receptor, type I 0.031
Il7r interleukin 7 receptor 0.031
Egr3 early growth response 3 0.030
Itgad integrin, alpha D 0.030
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.030
Hpgds hematopoietic prostaglandin D synthase 0.030
Il1b interleukin 1 beta 0.029
Ugt8 UDP glycosyltransferase 8 0.029
Prl8a9 prolactin family 8, subfamily a, member 9 0.029
Col10a1 collagen, type X, alpha 1 0.028
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.028
Teddm1 transmembrane epididymal protein 1 0.028
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.028
LOC24906 RoBo-1 0.027
Il4 interleukin 4 0.026
Serpinb7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 0.025
Inpp5d inositol polyphosphate-5-phosphatase D 0.025
Mmp10 matrix metallopeptidase 10 0.024
Ly86 lymphocyte antigen 86 0.024
Cxcl13 chemokine (C-X-C motif) ligand 13 0.023
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.023
Myh3 myosin, heavy chain 3, skeletal muscle, embryonic 0.023
Csn1s1 casein alpha s1 0.022
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.022
Tas2r123 taste receptor, type 2, member 123 0.022
Btc betacellulin 0.021
Svs1 seminal vesicle secretory protein 1 0.021
Prlh prolactin releasing hormone 0.021
Il6 interleukin 6 0.020
Il2rb interleukin 2 receptor, beta 0.020
Psp parotid secretory protein 0.020
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.020
Igsf6 immunoglobulin superfamily, member 6 0.020
Dnase1l3 deoxyribonuclease 1-like 3 0.020
Arl5c ADP-ribosylation factor-like 5C 0.020
Lcp2 lymphocyte cytosolic protein 2 0.019
Plin perilipin 0.019
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.019
Ccl5 chemokine (C-C motif) ligand 5 0.019
Syt8 synaptotagmin VIII 0.019
Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult 0.019
Calcr calcitonin receptor 0.019
Olr1500 olfactory receptor 1500 0.019
Tas2r126 taste receptor, type 2, member 126 0.019
Ret ret proto-oncogene 0.019
Mmp3 matrix metallopeptidase 3 0.019
Mobp myelin-associated oligodendrocyte basic protein 0.019
Btnl8 butyrophilin-like 8 0.019
Trh thyrotropin releasing hormone 0.019
Il6st interleukin 6 signal transducer 0.018
Gabarapl2 GABA(A) receptor-associated protein like 2 0.018
Mca32 mast cell antigen 32 0.018
Vip vasoactive intestinal peptide 0.018
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.018
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.018
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.018
Laptm5 lysosomal protein transmembrane 5 0.017
Nat1 N-acetyltransferase 1 0.017
Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) 0.017
Aldh6a1 aldehyde dehydrogenase 6 family, member A1 0.017
Slfn2 schlafen 2 0.017
Icos inducible T-cell co-stimulator 0.017
Il18 interleukin 18 0.017
Bin2 bridging integrator 2 0.017
Il16 interleukin 16 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism